未登录Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors
Zumbrunn, Cornelia; Remen, Lubos; Sager, Christoph P.; Grisostomi, Corinna; Stamm, Christina; Krusi, Daniela; Glutz, Sven; Schmidt, Gunther; Nayler, Oliver; Iglarz, Marc; Mac Sweeney, Aengus; Chambovey, Alain; Mueller, Manon; Mueller, Celia; Bourquin, Geoffroy; Meyer, Solange; Huhn, Eva; Cattaneo, Christophe; Vercauteren, Magali; Gatfield, John; Bolli, Martin H. .png)
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收藏The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosisBirker-Robaczewska, Magdalena; Boucher, Maxime; Ranieri, Giulia; Poirey, Sylvie; Studer, Rolf; Freti, Diego; Schnoebelen, Marie; Froidevaux, Sylvie; Morrison, Keith; Wyss, Conrad; Scherer, Jeremy; Lescop, Cyrille; Brotschi, Christine; Bolli, Martin H.; Kramberg, Markus; Di Stefano, Simone; Rey, Markus; Iglarz, Marc; Delahaye, Stephane; Vezzali, Enrico; Sieber, Patrick; Schafer, Anny; Caimi, Silvia L.; Hesse, Christina; Nayler, Oliver 分享 收藏 A uniquely efficacious type of CFTR corrector with complementary mode of actionMarchesin, Valentina; Monnier, Lucile; Blattmann, Peter; Chevillard, Florent; Kuntz, Christine; Forny, Camille; Kamper, Judith; Studer, Rolf; Bossu, Alexandre; Ertel, Eric A.; Nayler, Oliver; Brotschi, Christine; Williams, Jodi T.; Gatfield, John 分享 收藏 Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular ScaffoldLescop, Cyrille; Brotschi, Christine; Williams, Jodi T.; Sager, Christoph P.; Birker, Magdalena; Morrison, Keith; Froidevaux, Sylvie; Delahaye, Stephane; Nayler, Oliver; Bolli, Martin H. 分享 收藏 Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic DiseasesLescop, Cyrille; Birker, Magdalena; Brotschi, Christine; Burki, Cedric; Morrison, Keith; Froidevaux, Sylvie; Delahaye, Stephane; Nayler, Oliver; Bolli, Martin H. 分享 收藏 NF-KB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell modelSieber, Patrick; Schafer, Anny; Lieberherr, Raphael; Caimi, Silvia L.; Luthi, Urs; Ryge, Jesper; Bergmann, Jan H.; Le Goff, Francois; Stritt, Manuel; Blattmann, Peter; Renault, Berengere; Rammelt, Patrick; Sempere, Bruno; Freti, Diego; Studer, Rolf; White, Eric S.; Birker-Robaczewska, Magdalena; Boucher, Maxime; Nayler, Oliver 分享 收藏 Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: machine learning on proteomics from the DETECT cohortBauer, Yasmina; de Bernard, Simon; Hickey, Peter; Ballard, Karri; Cruz, Jeremy; Cornelisse, Peter; Chadha-Boreham, Harbajan; Distler, Oliver; Rosenberg, Daniel; Doelberg, Martin; Roux, Sebastien; Nayler, Oliver; Lawrie, Allan 分享 收藏 分享 收藏 分享 收藏 S1P1 Modulator-Induced Gαi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In VivoBirker-Robaczewska, Magdalena; Bolli, Martin; Rey, Markus; de Kanter, Ruben; Kohl, Christopher; Lescop, Cyrille; Boucher, Maxime; Poirey, Sylvie; Steiner, Beat; Nayler, Oliver 分享 收藏 Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization PotentialGatfield, John; Menyhart, Katalin; Wanner, Daniel; Gnerre, Carmela; Monnier, Lucile; Morrison, Keith; Hess, Patrick; Iglarz, Marc; Clozel, Martine; Nayler, Oliver 分享 收藏 Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulationWelford, Richard W. D.; Vercauteren, Magali; Trebaul, Annette; Cattaneo, Christophe; Eckert, Doriane; Garzotti, Marco; Sieber, Patrick; Segrestaa, Jerome; Studer, Rolf; Groenen, Peter M. A.; Nayler, Oliver 分享 收藏 Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridinesBolli, Martin H.; Lescop, Cyrille; Birker, Magdalena; de Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Nayler, Oliver; Rey, Markus; Sieber, Patrick; Velker, Jorg; Weller, Thomas; Steiner, Beat 分享 收藏 Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groupsLescop, Cyrille; Muller, Claus; Mathys, Boris; Birker, Magdalena; de Kanter, Ruben; Kohl, Christopher; Hess, Patrick; Nayler, Oliver; Rey, Markus; Sieber, Patrick; Steiner, Beat; Weller, Thomas; Bolli, Martin H. 分享 收藏 分享 收藏 分享 收藏 A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary FibrosisBauer, Yasmina; Tedrow, John; de Bernard, Simon; Birker-Robaczewska, Magdalena; Gibson, Kevin F.; Guardela, Brenda Juan; Hess, Patrick; Klenk, Axel; Lindell, Kathleen O.; Poirey, Sylvie; Renault, Berengere; Rey, Markus; Weber, Edgar; Nayler, Oliver; Kaminski, Naftali 分享 收藏 分享 收藏 Novel S1P1 Receptor Agonists - Part 3: From Thiophenes to PyridinesBolli, Martin H.; Abele, Stefan; Birker, Magdalena; Bravo, Roberto; Bur, Daniel; de Kanter, Ruben; Kohl, Christopher; Grimont, Julien; Hess, Patrick; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Rey, Markus; Scherz, Michael; Schmidt, Gunther; Seifert, Juergen; Steiner, Beat; Velker, Joerg; Weller, Thomas 分享 收藏 Novel S1P1 Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted ThiophenesBolli, Martin H.; Velker, Joerg; Mueller, Claus; Mathys, Boris; Birker, Magdalena; Bravo, Roberto; Bur, Daniel; de Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Lehmann, David; Meyer, Solange; Nayler, Oliver; Rey, Markus; Scherz, Michael; Steiner, Beat 分享 收藏 
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