A. A. Leslie Gunatilaka - Publications, H-index & Citations

A. A. Leslie Gunatilaka

University of Arizona

53H指数

301论文数

1.0W被引数

收录论文 108

发表时间

A Homodimer of Withaferin A Formed by Base-Promoted Elimination of Acetic Acid from 27-O-Acetylwithaferin A Followed by a Diels-Alder Reaction

JOURNAL OF NATURAL PRODUCTS

IF3.6

2024-02-28

PREAI

Wijeratne, E. M. Kithsiri; Xu, Ya-Ming; Padumadasa, Chayanika; Astashkin, Andrei V.; Gunatilaka, A. A. Leslie

Argentatin C Analogues with Potential Antinociceptive Activity and Other Triterpenoid Constituents from the Aerial Parts of Parthenium incanum 具有潜在镇痛活性的Argentatin C类似物和来自pathenium incanum地上部分的其他三萜类成分

ACS OMEGA

IF4.3

2023-05-25

OAAI

Xu, Ya-ming; Wijeratne, E. M. Kithsiri; Calderon-Rivera, Aida; Loya-Lopez, Santiago; Perez-Miller, Samantha; Khanna, Rajesh; Gunatilaka, A. A. Leslie

The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels 天然产物阿根廷霉素C通过抑制电压门控钠和T型电压门控钙通道减轻术后疼痛

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2023-01-15

OAAI

Duran, Paz; Loya-Lopez, Santiago; Ran, Dongzhi; Tang, Cheng; Calderon-Rivera, Aida; Gomez, Kimberly; Stratton, Harrison J.; Huang, Sun; Xu, Ya-ming; Wijeratne, E. M. Kithsiri; Perez-Miller, Samantha; Shan, Zhiming; Cai, Song; Gabrielsen, Anna T.; Dorame, Angie; Masterson, Kyleigh A.; Alsbiei, Omar; Madura, Cynthia L.; Luo, Guoqin; Moutal, Aubin; Streicher, John; Zamponi, Gerald W.; Gunatilaka, A. A. Leslie; Khanna, Rajesh

Physachenolide C is a Potent, Selective BET Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-28

PREAI

Zerio, Christopher J.; Sivinski, Jared; Wijeratne, E. M. Kithsiri; Xu, Ya-Ming; Ngo, Duc T.; Ambrose, Andrew J.; Villa-Celis, Luis; Ghadirian, Niloofar; Clarkson, Michael W.; Zhang, Donna D.; Horton, Nancy C.; Gunatilaka, A. A. Leslie; Fromme, Raimund; Chapman, Eli

Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl

MOLECULES

IF4.6

2022-01-28

OAAI

Xu, Ya-Ming; Wijeratne, E. M. Kithsiri; Liu, Manping X.; Xuan, Lijiang; Wang, Wenqiong; Gunatilaka, A. A. Leslie

Ring A/B-Modified 17β-Hydroxywithanolide Analogues as Antiproliferative Agents for Prostate Cancer and Potentiators of Immunotherapy for Renal Carcinoma and Melanoma

JOURNAL OF NATURAL PRODUCTS

IF3.6

2021-12-01

PREAI

Wijeratne, E. M. Kithsiri; Xu, Ya-Ming; Liu, Manping X.; Inacio, Marielle C.; Brooks, Alan D.; Tewary, Poonam; Sayers, Thomas J.; Gunatilaka, A. A. Leslie

Strobiloscyphones A-F, 6-Isopentylsphaeropsidones and Other Metabolites from Strobiloscypha sp. AZ0266, a Leaf-Associated Fungus of Douglas Fir

JOURNAL OF NATURAL PRODUCTS

IF3.6

2021-09-08

PREAI

Qu, Wei; Wijeratne, E. M. Kithsiri; Bashyal, Bharat P.; Xu, Jian; Xu, Ya-Ming; Liu, Manping X.; Inacio, Marielle C.; Arnold, A. Elizabeth; U'Ren, Jana M.; Gunatilaka, A. A. Leslie

Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model

JOURNAL OF NATURAL PRODUCTS

IF3.6

2021-08-17

PREAI

Misakyan, Micaela F. Freitas; Wijeratne, E. M. Kithsiri; Issa, Mark E.; Xu, Ya-Ming; Monteillier, Aymeric; Gunatilaka, A. A. Leslie; Cuendet, Muriel

Cycloartane- and Lanostane-Type Triterpenoids from the Resin of Parthenium argentatum AZ-2, a Byproduct of Guayule Rubber Production

ACS OMEGA

IF4.3

2021-06-04

OAAI

Xu, Ya-ming; Madasu, Chandrashekhar; Liu, Manping X.; Wijeratne, E. M. Kithsiri; Dierig, David; White, Bob; Molnar, Istvan; Gunatilaka, A. A. Leslie

Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

CANCER RESEARCH

IF16.6

2021-04-09

OAAI

Tewary, Poonam; Brooks, Alan D.; Xu, Ya-Ming; Wijeratne, E. M. Kithsiri; Babyak, Ashley L.; Back, Timothy C.; Chari, Raj; Evans, Christine N.; Henrich, Curtis J.; Meyer, Thomas J.; Edmondson, Elijah F.; de Aquino, Maria T. Prudente; Kanagasabai, Thanigaivelan; Shanker, Anil; Gunatilaka, A. A. Leslie; Sayers, Thomas J.

