Gary L. Johnson - Publications, H-index & Citations

Gary L. Johnson

University of North Carolina School of Medicine

103H指数

963论文数

4.5W被引数

收录论文 187

发表时间

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart MEK抑制剂trametinib导致小鼠心脏线粒体损伤并诱导固有免疫反应

Science Advances

IF12.5

2026-07-10

OAAI

Kelsey H. Fisher-Wellman; Richard D. Lutze; Logan G. Kirkland; Ju Youn Beak; Mansi Goyal; Raghu Nagalingam; Samantha M. Morrissey; Peyton B. Sandroni; Wei Huang; Julian D. Bailon; Melissa A. Schroder; Lars A. Albrecht; Ethelyn Ofei; Andrew L. Chin; Thomas D. Green; Joseph M. McClung; McLane M. Montgomery; James T. Hagen; Brett R. Chrest; Edziu M. Franczak; Polina Krassovkaia; Raphael T. Aruleba; Jon S. Zawistowski; Timothy J. Stuhlmiller; Shawn M. Gomez; Nanthip Prathumsap; Qing Zhang; Jing Zhang; Weiyi Xu; Lilei Zhang; Jeremy A. Meier; Lisa A. Carey; Jonathan C. Schisler; Gary L. Johnson; Brian C. Jensen

Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4 肿瘤内缺氧通过慢性激活整合应激反应转录因子ATF4促进CD8+ T细胞功能障碍

Immunity

IF26.3

2025-09-25

OAAI

Coral del Mar Alicea Pauneto; Brian P. Riesenberg; Evelyn J. Gandy; Andrew S. Kennedy; Genevieve T. Clutton; Jessica W. Hem; Katie E. Hurst; Elizabeth G. Hunt; Jarred M. Green; Brian C. Miller; Steven P. Angus; Gary L. Johnson; Robert J. Esther; Jennifer L. Guerriero; Peng Gao; David R. Soto-Pantoja; Robert L. Ferris; Jennifer L. Modliszewski; Michael F. Coleman; H. Kay Chung; J. Justin Milner; Stergios J. Moschos; R. Luke Wiseman; Jessica E. Thaxton

Phase II study of MEK inhibitor trametinib alone and in combination with AKT inhibitor GSK2141795/uprosertib in patients with metastatic triple negative breast cancer MEK抑制剂曲美替尼单独或与AKT抑制剂GSK2141795/乌普罗替尼联合治疗转移性三阴性乳腺癌患者的II期研究

BREAST CANCER RESEARCH AND TREATMENT

IF3

2024-12-07

PREAI

Prasath, Vishnu; Boutrid, Hinda; Wesolowski, Robert; Abdel-Rasoul, Mahmoud; Timmers, Cynthia; Lustberg, Maryam; Layman, Rachel M.; Macrae, Erin; Mrozek, Ewa; Shapiro, Charles; Glover, Kristyn; Vater, Mark; Budd, G. Thomas; Harris, Lyndsay; Isaacs, Claudine; Dees, Claire; Perou, Charles M.; Johnson, Gary L.; Poklepovic, Andrew; Chen, Helen; Villalona-Calero, Miguel; Carson, William; Stover, Daniel G.; Ramaswamy, Bhuvaneswari

INTEGRATED MULTIOMIC ANALYSIS OF ISOGENIC EGFRVIII MODELS OF GBM REVEALS EXPLOITABLE THERAPEUTIC VULNERABILITIES

NEURO-ONCOLOGY

IF13.4

2024-11-11

PREAI

Lin, Benjamin; Shelton, Abigail; Skinner, Kasey; Smithberger, Erin; Ziebro, Julia; Bash, Ryan; Angus, Steven; East, Michael; Johnson, Gary; Furnari, Frank; Miller, C. Ryan

Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition

FRONTIERS IN ONCOLOGY

IF3.3

2024-05-16

OAAI

Dubose, Evan; Bevill, Samantha M.; Mitchell, Dana K.; Sciaky, Noah; Golitz, Brian T.; Dixon, Shelley A. H.; Rhodes, Steven D.; Bear, James E.; Johnson, Gary L.; Angus, Steven P.

