未登录Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Zidar, Nace; Onali, Alessia; Persolja, Peter; Tiz, Davide Benedetto; Dernovsek, Jaka; Skok, Ziga; Durcik, Martina; Cotman, Andrej Emanuel; Rambaher, Martina Hrast; Cruz, Cristina D.; Tammela, Paivi; Senerovic, Lidija; Jovanovic, Milija; Szili, Petra Eva; Czikkely, Marton Simon; Pal, Csaba; Zega, Anamarija; Masic, Lucija Peterlin; Ilas, Janez; Tomasic, Tihomir; Kikelj, Danijel .png)
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收藏Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteriaSterle, Masa; Habjan, Eva; Piga, Martina; Persolja, Peter; Durcik, Martina; Dernovsek, Jaka; Szili, Petra; Czikkely, Marton Simon; Zidar, Nace; Janez, Ilas; Pal, Csaba; Accetto, Tomaz; Pardo, Luis A.; Kikelj, Danijel; Masic, Lucija Peterlin; Tomasic, Tihomir; Bitter, Wilbert; Cotman, Andrej Emanuel; Speer, Alexander; Zega, Anamarija 分享 收藏 Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor: A medicinal chemistry and QTAIM study探索N-(benzothiazol-2-yl) 吡咯酰胺DNA促旋酶抑制剂与GyrB ATP结合位点亲脂性底板的相互作用: 药物化学和QTAIM研究Zidar, Nace; Cotman, Andrej Emanuel; Sinnige, Wessel; Benek, Ondrej; Barancokova, Michaela; Zega, Anamarija; Masic, Lucija Peterlin; Tomasic, Tihomir; Ilas, Janez; Henderson, Sara R.; Mundy, Julia E. A.; Maxwell, Anthony; Stevenson, Clare E. M.; Lawson, David M.; Sterk, Geert Jan; Tosso, Rodrigo; Gutierrez, Lucas; Enriz, Ricardo D.; Kikelj, Danijel 分享 收藏 分享 收藏 分享 收藏 Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE PathogensSterle, Masa; Durcik, Martina; Stevenson, Clare E. M.; Henderson, Sara R.; Szili, Petra Eva; Czikkely, Marton; Lawson, David M.; Maxwell, Anthony; Cahard, Dominique; Kikelj, Danijel; Zidar, Nace; Pal, Csaba; Masic, Lucija Peterlin; Ilas, Janez; Tomasic, Tihomir; Cotman, Andrej Emanuel; Zega, Anamarija 分享 收藏 New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureusDurcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan; Skok, Ziga; Szili, Petra Eva; Czikkely, Marton; Maharramov, Elvin; Vu, Thu Hien; Piras, Maria Vittoria; Zidar, Nace; Ilas, Janez; Zega, Anamarija; Trontelj, Jurij; Pardo, Luis A.; Hughes, Diarmaid; Huseby, Douglas; Berruga-Fernandez, Talia; Cao, Sha; Simoff, Ivailo; Svensson, Richard; Korol, Sergiy V.; Jin, Zhe; Vicente, Francisca; Ramos, Maria C.; Mundy, Julia E. A.; Maxwell, Anthony; Stevenson, Clare E. M.; Lawson, David M.; Glinghammar, Bjorn; Sjostrom, Eva; Bohlin, Martin; Oreskar, Joanna; Alver, Sofie; Janssen, Guido V.; Sterk, Geert Jan; Kikelj, Danijel; Pal, Csaba; Tomasic, Tihomir; Masic, Lucija Peterlin 分享 收藏 ATP-competitive inhibitors of human DNA topoisomerase II? with improved antiproliferative activity based on N-phenylpyrrolamide scaffoldSkok, Ziga; Durcik, Martina; Zajex, Ziva; Skledar, Darja Gramec; Bozovic, Kristof; Pis, Anja; Tomas, Tihomir; Zega, Anamarija; Mas, Lucija Peterlin; Kikelj, Danijel; Zidar, Nace; Ilas, Janez 分享 收藏 Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosaCotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica; Secci, Daniela; Sterle, Masa; Mozina, Stefan; Skok, Ziga; Zidar, Nace; Zega, Anamarija; Ilas, Janez; Masic, Lucija Peterlin; Tomasic, Tihomir; Hughes, Diarmaid; Huseby, Douglas