未登录 De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8 Roy, Anindya; Shi, Lei; Chang, Ashley; Dong, Xianchi; Fernandez, Andres; Kraft, John C.; Li, Jing; Le, Viet Q.; Winegar, Rebecca Viazzo; Cherf, Gerald Maxwell; Slocum, Dean; Poulson, P. Daniel; Casper, Garrett E.; Vallecillo-Zuniga, Mary L.; Valdoz, Jonard Corpuz; Miranda, Marcos C.; Bai, Hua; Kipnis, Yakov; Olshefsky, Audrey; Priya, Tanu; Carter, Lauren; Ravichandran, Rashmi; Chow, Cameron M.; Johnson, Max R.; Cheng, Suna; Smith, McKaela; Overed-Sayer, Catherine; Finch, Donna K.; Lowe, David; Bera, Asim K.; Matute-Bello, Gustavo; Birkland, Timothy P.; DiMaio, Frank; Raghu, Ganesh; Cochran, Jennifer R.; Stewart, Lance J.; Campbell, Melody G.; Van Ry, Pam M.; Springer, Timothy; Baker, David 分享 收藏
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction England, Elizabeth; Rees, D. Gareth; Scott, Ian Christopher; Carmen, Sara; Chan, Denice T. Y.; Huntington, Catherine Chaillan E.; Houslay, Kirsty F.; Erngren, Teodor; Penney, Mark; Majithiya, Jayesh B.; Rapley, Laura; Sims, Dorothy A.; Hollins, Claire; Hinchy, Elizabeth C.; Strain, Martin D.; Kemp, Benjamin P.; Corkill, Dominic J.; May, Richard D.; Vousden, Katherine A.; Butler, Robin J.; Mustelin, Tomas; Vaughan, Tristan J.; Lowe, David C.; Colley, Caroline; Cohen, E. Suzanne 分享 收藏
An in vivo platform to select and evolve aggregation-resistant proteins Ebo, Jessica S.; Saunders, Janet C.; Devine, Paul W. A.; Gordon, Alice M.; Warwick, Amy S.; Schiffrin, Bob; Chin, Stacey E.; England, Elizabeth; Button, James D.; Lloyd, Christopher; Bond, Nicholas J.; Ashcroft, Alison E.; Radford, Sheena E.; Lowe, David C.; Brockwell, David J. 分享 收藏
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 Vousden, Katherine A.; Lundqvist, Tomas; Popovic, Bojana; Naiman, Brian; Carruthers, Alan M.; Newton, Philip; Johnson, Daniel J. D.; Pomowski, Anja; Wilkinson, Trevor; Dufner, Patrick; de Mendez, Isabelle; Mallinder, Philip R.; Murray, Clare; Strain, Martin; Connor, Jane; Murray, Lynne A.; Sleeman, Matthew A.; Lowe, David C.; Huntington, James A.; Vaughan, Tristan J. 分享 收藏
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A high-throughput platform for population reformatting and mammalian expression of phage display libraries to enable functional screening as full-length IgG Xiao, Xiaodong; Douthwaite, Julie A.; Chen, Yan; Kemp, Ben; Kidd, Sara; Percival-Alwyn, Jennifer; Smith, Alison; Goode, Kate; Swerdlow, Bonnie; Lowe, David; Wu, Herren; Dall'Acqua, William F.; Chowdhury, Partha S. 分享 收藏
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Inducing protein aggregation by extensional flow Dobson, John; Kumar, Amit; Willis, Leon F.; Tuma, Roman; Higazi, Daniel R.; Turner, Richard; Lowe, David C.; Ashcroft, Alison E.; Radford, Sheena E.; Kapur, Nikil; Brockwell, David J. 分享 收藏
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues Phillips, Jonathan J.; Buchanan, Andrew; Andrews, John; Chodorge, Matthieu; Sridharan, Sudharsan; Mitchell, Laura; Burmeister, Nicole; Kippen, Alistair D.; Vaughan, Tristan J.; Higazi, Daniel R.; Lowe, David 分享 收藏
