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Stephan Siegel

Bayer AG
H指数:19
被引数:1,255
浏览量:0

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Mechanisms of resistance to BAY 2927088, the first reversible inhibitor targeting EGFR exon 20 insertion mutations in non-small cell lung cancer
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Uzunbas, Gizem Karsli; McVeigh, Quinn; Gupta, Akansha; Hoyt, Stephanie; Doucette, Kristen; Keshishian, Hasmik; Carr, Steven; Yang, Xiaoping; Root, David; Cherniack, Andrew D.; Siegel, Franziska; Siegel, Stephan; Meyerson, Matthew; Greulich, Heidi
Preclinical activity of BAY 2927088 in HER2 mutant non-small cell lung cancer
CANCER RESEARCH
IF16.6
2023-04-042
PRE
Siegel, Franziska; Karsli-Uzunbas, Gizem; Kotynkova, Kristyna; McVeigh, Quinn; Siegel, Stephan; Korr, Daniel; Schulze, Volker; Berger, Markus; Beckmann, Georg; Cherniack, Andrew; Meyerson, Matthew; Greulich, Heidi
Mechanisms of resistance to BAY 2927088, the first reversible inhibitor targeting EGFR exon 20 insertion mutations in non-small cell lung cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Uzunbas, Gizem Karsli; McVeigh, Quinn; Gupta, Akansha; Hoyt, Stephanie; Cherniack, Andrew; Siegel, Franziska; Siegel, Stephan; Meyerson, Matthew; Greulich, Heidi
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroi-sophthalamides as covalent PPARG inverse-agonists
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2023-01-014
OAAI
Orsi, Douglas L.; Ferrara, Steven J.; Siegel, Stephan; Friberg, Anders; Bouche, Lea; Pook, Elisabeth; Lienau, Philip; Bluck, Joseph P.; Lemke, Christopher T.; Akcay, Gizem; Stellfeld, Timo; Meyer, Hanna; Puetter, Vera; Holton, Simon J.; Korr, Daniel; Jerchel-Furau, Isabel; Pantelidou, Constantia; Strathdee, Craig A.; Meyerson, Matthew; Eis, Knut; Goldstein, Jonathan T.
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-09-2857
OAAI
Poongavanam, Vasanthanathan; Atilaw, Yoseph; Siegel, Stephan; Giese, Anja; Lehmann, Lutz; Meibom, Daniel; Erdelyi, Mate; Kihlberg, Jan
Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor
CANCER RESEARCH
IF16.6
2018-07-011
PRE
Gradl, Stefan; Steuber, Holger; Weiske, Joerg; Schmees, Norbert; Siegel, Stephan; Stoeckigt, Detlef; Christ, Clara D.; Li, Fengling; Organ, Shawna; Barsyte-Lovejoy, Dalia; Szewczyk, Magdalena M.; Kennedy, Steven; Trush, Viacheslav; Vedadi, Masoud; Arrowsmith, Cheryl H.; Brown, Peter J.; Husemann, Manfred; Fernandez-Montalvan, Amaury E.; Badock, Volker; Bauser, Marcus; Haegebarth, Andrea; Hartung, Ingo V.; Stresemann, Carlo
Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition
ONCOGENE
IF7.3
2017-10-0934
OAAI
Gelato, K. A.; Schoeckel, L.; Klingbeil, O.; Rueckert, T.; Lesche, R.; Toedling, J.; Kalfon, E.; Heroult, M.; Lejeune, P.; Moenning, U.; Fernandez-Montalvan, A. E.; Baeurle, S.; Siegel, S.; Haendler, B.
BAY-299, a novel chemical probe for in-depth analysis of the function of the bromodomain proteins BRPF2 and TAF1
CANCER RESEARCH
IF16.6
2017-07-011
PRE
Bouche, Lea; Christ, Clara D.; Siegel, Stephan; Tallant, Cynthia; Fernandez-Montalvan, Amaury E.; Huber, Kilian V.; Putter, Verra; Mueller, Susanne; Fedorov, Oleg; ter Laak, Antonius; Sugawara, Tatsuo; Stockigt, Detlef; Meier, Julia; Holton, Simon J.; Hartung, Ingo V.; Haendler, Bernard
Probing the cancer epigenome: empowering target validation by open innovation
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Hartung, Ingo V.; Arrowsmith, Cheryl; Badock, Volker; Barak, Naomi; Berger, Markus; Brown, Peter J.; Christ, Clara D.; Eggert, Erik; Egner, Ursula; Fedorov, Oleg; Fernandez-Montalvan, Amaury E.; Gorjanacz, Matyas; Haegebarth, Andrea; Haendler, Bernard; Hillig, Roman C.; Holton, Simon H.; Huber, Kilian V.; Koo, Seong J.; ter Laak, Antonius; Mueller, Susanne; Mueller-Fahrnow, Anke; Scholten, Cora; Siegel, Stephan; Stellfeld, Timo; Stoeckigt, Detlef; Stresemann, Carlo; Vedadi, Masoud; Weiske, Joerg; Weinmann, Hilmar
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

