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M

Mark Cushman

nih national cancer institute (nci)

58H指数
315论文数
9.8K被引数
收录论文 129
发表时间
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Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G-Quadruplex in the MYC Promoter and Inhibit Topoisomerase I
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-04-26
err3
PREAI
errHan, Yichen; Buric, Adam; Chintareddy, Venkat; DeMoss, Mercedes; Chen, Luying; Dickerhoff, Jonathan; De Dios, Robyn; Chand, Pooran; Riggs, Randall; Yang, Danzhou; Cushman, Mark
err分享
err收藏
Dual targeting MYC G-quadruplex and topoisomerase I by indenoisoquinolines for cancer therapy
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errYang, Danzhou; Cushman, Mark; Wang, Kai-Bo; Elsayed, Mohamed S.; Wu, Guanhui; Buric, Adam J.; DeMoss, Mercedes
err分享
err收藏
Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-12-08
err14
PREAI
errCushman, Mark
err分享
err收藏
Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2020-05-01
err25
PREAI
errFan, Bing-Zhi; Hiasa, Hiroshi; Lv, Wei; Brody, Scott; Yang, Zhao-Yong; Aldrich, Courtney; Cushman, Mark; Liang, Jian-Hua
err分享
err收藏
Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum
errINTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
IF3.4
err2019-12-01
err7
errOAAI
errGutierrez-Corbo, Camino; Alvarez-Velilla, Raquel; Reguera, Rosa M.; Garcia-Estrada, Carlos; Cushman, Mark; Balana-Fouce, Rafael; Perez-Pertejo, Yolanda
err分享
err收藏
Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2019-06-03
err82
errOAAI
errWang, Kai-Bo; Elsayed, Mohamed S. A.; Wu, Guanhui; Deng, Nanjie; Cushman, Mark; Yang, Danzhou
err分享
err收藏
Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2019-06-01
err10
PREAI
errLi, Xue-Meng; Lv, Wei; Guo, Si-Yang; Li, Ya-Xin; Fan, Bing-Zhi; Cushman, Mark; Kong, Fan-Sheng; Zhang, Jun; Liang, Jian-Hua
err分享
err收藏
Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2019-05-01
err16
PREAI
errMa, Cong-Xuan; Lv, Wei; Li, Ya-Xin; Fan, Bing-Zhi; Han, Xu; Kong, Fan-Sheng; Tian, Jing-Chao; Cushman, Mark; Liang, Jian-Hua
err分享
err收藏
Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[c]pyrrolo[2,3-h][1,6]naphthyridin-5-one (BPN) Series顺序钯催化在苯并 [c] 吡咯并 [2，3-h][1,6]naphthyridin-5-one (BPN) 系列中发现Janus激酶抑制剂中的应用
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2018-11-21
err15
errOAAI
errElsayed, Mohamed S. A.; Nielsen, Jeffery J.; Park, Sungtae; Park, Jeongho; Liu, Qingyang; Kim, Chang H.; Pommier, Yves; Agama, Keli; Low, Philip S.; Cushman, Mark
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err收藏
Activity of Aromathecins against African Trypanosomes
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2018-11-01
err5
errOAAI
errNenortas, Nathaniel P.; Cinelli, Maris A.; Morrell, Andrew E.; Cushman, Mark; Shapiro, Theresa A.
err分享
err收藏
Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2018-07-31
err32
errOAAI
errMarzi, Laetitia; Agama, Keli; Murai, Junko; Difilippantonio, Simone; James, Amy; Peer, Cody J.; Figg, William D.; Beck, Daniel; Elsayed, Mohamed S. A.; Cushman, Mark; Pommier, Yves
err分享
err收藏
Indotecan (LMP400), Imidotecan (LMP776) and LMP744: A new class of non-camptothecin TOP1 inhibitors selective for cancer cells with homologous recombination deficiencies and high SLFN11 expression
errCANCER RESEARCH
IF16.6
err2018-07-01
err0
PREAI
errPommier, Yves; Marzi, Laetitia; Ohler, Zoe Waever; Szabova, Ludmila; Sharan, Shyam; Murai, Junko; Cushman, Mark
err分享
err收藏
Indenoisoquinoline topoisomerase I inhibitors target the DNA G-quadruplex formed in the c-Myc promoter and cause MYC downregulation
errCANCER RESEARCH
IF16.6
err2018-07-01
err0
PREAI
errWang, Kaibo; Elsayed, Mohamed S. A.; Wu, Guanhui; Cushman, Mark; Yang, Danzhou
err分享
err收藏
Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2017-08-01
err21
PREAI
errLiang, Jian-Hua; Yang, Liang; Wu, Si; Liu, Si-Si; Cushman, Mark; Tian, Jing; Li, Nuo-Min; Yang, Qing-Hu; Zhang, He-Ao; Qiu, Yun-Jie; Xiang, Lin; Ma, Cong-Xuan; Li, Xue-Meng; Qing, Hong
err分享
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Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2017-06-28
err33
errOAAI
errElsayed, Mohamed S. A.; Su, Yafan; Wang, Ping; Sethi, Taresh; Agama, Keli; Ravji, Azhar; Redon, Christophe E.; Kiselev, Evgeny; Horzmann, Katharine A.; Freeman, Jennifer L.; Pommier, Yves; Cushman, Mark
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err收藏
Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2017-04-18
err52
errOAAI
errWang, Ping; Elsayed, Mohamed S. A.; Plescia, Caroline B.; Ravji, Azhar; Redon, Christophe E.; Kiselev, Evgeny; Marchand, Christophe; Zeleznik, Olga; Agama, Keli; Pommier, Yves; Cushman, Mark
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Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2017-03-15
err52
errOAAI
errMohammad, Haroon; Younis, Waleed; Chen, Lu; Peters, Christine E.; Pogliano, Joe; Pogliano, Kit; Cooper, Bruce; Zhang, Jianan; Mayhoub, Abdelrahman; Oldfield, Eric; Cushman, Mark; Seleem, Mohamed N.
err分享
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A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2016-11-01
err21
errOAAI
errZhao, Li-Ming; Jin, Hai-Shan; Liu, Jinzhong; Skaar, Todd C.; Ipe, Joseph; Lv, Wei; Flockhart, David A.; Cushman, Mark
err分享
err收藏
One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2016-05-06
err10
PREAI
errSteinhauer, Tamara N.; Girreser, Ulrich; Meier, Christopher; Cushman, Mark; Clement, Bernd
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Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2016-04-20
err48
errOAAI
errLv, Peng-Cheng; Elsayed, Mohamed S. A.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark
err分享
err收藏

研究方向

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合作学者
合作期刊
E
Erik De Clercq
H 指数: 162 · 论文数: 4.0K

Yves Pommier
H 指数: 138 · 论文数: 2.0K
K
K. C. Nicolaou
H 指数: 113 · 论文数: 941
P
Philip S. Low
H 指数: 108 · 论文数: 712
W
William Fenical
H 指数: 107 · 论文数: 702
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