未登录 High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions Lourenco, Andre Luiz; Chuo, Shih-Wei; Bohn, Markus F.; Hann, Byron; Khan, Shireen; Yevalekar, Neha; Patel, Nitin; Yang, Teddy; Xu, Lina; Lv, Dandan; Drakas, Robert; Lively, Sarah; Craik, Charles S. 分享 收藏
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors Ruiz-Saenz, Ana; Atreya, Chloe E.; Wang, Changjun; Pan, Bo; Dreyer, Courtney A.; Brunen, Diede; Prahallad, Anirudh; Munoz, Denise P.; Ramms, Dana J.; Burghi, Valeria; Spassov, Danislav S.; Fewings, Eleanor; Hwang, Yeonjoo C.; Cowdrey, Cynthia; Moelders, Christina; Schwarzer, Cecilia; Wolf, Denise M.; Hann, Byron; VandenBerg, Scott R.; Shokat, Kevan; Moasser, Mark M.; Bernards, Rene; Gutkind, J. Silvio; van 't Veer, Laura J.; Coppe, Jean-Philippe 分享 收藏
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma Ferguson, Ian D.; Lin, Yu-Hsiu T.; Lam, Christine; Shao, Hao; Tharp, Kevin M.; Hale, Martina; Kasap, Corynn; Mariano, Margarette C.; Kishishita, Audrey; Escobar, Bonell Patino; Mandal, Kamal; Steri, Veronica; Wang, Donghui; Phojanakong, Paul; Tuomivaara, Sami T.; Hann, Byron; Driessen, Christoph; Van Ness, Brian; Gestwicki, Jason E.; Wiita, Arun P. 分享 收藏
Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors 亚铁可激活的药物结合物在KRAS驱动的肿瘤中实现了有效的MAPK阻断 Jiang, Honglin; Muir, Ryan K.; Gonciarz, Ryan L.; Olshen, Adam B.; Yeh, Iwei; Hann, Byron C.; Zhao, Ning; Wang, Yung-Hua; Behr, Spencer C.; Korkola, James E.; Evans, Michael J.; Collisson, Eric A.; Renslo, Adam R. 分享 收藏
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers Lim, Shion A.; Zhou, Jie; Martinko, Alexander J.; Wang, Yung-Hua; Filippova, Ekaterina V.; Steri, Veronica; Wang, Donghui; Remesh, Soumya G.; Liu, Jia; Hann, Byron; Kossiakoff, Anthony A.; Evans, Michael J.; Leung, Kevin K.; Wells, James A. 分享 收藏
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Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy Dodagatta-Marri, Eswari; Ma, Hsiao-Yen; Liang, Benjia; Li, John; Meyer, Dominique S.; Chen, Szu-Ying; Sun, Kai-Hui; Ren, Xin; Zivak, Bahar; Rosenblum, Michael D.; Headley, Mark B.; Pinzas, Lauren; Reed, Nilgun, I; Del Cid, Joselyn S.; Hann, Byron C.; Yang, Sharon; Giddabasappa, Anand; Noorbehesht, Kavon; Yang, Bing; Dal Porto, Joseph; Tsukui, Tatsuya; Niessen, Kyle; Atakilit, Amha; Akhurst, Rosemary J.; Sheppard, Dean 分享 收藏
Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL Nix, Matthew A.; Mandal, Kamal; Geng, Huimin; Paranjape, Neha; Lin, Yu-Hsiu T.; Rivera, Jose M.; Marcoulis, Makeba; White, Kristie L.; Whitman, Jeffrey D.; Bapat, Sagar P.; Parker, Kevin R.; Ramirez, Jonathan; Deucher, Anne; Phojanokong, Paul; Steri, Veronica; Fattahi, Faranak; Hann, Byron C.; Satpathy, Ansuman T.; Manglik, Aashish; Stieglitz, Elliot; Wiita, Arun P. 分享 收藏
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Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma Huang, Hector H.; Ferguson, Ian D.; Thornton, Alexis M.; Bastola, Prabhakar; Lam, Christine; Lin, Yu-Hsiu T.; Choudhry, Priya; Mariano, Margarette C.; Marcoulis, Makeba D.; Teo, Chin Fen; Malato, Julia; Phojanakong, Paul J.; Martin, Thomas G., III; Wolf, Jeffrey L.; Wong, Sandy W.; Shah, Nina; Hann, Byron; Brooks, Angela N.; Wiita, Arun P. 分享 收藏
Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation 用于有效，稳定和位点特异性抗体生物缀合的工程化蛋氨酸和氧杂氮丙啶的系统鉴定 Elledge, Susanna K.; Tran, Hai L.; Christian, Alec H.; Steri, Veronica; Hann, Byron; Toste, F. Dean; Chang, Christopher J.; Wells, James A. 分享 收藏
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Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes Harel, Efrat; Shoji, Jun; Abraham, Vivek; Miller, Loan; Laszik, Zoltan G.; King, Andrew; Dobi, Dejan; Szabo, Gyula; Hann, Byron; Sarwal, Minnie M.; Craik, Charles S.; Vincenti, Flavio 分享 收藏
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors Atreya, Chloe E.; Ruiz-Saenz, Ana; Wang, Changjun; Pan, Bo; Dreyer, Courtney A.; Brunen, Diede; Prahallad, Anirudh; Spassov, Danislav; Steffen, Dana J.; Hann, Byron C.; VandenBerg, Scott R.; Gutkind, Silvio; Moasser, Mark M.; van't Veer, Laura J.; Coppe, Jean-Philippe 分享 收藏
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition Scott, Gary K.; Yau, Christina; Becker, Beatrice C.; Khateeb, Sana; Mahoney, Sophia; Jensen, Martin Borch; Hann, Byron; Cowen, Bryan J.; Pegan, Scott D.; Benz, Christopher C. 分享 收藏
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies Lou, Kevin; Steri, Veronica; Ge, Alex Y.; Hwang, Y. Christina; Yogodzinski, Christopher H.; Shkedi, Arielle R.; Choi, Alex L. M.; Mitchell, Dominique C.; Swaney, Danielle L.; Hann, Byron; Gordan, John D.; Shokat, Kevan M.; Gilbert, Luke A. 分享 收藏
α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by -TGF antibody to promote durable rejection and immunity in squamous cell carcinomas Α-pd-1治疗可提高Treg/Th平衡并增加肿瘤细胞pSmad3，这两者均被-TGF抗体靶向，以促进鳞状细胞癌的持久排斥和免疫力 Dodagatta-Marri, E.; Meyer, D. S.; Reeves, M. Q.; Paniagua, R.; To, M. D.; Binnewies, M.; Broz, M. L.; Mori, H.; Wu, D.; Adoumie, M.; Del Rosario, R.; Li, O.; Buchmann, T.; Liang, B.; Malato, J.; Arce Vargus, F.; Sheppard, D.; Hann, B. C.; Mirza, A.; Quezada, S. A.; Rosenblum, M. D.; Krummel, M. F.; Balmain, A.; Akhurst, R. J. 分享 收藏
In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates Henise, Jeff; Fontaine, Shaun D.; Hearn, Brian R.; Pfaff, Samuel J.; Schneider, Eric L.; Malato, Julia; Wang, Donghui; Hann, Byron; Ashley, Gary W.; Santi, Daniel V. 分享 收藏
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