未登录 Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1 超广谱广谱中和人-美洲驼双特异性HIV-1抗体 Xu, Jianliang; Zhou, Tongqing; McKee, Krisha; Zhang, Baoshan; Liu, Cuiping; Nazzari, Alexandra F.; Pegu, Amarendra; Shen, Chen-Hsiang; Becker, Jordan E.; Bender, Michael F.; Chan, Payton; Changela, Anita; Chaudhary, Ridhi; Chen, Xuejun; Einav, Tal; Kwon, Young Do; Lin, Bob C.; Louder, Mark K.; Merriam, Jonah S.; Morano, Nicholas C.; O'Dell, Sijy; Olia, Adam S.; Rawi, Reda; Roark, Ryan S.; Stephens, Tyler; Teng, I-Ting; Tourtellott-Fogt, Emily; Wang, Shuishu; Yang, Eun Sung; Shapiro, Lawrence; Tsybovsky, Yaroslav; Doria-Rose, Nicole A.; Casellas, Rafael; Kwong, Peter D. 分享 收藏
Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS Awan, Seemal F.; Pegu, Amarendra; Strom, Larisa; Carter, Cristina A.; Hendel, Cynthia S.; Holman, LaSonji A.; Costner, Pamela J.; Trofymenko, Olga; Dyer, Renunda; Gordon, Ingelise J.; Rothwell, Ro Shauna S.; Hickman, Somia P.; Conan-Cibotti, Michelle; Doria-Rose, Nicole A.; Lin, Bob C.; O'Connell, Sarah; Narpala, Sandeep R.; Almasri, Cassandra G.; Liu, Cuiping; Ko, Sungyoul; Kwon, Young D.; Namboodiri, Aryan M.; Pandey, Janardan P.; Arnold, Frank J.; Carlton, Kevin; Gall, Jason G.; Kwong, Peter D.; Capparelli, Edmund, V; Bailer, Robert T.; Mcdermott, Adrian B.; Chen, Grace L.; Koup, Richard A.; Mascola, John R.; Coates, Emily E.; Ledgerwood, Julie E.; Gaudinski, Martin R. 分享 收藏
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization Gloegl, Matthias; Friedrich, Nikolas; Cerutti, Gabriele; Lemmin, Thomas; Kwon, Young D.; Gorman, Jason; Maliqi, Liridona; Mittl, Peer R. E.; Hesselman, Maria C.; Schmidt, Daniel; Weber, Jacqueline; Foulkes, Caio; Dingens, Adam S.; Bylund, Tatsiana; Olia, Adam S.; Verardi, Raffaello; Reinberg, Thomas; Baumann, Nicolas S.; Rusert, Peter; Dreier, Birgit; Shapiro, Lawrence; Kwong, Peter D.; Plueckthun, Andreas; Trkola, Alexandra 分享 收藏
Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain Kwon, Young D.; Pegu, Amarendra; Yang, Eun Sung; Zhang, Baoshan; Bender, Michael F.; Asokan, Mangaiarkarasi; Liu, Qingbo; McKee, Krisha; Lin, Bob C.; Liu, Tracy; Louder, Mark K.; Rawi, Reda; Reveiz, Mateo; Schaub, Andrew J.; Shen, Chen-Hsiang; Doria-Rose, Nicole A.; Lusso, Paolo; Mascola, John R.; Kwong, Peter D. 分享 收藏
Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency Zhang, Baoshan; Gorman, Jason; Kwon, Young D.; Pegu, Amarendra; Chao, Cara W.; Liu, Tracy; Asokan, Mangaiarkarasi; Bender, Michael F.; Bylund, Tatsiana; Damron, Leland; Gollapudi, Deepika; Lei, Paula; Li, Yile; Liu, Cuiping; Louder, Mark K.; McKee, Krisha; Olia, Adam S.; Rawi, Reda; Schon, Arne; Wang, Shuishu; Yang, Eun Sung; Yang, Yongping; Carlton, Kevin; Doria-Rose, Nicole A.; Shapiro, Lawrence; Seaman, Michael S.; Mascola, John R.; Kwong, Peter D. 分享 收藏