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo Dobson, Claire L.; Devine, Paul W. A.; Phillips, Jonathan J.; Higazi, Daniel R.; Lloyd, Christopher; Popovic, Bojana; Arnold, Joanne; Buchanan, Andrew; Lewis, Arthur; Goodman, Joanne; van der Walle, Christopher F.; Thornton, Peter; Vinall, Lisa; Lowne, David; Aagaard, Anna; Olsson, Lise-Lotte; Wollberg, Anna Ridderstad; Welsh, Fraser; Karamanos, Theodoros K.; Pashley, Clare L.; Iadanza, Matthew G.; Ranson, Neil A.; Ashcroft, Alison E.; Kippen, Alistair D.; Vaughan, Tristan J.; Radford, Sheena E.; Lowe, David C. 分享 收藏
A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors Webster, Carl I.; Bryson, Christine J.; Cloake, Edward A.; Jones, Tim D.; Austin, Mark J.; Karle, Anette C.; Spindeldreher, Sebastian; Lowe, David C.; Baker, Matthew P. 分享 收藏
The INNs and outs of antibody nonproprietary names Jones, Tim D.; Carter, Paul J.; Plueckthun, Andreas; Vasquez, Max; Holgate, Robert G. E.; Hoetzel, Isidro; Popplewell, Andrew G.; Parren, Paul W. H. I.; Enzelberger, Markus; Rademaker, Hendrik J.; Clark, Michael R.; Lowe, David C.; Dahiyat, Bassil I.; Smith, Victoria; Lambert, John M.; Wu, Herren; Reilly, Mary; Haurum, John S.; Duebel, Stefan; Huston, James S.; Schirrmann, Thomas; Janssen, Richard A. J.; Steegmaier, Martin; Gross, Jane A.; Bradbury, Andrew R. M.; Burton, Dennis R.; Dimitrov, Dimiter S.; Chester, Kerry A.; Glennie, Martin J.; Davies, Julian; Walker, Adam; Martin, Steve; McCafferty, John; Baker, Matthew P. 分享 收藏
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation Cohen, E. Suzanne u; Scott, Ian C.; Majithiya, Jayesh B.; Rapley, Laura; Kemp, Benjamin P.; England, Elizabeth; Rees, D. Gareth; Overed-Sayer, Catherine L.; Woods, Joanne; Bond, Nicholas J.; Veyssier, Christel Seguy; Embrey, Kevin J.; Sims, Dorothy A.; Snaith, Michael R.; Vousden, Katherine A.; Strain, Martin D.; Chan, Denice T. Y.; Carmen, Sara; Huntington, Catherine E.; Flavell, Liz; Xu, Jianqing; Popovic, Bojana; Brightling, Christopher E.; Vaughan, Tristan J.; Butler, Robin; Lowe, David C.; Higazi, Daniel R.; Corkill, Dominic J.; May, Richard D.; Sleeman, Matthew A.; Mustelin, Tomas 分享 收藏
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase Klein, Tobias; Vajpai, Navratna; Phillips, Jonathan J.; Davies, Gareth; Holdgate, Geoffrey A.; Phillips, Chris; Tucker, Julie A.; Norman, Richard A.; Scott, Andrew D.; Higazi, Daniel R.; Lowe, David; Thompson, Gary S.; Breeze, Alexander L. 分享 收藏
Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1 Douthwaite, Julie A.; Sridharan, Sudharsan; Huntington, Catherine; Hammersley, Jayne; Marwood, Rose; Hakulinen, Jonna K.; Ek, Margareta; Sjoegren, Tove; Rider, David; Privezentzev, Cyril; Seaman, Jonathan C.; Cariuk, Peter; Knights, Vikki; Young, Joyce; Wilkinson, Trevor; Sleeman, Matthew; Finch, Donna K.; Lowe, David C.; Vaughan, Tristan J. 分享 收藏
In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus Vugmeyster, Yulia; Guay, Heath; Szklut, Pamela; Qian, Ming D.; Lin, Macy; Widom, Angela; Spaulding, Vikki; Bennett, Frann; Lowe, Leslie; Andreyeva, Tatyana; Lowe, David; Lane, Steven; Thom, George; Valge-Archer, Viia; Gill, Davinder; Young, Deborah; Bloom, Laird 分享 收藏
Monovalent IgG4 molecules Immunoglobulin Fc mutations that result in a monomeric structure Wilkinson, Ian C.; Fowler, Susan B.; Machiesky, LeeAnn; Miller, Kenneth; Hayes, David B.; Adib, Morshed; Her, Cheng; Borrok, M. Jack; Tsui, Ping; Burrell, Matthew; Corkill, Dominic J.; Witt, Susanne; Lowe, David C.; Webster, Carl I. 分享 收藏
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