Cytotoxic Physalins from Aeroponically Grown Physalis acutifolia

JOURNAL OF NATURAL PRODUCTS

IF3.6

2021-02-14

PREAI

Xu, Guo-Bo; Xu, Ya-Ming; Wijeratne, E. M. Kithsiri; Ranjbar, Fatemeh; Liu, Manping X.; Gunatilaka, A. A. Leslie

Teratopyrones A-C, Dimeric Naphtho-γ-Pyrones and Other Metabolites from Teratosphaeria sp. AK1128, a Fungal Endophyte of Equisetum arvense

MOLECULES

IF4.6

2020-10-30

OAAI

Xu, Ya-Ming; Arnold, A. Elizabeth; U'Ren, Jana M.; Xuan, Li-Jiang; Wang, Wen-Qiong; Gunatilaka, A. A. Leslie

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

MOLECULAR BRAIN

IF2.9

2020-05-11

OAAI

Zhou, Yuan; Cai, Song; Gomez, Kimberly; Wijeratne, E. M. Kithsiri; Ji, Yingshi; Bellampalli, Shreya S.; Luo, Shizhen; Moutal, Aubin; Gunatilaka, A. A. Leslie; Khanna, Rajesh

Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway Withanolide D通过抑制DNA损伤非同源末端连接修复途径增强人癌细胞的放射敏感性

FRONTIERS IN ONCOLOGY

IF3.3

2020-01-08

OAAI

Lacombe, Jerome; Cretignier, Titouan; Meli, Laetitia; Wijeratne, E. M. Kithsiri; Veuthey, Jean-Luc; Cuendet, Muriel; Gunatilaka, A. A. Leslie; Zenhausern, Frederic

Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation

CELL CHEMICAL BIOLOGY

IF7.2

2019-10-01

OAAI

Liu, Pengfei; Tian, Wang; Tao, Shasha; Tillotson, Joseph; Wijeratne, E. M. Kithsiri; Gunatilaka, A. A. Leslie; Zhang, Donna D.; Chapman, Eli

Withanolide D enhances radiosensitivity of human cancer cells to X-rays radiation

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Lacombe, Jerome; Cretignier, Titouan; Meli, Laetitia; Veuthey, Jean-Luc; Gunatilaka, Leslie; Cuendet, Muriel; Zenhausern, Frederic

Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels 小分子天然产物酸浆素F通过阻断CaV2.3 (R型) 和CaV2.2 (N型) 电压门控钙通道逆转外周神经病理性疼痛

ACS CHEMICAL NEUROSCIENCE

IF3.9

2019-04-04

PREAI

Shan, Zhiming; Cai, Song; Yu, Jie; Zhang, Zhongjun; Vallecillo, Tissiana Gabriela Menna; Serafini, Maria Jin; Thomas, Ann Mary; Nancy Yen Ngan Pham; Bellampalli, Shreya Sai; Moutal, Aubin; Zhou, Yuan; Xu, Guo-Bo; Xu, Ya-Ming; Luo, Shizhen; Patek, Marcel; Streicher, John M.; Gunatilaka, A. A. Leslie; Khanna, Rajesh

Rational Reprogramming of O-Methylation Regioselectivity for Combinatorial Biosynthetic Tailoring of Benzenediol Lactone Scaffolds

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-02-15

OAAI

Wang, Xiaojing; Wang, Chen; Duan, Lixin; Zhang, Liwen; Liu, Hang; Xu, Ya-ming; Liu, Qingpei; Mao, Tonglin; Zhang, Wei; Chen, Ming; Lin, Min; Gunatilaka, A. A. Leslie; Xu, Yuquan; Molnar, Istvan

(-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels

ACS CHEMICAL NEUROSCIENCE

IF3.9

2018-12-07

PREAI

Cai, Song; Bellampalli, Shreya S.; Yu, Jie; Li, Wennan; Ji, Yingshi; Wijeratne, E. M. Kithsiri; Dorame, Angie; Luo, Shizhen; Shan, Zhiming; Khanna, May; Moutal, Aubin; Streicher, John M.; Gunatilaka, A. A. Leslie; Khanna, Rajesh

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

PAIN

IF5.5

2018-08-28

OAAI

Bellampalli, Shreya S.; Ji, Yingshi; Moutal, Aubin; Cai, Song; Wijeratne, E. M. Kithsiri; Gandini, Maria A.; Yu, Jie; Chefdeville, Aude; Dorame, Angie; Chew, Lindsey A.; Madura, Cynthia L.; Luo, Shizhen; Molnar, Gabriella; Khanna, May; Streicher, John M.; Zamponi, Gerald W.; Gunatilaka, A. A. Leslie; Khanna, Rajesh

研究方向