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W. David Nes

Texas Tech University System

49H指数
234论文数
8.4K被引数
收录论文 67
发表时间
The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling
err2024-01-23
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errMadan, Babita; Wadia, Shawn R.; Patnaik, Siddhi; Harmston, Nathan; Tan, Emile; Tan, Iain Bee Huat; Nes, W. David; Petretto, Enrico; Virshup, David M.
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Steroidal Antimetabolites Protect Mice against Trypanosoma brucei
err2022-06-25
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errChaudhuri, Minu; Singha, Ujjal K.; Vanderloop, Boden H.; Tripathi, Anuj; Nes, W. David
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Unearthing the Janus-face cholesterogenesis pathways in cancer
err2022-02-01
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errMadan, Babita; Virshup, David M.; Nes, W. David J.; Leaver, David
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Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition
err2021-11-29
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errHargrove, Tatiana Y.; Wawrzak, Zdzislaw; Rachakonda, Girish; Nes, W. David; Villalta, Fernando; Guengerich, F. Peter; Lepesheva, Galina, I
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A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity
err2020-02-01
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errZhou, Wenxu; Fisher, Paxtyn M.; Vanderloop, Boden H.; Shen, Yun; Shi, Huazhong; Maldonado, Adrian J.; Leaver, David J.; Nes, W. David
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Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications
err2019-05-01
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errZhou, Wenxu; Ramos, Emilio; Zhu, Xunlu; Fisher, Paxtyn M.; Kidane, Medhanie E.; Vanderloop, Boden H.; Thomas, Crista D.; Yan, Juqiang; Singha, Ujjal; Chaudhuri, Minu; Nagel, Michael T.; Nes, W. David
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Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51
err2018-12-01
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errHargrove, Tatiana Y.; Wawrzak, Zdzislaw; Fisher, Paxtyn M.; Child, Stella A.; Nes, W. David; Guengerich, F. Peter; Waterman, Michael R.; Lepesheva, Galina I.
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Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae
err2018-11-19
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errFriggeri, Laura; Hargrove, Tatiana Y.; Rachakonda, Girish; Blobaum, Anna L.; Fisher, Paxtyn; de Oliveira, Gabriel Melo; da Silva, Cristiane Franca; Soeiro, Maria de Nazare C.; Nes, W. David; Lindsley, Craig W.; Villalta, Fernando; Guengerich, F. Peter; Lepesheva, Galina I.
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Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii棘阿米巴castellanii中固醇生物合成的发育调控的功能重要性
err2018-10-01
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errZhou, Wenxu; Warrilow, Andrew G. S.; Thomas, Crista D.; Ramos, Emilio; Parker, Josie E.; Price, Claire L.; Vanderloop, Boden H.; Fisher, Paxtyn M.; Loftis, Michael D.; Kelly, Diane E.; Kelly, Steven L.; Nes, W. David
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Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
err2018-09-13
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errZhou, Wenxu; Debnath, Anjan; Jennings, Gareth; Hahn, Hye Jee; Vanderloop, Boden H.; Chaudhuri, Minu; Nes, W. David; Podust, Larissa M.
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Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis
err2018-06-12
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errFriggeri, Laura; Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Blobaum, Anna L.; Rachakonda, Girish; Lindsley, Craig W.; Villalta, Fernando; Nes, W. David; Botta, Maurizio; Guengerich, F. Peter; Lepesheva, Galina, I
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Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design
err2017-12-01
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errKidane, Medhanie E.; Vanderloop, Boden H.; Zhou, Wenxu; Thomas, Crista D.; Ramos, Emilio; Singha, Ujjal; Chaudhuri, Minu; Nes, W. David
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The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51
err2017-07-01
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errWarrilow, Andrew G. S.; Parker, Josie E.; Price, Claire L.; Garvey, Edward P.; Hoekstra, William J.; Schotzinger, Robert J.; Wiederhold, Nathan P.; Nes, W. David; Kelly, Diane E.; Kelly, Steven L.
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The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme
err2016-08-01
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errWarrilow, Andrew G. S.; Parker, Josie E.; Price, Claire L.; Nes, W. David; Garvey, Edward P.; Hoekstra, William J.; Schotzinger, Robert J.; Kelly, Diane E.; Kelly, Steven L.
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Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa
err2016-06-13
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errWarrilow, Andrew G. S.; Price, Claire L.; Parker, Josie E.; Rolley, Nicola J.; Smyrniotis, Christopher J.; Hughes, David D.; Thoss, Vera; Nes, W. David; Kelly, Diane E.; Holman, Theodore R.; Kelly, Steven L.
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In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus
err2015-12-01
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errWarrilow, Andrew G. S.; Parker, Josie E.; Price, Claire L.; Nes, W. David; Kelly, Steven L.; Kelly, Diane E.
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Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)
err2015-08-01
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errLamb, David C.; Warrilow, Andrew G. S.; Rolley, Nicola J.; Parker, Josie E.; Nes, W. David; Smith, Stephen N.; Kelly, Diane E.; Kelly, Steven L.
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Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase
err2015-05-15
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errPrice, Claire L.; Warrilow, Andrew G. S.; Parker, Josie E.; Mullins, Jonathan G. L.; Nes, W. David; Kelly, Diane E.; Kelly, Steven L.
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