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Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction arimoclomol和独立于热休克蛋白诱导的I类组蛋白去乙酰化酶抑制剂逆转FUSR521G肌萎缩侧索硬化小鼠的认知缺陷 Pelaez, Mari Carmen; Fiore, Frederic; Larochelle, Nancy; Dabbaghizadeh, Afrooz; Comaduran, Mario Fernandez; Arbour, Danielle; Minotti, Sandra; Marcadet, Laetitia; Semaan, Martine; Robitaille, Richard; Nalbantoglu, Josephine N.; Sephton, Chantelle F.; Durham, Heather D. 分享 收藏
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS Comaduran, Mario Fernandez; Minotti, Sandra; Jacob-Tomas, Suleima; Rizwan, Javeria; Larochelle, Nancy; Robitaille, Richard; Sephton, Chantelle F.; Vera, Maria; Nalbantoglu, Josephine N.; Durham, Heather D. 分享 收藏
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Neurofilaments: neurobiological foundations for biomarker applications Gafson, Arie R.; Barthelemy, Nicolas R.; Bomont, Pascale; Carare, Roxana O.; Durham, Heather D.; Julien, Jean-Pierre; Kuhle, Jens; Leppert, David; Nixon, Ralph A.; Weller, Roy O.; Zetterberg, Henrik; Matthews, Paul M. 分享 收藏
Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models Kuta, Rachel; Larochelle, Nancy; Fernandez, Mario; Pal, Arun; Minotti, Sandra; Tibshirani, Michael; St. Louis, Kyle; Gentil, Benoit J.; Nalbantoglu, Josephine N.; Hermann, Andreas; Durham, Heather D. 分享 收藏
Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics 在共济失调ARSACS中突变的Sacsin调节中间丝的组装和动力学 Gentil, Benoit J.; Gia-Thanh Lai; Menade, Marie; Lariviere, Roxanne; Minotti, Sandra; Gehring, Kalle; Chapple, J. -Paul; Brais, Bernard; Durham, Heather D. 分享 收藏
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Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis Tibshirani, Michael; Zhao, Beibei; Gentil, Benoit J.; Minotti, Sandra; Marques, Christine; Keith, Julia; Rogaeva, Ekaterina; Zinman, Lorne; Rouaux, Caroline; Robertson, Janice; Durham, Heather D. 分享 收藏
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Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin Duncan, Emma J.; Lariviere, Roxanne; Bradshaw, Teisha Y.; Longo, Fabiana; Sgarioto, Nicolas; Hayes, Matthew J.; Romano, Lisa E. L.; Nethisinghe, Suran; Giunti, Paola; Bruntraeger, Michaela B.; Durham, Heather D.; Brais, Bernard; Maltecca, Francesca; Gentil, Benoit J.; Chapple, J. Paul 分享 收藏
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Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay Lariviere, Roxanne; Gaudet, Rebecca; Gentil, Benoit J.; Girard, Martine; Conte, Talita Cristiane; Minotti, Sandra; Leclerc-Desaulniers, Kim; Gehring, Kalle; McKinney, R. Anne; Shoubridge, Eric A.; McPherson, Peter S.; Durham, Heather D.; Brais, Bernard 分享 收藏
A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo 新型小分子HSP90抑制剂NXD30001在培养和体内的神经组织中差异诱导热休克蛋白 Cha, Jieun R. C.; St Louis, Kyle J. H.; Tradewell, Miranda L.; Gentil, Benoit J.; Minotti, Sandra; Jaffer, Zahara M.; Chen, Ruihong; Rubenstein, Allan E.; Durham, Heather D. 分享 收藏
Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S- thiolation Auclair, Jared R.; Salisbury, Joseph P.; Johnson, Joshua L.; Petsko, Gregory A.; Ringe, Dagmar; Bosco, Daryl A.; Agar, Nathalie Y. R.; Santagata, Sandro; Durham, Heather D.; Agar, Jeffrey N. 分享 收藏
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