A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins Chonira, Vikas; Kwon, Young D.; Gorman, Jason; Case, James Brett; Ke, Zhiqiang; Simeon, Rudo; Cosner, Ryan G.; Harris, Darcy R.; Olia, Adam S.; Stephens, Tyler; Shapiro, Lawrence; Bender, Michael F.; Boyd, Hannah; Teng, I-Ting; Tsybovsky, Yaroslav; Krammer, Florian; Zhang, Ningyan; Diamond, Michael S.; Kwong, Peter D.; An, Zhiqiang; Chen, Zhilei 分享 收藏
A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention Kwon, Young D.; Asokan, Mangaiarkarasi; Gorman, Jason; Zhang, Baoshan; Liu, Qingbo; Louder, Mark K.; Lin, Bob C.; McKee, Krisha; Pegu, Amarendra; Verardi, Raffaello; Yang, Eun Sung; Carlton, Kevin; Doria-Rose, Nicole A.; Lusso, Paolo; Mascola, John R.; Kwong, Peter D. 分享 收藏
Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography Do Kwon, Young; Wang, Xiangchun E.; Bender, Michael F.; Yang, Rong; Li, Yile; McKee, Krisha; Rawi, Reda; O'Dell, Sijy; Schneck, Nicole A.; Shaddeau, Andrew; Zhang, Baoshan; Arnold, Frank J.; Connors, Mark; Doria-Rose, Nicole A.; Kwong, Peter D.; Lei, Q. Paula 分享 收藏
Rational Engraftment of Quaternary-Interactive Acidic Loops for Anti-HIV-1 Antibody Improvement Liu, Qingbo; Zhang, Peng; Miao, Huiyi; Lin, Yin; Do Kwon, Young; Kwong, Peter D.; Rikhtegaran-Tehrani, Zahra; Seaman, Michael S.; DeVico, Anthony L.; Sajadi, Mohammad M.; Lusso, Paolo 分享 收藏
The covalent SNAP tag for protein display quantification and low-pH protein engineering Jin, Wei; Madan, Bharat; Mussman, Brooklyn K.; Hailemariam, Amen T.; Fahad, Ahmed S.; Wolfe, Jacy R.; Kwon, Young Do; Zhang, Baoshan; Shapiro, Lawrence; Kwong, Peter D.; DeKosky, Brandon J. 分享 收藏
HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies Rantalainen, Kimmo; Berndsen, Zachary T.; Antanasijevic, Aleksandar; Schiffner, Torben; Zhang, Xi; Lee, Wen-Hsin; Torres, Jonathan L.; Zhang, Lei; Irimia, Adriana; Copps, Jeffrey; Zhou, Kenneth H.; Kwon, Young D.; Law, William H.; Schramm, Chaim A.; Verardi, Raffaello; Krebs, Shelly J.; Kwong, Peter D.; Doria-Rose, Nicole A.; Wilson, Ian A.; Zwick, Michael B.; Yates, John R., III; Schief, William R.; Ward, Andrew B. 分享 收藏
Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial Gaudinski, Martin R.; Houser, Katherine V.; Doria-Rose, Nicole A.; Chen, Grace L.; Rothwell, Ro Shauna S.; Berkowitz, Nina; Costner, Pamela; Holman, LaSonji A.; Gordon, Ingelise J.; Hendel, Cynthia S.; Kaltovich, Florence; Conan-Cibotti, Michelle; Lorenzo, Margarita Gomez; Carter, Cristina; Sitar, Sandra; Carlton, Kevin; Gall, Jason; Laurencot, Carolyn; Lin, Bob C.; Bailer, Robert T.; McDermott, Adrian B.; Ko, Sung-Youl; Pegu, Amarendra; Kwon, Young D.; Kwong, Peter D.; Namboodiri, Aryan