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Howard B. Broughton

csic - centro de investigacion y desarrollo pascual vila (cid-csic)

30H指数
144论文数
3.2K被引数
收录论文 39
发表时间
Light-Regulated Agonists Spatiotemporally Activating the Vitamin D Receptor Mitigate Psoriasis-like Inflammation in Mice without Inducing Hypercalcemia
err2025-10-01
err1
PREAI
errRovira, Xavier; Espada, Alfonso; Serra, Carme; Catena, Juanlo; Lopez-Cano, Marc; Panarello, Silvia; Perez-Albaladejo, Elisabet; Broughton, Howard; Cano, Leticia; Ajieren, Hans; Khan, Sadid; Alvarez-Montoya, Paula; Munoz, Lourdes; Font, Joan; Trapero, Ana; Rivero, Pablo; Li, Yanrong; Ma, Donghui; Yin, Xianglin; Ma, Yanfei L.; Dodge, Jeffrey A.; Dai, Mingji; Irazoqui, Pedro; Ciruela, Francisco; Krishnan, Venkatesh; Llebaria, Amadeu
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Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754
err2025-03-01
err3
PREAI
errBeauchamp, Thomas J.; Cole, Kevin P.; Broughton, Howard B.; Coates, David A.; Cumming, Graham Robert; de Diego, Jose Eugenio; Frimpong, Kwame; Gutierrez, Julio; Holloway, William; Hotham, Ian; Jones, Spencer; Kaoudi, Talbi; Lander, Peter; Levinson, Adam M.; Lu, Yu; Lugar, Charles; Partridge, Katherine; Ruble, J. Craig; Saouane, Sofiane; Ummaneni, Narasimha Rao; Vandeveer, H. George; Watson, Brian
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Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
err2023-03-14
err0
errOAAI
errHosseini-Gerami, Layla; Ficulle, Elena; Humphryes-Kirilov, Neil; Airey, David C.; Scherschel, James; Kananathan, Sarubini; Eastwood, Brian J.; Bose, Suchira; Collier, David A.; Laing, Emma; Evans, David; Broughton, Howard; Bender, Andreas
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Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy (vol 8, 126, 2022)
err2022-12-28
err0
errOAAI
errGharbi, Severine Isabelle; Pelletier, Laura A.; Espada, Alfonso; Gutierrez, Jesus; Sanfeliciano, Sonia Maria Gutierrez; Rauch, Charles T.; Ganado, Maria Patricia; Baquero, Carmen; Zapatero, Elisabet; Zhang, Aiping; Benach, Jordi; Russell, Anna-Maria; Cano, Leticia; Gomez, Sandra; Broughton, Howard; Pulliam, Nicholas; Perez, Carmen Maria; Torres, Raquel; Debets, Marjoke F.; de Dios, Alfonso; Puig, Oscar; Hilgers, Mark T.; Lallena, Maria Jose
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Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
err2022-11-29
err11
errOAAI
errGharbi, Severine Isabelle; Pelletier, Laura A.; Espada, Alfonso; Gutierrez, Jesus; Sanfeliciano, Sonia Maria Gutierrez; Rauch, Charles T.; Ganado, Maria Patricia; Baquero, Carmen; Zapatero, Elisabet; Zhang, Aiping; Benach, Jordi; Russell, Anna-Maria; Cano, Leticia; Gomez, Sandra; Broughton, Howard; Pulliam, Nicholas; Perez, Carmen Maria; Torres, Raquel; Debets, Marjoke F.; de Dios, Alfonso; Puig, Oscar; Hilgers, Mark T.; Lallena, Maria Jose
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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt)
err2021-04-14
err4
PREAI
errLugar, Charles W.; Clarke, Christian A.; Morphy, Richard; Rudyk, Helene; Sapmaz, Selma; Stites, Ryan E.; Vaught, Grant M.; Furness, Kelly; Broughton, Howard B.; Durst, Greg L.; Clawson, David K.; Stout, Stephanie L.; Guo, Sherry Y.; Durbin, Jim D.; Stayrook, Keith R.; Edmondson, Denise D.; Kikly, Kristy; New, Nicole E.; Bina, Holly A.; Chambers, Mark G.; Shetler, Pamela; Chang, William Y.; Chang, Veavi Ching-Yun; Barr, Rob; Gough, Wendy H.; Steele, Jimmy P.; Getman, Brian; Patel, Nita; Mathes, Brian M.; Richardson, Timothy, I
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The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage
err2021-03-03
err30
PREAI
errJin, Najia; Matter, William F.; Michael, Laura F.; Qian, Yuewei; Gheyi, Tarun; Cano, Leticia; Perez, Carlos; Lafuente, Celia; Broughton, Howard B.; Espada, Alfonso
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A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments用于氢/氘交换质谱实验的解耦自动化平台
err2019-11-13
err14
PREAI
errEspada, Alfonso; Haro, Ruben; Castanon, Jesus; Sayago, Cristina; Perez-Cozar, Francisco; Cano, Leticia; Redero, Pablo; Molina-Martin, Manuel; Broughton, Howard; Stites, Ryan E.; Pascal, Bruce D.; Griffin, Patrick R.; Dodge, Jeffrey A.; Chalmers, Michael J.
