Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754ORGANIC PROCESS RESEARCH & DEVELOPMENTIF3.52025-03-013PRE
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE InhibitorJOURNAL OF MEDICINAL CHEMISTRYIF6.82021-06-0314PREAI
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6JOURNAL OF MEDICINAL CHEMISTRYIF6.82021-02-1619OA
Synthesis, Optimization, and Large-Scale Preparation of the Low Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3+2] Nitrone CycloadditionORGANIC PROCESS RESEARCH & DEVELOPMENTIF3.52020-01-298PREAI
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraintsBIOORGANIC & MEDICINAL CHEMISTRYIF32020-01-0113PREAI
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 ReceptorJOURNAL OF MEDICINAL CHEMISTRYIF6.82019-09-1845PREAI
Practical Asymmetric Fluorination Approach to the Scalable Synthesis of New Fluoroaminothiazine BACE InhibitorsORGANIC PROCESS RESEARCH & DEVELOPMENTIF3.52018-04-248PREAI
Preparation and biological evaluation of conformationally constrained BACE1 inhibitorsBIOORGANIC & MEDICINAL CHEMISTRYIF32015-07-0116OAAI
3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organismsJOURNAL OF MEDICINAL CHEMISTRYIF6.82006-10-0458PREAI
个人简介
教育背景
工作经历
荣誉奖项
未登录.png){kind=icon}
未登录个人简介教育背景工作经历荣誉奖项
研究方向