Seema Qamar - Publications, H-index & Citations

Seema Qamar

Cambridge Institute for Medical Research

30H指数

122论文数

5.5K被引数

收录论文 29

发表时间

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk CD33和clusterin通过生物物理和遗传途径相互作用以调节阿尔茨海默病风险

Nature Communications

IF15.7

2026-07-17

OAAI

Roger B. Dodd; Masahiro Enomoto; Ye Zhou; Kanayo Satoh; Yalun Zhang; Fusheng Chen; Beatrice Acheson; Deniz Ghaffari; Elizabeth Sayn-Wittgenstein; Jamie J. Manning; George V. Dukas; Ronak Patel; Alondra Schweizer Burguete; Mason J. Kralovec; Mamunur Rashid; Jennifer L. Hall; Kirstin A. Tamucci; Zena Chatila; Minghua Liu; Annie J. Lee; Badri N. Vardarajan; Mariko F. Taga; Sirkku Pollari; Alon Rabinovitch; Cory D. Rillahan; Andrey A. Bobkov; Eduard Sergienko; William Meadows; Seema Qamar; Suzanne J. Randle; Christopher M. Johnson; Jean Sevalle; Jennifer Griffin; Christopher Bohm; Mitsuhiko Ikura; Xunde Xian; Joachim Herz; Megan A. Kelly; Jennifer West; Sandeep Satapathy; Mark R. Wilson; Jonathan A. Javitch; Paul E. Fraser; David A. Bennett; Philip L. De Jager; Zvi Fishelson; Dan Frenkel; Wesley B. Asher; Elizabeth M. Bradshaw; Peter St George-Hyslop

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity 多通路神经退行性蛋白毒性平台揭示DNAJB6促进非毒性FUS凝聚体凝胶化并抑制神经毒性

Nature Communications

IF15.7

2025-11-21

OAAI

Samuel J. Resnick; Seema Qamar; Pushya Krishna; Vladislav Korobeynikov; Hannes Ausserwoger; Alyssa Miller; Pietro Esposito; Juan A. Varela; Jenny Sheng; Lei Haley Huang; Jonathon Nixon-Abell; Schuyler Melore; Chyi Wei Chung; Nino F. Läubli; Sofia Kapsiani; Xuecong Li; Jingshu Wang; Nancy Zhang; Mahabub Maraj Alam; Alondra S. Burguete; Theresa C. Swayne; Yanyan Chen; Ya-Cheng Liao; Neil A. Shneider; Michele Vendruscolo; Tuomas P. J. Knowles; Clemens F. Kaminski; Francesco Simone Ruggeri; Gabriele S. Kaminski Schierle; Peter St George-Hyslop; Alejandro Chavez

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates FUS凝聚体老化过程中分子间相互作用演变的纳米级表征

Communications Chemistry

IF6.2

2025-09-29

OAAI

Alyssa Miller; Zenon Toprakcioglu; Seema Qamar; Peter St George-Hyslop; Francesco Simone Ruggeri; Tuomas P. J. Knowles; Michele Vendruscolo

Diffusing protein binders to intrinsically disordered proteins 将蛋白质结合剂扩散到本质上无序的蛋白质

Nature

IF48.5

2025-07-30

OAAI

Caixuan Liu; Kejia Wu; Hojun Choi; Hannah L. Han; Xueli Zhang; Joseph L. Watson; Green Ahn; Jason Z. Zhang; Sara Shijo; Lydia L. Good; Charlotte M. Fischer; Asim K. Bera; Alex Kang; Evans Brackenbrough; Brian Coventry; Derrick R. Hick; Seema Qamar; Xinting Li; Justin Decarreau; Stacey R. Gerben; Wei Yang; Inna Goreshnik; Dionne Vafeados; Xinru Wang; Mila Lamb; Analisa Murray; Sebastian Kenny; Magnus S. Bauer; Andrew N. Hoofnagle; Ping Zhu; Tuomas P. J. Knowles; David Baker