L.; Cao, Sha; Garoff, Linnea; Fernandez, Talia Berruga; Giachou, Paraskevi; Crone, Lisa; Simoff, Ivailo; Svensson, Richard; Birnir, Bryndis; Korol, Sergiy V.; Jin, Zhe; Vicente, Francisca; Ramos, Maria C.; de la Cruz, Mercedes; Glinghammar, Bjorn; Lenhammar, Lena; Henderson, Sara R.; Mundy, Julia E. A.; Maxwell, Anthony; Stevenson, Clare E. M.; Lawson, David M.; Janssen, Guido V.; Sterk, Geert Jan; Kikelj, Danijel 分享 收藏 A Potent N-(piperidin-4-yl)-1H-pyrrole-2-carboxamide Inhibitor of Adenylyl Cyclase of G. lamblia: Biological Evaluation and Molecular Modelling StudiesVega Hissi, Esteban G.; De Costa Guardamagna, Antonella B.; Garro, Adriana D.; Falcon, Cristian R.; Anderluh, Marko; Tomasic, Tihomir; Kikelj, Danijel; Yaneff, Agustin; Davio, Carlos A.; Enriz, Ricardo D.; Zurita, Adolfo R. 分享 收藏 New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens对ESKAPE病原体具有活性的细菌DNA旋转酶和拓扑异构酶IV的新型双重ATP竞争性抑制剂Durcik, Martina; Nyerges, Akos; Skok, Ziga; Skledar, Darja Gramec; Trontelj, Jurij; Zidar, Nace; Ilas, Janez; Zega, Anamarija; Cruz, Cristina D.; Tammela, Paivi; Welin, Martin; Kimbung, Yengo R.; Focht, Dorota; Benek, Ondrej; Revesz, Tamas; Draskovits, Gabor; Szili, Petra Eva; Daruka, Lejla; Pal, Csaba; Kikelj, Danijel; Masic, Lucija Peterlin; Tomasic, Tihomir 分享 收藏 Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and EvaluationDNA促旋酶A和B杂合抑制剂的设计、合成与评价Durcik, Martina; Skok, Ziga; Ilas, Janez; Zidar, Nace; Zega, Anamarija; Szili, Petra Eva; Draskovits, Gabor; Revesz, Tamas; Kikelj, Danijel; Nyerges, Akos; Pal, Csaba; Masic, Lucija Peterlin; Tomasic, Tihomir 分享 收藏 Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B InhibitorsSkok, Ziga; Barancokova, Michaela; Benek, Ondrej; Cruz, Cristina Durante; Tammela, Paivi; Tomasic, Tihomir; Zidar, Nace; Masic, Lucija Peterlin; Zega, Anamarija; Stevenson, Clare E. M.; Mundy, Julia E. A.; Lawson, David M.; Maxwell, Anthony; Kikelj, Danijel; Ilas, Janez 分享 收藏 分享 收藏 Second-generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitorsLamut, Andraz; Skok, Ziga; Barancokova, Michaela; Gutierrez, Lucas J.; Cruz, Cristina D.; Tammela, Paivi; Draskovits, Gabor; Szili, Petra Eva; Nyerges, Akos; Pal, Csaba; Molek, Peter; Bratkovic, Tomaz; Ilas, Janez; Zidar, Nace; Zega, Anamarija; Enriz, Ricardo D.; Kikelj, Danijel; Tomaic, Tihomir 分享 收藏 Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1H-indolesZidar, Nace; Secci, Daniela; Tomasic, Tihomir; Masic, Lucija Peterlin; Kikelj, Danijel; Passarella, Daniele; Argaez, Aida Nelly Garcia; Hyeraci, Mariafrancesca; Dalla Via, Lisa 分享 收藏 Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial ActivityFois, Benedetta; Skok, Ziga; Tomasic, Tihomir; Ilas, Janez; Zidar, Nace; Zega, Anamarija; Peterlin Masic, Lucija; Szili, Petra; Draskovits, Gabor; Nyerges, Akos; Pal, Csaba; Kikelj, Danijel 分享 收藏 分享 收藏 分享 收藏 An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitorsTiz, Davide Benedetto; Skok, Ziga; Durcik, Martina; Tomasic, Tihomir; Masic, Lucija Peterlin; Ilas, Janez; Zega, Anamarija; Draskovits, Gabor; Revesz, Tamas; Nyerges, Akos; Pal, Csaba; Cruz, Cristina D.; Tammela, Paivi; Zigon, Dusan; Kikelj, Danijel; Zidar, Nace 分享 收藏 
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