苯并异喹啉二酮作为BRPF2和TAF1/TAF1L溴结构域的有效和选择性抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-05-0154
OAAI
Bouche, Lea; Christ, Clara D.; Siegel, Stephan; Fernandez-Montalvan, Amaury E.; Holton, Simon J.; Fedorov, Oleg; ter Laak, Antonius; Sugawara, Tatsuo; Stoeckigt, Detlef; Tallant, Cynthia; Bennett, James; Monteiro, Octovia; Diaz-Saez, Laura; Siejka, Paulina; Meier, Julia; Puetter, Vera; Weiske, Joerg; Mueller, Susanne; Huber, Kilian V. M.; Hartung, Ingo V.; Haendler, Bernard
In vivo efficacy of BET inhibitor BAY 1238097 in preclinical models of melanoma and lung cancer
CANCER RESEARCH
IF16.6
2016-07-150
PRE
Klingbeil, Olaf; Haendler, Bernard; Stresemann, Antje; Merz, Claudia; Walter, Annette; Fernandez-Montalvan, Amaury Ernesto; Ocker, Matthias; Siegel, Stephan; Lejeune, Pascale
The BET inhibitor BAY 1238097 shows efficacy in BRAF wild-type and mutant melanoma models
CANCER RESEARCH
IF16.6
2016-07-151
PRE
Haendler, Bernard; Gelato, Kathy A.; Schockel, Laura; Sugawara, Tatsuo; Lejeune, Pascale; Ellinger-Ziegelbauer, Heidrun; Fernandez-Montalvan, Amaury E.; Holton, Simon; Siegel, Stephan; Heroult, Melanie; Walter, Annette; Ince, Stuart; Ocker, Matthias
Identification and characterization of BRPF1 bromodomain inhibitors
CANCER RESEARCH
IF16.6
2016-07-151
PRE
Haendler, Bernard; Bouche, Lea; Siegel, Stephan; Fernandez-Montalvan, Amaury E.; Sugawara, Tatsuo; Meier, Julia; Knapp, Stefan; Gamble, Vicki
BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models
CANCER RESEARCH
IF16.6
2015-08-017
PRE
Lejeune, Pascale; Sugawara, Tatsuo; Gelato, Kathy A.; Ellinger-Ziegelbauer, Heidrun; Fernandez-Montalvan, Amaury E.; Schmees, Norbert; Siegel, Stephan; Weinmann, Hilmar; Gekeler, Volker; Walter, Annette O.; Ocker, Matthias; Ince, Stuart; Haendler, Bernard
Targeting BET bromodomains for cancer treatment
EPIGENOMICS
IF2.6
2015-06-16152
PREAI
Jung, Marie; Gelato, Kathy A.; Fernandez-Montalvan, Amaury; Siegel, Stephan; Haendler, Bernard
Suppression of c-Myc oncogene and hematological tumor growth by a novel benzazepine BET inhibitor
EUROPEAN JOURNAL OF CANCER
IF7.1
2014-11-010
PREAI
Gelato, K. A.; Lejeune, P.; Fernandez-Montalvan, A. E.; Neuhaus, R.; Schmees, N.; Siegel, S.; Weinmann, H.; Gekeler, V.; Haendler, B.
New benzazepine BET-inhibitors with improved oral bioavailability
CANCER RESEARCH
IF16.6
2014-10-012
PRE
Schmees, Norbert; Haendler, Bernard; Lejeune, Pascale; Stresemann, Antje; Neuhaus, Roland; Siegel, Stephan; Fernandez-Montalvan, Amaury Ernesto; Weinmann, Hilmar; Gekeler, Volker
Selective indole-based ECE inhibitors:: Synthesis and pharmacological evaluation
CHEMMEDCHEM
IF3.4
2006-01-058
PREAI
Brands, Michael; Ergueden, Jens-Kerim; Hashimoto, Kentaro; Heimbach, Dirk; Krahn, Thomas; Schroeder, Christian; Siegel, Stephan; Stasch, Johannes-Peter; Tsujishita, Hideki; Weigand, Stefan; Yoshida, Nagahiro H.
New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2004-02-0168
OAAI
Beyer, D; Kroll, HP; Endermann, R; Schiffer, G; Siegel, S; Bauser, M; Pohlmann, J; Brands, M; Ziegelbauer, K; Haebich, D; Eymann, C; Brötz-Oesterhelt, H
Memory of chirality in electron transfer mediated benzylic umpolung reactions of arene-Cr(CO)3 complexes
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
1999-06-0162
PREAI
Schmalz, HG; de Koning, CB; Bernicke, D; Siegel, S; Pfletschinger, A

研究方向

暂未获取到该数据
A
Amaury E. Fernández‐Montalván
H 指数:24论文数:91被引数:2,025
B
Bernard Haendler
H 指数:45论文数:173被引数:6,738
P
Pascale Lejeune
H 指数:17论文数:116被引数:2,192
K
Kathy A. Gelato
H 指数:14论文数:55被引数:1,020
T
Tatsuo Sugawara
H 指数:9论文数:41被引数:453
M
Matthew Meyerson
H 指数:223论文数:1,858被引数:30.7万
N
Norbert Schmees
H 指数:14论文数:36被引数:1,257
I
Ingo V. Hartung
H 指数:20论文数:85被引数:1,718
L
Léa Bouché
H 指数:9论文数:20被引数:235
C
Clara D. Christ
H 指数:23论文数:46被引数:2,244