未登录 Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model 阵列CRISPR揭示阿尔茨海默病模型中tau聚集，自噬和线粒体的遗传调节因子 Duan, Lishu; Hu, Mufeng; Tamm, Joseph A.; Grinberg, Yelena Y.; Shen, Fang; Chai, Yating; Xi, Hualin; Gibilisco, Lauren; Ravikumar, Brinda; Gautam, Vivek; Karran, Eric; Townsend, Matthew; Talanian, Robert, V 分享 收藏
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Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation 使用44个人类组织的基因调控图谱来告知复杂的疾病和性状相关变异 Gamazon, Eric R.; Segre, Ayellet V.; van de Bunt, Martijn; Wen, Xiaoquan; Xi, Hualin S.; Hormozdiari, Farhad; Ongen, Halit; Konkashbaev, Anuar; Derks, Eske M.; Aguet, Francois; Quan, Jie; Nicolae, L.; Eskin, Eleazar; Kellis, Manolis; Getz, Gad; McCarthy, Mark I.; Dermitzakis, Emmanouil T.; Cox, Nancy J.; Ardlie, Kristin G. 分享 收藏
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Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury Piro, Justin R.; Suidan, Georgette L.; Quan, Jie; Pi, YeQing; O'Neill, Sharon M.; Ilardi, Marissa; Pozdnyakov, Nikolay; Lanz, Thomas A.; Xi, Hualin; Bell, Robert D.; Samad, Tarek A. 分享 收藏
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression 全基因组关联分析确定了44种风险变异并完善了抑郁症的遗传结构 Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till M. F.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan F. T.; Bigdeli, Tim B.; Binder, Elisabeth B.; Blackwood, Douglas R. H.; Bryois, Julien; Buttenschon, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane Hvarregaard; Clarke, Toni-Kim; Coleman, Jonathan I. R.; Colodro-Conde, Lucia; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Crowley, Cheynna A.; Dashti, Hassan S.; Davies, Gail; Deary, Ian J.; Degenhardt, Franziska; Derks, Eske M.; Direk, Nese; Dolan, Conor V.; Dunn, Erin C.; Eley, Thalia C.; Eriksson, Nicholas; Escott-Price, Valentina; Kiadeh, Farnush Hassan Farhadi; Finucane, Hilary K.; Forstner, Andreas J.; Frank, Josef; Gaspar, Helena A.; Gill, Michael; Giusti-Rodriguez, Paola; Goes, Fernando S.; Gordon, Scott D.; Grove, Jakob; Hall, Lynsey S.; Hannon, Eilis; Hansen, Christine Soholm; Hansen, Thomas F.; Herms, Stefan; Hickie, Ian B.; Hoffmann, Per; Homuth, Georg; Horn, Carsten; Hottenga, Jouke-Jan; Hougaard, David M.; Hu, Ming; Hyde, Craig L.; Ising, Marcus; Jansen, Rick; Jin, Fulai; Jorgenson, Eric; Knowles, James A.; Kohane, Isaac S.; Kraft, Julia; Kretzschmar, Warren W.; Krogh, Jesper; Kutalik, Zoltan; Lane, Jacqueline M.; Li, Yihan; Li, Yun; Lind, Penelope A.; Liu, Xiaoxiao; Lu, Leina; MacIntyre, Donald J.; MacKinnon, Dean F.; Maier, Robert M.; Maier, Wolfgang; Marchini, Jonathan; Mbarek, Hamdi; McGrath, Patrick; McGuffin, Peter; Medland, Sarah E.; Mehta, Divya; Middeldorp, Christel M.; Mihailov, Evelin; Milaneschi, Yuri; Milani, Lili; Mill, Jonathan; Mondimore, Francis M.; Montgomery, Grant W.; Mostafavi, Sara; Mullins, Niamh; Nauck, Matthias; Ng, Bernard; Nivard, Michel G.; Nyholt, Dale R.; O'Reilly, Paul F.; Oskarsson, Hogni; Owen, Michael J.; Painter, Jodie N.; Pedersen, Carsten Bocker; Pedersen, Marianne Giortz; Peterson, Roseann E.; Pettersson, Erik; Peyrot, Wouter J.; Pistis, Giorgio; Posthuma, Danielle; Purcell, Shaun M.; Quiroz, Jorge A.; Qvist, Per; Rice, John P.; Riley, Brien P.; Rivera, Margarita; Mirza, Saira Saeed; Saxena, Richa; Schoevers, Robert; Schulte, Eva C.; Shen, Ling; Shi, Jianxin; Shyn, Stanley I.; Sigurdsson, Engilbert; Sinnamon, Grant B. C.; Smit, Johannes H.; Smith, Daniel