Pharmacologic inhibition of YTHDC1 biomolecular condensates as a novel approach to targeting L-MYC driven small cell lung cancer

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Centore, R.; Charles, M.; Arora, M.; Chen, Y.; Watson, M.; Kelley, C.; Czekalska, M.; Rebmann, M.; Ghandi, M.; Cattin, J.; Bharatham, N.; Radhakrishnan, P.; Howarth, A.; Arter, W.; Qamar, S.; Saar, K.; Seeber, A.; Kulander, M.; Knowles, T.; Arora, S.

Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Centore, Richard C.; Watson, Matthew; Doh, Julia; Cattin, Jerome; Sgambato, Cinzia; Alex, Amal; Sawant, Janhavi; Radhakrishnan, Prathima; Cornish, Jasmine; Howarth, Alex; Bharatham, Nagakumar; Arter, William E.; Qamar, Seema; Saar, Kadi L.; Williamson, Douglas; Seeber, Andrew; Groenewegen, Neils; Czekalska, Magdalena; Kartanas, Tadas; Ermann, Niklas; Taher, Ahmed; Knowles, Tuomas; Arora, Shilpi

Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Saar, Kadi L.; Rebmann, Marius; Kanchwala, Mohammed; Qamar, Seema; Radhakrishnan, Prathima; Cornish, Jasmine; Doh, Julia; Cattin, Jerome; Rotem, Assaf; Ghandi, Mahmoud; Seeber, Andrew; Centore, Richard C.; Teichmann, Sarah A.; Knowles, Tuomas; Arora, Shilpi

Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Centore, Richard C.; Charles, Mark; Arora, Mansi; Chen, Yiwen; Watson, Matthew; Kelley, Charlotte; Czekalska, Magdalena; Rebmann, Marius; Ghandi, Mahmoud; Cattin, Jerome; Bharatham, Nagakumar; Radhakrishnan, Prathima; Howarth, Alex; Rudlaff, Gale; Arter, William E.; Qamar, Seema; Saar, Kadi; Williamson, Douglas; Seeber, Andrew; Knowles, Tuomas; Arora, Shilpi

Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2023-12-18

OAAI

Kim, Seung Chan; Mitchell, Scott J.; Qamar, Seema; Whitcomb, Daniel J.; Ruepp, Marc-David; St George-Hyslop, Peter; Cho, Kwangwook

The liquid- to- solid transition of FUS is promoted by the condensate surface

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-08-07

OAAI

Shen, Yi; Chen, Anqi; Wang, Wenyun; Shen, Yinan; Ruggeri, Francesco Simone; Aime, Stefano; Wang, Zizhao; Qamar, Seema; Espinosa, Jorge R.; Garaizar, Adiran; St George-Hyslop, Peter; Collepardo-Guevara, Rosana; Weitz, David A.; Vigolo, Daniele; Knowles, Tuomas P. J.

Spatially non-uniform condensates emerge from dynamically arrested phase separation

NATURE COMMUNICATIONS

IF15.7

2023-02-08

OAAI

Erkamp, Nadia A.; Sneideris, Tomas; Ausserwoger, Hannes; Qian, Daoyuan; Qamar, Seema; Nixon-Abell, Jonathon; St George-Hyslop, Peter; Schmit, Jeremy D.; Weitz, David A.; Knowles, Tuomas P. J.

Tie-Line Analysis Reveals Interactions Driving Heteromolecular Condensate Formation

PHYSICAL REVIEW X

IF15.7

2022-12-30

OAAI

Qian, Daoyuan; Welsh, Timothy J.; Erkamp, Nadia A.; Qamar, Seema; Nixon-Abell, Jonathon; Krainer, Georg; St George-Hyslop, Peter; Michaels, Thomas C. T.; Knowles, Tuomas P. J.

