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Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca2+ influx 破骨细胞中NLRP3炎症小体的活化被一种Tmem178依赖的机制所抑制,该机制限制了Ca2+内流 Kaur, Khushpreet; Alippe, Yael; Wang, Chun; Semenkovich, Nicholas P.; Hassan, Mohamed G.; Bhagat, Saumya; Khanna, Kunjan; Li, Yongjia; Pokhrel, Nitin; Peterson, Timothy; Scheller, Erica L.; Veis, Deborah J.; Abu-Amer, Yousef; Faccio, Roberta; Mbalaviele, Gabriel 分享 收藏
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DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 Swarnkar, Gaurav; Semenkovich, Nicholas P.; Arra, Manoj; Mims, Dorothy K.; Naqvi, Syeda Kanwal; Peterson, Timothy; Mbalaviele, Gabriel; Wu, Chia- Lung; Abu-Amer, Yousef; Nathan, Carl F. 分享 收藏
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Glutamine metabolism modulates chondrocyte inflammatory response Arra, Manoj; Swarnkar, Gaurav; Adapala, Naga Suresh; Naqvi, Syeda Kanwal; Cai, Lei; Farooq Rai, Muhammad; Singamaneni, Srikanth; Mbalaviele, Gabriel; Brophy, Robert; Abu-Amer, Yousef 分享 收藏
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Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling Sun, Kai; Wang, Chun; Xiao, Jianqiu; Brodt, Michael D.; Yuan, Luorongxin; Yang, Tong; Alippe, Yael; Hu, Huimin; Hao, Dingjun; Abu-Amer, Yousef; Silva, Matthew J.; Shen, Jie; Mbalaviele, Gabriel 分享 收藏
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NLRP3 inflammasome activation triggers gasdermin D-independent inflammation NLRP3炎性体激活触发gasdermin D非依赖性炎症 Wang, Chun; Yang, Tong; Xiao, Jianqiu; Xu, Canxin; Alippe, Yael; Sun, Kai; Kanneganti, Thirumala-Devi; Monahan, Joseph B.; Abu-Amer, Yousef; Lieberman, Judy; Mbalaviele, Gabriel 分享 收藏
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria Gonzalez-Dominguez, Alvaro; Montanez, Raul; Castejon-Vega, Beatriz; Nunez-Vasco, Jessica; Lendines-Cordero, Debora; Wang, Chun; Mbalaviele, Gabriel; Navarro-Pando, Jose M.; Alcocer-Gomez, Elisabet; Cordero, Mario D. 分享 收藏
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NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis Berke, I. M.; Jain, E.; Yavuz, B.; McGrath, T.; Chen, L.; Silva, M. J.; Mbalaviele, G.; Guilak, F.; Kaplan, D. L.; Setton, L. A. 分享 收藏
Inhibition of the NLRP3 inflammasome prevents ovarian aging Navarro-Pando, Jose M.; Alcocer-Gomez, Elisabet; Castejon-Vega, Beatriz; Navarro-Villaran, Elena; Condes-Hervas, Monica; Mundi-Roldan, Maria; Muntande, Jordi; Perez-Pulido, Antonio J.; Bullon, Pedro; Wang, Chun; Hoffman, Hal M.; Sanz, Alberto; Mbalaviele, Gabriel; Ryffel, Bernhard; Cordero, Mario D. 分享 收藏
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis 软骨细胞中LDHA介导的ROS生成是骨关节炎的潜在治疗靶点 Arra, Manoj; Swarnkar, Gaurav; Ke, Ke; Otero, Jesse E.; Ying, Jun; Duan, Xin; Maruyama, Takashi; Rai, Muhammad Farooq; O'Keefe, Regis J.; Mbalaviele, Gabriel; Shen, Jie; Abu-Amer, Yousef 分享 收藏
Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure Zou, Wei; Rohatgi, Nidhi; Brestoff, Jonathan R.; Moley, John R.; Li, Yongjia; Williams, Jesse W.; Alippe, Yael; Pan, Hua; Pietka, Terri A.; Mbalaviele, Gabriel; Newberry, Elizabeth P.; Davidson, Nicholas O.; Dey, Anwesha; Shoghi, Kooresh, I; Head, Richard D.; Wickline, Samuel A.; Randolph, Gwendalyn J.; Abumrad, Nada A.; Teitelbaum, Steven L. 分享 收藏