未登录 Discovery of N-[Bis(4-methoxyphenyl)methy1]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia Debenham, John S.; Madsen-Duggan, Christina; Clements, Matthew J.; Walsh, Thomas F.; Kuethe, Jeffrey T.; Reibarkh, Mikhail; Salowe, Scott P.; Sonatore, Lisa M.; Hajdu, Richard; Milligan, James A.; Visco, Denise M.; Zhou, Dan; Lingham, Russell B.; Stickens, Dominique; DeMartino, Julie A.; Tong, Xinchun; Wolff, Michael; Pang, Jianmei; Miller, Randy R.; Sherer, Edward C.; Hale, Jeffrey J. 分享 收藏
Optimization of erythropoietin production with controlled glycosylation-PEGylated erythropoietin produced in glycoengineered Pichia pastoris Nett, Juergen H.; Gomathinayagam, Sujatha; Hamilton, Stephen R.; Gong, Bing; Davidson, Robert C.; Du, Min; Hopkins, Daniel; Mitchell, Teresa; Mallem, Muralidhar R.; Nylen, Adam; Shaikh, Seemab S.; Sharkey, Nathan; Barnard, Gavin C.; Copeland, Victoria; Liu, Liming; Evers, Raymond; Li, Yan; Gray, Peter M.; Lingham, Russell B.; Visco, Denise; Forrest, Gail; DeMartino, Julie; Linden, Thomas; Potgieter, Thomas I.; Wildt, Stefan; Stadheim, Terrance A.; d'Anjou, Marc; Li, Huijuan; Sethuraman, Natarajan 分享 收藏
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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat Ali, Amjad; Balkovec, James M.; Greenlee, Mark; Hammond, Milton L.; Rouen, Greg; Taylor, Gayle; Einstein, Monica; Ge, Lan; Harris, Georgianna; Kelly, Terri M.; Mazur, Paul; Pandit, Shilpa; Santoro, Joseph; Sitlani, Ayesha; Wang, Chuanlin; Williamson, Joann; Forrest, Michael J.; Carballo-Jane, Ester; Luell, Silvi; Lowitz, Karen; Visco, Denise 分享 收藏
Chemical genetics define the roles of p38α and p38β in acute and chronic inflammation O'Keefe, Stephen J.; Mudgett, John S.; Cupo, Susan; Parsons, Janey N.; Chartrain, Nicole A.; Fitzgerald, Catherine; Chen, Shiow-Ling; Lowitz, Karen; Rasa, Cordelia; Visco, Denise; Luell, Silvi; Carballo-Jane, Ester; Owens, Karen; Zaller, Dennis M. 分享 收藏
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Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase Liverton, NJ; Butcher, JW; Claiborne, CF; Claremon, DA; Libby, BE; Nguyen, KT; Pitzenberger, SM; Selnick, HG; Smith, GR; Tebben, A; Vacca, JP; Varga, SL; Agarwal, L; Dancheck, K; Forsyth, AJ; Fletcher, DS; Frantz, B; Hanlon, WA; Harper, CF; Hofsess, SJ; Kostura, M; Lin, J; Luell, S; O'Neill, EA; Orevillo, CJ; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Visco, DM; O'Keefe, SJ 分享 收藏
2,3-diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors Black, WC; Brideau, C; Chan, CC; Charleson, S; Chauret, N; Claveau, D; Ethier, D; Gordon, R; Greig, G; Guay, J; Hughes, G; Jolicoeur, P; Leblanc, Y; Nicoll-Griffith, D; Ouimet, N; Riendeau, D; Visco, D; Wang, ZY; Xu, L; Prasit, P 分享 收藏
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis Singer, II; Scott, S; Kawka, DW; Bayne, EK; Weidner, JR; Williams, HR; Mumford, RA; Lark, MW; McDonnell, J; Christen, AJ; Moore, VL; Mudgett, JS; Visco, DM 分享 收藏
Inhibition of stromelysin-1 (MMP-3) by P-1'-biphenylylethyl carboxyalkyl dipeptides Esser, CK; Bugianesi, RL; Caldwell, CG; Chapman, KT; Durette, PL; Girotra, NN; Kopka, IE; Lanza, TJ; Levorse, DA; MacCoss, M; Owens, KA; Ponpipom, MM; Simeone, JP; Harrison, RK; Niedzwiecki, L; Becker, JW; Marcy, AI; Axel, MG; Christen, AJ; McDonnell, J; Moore, VL; Olszewski, JM; Saphos, C; Visco, DM; Shen, F; Colletti, A; Krieter, PA; Hagmann, WK 分享 收藏
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