未登录Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes突变IDH1与NPM1c或FLT3ITD协同作用,驱动不同的髓系疾病和分子结局。
Sakamoto, Takashi; Leca, Julie; Zhang, Xin; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Hendrikse, Liam D.; Zhou, Wenjing; Berger, Thorsten; Fortin, Jerome; Chan, Steven M.; Chiang, Ming-Feng; Inoue, Satoshi; Li, Wanda Y.; Chu, Mandy F.; Duncan, Gordon S.; Wakeham, Andrew; Lemonnier, Francois; Tobin, Chantal; Mcwilliam, Ryan; Colonna, Isabelle; Bontoux, Christophe; Jafari, Soode Moghadas; Bowman, Robert L.; Nicolay, Brandon; Ronseaux, Sebastien; Narayanaswamy, Rohini; Levine, Ross L.; Melnick, Ari M.; Mason, Christopher E.; Minden, Mark D.
分享
收藏
分享
收藏Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment
Roehlen, Natascha; Muller, Marion; Nehme, Zeina; Crouchet, Emilie; Juhling, Frank; Del Zompo, Fabio; Cherradi, Sara; Duong, Francois H. T.; Almeida, Nuno; Saviano, Antonio; Fernandez-Vaquero, Mirian; Riedl, Tobias; El Saghire, Houssein; Durand, Sarah C.; Ponsolles, Clara; Oudot, Marine A.; Martin, Romain; Brignon, Nicolas; Felli, Emanuele; Pessaux, Patrick; Lallement, Antonin; Davidson, Irwin; Bandiera, Simonetta; Thumann, Christine; Marchand, Patrice; Moll, Solange; Nicolay, Brandon; Bardeesy, Nabeel; Hoshida, Yujin; Heikenwaelder, Mathias; Iacone, Roberto; Toso, Alberto; Meyer, Markus; Elson, Greg; Schweighoffer, Tamas; Teixeira, Geoffrey; Zeisel, Mirjam B.; Laquerriere, Patrice; Lupberger, Joachim; Schuster, Catherine; Mailly, Laurent; Baumert, Thomas F.
分享
收藏Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells抑制突变型IDH1促进急性髓系白血病干细胞的循环
Gruber, Emily; So, Joan; Lewis, Alexander C.; Franich, Rheana; Cole, Rachel; Martelotto, Luciano G.; Rogers, Amy J.; Vidacs, Eva; Fraser, Peter; Stanley, Kym; Jones, Lisa; Trigos, Anna; Thio, Niko; Li, Jason; Nicolay, Brandon; Daigle, Scott; Tron, Adriana E.; Hyer, Marc L.; Shortt, Jake; Johnstone, Ricky W.; Kats, Lev M.
分享
收藏Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemiaEnasidenib诱导的分化促进IDH2-mutated急性髓系白血病对venetoclax的敏感性
Cathelin, Severine; Sharon, David; Subedi, Amit; Cojocari, Dan; Phillips, Darren C.; Leverson, Joel D.; MacBeth, Kyle J.; Nicolay, Brandon; Narayanaswamy, Rohini; Ronseaux, Sebastien; Liu, Guowen; Chan, Steven M.
