Patrick R. Sears - Publications, H-index & Citations

Patrick R. Sears

University of North Carolina at Chapel Hill

19H指数

53论文数

1.3K被引数

收录论文 20

发表时间

Variants in CEP135 Cause Congenital Microcephaly and Primary Ciliary Dyskinesia CEP135基因变异导致先天性小头畸形和原发性纤毛运动障碍

Pediatric Pulmonology

IF2.3

2026-10-05

OAAI

Abigail Bergman-Sieger; Marc-André Turcot; Lawrence E. Ostrowski; Patrick R. Sears; Maimoona A. Zariwala; Fateh Bechkir; Lisa R. Young; Adam J. Shapiro; Maureen B. Parenti

Lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models 脂质纳米颗粒包封的Dnai1 mRNA在原发性纤毛运动障碍小鼠细胞模型中恢复纤毛活性

JOURNAL OF CELL SCIENCE

IF3.6

2025-10-01

OAAI

Smith, Amanda J.; Sears, Patrick R.; Hennig, Mirko; Bhattacharjee, Rumpa B.; Yin, Weining; Golliher, Hannah; Ishimaru, Daniella; Lombana, T. Noelle; Lockhart, David J.; Wustman, Brandon A.; Ostrowski, Lawrence E.

Cells 2025, Vol. 14, Page 1460

IF5.2

2025-09-20

OAAI

Marie-Hélène Bourassa; Guillaume Sillon; Shuizi Ding; Maurizio Chioccioli; Monkol Lek; Kaiyue Ma; Alejandro Mejia-Garcia; Simon Gravel; Donald C. Vinh; Michael R. Knowles; Margaret W. Leigh; Stephanie D. Davis; Thomas Ferkol; Kenneth N. Olivier; Elizabeth N. Schecterman; Weining Yin; Patrick R. Sears; Martina Gentzsch; Susan E. Boyles; William D. Bennett; Kirby L. Zeman; Lawrence E. Ostrowski; Maimoona A. Zariwala; Adam J. Shapiro

Development of an inhalable contrast agent targeting the respiratory tract mucus layer for pulmonary ultrasonic imaging

SCIENTIFIC REPORTS

IF3.9

2024-12-01

OAAI

Tsuruta, James K.; Sears, Patrick R.; Rebuli, Meghan E.; Weitz, Andrew S.; Durham, Phillip G.; Clapp, Phillip W.; Hill, David B.; Ostrowski, Lawrence E.; Dayton, Paul A.; Caughey, Melissa C.

Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2024-04-16

OAAI

Dougherty, Gerard W.; Ostrowski, Lawrence E.; Noethe-Menchen, Tabea; Raidt, Johanna; Schramm, Andre; Olbrich, Heike; Yin, Weining; Sears, Patrick R.; Dang, Hong; Smith, Amanda J.; Beule, Achim G.; Hjeij, Rim; Rutjes, Niels; Haarman, Eric G.; Maas, Saskia M.; Ferkol, Thomas W.; Noone, Peadar G.; Olivier, Kenneth N.; Bracht, Diana C.; Barbry, Pascal; Zaragosi, Laure-Emmanuelle; Fierville, Morgane; Kliesch, Sabine; Wohlgemuth, Kai; Koenig, Julia; George, Sebastian; Loges, Niki T.; Ceppe, Agathe; Markovetz, Matthew R.; Luo, Hong; Guo, Ting; Rizk, Hoda; Eldesoky, Tarek; Dahlke, Katrin; Boldt, Karsten; Ueffing, Marius; Hill, David B.; Pang, Yuan-Ping; Knowles, Michael R.; Zariwala, Maimoona A.; Omran, Heymut

The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia

JOURNAL OF CELL SCIENCE

IF3.6

2022-03-31

OAAI

Smith, Amanda J.; Bustamante-Marin, Ximena M.; Yin, Weining; Sears, Patrick R.; Herring, Laura E.; Dicheva, Nedyalka N.; Lopez-Giraldez, Francesc; Mane, Shrikant; Tarran, Robert; Leigh, Margaret W.; Knowles, Michael R.; Zariwala, Maimoona A.; Ostrowski, Lawrence E.

Structural insights into the cause of human RSPH4A primary ciliary dyskinesia

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2021-06-01

OAAI

Zhao, Yanhe; Pinskey, Justine; Lin, Jianfeng; Yin, Weining; Sears, Patrick R.; Daniels, Leigh A.; Zariwala, Maimoona A.; Knowles, Michael R.; Ostrowski, Lawrence E.; Nicastro, Daniela

Induction of ciliary orientation by matrix patterning and characterization of mucociliary transport

BIOPHYSICAL JOURNAL

IF3.1

2021-04-01

OAAI

Sears, Patrick R.; Bustamante-Marin, Ximena M.; Gong, Henry; Markovetz, Matthew R.; Superfine, Richard; Hill, David B.; Ostrowski, Lawrence E.

Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms inChlamydomonas, causes primary ciliary dyskinesia

PLOS GENETICS

IF3.7

2020-08-07

OAAI

Bustamante-Marin, Ximena M.; Horani, Amjad; Stoyanova, Mihaela; Charng, Wu-Lin; Bottier, Mathieu; Sears, Patrick R.; Yin, Wei-Ning; Daniels, Leigh Anne; Bowen, Hailey; Conrad, Donald F.; Knowles, Michael R.; Ostrowski, Lawrence E.; Zariwala, Maimoona A.; Dutcher, Susan K.

A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance (vol 75, pg 878, 2020)

NATURE MEDICINE

IF50

2020-01-29

OAAI

Chivukula, Raghu R.; Montoro, Daniel T.; Leung, Hui Min; Yang, Jason; Shamseldin, Hanan E.; Taylor, Martin S.; Dougherty, Gerard W.; Zariwala, Maimoona A.; Carson, Johnny; Daniels, M. Leigh Anne; Sears, Patrick R.; Black, Katharine E.; Hariri, Lida P.; Almogarri, Ibrahim; Frenkel, Evgeni M.; Vinarsky, Vladimir; Omran, Heymut; Knowles, Michael R.; Tearney, Guillermo J.; Alkuraya, Fowzan S.; Sabatini, David M.

A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

NATURE MEDICINE

IF50

2020-01-20

OAAI

Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary Clearance and Develop a Primary Ciliary Dyskinesia Phenotype Rsph1缺失的小鼠表现出低水平的粘液纤毛清除，并发展为原发性纤毛运动障碍表型

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2019-09-01

OAAI

Yin, Weining; Livraghi-Butrico, Alessandra; Sears, Patrick R.; Rogers, Troy D.; Burns, Kimberlie A.; Grubb, Barbara R.; Ostrowski, Lawrence E.

Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2019-02-01

OAAI

Bustamante-Marin, Ximena M.; Yin, Wei-Ning; Sears, Patrick R.; Werner, Michael E.; Brotslaw, Eva J.; Mitchell, Brian J.; Jania, Corey M.; Zeman, Kirby L.; Rogers, Troy D.; Herring, Laura E.; Refabert, Luc; Thomas, Lucie; Amselem, Serge; Escudier, Estelle; Legendre, Marie; Grubb, Barbara R.; Knowles, Michael R.; Zariwala, Maimoona A.; Ostrowski, Lawrence E.

Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

NANOSCALE

IF5.1

2017-01-01

OAAI

Blackmon, R. L.; Kreda, S. M.; Sears, P. R.; Chapman, B. S.; Hill, D. B.; Tracy, J. B.; Ostrowski, L. E.; Oldenburg, A. L.

High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

OPTICS LETTERS

IF3.3

2016-12-02

OAAI

Barrick, Jessica; Doblas, Ana; Gardner, Michael R.; Sears, Patrick R.; Ostrowski, Lawrence E.; Oldenburg, Amy L.

Continuous mucociliary transport by primary human airway epithelial cells in vitro

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2015-07-15

OAAI

Sears, Patrick R.; Yin, Wei-Ning; Ostrowski, Lawrence E.

Mutations in RSPH1 Cause Primary Ciliary Dyskinesia with a Unique Clinical and Ciliary Phenotype

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2014-03-15

184

OAAI

Knowles, Michael R.; Ostrowski, Lawrence E.; Leigh, Margaret W.; Sears, Patrick R.; Davis, Stephanie D.; Wolf, Whitney E.; Hazucha, Milan J.; Carson, Johnny L.; Olivier, Kenneth N.; Sagel, Scott D.; Rosenfeld, Margaret; Ferkol, Thomas W.; Dell, Sharon D.; Milla, Carlos E.; Randell, Scott H.; Yin, Weining; Sannuti, Aruna; Metjian, Hilda M.; Noone, Peadar G.; Noone, Peter J.; Olson, Christina A.; Patrone, Michael V.; Dang, Hong; Lee, Hye-Seung; Hurd, Toby W.; Gee, Heon Yung; Otto, Edgar A.; Halbritter, Jan; Kohl, Stefan; Kircher, Martin; Krischer, Jeffrey; Bamshad, Michael J.; Nickerson, Deborah A.; Hildebrandt, Friedhelm; Shendure, Jay; Zariwala, Maimoona A.

Human airway ciliary dynamics

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2013-02-01

OAAI

Sears, Patrick R.; Thompson, Kristin; Knowles, Michael R.; Davis, C. William

Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2011-08-01

OAAI

Sears, Patrick R.; Davis, C. William; Chua, Michael; Sheehan, John K.