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E

Emily Chan

roche holding
H指数:45
被引数:1.1万

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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models (vol 67, pg 1262, 2024)

PROTACs靶向BRM（SMARCA2）可在体内实现对BRG1（SMARCA4）的选择性降解，并在BRG1突变异种移植肿瘤模型中表现出活性（vol 67, pg 1262, 2024）

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-210
PRE
Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Crew, Andrew P.; Davenport, Kim; Dinicola, Dean; Dong, Hanqing; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Snyder, Lawrence B.; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Gan; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S.
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-057
PRE
Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Davenport, Kim; DiNicola, Dean; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-09-2916
PRE
Taylor, Alexander M.; Williams, Bret R.; Giordanetto, Fabrizio; Kelley, Elizabeth H.; Lescarbeau, Andre; Shortsleeves, Kelley; Tang, Yong; Walters, W. Patrick; Arrazate, Alfonso; Bowman, Christine; Brophy, Erin; Chan, Emily W.; Deshmukh, Gauri; Greisman, Jack B.; Hunsaker, Thomas L.; Kipp, D. Randal; Lopez-Larrocha, Pablo Saenz; Maddalo, Danilo; Martin, Iain J.; Maragakis, Paul; Merchant, Mark; Murcko, Mark; Nisonoff, Hunter; Nguyen, Vi; Nguyen, Vy; Orozco, Olivia; Owen, Christopher; Pierce, Levi; Schmidt, Molly; Shaw, David E.; Smith, Sherri; Therrien, Eric; Tran, John C.; Watters, Jim; Waters, Nigel J.; Wilbur, Jeremy; Willmore, Lindsay
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

变构泛TEAD抑制剂阻断致癌YAP/TAZ信号传导并克服KRAS G12C抑制剂抗性

NATURE CANCER
IF28.5
2023-06-0562
OAAI
Hagenbeek, Thijs J. J.; Zbieg, Jason R. R.; Hafner, Marc; Mroue, Rana; Lacap, Jennifer A. A.; Sodir, Nicole M. M.; Noland, Cameron L. L.; Afghani, Shervin; Kishore, Ayush; Bhat, Kamakoti P. P.; Yao, Xiaosai; Schmidt, Stephen; Clausen, Saundra; Steffek, Micah; Lee, Wendy; Beroza, Paul; Martin, Scott; Lin, Eva; Fong, Rina; Di Lello, Paola; Kubala, Marta H. H.; Yang, Michelle N. -Y.; Lau, Jeffrey T. T.; Chan, Emily; Arrazate, Alfonso; An, Le; Levy, Elizabeth; Lorenzo, Maria N. N.; Lee, Ho-June; Pham, Trang H. H.; Modrusan, Zora; Zang, Richard; Chen, Yi-Chen; Kabza, Michal; Ahmed, Musaddeque; Li, Jason; Chang, Matthew T. T.; Maddalo, Danilo; Evangelista, Marie; Ye, Xin; Crawford, James J. J.; Dey, Anwesha
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
NATURE COMMUNICATIONS
IF15.7
2022-11-1050
OAAI
Cantley, Jennifer; Ye, Xiaofen; Rousseau, Emma; Januario, Tom; Hamman, Brian D.; Rose, Christopher M.; Cheung, Tommy K.; Hinkle, Trent; Soto, Leofal; Quinn, Connor; Harbin, Alicia; Bortolon, Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva; Yu, Shang-Fan; Del Rosario, Geoff; Chan, Emily; Dunlap, Debra; Koeppen, Hartmut; Martin, Scott; Merchant, Mark; Grimmer, Matt; Broccatelli, Fabio; Wang, Jing; Pizzano, Jennifer; Dragovich, Peter S.; Berlin, Michael; Yauch, Robert L.
Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Berlin, Michael; Cantley, Jennifer; Wang, Jing; Bookbinder, Mark; Cadelina, Gregory; Chan, Emily; Chen, Huifen; Chen, Xin; Davenport, Kim; Fernando, Tharu; Gordon, Debbie; Hamman, Brian; Haskell, Roy; Ishchenko, Alexey; Kirkpatrick, Donald S.; Maher, Jonathan; Merchant, Mark; Moffat, John; Morgan, Alicia; Nguyen, An; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Sethuraman, Vijay; Staben, Leanna; Wilson, Catherine; Ye, Xiaofen; Broccatelli, Fabio; Yauch, Robert; Dragovich, Peter S.
Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer The SUNSHINE Randomized Clinical Trial
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
IF55
2019-04-09139
OAAI
Ng, Kimmie; Nimeiri, Halla S.; McCleary, Nadine J.; Abrams, Thomas A.; Yurgelun, Matthew B.; Cleary, James M.; Rubinson, Douglas A.; Schrag, Deborah; Miksad, Rebecca; Bullock, Andrea J.; Allen, Jill; Zuckerman, Dan; Chan, Emily; Chan, Jennifer A.; Wolpin, Brian M.; Constantine, Michael; Weckstein, Douglas J.; Faggen, Meredith A.; Thomas, Christian A.; Kournioti, Chryssanthi; Yuan, Chen; Ganser, Christine; Wilkinson, Brittney; Mackintosh, Christopher; Zheng, Hui; Hollis, Bruce W.; Meyerhardt, Jeffrey A.; Fuchs, Charles S.
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-09-2199
PREAI
Romero, F. Anthony; Murray, Jeremy; Lai, Kwong Wah; Tsui, Vickie; Albrecht, Brian K.; An, Le; Beresini, Maureen H.; Boenig, Gladys de Leon; Bronner, Sarah M.; Chan, Emily W.; Chen, Kevin X.; Chen, Zhongguo; Choo, Edna F.; Clagg, Kyle; Clark, Kevin; Crawford, Terry D.; Cyr, Patrick; Nagata, Denise de Almeida; Gascoigne, Karen E.; Grogan, Jane L.; Hatzivassiliou, Georgia; Huang, Wei; Hunsaker, Thomas L.; Kaufman, Susan; Koenig, Stefan G.; Li, Ruina; Li, Yingjie; Liang, Xiaorong; Liao, Jiangpeng; Liu, Wenfeng; Ly, Justin; Maher, Jonathan; Masui, Colin; Merchant, Mark; Ran, Yingqing; Taylor, Alexander M.; Wai, John; Wang, Fei; Wei, Xiaocang; Yu, Dong; Zhu, Bing-Yan; Zhu, Xiaoyu; Magnuson, Steven

研究方向

暂未获取到该数据
M
Mark Merchant
H 指数:48论文数:380被引数:1.0万
T
Tanios Bekaii‐Saab
H 指数:82论文数:1,167被引数:2.6万
P
Peter S. Dragovich
H 指数:44论文数:170被引数:6,088
R
Robert L. Yauch
H 指数:46论文数:244被引数:1.6万
X
Xiaofen Ye
H 指数:20论文数:109被引数:2,956
K
Karen E. Gascoigne
H 指数:23论文数:87被引数:4,027
J
Jennifer Pizzano
H 指数:14论文数:47被引数:1,041
C
Charles S. Fuchs
H 指数:171论文数:1,724被引数:11.3万
D
David Shibata
H 指数:56论文数:541被引数:1.6万
J
Jing Wang
H 指数:85论文数:1,205被引数:3.4万