Jennifer Pizzano

Genentech

H指数:14

被引数:1,053

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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models (vol 67, pg 1262, 2024)

PROTACs靶向BRM（SMARCA2）可在体内实现对BRG1（SMARCA4）的选择性降解，并在BRG1突变异种移植肿瘤模型中表现出活性（vol 67, pg 1262, 2024）

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-05-210

PRE

Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Crew, Andrew P.; Davenport, Kim; Dinicola, Dean; Dong, Hanqing; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Snyder, Lawrence B.; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Gan; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S.

Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

COMMUNICATIONS MEDICINE

IF6.3

2024-05-163

PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-01-057

PRE

Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Davenport, Kim; DiNicola, Dean; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S.

Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs

PHARMACEUTICS

IF5.5

2023-08-0810

OAAI

KRAS-targeted PROTAC degraders are broadly efficacious against KRAS-dependent tumor models

MOLECULAR CANCER RESEARCH

IF4.7

2023-05-012

PRE

Enhanced efficacy of ARV-471, a novel PROTAC® estrogen receptor degrader, in combination with targeted agents in estrogen receptor-positive (ER plus ) breast cancer models

CANCER RESEARCH

IF16.6

2023-04-043

PRE

Mechanisms of acquired resistance to ARV-471, a novel PROTAC® estrogen receptor degrader

CANCER RESEARCH

IF16.6

2023-04-042

PRE

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

NATURE COMMUNICATIONS

IF15.7

2022-11-1050

OAAI

Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models

CANCER RESEARCH

IF16.6

2020-08-150

PRE

Berlin, Michael; Cantley, Jennifer; Wang, Jing; Bookbinder, Mark; Cadelina, Gregory; Chan, Emily; Chen, Huifen; Chen, Xin; Davenport, Kim; Fernando, Tharu; Gordon, Debbie; Hamman, Brian; Haskell, Roy; Ishchenko, Alexey; Kirkpatrick, Donald S.; Maher, Jonathan; Merchant, Mark; Moffat, John; Morgan, Alicia; Nguyen, An; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Sethuraman, Vijay; Staben, Leanna; Wilson, Catherine; Ye, Xiaofen; Broccatelli, Fabio; Yauch, Robert; Dragovich, Peter S.

ARV-471, an oral estrogen receptor PROTAC degrader for breast cancer

CANCER RESEARCH

IF16.6

2019-02-15114

PRE

ARV-110: An androgen receptor PROTAC degrader for prostate cancer

CANCER RESEARCH

IF16.6

2018-07-0149

PRE

Jennifer Pizzano

个人简介

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