分享
收藏Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses (vol 4, 977, 2021)
Rajasekaran, Swetha; Siddiqui, Jalal; Rakijas, Jessica; Nicolay, Brandon; Lin, Chenyu; Khan, Eshan; Patel, Rahi; Morris, Robert; Wyler, Emanuel; Boukhali, Myriam; Balasubramanyam, Jayashree; Ranjith Kumar, R.; Van Rechem, Capucine; Vogel, Christine; Elchuri, Sailaja V.; Landthaler, Markus; Obermayer, Benedikt; Haas, Wilhelm; Dyson, Nicholas; Miles, Wayne
分享
收藏Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
Rajasekaran, Swetha; Siddiqui, Jalal; Rakijas, Jessica; Nicolay, Brandon; Lin, Chenyu; Khan, Eshan; Patel, Rahi; Morris, Robert; Wyler, Emanuel; Boukhali, Myriam; Balasubramanyam, Jayashree; Ranjith Kumar, R.; Van Rechem, Capucine; Vogel, Christine; Elchuri, Sailaja V.; Landthaler, Markus; Obermayer, Benedikt; Haas, Wilhelm; Dyson, Nicholas; Miles, Wayne
分享
收藏E2F/Dp inactivation in fat body cells triggers systemic metabolic changes
Zappia, Maria Paula; Guarner, Ana; Kellie-Smith, Nadia; Rogers, Alice; Morris, Robert; Nicolay, Brandon; Boukhali, Myriam; Haas, Wilhelm; Dyson, Nicholas J.; Frolov, Maxim, V
分享
收藏Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression
Zhang, Meng; Aguilar, Angelo; Xu, Shilin; Huang, Liyue; Chinnaswamy, Krishnapriya; Sleger, Taryn; Wang, Bo; Gross, Stefan; Nicolay, Brandon N.; Ronseaux, Sebastien; Harvey, Kaitlin; Wang, Yu; McEachern, Donna; Kirchhoff, Paul D.; Liu, Zhaomin; Stuckey, Jeanne; Tron, Adriana E.; Liu, Tao; Wang, Shaomeng
分享
收藏Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion
Konteatis, Zenon; Travins, Jeremy; Gross, Stefan; Marjon, Katya; Barnett, Amelia; Mandley, Everton; Nicolay, Brandon; Nagaraja, Raj; Chen, Yue; Sun, Yabo; Liu, Zhixiao; Yu, Jie; Ye, Zhixiong; Jiang, Fan; Wei, Wentao; Fang, Cheng; Gao, Yi; Kalev, Peter; Hyer, Marc L.; DeLaBarre, Byron; Jin, Lei; Padyana, Anil K.; Dang, Lenny; Murtie, Joshua; Biller, Scott A.; Sui, Zhihua; Marks, Kevin M.
分享
收藏Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
Stuani, Lucille; Sabatier, Marie; Saland, Estelle; Cognet, Guillaume; Poupin, Nathalie; Bosc, Claudie; Castelli, Florence A.; Gales, Lara; Turtoi, Evgenia; Montersino, Camille; Farge, Thomas; Boet, Emeline; Broin, Nicolas; Larrue, Clement; Baran, Natalia; Cisse, Madi Y.; Conti, Marc; Loric, Sylvain; Kaoma, Tony; Hucteau, Alexis; Zavoriti, Aliki; Sahal, Ambrine; Mouchel, Pierre-Luc; Gotanegre, Mathilde; Cassan, Cedric; Fernando, Laurent; Wang, Feng; Hosseini, Mohsen; Chu-Van, Emeline; Le Cam, Laurent; Carroll, Martin; Selak, Mary A.; Vey, Norbert; Castellano, Remy; Fenaille, Francois; Turtoi, Andrei; Cazals, Guillaume; Bories, Pierre; Gibon, Yves; Nicolay, Brandon; Ronseaux, Sebastien; Marszalek, Joseph R.; Takahashi, Koichi; DiNardo, Courtney D.; Konopleva, Marina; Pancaldi, Vera; Collette, Yves; Bellvert, Floriant; Jourdan, Fabien; Linares, Laetitia K.; Recher, Christian; Portais, Jean-Charles; Sarry, Jean-Emmanuel
分享
收藏The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma
Wu, Meng-Ju; Shi, Lei; Dubrot, Juan; Hudson, Christine; Merritt, Joshua; Adil, Ramzi; Wu, Qibiao; Ronseaux, Sebastien; Narayanaswamy, Rohini; Manguso, Robert; Nicolay, Brandon; Bardeesy, Nabeel
分享
收藏Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML
Choe, Sung; Wang, Hongfang; DiNardo, Courtney D.; Stein, Eytan M.; de Botton, Stephane; Roboz, Gail J.; Altman, Jessica K.; Mims, Alice S.; Watts, Justin M.; Pollyea, Daniel A.; Fathi, Amir T.; Tallman, Martin S.; Kantarjian, Hagop M.; Stone, Richard M.; Quek, Lynn; Konteatis, Zenon; Dang, Lenny; Nicolay, Brandon; Nejad, Parham; Liu, Guowen; Zhang, Vickie; Liu, Hua; Goldwasser, Meredith; Liu, Wei; Marks, Kevin; Bowden, Chris; Biller, Scott A.; Attar, Eyal C.; Wu, Bin
分享
收藏Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma
Konteatis, Zenon; Artin, Erin; Nicolay, Brandon; Straley, Kimberly; Padyana, Anil K.; Jin, Lei; Chen, Yue; Narayaraswamy, Rohini; Tong, Shuilong; Wang, Feng; Zhou, Ding; Cui, Dawei; Cai, Zhenwei; Luo, Zhiyong; Fang, Cheng; Tang, Huachun; Lv, Xiaobing; Nagaraja, Raj; Yang, Hua; Su, Shin-San M.; Sui, Zhihua; Dang, Lenny; Yen, Katharine; Popovici-Muller, Janeta; Codega, Paolo; Campos, Carl; Mellinghoff, Ingo K.; Biller, Scott A.