J.; Stefansson, Hreinn; Steinberg, Stacy; Stockmeier, Craig A.; Streit, Fabian; Strohmaier, Jana; Tansey, Katherine E.; Teismann, Henning; Teumer, Alexander; Thompson, Wesley; Thomson, Pippa A.; Thorgeirsson, Thorgeir E.; Tian, Chao; Traylor, Matthew; Treutlein, Jens; Trubetskoy, Vassily; Uitterlinden, Andre G.; Umbricht, Daniel; Van der Auwera, Sandra; van Hemert, Albert M.; Viktorin, Alexander; Visscher, Peter M.; Wang, Yunpeng; Webb, Bradley T.; Weinsheimer, Shantel Marie; Wellmann, Juegen; Willemsen, Gonneke; Witt, Stephanie H.; Wu, Yang; Xi, Hualin S.; Yang, Jian; Zhang, Futao; Arolt, Volker; Baune, Bernhard T.; Berger, Klaus; Boomsma, Dorret I.; Cichon, Sven; Dannlowski, Udo; de Geus, E. C. J.; DePaulo, J. Raymond; Domenici, Enrico; Domschke, Katharina; Esko, Tonu; Grabe, Hans J.; Hamilton, Steven P.; Hayward, Caroline; Heath, Andrew C.; Hinds, David A.; Kendler, Kenneth S.; Kloiber, Stefan; Lewis, Glyn; Li, Qingqin S.; Lucae, Susanne; Madden, Pamela F. A.; Magnusson, Patrik K.; Martin, Nicholas G.; McIntosh, Andrew M.; Metspalu, Andres; Mors, Ole; Mortensen, Preben Bo; Mueller-Myhsok, Bertram; Nordentoft, Merete; Noethen, Markus M.; O'Donovan, Michael C.; Paciga, Sara A.; Pedersen, Nancy L.; Penninx, Brenda W. J. H.; Perlis, Roy H.; Porteous, David J.; Potash, James B.; Preisig, Martin; Rietschel, Marcella; Schaefer, Catherine; Schulze, Thomas G.; Smoller, Jordan W.; Stefansson, Kari; Tiemeier, Henning; Uher, Rudolf; Voelzke, Henry; Weissman, Myrna M.; Werge, Thomas; Winslow, Ashley R.; Lewis, Cathryn M.; Levinson, Douglas F.; Breen, Gerome; Borglum, Anders D.; Sullivan, Patrick F. 分享 收藏
Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma Venkatesan, Arvind M.; Vyas, Rajesh; Gramann, Alec K.; Dresser, Karen; Gujja, Sharvari; Bhatnagar, Sanchita; Chhangawala, Sagar; Gomes, Camilla Borges Ferreira; Xi, Hualin Simon; Lian, Christine G.; Houvras, Yariv; Edwards, Yvonne J. K.; Deng, April; Green, Michael; Ceol, Craig J. 分享 收藏
Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment Zhou, Y.; Dong, F.; Lanz, T. A.; Reinhart, V.; Li, M.; Liu, L.; Zou, J.; Xi, H. S.; Mao, Y. 分享 收藏
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia Witt, S. H.; Streit, F.; Jungkunz, M.; Frank, J.; Awasthi, S.; Reinbold, C. S.; Treutlein, J.; Degenhardt, F.; Forstner, A. J.; Heilmann-Heimbach, S.; Dietl, L.; Schwarze, C. E.; Schendel, D.; Strohmaier, J.; Abdellaoui, A.; Adolfsson, R.; Air, T. M.; Akil, H.; Alda, M.; Alliey-Rodriguez, N.; Andreassen, O. A.; Babadjanova, G.; Bass, N. J.; Bauer, M.; Baune, B. T.; Bellivier, F.; Bergen, S.; Bethell, A.; Biernacka, J. M.; Blackwood, D. H. R.; Boks, M. P.; Boomsma, D. I.; Borglum, A. D.; Borrmann-Hassenbach, M.; Brennan, P.; Budde, M.; Buttenschon, H. N.; Byrne, E. M.; Cervantes, P.; Clarke, T-K; Craddock, N.; Cruceanu, C.; Curtis, D.; Czerski, P. M.; Dannlowski, U.; Davis, T.; de Geus, E. J. C.; Di