M.; Pandey, Janardan P.; Schwartz, Richard; Arnold, Frank; Hu, Zonghui; Zhang, Lily; Huang, Yunda; Koup, Richard A.; Capparelli, Edmund V.; Graham, Barney S.; Mascola, John R.; Ledgerwood, Julie E.; Mendoza, Floreliz; Novik, Laura; Zephir, Kathy; Whalen, William; Larkin, Brenda; Saunders, Jamie; Cunningham, Jennifer; Levinson, Carol; Wang, Xiaolin; Plummer, Sarah; Victorino, Milalynn; Ola, Abidemi; Boyd, Catina; Jayasinghe, Nilusha; Apte, Preeti; Cartagena, Cora Trelles; Hicks, Renunda; Williams, Pernell; Vasilenko, Olga; Yamshchikov, Galina; Florez, Maria Burgos; Pittman, Iris; Gama, Lucio; Casazza, Joseph; DeCederfelt, Hope; Cheng, K. C.; Stein, Judy 分享 收藏
Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual Krebs, Shelly J.; Kwon, Young D.; Schramm, Chaim A.; Law, William H.; Donofrio, Gina; Zhou, Kenneth H.; Gift, Syna; Dussupt, Vincent; Georgiev, Ivelin S.; Schatzle, Sebastian; McDaniel, Jonathan R.; Lai, Yen-Ting; Sastry, Mallika; Zhang, Baoshan; Jarosinski, Marissa C.; Ransier, Amy; Chenine, Agnes L.; Asokan, Mangaiarkarasi; Bailer, Robert T.; Bose, Meera; Cagigi, Alberto; Cale, Evan M.; Chuang, Gwo-Yu; Darko, Samuel; Driscoll, Jefferson, I; Druz, Aliaksandr; Gorman, Jason; Laboune, Farida; Louder, Mark K.; McKee, Krisha; Mendez, Letzibeth; Moody, M. Anthony; O'Sullivan, Anne Marie; Owen, Christopher; Peng, Dongjun; Rawi, Reda; Sanders-Buell, Eric; Shen, Chen-Hsiang; Shiakolas, Andrea R.; Stephens, Tyler; Tsybovsky, Yaroslav; Tucker, Courtney; Verardi, Raffaello; Wang, Keyun; Zhou, Jing; Zhou, Tongqing; Georgiou, George; Alam, S. Munir; Haynes, Barton F.; Rolland, Morgane; Matyas, Gary R.; Polonis, Victoria R.; McDermott, Adrian B.; Douek, Daniel C.; Shapiro, Lawrence; Tovanabutra, Sodsai; Michael, Nelson L.; Mascola, John R.; Robb, Merlin L.; Kwong, Peter D.; Doria-Rose, Nicole A. 分享 收藏
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 Xu, Kai; Acharya, Priyamvada; Kong, Rui; Cheng, Cheng; Chuang, Gwo-Yu; Liu, Kevin; Louder, Mark K.; O'Dell, Sijy; Rawi, Reda; Sastry, Mallika; Shen, Chen-Hsiang; Zhang, Baoshan; Zhou, Tongqing; Asokan, Mangaiarkarasi; Bailer, Robert T.; Chambers, Michael; Chen, Xuejun; Choi, Chang W.; Dandey, Venkata P.; Doria-Rose, Nicole A.; Druz, Aliaksandr; Eng, Edward T.; Farney, S. Katie; Foulds, Kathryn E.; Geng, Hui; Georgiev, Ivelin S.; Gorman, Jason; Hill, Kurt R.; Jafari, Alexander J.; Kwon, Young D.; Lai, Yen-Ting; Lemmin, Thomas; McKee, Krisha; Ohr, Tiffany Y.; Ou, Li; Peng, Dongjun; Rowshan, Ariana P.; Sheng, Zizhang; Todd, John-Paul; Tsybovsky, Yaroslav; Viox, Elise G.; Wang, Yiran; Wei, Hui; Yang, Yongping; Zhou, Amy F.; Chen, Rui; Yang, Lu; Scorpio, Diana G.; McDermott, Adrian B.; Shapiro, Lawrence; Carragher, Bridget; Potter, Clinton S.; Mascola, John R.; Kwong, Peter D. 分享 收藏
Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120 Curreli, Francesca; Belov, Dmitry S.; Do Kwon, Young; Ramesh, Ranjith; Furimsky, Anna M.; O'Loughlin, Kathleen; Byrge, Patricia C.; Iyer, Lalitha V.; Mirsalis, Jon C.; Kurkin, Alexander V.; Altieri, Andrea; Debnath, Asim K. 分享 收藏
Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody Kwon, Young D.; Chuang, Gwo-Yu; Zhang, Baoshan; Bailer, Robert T.; Doria-Rose, Nicole A.; Gindin, Tatyana S.; Lin, Bob; Louder, Mark K.; McKee, Krisha; O'Dell, Sijy; Pegu, Amarendra; Schmidt, Stephen D.; Asokan, Mangaiarkarasi; Chen, Xuejun; Choe, Misook; Georgiev, Ivelin S.; Jin, Vivian; Pancera, Marie; Rawi, Reda; Wang, Keyun; Chaudhuri, Rajoshi; Kueltzo, Lisa A.; Manceva, Slobodanka D.; Todd, John-Paul; Scorpio, Diana G.; Kim, Mikyung; Reinherz, Ellis L.; Wagh, Kshitij; Korber, Bette M.; Connors, Mark; Shapiro, Lawrence; Mascola, John R.; Kwong, Peter D. 分享 收藏
Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains Joyce, M. Gordon; Georgiev, Ivelin S.; Yang, Yongping; Druz, Aliaksandr; Geng, Hui; Chuang, Gwo-Yu; Do Kwon, Young; Pancera, Marie; Rawi, Reda; Sastry, Mallika; Stewart-Jones, Guillaume B. E.; Zheng, Angela; Zhou, Tongqing; Choe, Misook; Van Galen, Joseph G.; Chen, Rita E.; Lees, Christopher R.; Narpala, Sandeep; Chambers, Michael; Tsybovsky, Yaroslav; Baxa, Ulrich; McDermott, Adrian B.; Mascola, John R.; Kwong, Peter D. 分享 收藏
Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120 (vol 60, pg 3124, 2017) Curreli, Francesca; Kwon, Young Do; Belov, Dmitry S.; Ramesh, Ranjith R.; Kurkin, Alexander V.; Altieri, Andrea; Kwong, Peter D.; Debnath, Asim K. 分享 收藏
Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation Zhou, Tongqing; Doria-Rose, Nicole A.; Cheng, Cheng; Stewart-Jones, Guillaume B. E.; Chuang, Gwo-Yu; Chambers, Michael; Druz, Aliaksandr; Geng, Hui; McKee, Krisha; Kwon, Young Do; O'Dell, Sijy; Sastry, Mallika; Schmidt, Stephen D.; Xu, Kai; Chen, Lei; Chen, Rita E.; Louder, Mark K.; Pancera, Marie; Wanninger, Timothy G.; Zhang, Baoshan; Zheng, Anqi; Farney, S. Katie; Foulds, Kathryn E.; Georgiev, Ivelin S.; Joyce, M. Gordon; Lemmin, Thomas; Narpala, Sandeep; Rawi, Reda; Soto, Cinque; Todd, John-Paul; Shen, Chen-Hsiang; Tsybovsky, Yaroslav; Yang, Yongping; Zhao, Peng; Haynes, Barton F.; Stamatatos, Leonidas; Tiemeyer, Michael; Wells, Lance; Scorpio, Diana G.; Shapiro, Lawrence; McDermott, Adrian B.; Mascola, John R.; Kwong, Peter D. 分享 收藏
Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120 Curreli, Francesca; Kwon, Young Do; Belov, Dmitry S.; Ramesh, Ranjith R.; Kurkin, Alexander V.; Altieri, Andrea; Kwong, Peter D.; Debnath, Asim K. 分享 收藏
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