Biomolecular condensate phase diagrams with a combinatorial microdroplet platform 具有组合微滴平台的生物分子冷凝物相图

NATURE COMMUNICATIONS

IF15.7

2022-12-21

OAAI

Arter, William E.; Qi, Runzhang; Erkamp, Nadia A.; Krainer, Georg; Didi, Kieran; Welsh, Timothy J.; Acker, Julia; Nixon-Abell, Jonathan; Qamar, Seema; Guillen-Boixet, Jordina; Franzmann, Titus M.; Kuster, David; Hyman, Anthony A.; Borodavka, Alexander; George-Hyslop, Peter St; Alberti, Simon; Knowles, Tuomas P. J.

Differential interaction with TREM2 modulates microglial uptake of modified Aβ species

GLIA

IF5.1

2021-08-24

OAAI

Joshi, Pranav; Riffel, Florian; Satoh, Kanayo; Enomoto, Masahiro; Qamar, Seema; Scheiblich, Hannah; Villacampa, Nadia; Kumar, Sathish; Theil, Sandra; Parhizkar, Samira; Haass, Christian; Heneka, Michael T.; Fraser, Paul E.; Walter, Jochen

Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia

ALZHEIMERS & DEMENTIA

IF11.1

2021-05-31

OAAI

Esteras, Noemi; Kopach, Olga; Maiolino, Marta; Lariccia, Vincenzo; Amoroso, Salvatore; Qamar, Seema; Wray, Selina; Rusakov, Dmitri A.; Jaganjac, Morana; Abramov, Andrey Y.

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions 蛋白质的折返液体冷凝相通过疏水和非离子相互作用稳定

NATURE COMMUNICATIONS

IF15.7

2021-02-17

259

OAAI

Krainer, Georg; Welsh, Timothy J.; Joseph, Jerelle A.; Espinosa, Jorge R.; Wittmann, Sina; de Csillery, Ella; Sridhar, Akshay; Toprakcioglu, Zenon; Gudiskyte, Giedre; Czekalska, Magdalena A.; Arter, William E.; Guillen-Boixet, Jordina; Franzmann, Titus M.; Qamar, Seema; St George-Hyslop, Peter; Hyman, Anthony A.; Collepardo-Guevara, Rosana; Alberti, Simon; Knowles, Tuomas P. J.

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Vilalta, Anna; Zhou, Ye; Sevalle, Jean; Griffin, Jennifer K.; Satoh, Kanayo; Allendorf, David H.; De, Suman; Puigdellivol, Mar; Bruzas, Arturas; Burguillos, Miguel A.; Dodd, Roger B.; Chen, Fusheng; Zhang, Yalun; Flagmeier, Patrick; Needham, Lisa-Maria; Enomoto, Masahiro; Qamar, Seema; Henderson, James; Walter, Jochen; Fraser, Paul E.; Klenerman, David; Lee, Steven F.; St George-Hyslop, Peter; Brown, Guy C.

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition 生物分子缩合物经历了一般的剪切介导的液-固转变

NATURE NANOTECHNOLOGY

IF34.9

2020-07-13

107

OAAI

Shen, Yi; Ruggeri, Francesco Simone; Vigolo, Daniele; Kamada, Ayaka; Qamar, Seema; Levin, Aviad; Iserman, Christiane; Alberti, Simon; St George-Hyslop, Peter; Knowles, Tuomas P. J.

Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins

HUMAN MOLECULAR GENETICS

IF3.2

2019-10-10

OAAI

Fernandopulle, Michael; Wang, GuoZhen; Nixon-Abell, Jonathon; Qamar, Seema; Balaji, Varun; Morihara, Ryuta; St George-Hyslop, Peter H.

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

ACS CHEMICAL NEUROSCIENCE

IF3.9

2018-06-28

OAAI

Kjaergaard, Magnus; Dear, Alexander J.; Kundel, Franziska; Qamar, Seema; Meisl, Georg; Knowles, Tuomas P. J.; Klenerman, David

研究方向