未登录 A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC) Wise, David R.; Pachynski, Russell K.; Denmeade, Samuel R.; Aggarwal, Rahul R.; Deng, Jiehui; Febles, Victor Adorno; Balar, Arjun V.; Economides, Minas P.; Loomis, Cynthia; Selvaraj, Shanmugapriya; Haas, Michael; Kagey, Michael H.; Newman, Walter; Baum, Jason; Troxel, Andrea B.; Griglun, Sarah; Leis, Dayna; Yang, Nina; Aranchiy, Viktoriya; Machado, Sabrina; Waalkes, Erika; Gargano, Gabrielle; Soamchand, Nadia; Puranik, Amrutesh; Chattopadhyay, Pratip; Fedal, Ezeddin; Deng, Fang-Ming; Ren, Qinghu; Chiriboga, Luis; Melamed, Jonathan; Sirard, Cynthia A.; Wong, Kwok-Kin 分享 收藏
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01 Jarman, Edward J.; Horcas-Lopez, Marta; Waddell, Scott H.; MacMaster, Stephanie; Gournopanos, Konstantinos; Soong, Daniel Y. H.; Musialik, Kamila, I; Tsokkou, Panagiota; Ng, Minn-E; Cambridge, William A.; Wilson, David H.; Kagey, Michael H.; Newman, Walter; Pollard, Jeffrey W.; Boulter, Luke 分享 收藏
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism He, Changhao; Maniyar, Rachana R.; Avraham, Yahel; Zappasodi, Roberta; Rusinova, Radda; Newman, Walter; Heath, Heidi; Wolchok, Jedd D.; Dahan, Rony; Merghoub, Taha; Meyerson, Joel R. 分享 收藏
Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors Caldwell, Charles; Rottman, James B.; Paces, Will; Bueche, Elizabeth; Reitsma, Sofia; Gibb, Joseph; Adisetiyo, Vitria; Haas, Michael S.; Heath, Heidi; Newman, Walter; Baum, Jason; Gianani, Roberto; Kagey, Michael H. 分享 收藏
分享 收藏
Mechanistic insight into anti-tumor activity of DKN-01, a therapeutic antibody with immune modulatory activity Haas, Michael; Heath, Heidi; Schurpf-Huber, Franziska; Wu, Yinyuan; Zhang, Xinjun; He, Xi; Yang, Min; Newman, Walter; Kagey, Michael 分享 收藏
Rational combination of GITR agonism with PD-1 blockade Zappasodi, Roberta; Sirard, Cynthia; Li, Yanyun; Budhu, Sadna; Abu-Akeel, Moshen; Liu, Cailian; Yang, Xia; Zhong, Hong; Newman, Walter; Qi, Jingjing; Wong, Philip; Schaer, David; Koon, Henry; Velcheti, Vamsidhar; Callahan, Margaret K.; Wolchok, Jedd; Merghoub, Taha 分享 收藏
GITR cancer immunotherapy: Epitope swapping of anti-GITR TRX518 to inform functional translatability from mouse to human Zappasodi, Roberta; Heath, Heidi; Zhang, Yang; Haas, Michael; Yang, Min; Mirabelli, Christopher; Wolchok, Jedd D.; Sirard, Cyndi; Newman, Walter; Merghoub, Taha 分享 收藏
Rational design of anti-GITR-based combination immunotherapy Zappasodi, Roberta; Sirard, Cynthia; Li, Yanyun; Budhu, Sadna; Abu-Akeel, Mohsen; Liu, Cailian; Yang, Xia; Zhong, Hong; Newman, Walter; Qi, Jingjing; Wong, Phillip; Schaer, David; Koon, Henry; Velcheti, Vamsidhar; Hellmann, Matthew D.; Postow, Michael A.; Callahan, Margaret K.; Wolchok, Jedd D.; Merghoub, Taha 分享 收藏
分享 收藏
DKN-01, a therapeutic DKK1 neutralizing antibody, has immune modulatory activity in nonclinical tumor models Haas, Michael; Heath, Heidi; Wu, Yinyuan; Zhang, Xinjun; Sirard, Cynthia; He, Xi; Newman, Walter; Kagey, Michael 分享 收藏
Intratumor and peripheral Treg modulation as a pharmacodynamic biomarker of the GITR agonist antibody TRX-518 in the first in-human trial Zappasodi, Roberta; Li, Yanyun; Abu-Akeel, Mohsen; Qi, Jingjing; Wong, Philip; Sirard, Cynthia; Postow, Michael; Schaer, David A.; Newman, Walter; Koon, Henry; Velcheti, Vamsidhar; Callahan, Margaret K.; Wolchok, Jedd D.; Merghoub, Taha 分享 收藏
Role of HMGB1 in apoptosis-mediated sepsis lethality Qin, Shixin; Wang, Haichao; Yuan, Renqi; Li, Hui; Ochani, Mahendar; Ochani, Kanta; Rosas-Ballina, Mauricio; Czura, Chris J.; Huston, Jared M.; Miller, Ed; Lin, Xinchun; Sherry, Barbara; Kumar, Anjali; LaRosa, Greg; Newman, Walter; Tracey, Kevin J.; Yang, Huan 分享 收藏
Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis Bocchino, V; Bertorelli, G; Bertrand, CP; Ponath, PD; Newman, W; Franco, C; Marruchella, A; Merlini, S; Del Donno, M; Zhuo, X; Olivieri, D 分享 收藏
分享 收藏
分享 收藏
The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways Ganju, RK; Brubaker, SA; Meyer, J; Dutt, P; Yang, YM; Qin, SX; Newman, W; Groopman, JE 分享 收藏
CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro Wu, LJ; Paxton, WA; Kassam, N; Ruffing, N; Rottman, JB; Sullivan, N; Choe, H; Sodroski, J; Newman, W; Koup, RA; Mackay, CR 分享 收藏
分享 收藏
Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines 气道细胞制备新型c-c趋化因子MCP-4及其与其他c-c趋化因子生物学活性的比较 Stellato, C; Collins, P; Ponath, PD; Soler, D; Newman, W; LaRosa, G; Li, HD; White, J; Schwiebert, LM; Bickel, C; Liu, M; Bochner, BS; Williams, T; Schleimer, RP 分享 收藏
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
未登录.png){kind=icon}