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Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands
err2018-08-01
err15
errOAAI
errSayago, Cristina; Valcarcel, Isabel C. Gonzalez; Qian, Yuewei; Lee, John; Alsina-Fernandez, Jorge; Fite, Nathan C.; Carrillo, Juan J.; Zhang, Feiyu F.; Chalmers, Michael J.; Dodge, Jeffrey A.; Broughton, Howard; Espada, Alfonso
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Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences
err2017-11-28
err8
PREAI
errBueno, Ana B.; Agejas, Javier; Broughton, Howard; Dally, Robert; Durham, Timothy B.; Espinosa, Juan Felix; Gonzalez, Rosario; Hahn, Patric J.; Marcos, Alicia; Rodriguez, Ramon; Sanz, Gema; Soriano, Jose F.; Timm, David; Vidal, Paloma; Yang, Hsiu-Chiung; McCarthy, James R.
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Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform
err2016-06-13
err32
PREAI
errCummins, David J.; Espada, Alfonso; Novick, Scott J.; Molina-Martin, Manuel; Stites, Ryan E.; Felix Espinosa, Juan; Broughton, Howard; Goswami, Devrishi; Pascal, Bruce D.; Dodge, Jeffrey A.; Chalmers, Michael J.; Griffin, Patrick R.
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A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
err2016-02-18
err23
PREAI
errEspada, Alfonso; Broughton, Howard; Jones, Spencer; Chalmers, Michael J.; Dodge, Jeffrey A.
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Conformational Features of Secondary N-Cyclopropyl Amides
err2015-04-08
err14
PREAI
errGonzalez-de-Castro, Angela; Broughton, Howard; Martinez-Perez, Jose A.; Espinosa, Juan F.
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The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin
err2013-09-11
err116
errOAAI
errWadsworth, John M.; Clarke, David J.; McMahon, Stephen A.; Lowther, Jonathan P.; Beattie, Ashley E.; Langridge-Smith, Pat R. R.; Broughton, Howard B.; Dunn, Teresa M.; Naismith, James H.; Campopiano, Dominic J.
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The Synthesis of Azadirachtin: A Potent Insect Antifeedant
err2008-11-21
err63
PREAI
errLey, Steven V.; Abad-Somovilla, Antonio; Anderson, James C.; Ayats, Caries; Baenteli, Rolf; Beckmann, Edith; Boyer, Alistair; Brasca, Maria G.; Brice, Abigail; Broughton, Howard B.; Burke, Brenda J.; Cleator, Ed; Craig, Donald; Denholm, Alastair A.; Denton, Ross M.; Durand-Reville, Thomas; Gobbi, Luca B.; Goebel, Michael; Gray, Brian Lawrence; Grossmann, Robert B.; Gutteridge, Claire E.; Hahn, Norbert; Harding, Sarah L.; Jennens, David C.; Jennens, Lynn; Lovell, Peter J.; Lovell, Helen J.; de la Puente, Mary L.; Kolb, Hartmuth C.; Koot, Win-Jan; Maslen, Sarah L.; McCusker, Catherine F.; Mattes, Amos; Pape, Andrew R.; Pinto, Andrea; Santafianos, Dinos; Scott, James S.; Smith, Stephen C.; Somers, Andrew Q.; Spilling, Christopher D.; Stelzer, Frank; Toogood, Peter L.; Turner, Richard M.; Veitch, Gemma E.; Wood, Anthony; Zumbrunn, Cornelia
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Assignment of absolute configuration on the basis of the conformational effects induced by chiral derivatizing agents: The 2-arylpyrrolidine case
err2007-09-21
err11
PREAI
errVidal, Paloma; Pedregal, Concepcon; Diaz, Nuria; Broughton, Howard; Acena, Jose L.; Jimenez, Alma; Espinosa, Juan F.
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Preorganization of the hydroxyethylene dipeptide isostere:: The preferred conformation in solution resembles the conformation bound to BACE
err2005-11-02
err8
PREAI
errVidal, P; Timm, D; Broughton, H; Chen, SH; Martín, JA; Rivera-Sagredo, A; McCarthy, JR; Shapiro, MJ; Espinosa, JF
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