Florio, A.; Djurovic, S.; Domenici, E.; Edenberg, H. J.; Etain, B.; Fischer, S. B.; Forty, L.; Fraser, C.; Frye, M. A.; Fullerton, J. M.; Gade, K.; Gershon, E. S.; Giegling, I.; Gordon, S. D.; Gordon-Smith, K.; Grabe, H. J.; Green, E. K.; Greenwood, T. A.; Grigoroiu-Serbanescu, M.; Guzman-Parra, J.; Hall, L. S.; Hamshere, M.; Hauser, J.; Hautzinger, M.; Heilbronner, U.; Herms, S.; Hitturlingappa, S.; Hoffmann, P.; Holmans, P.; Hottenga, J-J; Jamain, S.; Jones, I.; Jones, L. A.; Jureus, A.; Kahn, R. S.; Kammerer-Ciernioch, J.; Kirov, G.; Kittel-Schneider, S.; Kloiber, S.; Knott, S. V.; Kogevinas, M.; Landen, M.; Leber, M.; Leboyer, M.; Li, Q. S.; Lissowska, J.; Lucae, S.; Martin, N. G.; Mayoral-Cleries, F.; McElroy, S. L.; McIntosh, A. M.; McKay, J. D.; McQuillin, A.; Medland, S. E.; Middeldorp, C. M.; Milaneschi, Y.; Mitchell, P. B.; Montgomery, G. W.; Morken, G.; Mors, O.; Muehleisen, T. W.; Mueller-Myhsok, B.; Myers, R. M.; Nievergelt, C. M.; Nurnberger, J. I.; O'Donovan, M. C.; Loohuis, L. M. O.; Ophoff, R.; Oruc, L.; Owen, M. J.; Paciga, S. A.; Penninx, B. W. J. H.; Perry, A.; Pfennig, A.; Potash, J. B.; Preisig, M.; Reif, A.; Rivas, F.; Rouleau, G. A.; Schofield, P. R.; Schulze, T. G.; Schwarz, M.; Scott, L.; Sinnamon, G. C. B.; Stahl, E. A.; Strauss, J.; Turecki, G.; Van der Auwera, S.; Vedder, H.; Vincent, J. B.; Willemsen, G.; Witt, C. C.; Wray, N. R.; Xi, H. S.; Tadic, A.; Dahmen, N.; Schott, B. H.; Cichon, S.; Noethen, M. M.; Ripke, S.; Mobascher, A.; Rujescu, D.; Lieb, K.; Roepke, S.; Schmahl, C.; Bohus, M.; Rietschel, M. 分享 收藏
Identification of Preferred Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing? Amata, Emanuele; Xi, Hualin; Colmenarejo, Gonzalo; Diaz-Gonzalez, Rosario; Cordon-Obras, Carlos; Berlanga, Manuela; Manzano, Pilar; Erath, Jessey; Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Rodriguez, Ana; Sciotti, Richard J.; Navarro, Miguel; Pollastri, Michael P. 分享 收藏
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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders Schubert, Christian R.; O'Donnell, Patricio; Quan, Jie; Wendland, Jens R.; Xi, Hualin S.; Winslow, Ashley R.; Domenici, Enrico; Essioux, Laurent; Kam-Thong, Tony; Airey, David C.; Calley, John N.; Collier, David A.; Wang, Hong; Eastwood, Brian; Ebert, Philip; Liu, Yushi; Nisenbaum, Laura; Ruble, Cara; Scherschel, James; Smith, Ryan Matthew; Qian, Hui-Rong; Merchant, Kalpana; Didriksen, Michael; Matsumoto, Mitsuyuki; Saito, Takeshi; Brandon, Nicholas J.; Cross, Alan J.; Wang, Qi; Manji, Husseini; Kolb, Hartmuth; Furey, Maura; Drevets, Wayne C.; Shin, Joo Heon; Jaffe, Andrew E.; Jia, Yankai; Straub, Richard E.; Deep-Soboslay, Amy; Hyde, Thomas M.; Kleinman, Joel E.; Weinberger, Daniel R. 分享 收藏
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Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia Malik, Manasi; Chiles, Joe, III; Xi, Hualin S.; Medway, Christopher; Simpson, James; Potluri, Shobha; Howard, Dianna; Liang, Ying; Paumi, Christian M.; Mukherjee, Shubhabrata; Crane, Paul; Younkin, Steven; Fardo, David W.; Estus, Steven 分享 收藏
VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Defi ne a Novel Mechanism of Aggressive Prostate Cancer Goel, Hira Lal; Chang, Cheng; Pursell, Bryan; Leav, Irwin; Lyle, Stephen; Xi, Hualin Simon; Hsieh, Chung-Cheng; Adisetiyo, Helty; Roy-Burman, Pradip; Coleman, Ilsa M.; Nelson, Peter S.; Vessella, Robert L.; Davis, Roger J.; Plymate, Stephen R.; Mercurio, Arthur M. 分享 收藏
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Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome 人类基因组中细胞类型特异性和普遍存在的染色质调控结构的鉴定和表征 Xi, Hualin; Shulha, Hennady P.; Lin, Jane M.; Vales, Teresa R.; Fu, Yutao; Bodine, David M.; Mckay, Ronald D. G.; Chenoweth, Josh G.; Tesar, Paul J.; Furey, Terrence S.; Ren, Bing; Weng, Zhiping; Crawford, Gregory E. 分享 收藏
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