分享
收藏Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy
Nelson, Barbara S.; Lin, Lin; Kremer, Daniel M.; Sousa, Cristovao M.; Cotta-Ramusino, Cecilia; Myers, Amy; Ramos, Johanna; Gao, Tina; Kovalenko, Ilya; Wilder-Romans, Kari; Dresser, Joseph; Davis, Mary; Lee, Ho-Joon; Nwosu, Zeribe C.; Campit, Scott; Mashadova, Oksana; Nicolay, Brandon N.; Tolstyka, Zachary P.; Halbrook, Christopher J.; Chandrasekaran, Sriram; Asara, John M.; Crawford, Howard C.; Cantley, Lewis C.; Kimmelman, Alec C.; Wahl, Daniel R.; Lyssiotis, Costas A.
分享
收藏
分享
收藏
分享
收藏Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma
Sahoo, Swagatika; Ravi Kumar, Ranjith Kumar; Nicolay, Brandon; Mohite, Omkar; Sivaraman, Karthikeyan; Khetan, Vikas; Rishi, Pukhraj; Ganesan, Suganeswari; Subramanyan, Krishnakumar; Raman, Karthik; Miles, Wayne; Elchuri, Sailaja V.
分享
收藏Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate癌代谢物 (R)-2-羟基戊二酸酯抑制抗肿瘤T细胞免疫
Bunse, Lukas; Pusch, Stefan; Bunse, Theresa; Sahm, Felix; Sanghvi, Khwab; Friedrich, Mirco; Alansary, Dalia; Sonner, Jana K.; Green, Edward; Deumelandt, Katrin; Kilian, Michael; Neftel, Cyril; Uhlig, Stefanie; Kessler, Tobias; von Landenberg, Anna; Berghoff, Anna S.; Marsh, Kelly; Steadman, Mya; Zhu, Dongwei; Nicolay, Brandon; Wiestler, Benedikt; Breckwoldt, Michael O.; Al-Ali, Ruslan; Karcher-Bausch, Simone; Bozza, Matthias; Oezen, Iris; Kramer, Magdalena; Meyer, Jochen; Habel, Antje; Eisel, Jessica; Poschet, Gernot; Weller, Michael; Preusser, Matthias; Nadji-Ohl, Minou; Thon, Niklas; Burger, Michael C.; Harter, Patrick N.; Ratliff, Miriam; Harbottle, Richard; Benner, Axel; Schrimpf, Daniel; Okun, Jurgen; Herold-Mende, Christel; Turcan, Sevin; Kaulfuss, Stefan; Hess-Stumpp, Holger; Bieback, Karen; Cahill, Daniel P.; Plate, Karl H.; Haenggi, Daniel; Dorsch, Marion; Suva, Mario L.; Niemeyer, Barbara A.; von Deimling, Andreas; Wick, Wolfgang; Platten, Michael
分享
收藏AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies
Yen, Katharine; Konteatis, Zenon; Sui, Zhihua; Artin, Erin; Dang, Lenny; Straley, Kimberly; Tobin, Erica; Campos, Carl; Yang, Hua; Nagaraja, Raj; Chen, Yue; Kim, Hyeryun; Gliser, Camelia; Nicolay, Brandon; Olaharski, Andrew; Silverman, Lee; Biller, Scott; Su, Shinsan M.; Mellinghoff, Ingo; Popovici-Muller, Janeta
分享
收藏