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-05-01

OAAI

Asquith, Christopher R. M.; East, Michael P.; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I.; Axtman, Alison D.; Drewry, David H.; Tizzard, Graham J.; Poso, Antti; Willson, Timothy M.; Johnson, Gary L.

Phase II study of trametinib alone and in combination with uprosertib in patients with metastatic triple negative breast cancer previously treated with chemotherapy: OSU 13317

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Prasath, Vishnu; Boutrid, Hinda; Mrozek, Ewa; Lustberg, Maryam; Weslowski, Robert; Layman, Rachel; Abdel-Rasoul, Mahmoud; Timmers, Cynthia; MacRae, Erin; Budd, G. Thomas; Harris, Lyndsay; Isaacs, Claudine; Ismail-Khan, Roohi; Dees, Elizabeth Claire; Poklepovic, Andrew S.; Chen, Helen X.; Villalona-Calero, Miguel; Carson, William; Johnson, Gary L.; Stover, Daniel G.; Ramaswamy, Bhuvaneswari

Illuminating function of the understudied kinome

DRUG DISCOVERY TODAY

IF7.5

2024-03-01

PREAI

Gomez, Shawn M.; Axtman, Alison D.; Willson, Timothy M.; Major, Michael B.; Townsend, Reid R.; Sorger, Peter K.; Johnson, Gary L.

Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

OAAI

Fanger, GR; Vaillancourt, RR; Heasley, LE; Montmayeur, JPR; Johnson, GL; Maue, RA

Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Kharbanda, S; Pandey, P; Yamauchi, T; Kumar, S; Kaneki, M; Kumar, V; Bharti, A; Yuan, ZM; Ghanem, L; Rana, A; Weichselbaum, R; Johnson, G; Kufe, D

Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

263

OAAI

Gibson, SB; Oyer, R; Spalding, AC; Anderson, SM; Johnson, GL

Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Nakamura, Kazuhiro; Johnson, Gary L.

MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Xia, Yan; Wang, Ji; Xu, Shuichan; Johnson, Gary L.; Hunters, Tony; Lu, Zhimin

MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

234

OAAI

Widmann, C; Gerwins, P; Johnson, L; Jarpe, MB; Johnson, GL

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Sun, WY; Wei, XD; Kesavan, K; Garrington, TP; Fan, RH; Mei, JJ; Anderson, SM; Gelfand, EW; Johnson, GL

Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Abell, AN; Rivera-Perez, JA; Cuevas, BD; Uhlik, MT; Sather, S; Johnson, NL; Minton, SK; Lauder, JM; Winter-Vann, AM; Nakamura, K; Magnuson, T; Vaillancourt, RR; Heasley, LE; Johnson, GL

PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation 细胞外信号调节激酶5激活需要PB1结构域依赖性信号复合物

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Nakamura, K; Uhlik, MT; Johnson, NL; Hahn, KM; Johnson, GL

Trophoblast Stem Cell Maintenance by Fibroblast Growth Factor 4 Requires MEKK4 Activation of Jun N-Terminal Kinase

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Abell, Amy N.; Granger, Deborah A.; Johnson, Nancy L.; Vincent-Jordan, Nicole; Dibble, Christopher F.; Johnson, Gary L.

SWI/SNF Chromatin-Remodeling Factor Smarcd3/Baf60c Controls Epithelial-Mesenchymal Transition by Inducing Wnt5a Signaling SWI/SNF染色质重塑因子Smarcd3/Baf60c通过诱导Wnt5a信号调控上皮间质转化

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Jordan, Nicole Vincent; Prat, Aleix; Abell, Amy N.; Zawistowski, Jon S.; Sciaky, Noah; Karginova, Olga A.; Zhou, Bingying; Golitz, Brian T.; Perou, Charles M.; Johnson, Gary L.

MicroRNA 9-3p Targets β1 Integrin To Sensitize Claudin-Low Breast Cancer Cells to MEK Inhibition

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Zawistowski, Jon S.; Nakamura, Kazuhiro; Parker, Joel S.; Granger, Deborah A.; Golitz, Brian T.; Johnson, Gary L.

研究方向