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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment ATR抑制剂ceralasertib通过调节肿瘤微环境来增强癌症检查点免疫治疗 Hardaker, Elizabeth L.; Sanseviero, Emilio; Karmokar, Ankur; Taylor, Devon; Milo, Marta; Michaloglou, Chrysis; Hughes, Adina; Mai, Mimi; King, Matthew; Solanki, Anisha; Magiera, Lukasz; Miragaia, Ricardo; Kar, Gozde; Standifer, Nathan; Surace, Michael; Gill, Shaan; Peter, Alison; Talbot, Sara; Tohumeken, Sehmus; Fryer, Henderson; Mostafa, Ali; Mulgrew, Kathy; Lam, Carolyn; Hoffmann, Scott; Sutton, Daniel; Carnevalli, Larissa; Calero-Nieto, Fernando J.; Jones, Gemma N.; Pierce, Andrew J.; Wilson, Zena; Campbell, David; Nyoni, Lynet; Martins, Carla P.; Baker, Tamara; de Almeida, Gilberto Serrano; Ramlaoui, Zainab; Bidar, Abdel; Phillips, Benjamin; Boland, Joseph; Iyer, Sonia; Barrett, J. Carl; Loembe, Arsene-Bienvenu; Fuchs, Serge Y.; Duvvuri, Umamaheswar; Lou, Pei-Jen; Nance, Melonie A.; Gomez Roca, Carlos Alberto; Cadogan, Elaine; Critichlow, Susan E.; Fawell, Steven; Cobbold, Mark; Dean, Emma; Valge-Archer, Viia; Lau, Alan; Gabrilovich, Dmitry I.; Barry, Simon T. 分享 收藏
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models Kaistha, Brajesh P.; Kar, Gozde; Dannhorn, Andreas; Watkins, Amanda; Opoku-Ansah, Grace; Ilieva, Kristina; Mullins, Stefanie; Anderton, Judith; Galvani, Elena; Garcon, Fabien; Lapointe, Jean-Martin; Brown, Lee; Hair, James; Slidel, Tim; Luheshi, Nadia; Ryan, Kelli; Hardaker, Elizabeth; Dovedi, Simon; Kumar, Rakesh; Wilkinson, Robert W.; Hammond, Scott A.; Eyles, Jim 分享 收藏
Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer Tcyganov, Evgenii N.; Hanabuchi, Shino; Hashimoto, Ayumi; Campbell, David; Kar, Gozde; Slidel, Timothy W. F.; Cayatte, Corinne; Landry, Aimee; Pilataxi, Fernanda; Hayes, Susana; Dougherty, Brian; Hicks, Kristin C.; Mulgrew, Kathy; Tang, Chih-Hang Anthony; Hu, Chih-Chi Andrew; Guo, Wei; Grivennikov, Sergei; Ali, Mohammed-Alkhatim A.; Beltra, Jean-Christophe; Wherry, E. John; Nefedova, Yulia; Gabrilovich, Dmitry, I 分享 收藏
Tumors induce de novo steroid biosynthesis in T cells to evade immunity Mahata, Bidesh; Pramanik, Jhuma; van der Weyden, Louise; Polanski, Krzysztof; Kar, Gozde; Riedel, Angela; Chen, Xi; Fonseca, Nuno A.; Kundu, Kousik; Campos, Lia S.; Ryder, Edward; Duddy, Graham; Walczak, Izabela; Okkenhaug, Klaus; Adams, David J.; Shields, Jacqueline D.; Teichmann, Sarah A. 分享 收藏
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth Davidson, Sarah; Efremova, Mirjana; Riedel, Angela; Mahata, Bidesh; Pramanik, Jhuma; Huuhtanen, Jani; Kar, Gozde; Vento-Tormo, Roser; Hagai, Tzachi; Chen, Xi; Haniffa, Muzlifah A.; Shields, Jacqueline D.; Teichmann, Sarah A. 分享 收藏
