未登录 BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate Cherney, Robert J.; Anjanappa, Prakash; Selvakumar, Kumaravel; Batt, Douglas G.; Brown, Gregory D.; Rose, Anne, V; Vuppugalla, Ragini; Chen, Jing; Pang, Jian; Xu, Songmei; Yarde, Melissa; Tebben, Andrew J.; Paidi, Venkatram Reddy; Cvijic, Mary Ellen; Mathur, Arvind; Barrish, Joel C.; Mandlekar, Sandhya; Zhao, Qihong; Carter, Percy H. 分享 收藏
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2 Yang, Michael G.; Xiao, Zili; Zhao, Rulin; Tebben, Andrew J.; Wang, Bei; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Cvijic, Mary Ellen; Duncia, John, V; Gallela, Michael A.; Gardner, Daniel S.; Khandelwal, Purnima; Malley, Mary F.; Pang, Jian; Rose, Anne, V; Santella, Joseph B., III; Sarjeant, Amy A.; Xu, Songmei; Mathur, Arvind; Mandlekar, Sandhya; Vuppugalla, Ragini; Zhao, Qihong; Carter, Percy H. 分享 收藏
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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches Xiao, Hai-Yun; Li, Ning; Duan, James J-W; Jiang, Bin; Lu, Zhonghui; Khehyong Ngu; Tino, Joseph; Kopcho, Lisa M.; Lu, Hao; Chen, Jing; Tebben, Andrew J.; Sheriff, Steven; Chang, ChiehYing Y.; Yanchunas, Joseph, Jr.; Calambur, Deepa; Gao, Mian; Shuster, David J.; Susulic, Vojkan; Xie, Jenny H.; Guarino, Victor R.; Wu, Dauh-Rurng; Gregor, Kurt R.; Goldstine, Christine B.; Hynes, John, Jr.; Macor, John E.; Salter-Cid, Luisa; Burke, James R.; Shaw, Patrick J.; Dhar, T. G. Murali 分享 收藏
Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent Velaparthi, Upender; Darne, Chetan Padmakar; Warder, Jayakumar; Liu, Peiying; Rahaman, Hasibur; Augustine-Rauch, Karen; Parrish, Karen; Yang, Zheng; Swanson, Jesse; Brown, Jennifer; Dhar, Gopal; Anandam, Aravind; Holenarsipur, Vinay K.; Palanisamy, Kamalavenkatesh; Wautlet, Barn S.; Fereshteh, Mark P.; Lippy, Jonathan; Tebben, Andrew J.; Sheriff, Steven; Ruzanov, Max; Yan, Chunhong; Gupta, Anuradha; Gupta, Arun Kumar; Vetrichelvan, Muthalagu; Mathur, Arvind; Gelman, Marina; Singh, Rajinder; Kinsella, Todd; Murtaza, Anwar; Fargnoli, Joseph; Vite, Gregory; Borzilleri, Robert M. 分享 收藏
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK) Watterson, Scott H.; Liu, Qingjie; Bertrand, Myra Beaudoin; Batt, Douglas G.; Li, Ling; Pattoli, Mark A.; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T.; Moore, Robin; Yang, Zheng; Vickery, Rodney; Elzinga, Paul A.; Discenza, Lorell; D'Arienzo, Celia; Gillooly, Kathleen M.; Taylor, Tracy L.; Pulicicchio, Claudine; Zhang, Yifan; Heimrich, Elizabeth; McIntyre, Kim W.; Ruan, Qian; Westhouse, Richard A.; Catlett, Ian M.; Zheng, Naiyu; Chaudhry, Charu; Dai, Jun; Galella, Michael A.; Tebben, Andrew J.; Pokross, Matt; Li, Jianqing; Zhao, Rulin; Smith, Daniel; Rampulla, Richard; Allentoff, Alban; Wallace, Michael A.; Mathur, Arvind; Salter-Cid, Luisa; Macor, John E.; Carter, Percy H.; Fura, Aberra; Burke, James R.; Tino, Joseph A. 分享 收藏
Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672 Yang, Michael G.; Xiao, Zili; Cherney, Robert J.; Tebben, Andrew J.; Batt, Douglas G.; Brown, Gregory D.; Chen, Jing; Cvijic, Mary Ellen; Dabros, Marta; Duncia, John V.; Galena, Michael; Gardner, Daniel S.; Khandelwal, Purnima; Ko, Soo S.; Malley, Mary F.; Mo, Ruowei; Pang, Jian; Rose, Anne V.; Santella, Joseph B., III; Shi, Hong; Srivastava, Anurag; Traeger, Sarah C.; Wang, Bei; Xu, Songmei; Zhao, Rulin; Barrish, Joel C.; Mandlekar, Sandhya; Zhao, Qihong; Carter, Percy H. 分享 收藏
Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor 四氢异喹啉CXCR4拮抗剂在CXCR4受体的肽亚口袋内采用杂交结合模式 Katzman, Brooke M.; Cox, Bryan D.; Prosser, Anthony R.; Alcaraz, Ana A.; Murat, Brigitte; Heroux, Madeleine; Tebben, Andrew; Zhang, Yong; Schroeder, Gretchen M.; Snyder, James P.; Wilson, Lawrence J.; Liotta, Dennis C. 分享 收藏
Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents Zhang, Yong; Zhao, Yufen; Tebben, Andrew J.; Sheriff, Steven; Ruzanov, Max; Fereshteh, Mark P.; Fan, Yi; Lippy, Jonathan; Swanson, Jesse; Ho, Ching-Ping; Wautlet, Barri S.; Rose, Anne; Parrish, Karen; Yang, Zheng; Donnell, Andrew F.; Zhang, Liping; Fink, Brian E.; Vite, Gregory D.; Augustine-Rauch, Karen; Fargnoli, Joseph; Borzilleri, Robert M. 分享 收藏
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI) Harikrishnan, Lalgudi S.; Warrier, Jayakumar; Tebben, Andrew J.; Tonukunuru, Gopikishan; Madduri, Sudhakara R.; Baligar, Vishweshwaraiah; Mannoori, Raju; Seshadri, Balaji; Rahaman, Hasibur; Arunachalam, P. N.; Dikundwar, Amol G.; Fink, Brian E.; Fargnoli, Joseph; Fereshteh, Mark; Fan, Yi; Lippy, Jonathan; Ho, Ching-Ping; Wautlet, Barri; Sheriff, Steven; Ruzanov, Max; Borzilleri, Robert M. 分享 收藏
Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177) De Lucca, George V.; Shi, Qing; Liu, Qingjie; Batt, Douglas G.; Bertrand, Myra Beaudoin; Rampulla, Rick; Mathur, Arvind; Discenza, Lorell; D'Arienzo, Celia; Dai, Jun; Obermeier, Mary; Vickery, Rodney; Zhang, Yingru; Yang, Zheng; Marathe, Punit; Tebben, Andrew J.; Muckelbauer, Jodi K.; Chang, ChiehYing J.; Zhang, Huiping; Gillooly, Kathleen; Taylor, Tracy; Pattoli, Mark A.; Skala, Stacey; Kukral, Daniel W.; McIntyre, Kim W.; Salter-Cid, Luisa; Fura, Aberra; Burke, James R.; Banish, Joel C.; Carter, Percy H.; Tino, Joseph A. 分享 收藏
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1) Gilmore, John L.; Sheppeck, James E., II; Watterson, Scott H.; Hague, Lauren; Mukhopadhyay, Parag; Tebben, Andrew J.; Galena, Michael A.; Shen, Ding Ren; Yarde, Melissa; Cvijic, Mary Ellen; Borowski, Virna; Gillooly, Kathleen; Taylor, Tracy; McIntyre, Kim W.; Warrack, Bethanne; Levesque, Paul C.; Li, Julia P.; Cornelius, Georgia; D'Arienzo, Celia; Marino, Anthony; Balimane, Praveen; Salter-Cid, Luisa; Barrish, Joel C.; Pitts, William J.; Carter, Percy H.; Xie, Jenny; Dyckman, Alaric J. 分享 收藏
Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer 用于治疗前列腺癌的选择性CYP17A1裂解酶抑制剂BMS-351的发现 Huang, Audris; Jayaraman, Lata; Fura, Aberra; Vite, Gregory D.; Trainor, George L.; Gottardis, Marco M.; Spires, Thomas E.; Spires, Vanessa M.; Rizzo, Cheryl A.; Obermeier, Mary T.; Elzinga, Paul A.; Todderud, Gordon; Fan, Yi; Newitt, John A.; Beyer, Sophie M.; Zhu, Yongxin; Warrack, Bethanne M.; Goodenough, Angela K.; Tebben, Andrew J.; Doweyko, Arthur M.; Gold, David L.; Balog, Aaron 分享 收藏
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors Gavai, Ashvinikumar V.; Quesnelle, Claude; Norris, Derek; Han, Wen-Ching; Gill, Patrice; Shan, Weifang; Balog, Aaron; Chen, Ke; Tebben, Andrew; Rampulla, Richard; Wu, Dauh-Rurng; Zhang, Yingru; Mathur, Arvind; White, Ronald; Rose, Anne; Wang, Haiqing; Yang, Zheng; Ranasinghe, Asoka; D'Arienzo, Celia; Guarino, Victor; Xiao, Lan; Su, Ching; Everlof, Gerry; Arora, Vinod; Shen, Ding Ren; Cvijic, Mary Ellen; Menard, Krista; Wen, Mei-Li; Meredith, Jere; Trainor, George; Lombardo, Louis J.; Olson, Richard; Baran, Phil S.; Hunt, John T.; Vite, Gregory D.; Fischer, Bruce S.; Westhouse, Richard A.; Lee, Francis Y. 分享 收藏
Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5 Carter, Percy H.; Brown, Gregory D.; Cherney, Robert J.; Batt, Douglas G.; Chen, Jing; Clark, Cheryl M.; Cvijic, Mary Ellen; Duncia, John V.; Ko, Soo S.; Mandlekar, Sandhya; Mo, Ruowei; Nelson, David J.; Pang, Jian; Rose, Anne V.; Santella, Joseph B., III; Tebben, Andrew J.; Traeger, Sarah C.; Xu, Songmei; Zhao, Qihong; Barrish, Joel C. 分享 收藏
Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers Modugno, Michele; Banfi, Patrizia; Gasparri, Fabio; Borzilleri, Robert; Carter, Percy; Cornelius, Lyndon; Gottardis, Marco; Lee, Ving; Mapelli, Claudio; Naglich, Joseph G.; Tebben, Andrew; Vite, Gregory; Pastori, Wilma; Albanese, Clara; Corti, Emiliana; Ballinari, Dario; Galvani, Arturo 分享 收藏
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BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer Gavai, Ashvinikumar V.; Zhao, Yufen; O'Malley, Daniel; Fink, Brian; Quesnelle, Claude; Norris, Derek; Chen, Libing; Kim, Soong-Hoon; Han, Wen-Ching; Gill, Patrice; Shan, Weifang; Balog, Aaron; Tebben, Andrew; Rampulla, Richard; Wu, Dauh-Rurng; Zhang, Yingru; Mathur, Arvind; Wang, Haiqing; Yang, Zheng; Ruan, Qian; Moore, Robin; Rodrigues, David; Ranasinghe, Asoka; D'Arienzo, Celia; Tye, Ching Kim; Su, Ching; Everlof, Gerry; Yarde, Melissa; Cvijic, Mary Ellen; Menard, Krista; Wen, Mei-Li; Trainor, George; Fischer, Bruce; Hunt, John; Vite, Gregory; Westhouse, Richard; Lee, Francis 分享 收藏
Discovery of the CCR1 Antagonist, BMS-817399, for the Treatment of Rheumatoid Arthritis Santella, Joseph B., III; Gardner, Daniel S.; Duncia, John V.; Wu, Hong; Dhar, Murali; Cavallaro, Cullen; Tebben, Andrew J.; Carter, Percy H.; Barrish, Joel C.; Yarde, Melissa; Briceno, Stephanie W.; Cvijic, Mary Ellen; Grafstrom, R. Robert; Liu, Richard; Patel, Sima R.; Watson, Andrew J.; Yang, Guchen; Rose, Anne V.; Vickery, Rodney D.; Caceres-Cortes, Janet; Caporuscio, Christian; Camac, Daniel M.; Khan, Javed A.; An, Yongmi; Foster, William R.; Davies, Paul; Hynes, John, Jr. 分享 收藏
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