未登录 Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding (vol 8, 111, 2025) 影响EGFR不可逆抑制的因素以及手性对共价结合的影响（卷8，111，2025） Morese, Pasquale A.; Ahmad, Ayaz; Martin, Mathew P.; Noble, Richard A.; Pintar, Sara; Wang, Lan Z.; Xu, Shangze; Lister, Andrew; Ward, Richard A.; Bronowska, Agnieszka K.; Noble, Martin E. M.; Stewart, Hannah L.; Waring, Michael J. 分享 收藏
Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding 影响EGFR不可逆抑制的因素以及手性对共价结合的影响 Morese, Pasquale A.; Ahmad, Ayaz; Martin, Mathew P.; Noble, Richard A.; Pintar, Sara; Wang, Lan Z.; Xu, Shangze; Lister, Andrew; Ward, Richard A.; Bronowska, Agnieszka K.; Noble, Martin E. M.; Stewart, Hannah L.; Waring, Michael J. 分享 收藏
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations Thomson, Clare; Braybrooke, Erin; Colclough, Nicola; Davies, Nichola L.; Floc'h, Nicolas; Greenwood, Ryan; Guerot, Carine; Hargreaves, David; Johnstrom, Peter; Khurana, Puneet; Kostomiris, Demetrios H.; Li, Songlei; Lister, Andrew; Lorthioir, Olivier; Martin, Scott; Mccoull, William; Mclean, Neville J.; Mcwilliams, Lisa; Orme, Jonathan P.; Packer, Martin J.; Pearson, Stuart; Swaih, Aisha M.; Tentarelli, Sharon; Tucker, Michael J.; Ward, Richard A.; Wilkinson, Stephen; Winlow, Poppy; Wood, Isabel L. 分享 收藏
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations Thomson, Clare; Barton, Peter; Braybrooke, Erin; Colclough, Nicola; Dong, Zhiqiang; Evans, Laura; Floc'h, Nicolas; Guerot, Carine; Hargreaves, David; Khurana, Puneet; Li, Songlei; Li, Xiuwei; Lister, Andrew; McCoull, William; McWilliams, Lisa; Orme, Jonathan P.; Packer, Martin J.; Swaih, Aisha M.; Ward, Richard A.; Winlow, Poppy; Ye, Yang 分享 收藏
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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release Morese, Pasquale A.; Anthony, Nahoum; Bodnarchuk, Michael; Jennings, Claire; Martin, Mathew P.; Noble, Richard A.; Phillips, Nicole; Thomas, Huw D.; Wang, Lan Z.; Lister, Andrew; Noble, Martin E. M.; Ward, Richard A.; Wedge, Stephen R.; Stewart, Hannah L.; Waring, Michael J. 分享 收藏
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Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance Finlay, M. Raymond, V; Barton, Peter; Bickerton, Sue; Bista, Michal; Colclough, Nicola; Cross, Darren A. E.; Evans, Laura; Floc'h, Nicolas; Gregson, Clare; Guerot, Carine M.; Hargreaves, David; Kang, Xiaoming; Lenz, Eva M.; Li, Xu; Liu, Yi; Lorthioir, Olivier; Martin, Matthew J.; McKerrecher, Darren; McWhirter, Claire; O'Neill, Daniel; Orme, Jonathan P.; Mosallanejad, Arash; Rahi, Amar; Smith, Paul D.; Talbot, Verity; Ward, Richard A.; Wrigley, Gail; Wylot, Marta; Xue, Lin; Yao, Tieguang; Ye, Yang; Zhao, Xiliang 分享 收藏
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AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib Flemington, Vikki; Davies, Emma J.; Robinson, David; Sandin, Linda C.; Delpuech, Oona; Zhang, Pei; Hanson, Lyndsey; Farrington, Paul; Bell, Sigourney; Falenta, Katarzyna; Gibbons, Francis D.; Lindsay, Nicola; Smith, Aaron; Wilson, Joanne; Roberts, Karen; Tonge, Michael; Hopcroft, Philip; Willis, Sophie E.; Roudier, Martine P.; Rooney, Claire; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Fawell, Stephen E.; Jones, Clifford D.; Ward, Richard A.; Simpson, Iain; Cosulich, Sabina C.; Pease, J. Elizabeth; Smith, Paul D. 分享 收藏