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors Segal, Joe M.; Kent, Deniz; Wesche, Daniel J.; Ng, Soon Seng; Serra, Maria; Oules, Benedicte; Kar, Gozde; Emerton, Guy; Blackford, Samuel J., I; Darmanis, Spyros; Miquel, Rosa; Tu Vinh Luong; Yamamoto, Ryo; Bonham, Andrew; Jassem, Wayel; Heaton, Nigel; Vigilante, Alessandra; King, Aileen; Sancho, Rocio; Teichmann, Sarah; Quake, Stephen R.; Nakauchi, Hiromitsu; Rashid, S. Tamir 分享 收藏
A cellular census of human lungs identifies novel cell states in health and in asthma Braga, Felipe A. Vieira; Kar, Gozde; Berg, Marijn; Carpaij, Orestes A.; Polanski, Krzysztof; Simon, Lukas M.; Brouwer, Sharon; Gomes, Tomas; Hesse, Laura; Jiang, Jian; Fasouli, Eirini S.; Efremova, Mirjana; Vento-Tormo, Roser; Talavera-Lopez, Carlos; Jonker, Marnix R.; Affleck, Karen; Palit, Subarna; Strzelecka, Paulina M.; Firth, Helen V.; Mahbubani, Krishnaa T.; Cvejic, Ana; Meyer, Kerstin B.; Saeb-Parsy, Kourosh; Luinge, Marjan; Brandsma, Corry-Anke; Timens, Wim; Angelidis, Ilias; Strunz, Maximilian; Koppelman, Gerard H.; van Oosterhout, Antoon J.; Schiller, Herbert B.; Theis, Fabian J.; van den Berge, Maarten; Nawijn, Martijn C.; Teichmann, Sarah A. 分享 收藏
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Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression Kar, Gozde; Kim, Jong Kyoung; Kolodziejczyk, Aleksandra A.; Natarajan, Kedar Nath; Triglia, Elena Torlai; Mifsud, Borbala; Elderkin, Sarah; Marioni, John C.; Pombo, Ana; Teichmann, Sarah A. 分享 收藏
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Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Donati, Giacomo; Rognoni, Emanuel; Hiratsuka, Toru; Liakath-Ali, Kifayathullah; Hoste, Esther; Kar, Gozde; Kayikci, Melis; Russell, Roslin; Kretzschmar, Kai; Mulder, Klaas W.; Teichmann, Sarah A.; Watt, Fiona M. 分享 收藏
Single cell analysis of CD4+ T cell differentiation reveals three major cell states and progressive acceleration of proliferation (vol 17, 103, 2016) Proserpio, Valentina; Piccolo, Andrea; Haim-Vilmovsky, Liora; Kar, Gozde; Lonnberg, Tapio; Svensson, Valentine; Pramanik, Jhuma; Natarajan, Kedar Nath; Zhai, Weichao; Zhang, Xiuwei; Donati, Giacomo; Kayikci, Melis; Kotar, Jurij; McKenzie, Andrew N. J.; Montandon, Ruddy; James, Kylie R.; Fernandez-Ruiz, Daniel; Heath, William R.; Haque, Ashraful; Billker, Oliver; Woodhouse, Steven; Cicuta, Pietro; Nicodemi, Mario; Teichmann, Sarah A. 分享 收藏
Single-cell analysis of CD4+T-cell differentiation reveals three major cell states and progressive acceleration of proliferation Proserpio, Valentina; Piccolo, Andrea; Haim-Vilmovsky, Liora; Kar, Gozde; Lonnberg, Tapio; Svensson, Valentine; Pramanik, Jhuma; Natarajan, Kedar Nath; Zhai, Weichao; Zhang, Xiuwei; Donati, Giacomo; Kayikci, Melis; Kotar, Jurij; McKenzie, Andrew N. J.; Montandon, Ruddy; Billker, Oliver; Woodhouse, Steven; Cicuta, Pietro; Nicodemi, Mario; Teichmann, Sarah A. 分享 收藏
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