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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors McAulay, Kirsten; Hoyt, Emily A.; Thomas, Morgan; Schimpl, Marianne; Bodnarchuk, Michael S.; Lewis, Hilary J.; Barratt, Derek; Bhavsar, Deepa; Robinson, David M.; Deery, Michael J.; Ogg, Derek J.; Bernardes, Goncalo J. L.; Ward, Richard A.; Waring, Michael J.; Kettle, Jason G. 分享 收藏
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC) Ward, Richard A.; Anderton, Mark J.; Bethel, Paul; Breed, Jason; Cook, Calum; Davies, Emma J.; Dobson, Andrew; Dong, Zhiqiang; Fairley, Gary; Farrington, Paul; Feron, Lyman; Flemington, Vikki; Gibbons, Francis D.; Graham, Mark A.; Greenwood, Ryan; Hanson, Lyndsey; Hopcroft, Philip; Howells, Rachel; Hudson, Julian; James, Michael; Jones, Clifford D.; Jones, Christopher R.; Li, Yongchao; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; McCabe, James; McGuire, Thomas; Rawlins, Philip; Roberts, Karen; Sandin, Linda; Simpson, Iain; Swallow, Steve; Tang, Jia; Tomkinson, Gary; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang 分享 收藏
Evaluation of the therapeutic potential of phosphine oxide pyrazole inhibitors in tumors harboring EGFR C797S mutation Floch, Nicolas; Finlay, M. Raymond V.; Bianco, Ambra; Bickerton, Sue; Colclough, Nicola; Cross, Darren A.; Cuomo, Emanuela M.; Guerot, Carine M.; Hargreaves, David; Martin, Matthew J.; McKerrecher, Darren; O'Neill, Daniel J.; Orme, Jonathan P.; Rahi, Amar; Smith, Paul D.; Ward, Richard A. 分享 收藏
Comparative activity profiling of tyrosine kinase inhibitors (TKIs) against exon 20 insertions and the wild-type form of epidermal growth factor receptor (EGFR) Ward, Richard A.; Bianco, Ambra; Colclough, Nicola; Cross, Darren; Cuomo, Emanuela M.; Finlay, M. Raymond V.; Fitzek, Martina; Floc'h, Nicolas; Gagrica, Sladjana; Hammond, Beverley; Martin, Matthew J.; McKerrecher, Darren; O'Neill, Daniel J.; Orme, Jonathan P.; Smith, Paul D.; Staniszewska, Anna D.; Urosevic, Jelena; Whalley, Nicky; Yates, James W. 分享 收藏
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Discovery of AZD0364, a potent and selective oral inhibitor of ERK1/2 that is efficacious in both monotherapy and combination therapy in models of NSCLC Simpson, Iain; Anderton, Mark J.; Andrews, David M.; Breed, Jason; Davies, Emma; Debreczeni, Judit E.; Flemington, Vikki; Gibbons, Francis D.; Graham, Mark A.; Hopcroft, Philip; Howard, Tina; Hudson, Julian; Jones, Clifford D.; Jones, Christopher; Lindsay, Nicola; Pease, J. Elizabeth; Rawlins, Philip; Roberts, Karen; Swallow, Steve; St-Gallay, Steve; Tonge, Michael E.; Ward, Richard A. 分享 收藏
Combination of the novel ERK inhibitor AZD0364 with the MEK inhibitor selumetinib significantly enhances antitumor activity in KRAS mutant tumor models Flemington, Vikki; Simpson, Iain; Breed, Jason; Davies, Emma; Gibbons, Francis; Hopcroft, Phillip; Lyndsay, Nicola; Jones, Christopher; Jones, Clifford; Robinson, David; Rooney, Claire; Roberts, Karen; Sandin, Linda; Ward, Richard; Zhang, Pei; Pease, Elizabeth 分享 收藏
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