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Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents Stockwell, Simon R.; Scott, Duncan E.; Fischer, Gerhard; Guarino, Estrella; Rooney, Timothy P. C.; Feng, Tzu-Shean; Moschetti, Tommaso; Srinivasan, Rajavel; Alza, Esther; Asteian, Alice; Dagostin, Claudio; Alcaide, Anna; Rocaboy, Mathieu; Blaszczyk, Beata; Higueruelo, Alicia; Wang, Xuelu; Rossmann, Maxim; Perrior, Trevor R.; Blundell, Tom L.; Spring, David R.; Mckenzie, Grahame; Abell, Chris; Skidmore, John; Venkitaraman, Ashok R.; Hyvonen, Marko 分享 收藏
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Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia Ferrer, Miriam; Mourikis, Nicholas; Davidson, Emma E.; Kleeman, Sam O.; Zaccaria, Marta; Habel, Jill; Rubino, Rachel; Flint, Thomas R.; Connell, Claire M.; Lukey, Michael J.; White, Eileen P.; Coll, Anthony P.; Venkitaraman, Ashok R.; Janowitz, Tobias 分享 收藏
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Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity p53快速募集到DNA损伤位点指导DNA修复选择和完整性 Wang, Yu-Hsiu; Ho, Teresa L. F.; Hariharan, Anushya; Goh, Hui Chin; Wong, Yao Liang; Verkaik, Nicole S.; Lee, May Yin; Tam, Wai Leong; van Gent, Dik C.; Venkitaraman, Ashok R.; Sheetz, Michael P.; Lane, David P. 分享 收藏
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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library Emery, Amy; Hardwick, Bryn S.; Crooks, Alex T.; Milech, Nadia; Watt, Paul M.; Mithra, Chandan; Kumar, Vikrant; Giridharan, Saranya; Sadasivam, Gayathri; Mathivanan, Subashini; Sudhakar, Sneha; Bairy, Sneha; Bharatham, Kavitha; Hurakadli, Manjunath A.; Prasad, Thazhe K.; Kamariah, Neelagandan; Muellner, Markus; Coelho, Miguel; Torrance, Christopher J.; McKenzie, Grahame J.; Venkitaraman, Ashok R. 分享 收藏
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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death Scott, Duncan E.; Francis-Newton, Nicola J.; Marsh, May E.; Coyne, Anthony G.; Fischer, Gerhard; Moschetti, Tommaso; Bayly, Andrew R.; Sharpe, Timothy D.; Haas, Kalina T.; Barber, Lorraine; Valenzano, Chiara R.; Srinivasan, Rajavel; Huggins, David J.; Lee, Miyoung; Emery, Amy; Hardwick, Bryn; Ehebauer, Matthias; Dagostin, Claudio; Esposito, Alessandro; Pellegrini, Luca; Perrior, Trevor; McKenzie, Grahame; Blundell, Tom L.; Hyvonen, Marko; Skidmore, John; Venkitaraman, Ashok R.; Abell, Chris 分享 收藏
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A systems view of spliceosomal assembly and branchpoints with iCLIP (vol 26, pg 930, 2019) Briese, Michael; Haberman, Nejc; Sibley, Christopher R.; Faraway, Rupert; Elser, Andrea S.; Chakrabarti, Anob M.; Wang, Zhen; Konig, Julian; Perera, David; Wickramasinghe, Vihandha O.; Venkitaraman, Ashok R.; Luscombe, Nicholas M.; Saieva, Luciano; Pellizzoni, Livio; Smith, Christopher W. J.; Curk, Tomaz; Ule, Jernej 分享 收藏
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A systems view of spliceosomal assembly and branchpoints with iCLIP (vol 56, pg 931, 2019) Briese, Michael; Haberman, Nejc; Sibley, Christopher R.; Faraway, Rupert; Elser, Andrea S.; Chakrabarti, Anob M.; Wang, Zhen; Koenig, Julian; Perera, David; Wickramasinghe, Vihandha O.; Venkitaraman, Ashok R.; Luscombe, Nicholas M.; Saieva, Luciano; Pellizzoni, Livio; Smith, Christopher W. J.; Curk, Tomaz; Ule, Jernej 分享 收藏
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation 通过诱导p53乙酰化靶向158位密码子p53-mutant癌症 Kong, Li Ren; Ong, Richard Weijie; TariD, Tuan Zea; Salleh, Nur Afiqah Binte Mohamed; Thangavelu, Matan; Chan, Jane Vin; Koh, Lie Yong Judice; Periyasamy, Giridharan; Lau, Jieying Amelia; Le, Thi Bich Uyen; Wang, Lingzhi; Lee, Miyoung; Kannan, Srinivasaraghavan; Verma, Chandra S.; Lim, Chwee Ming; Chng, Wee Joo; Lane, David P.; Venkitaraman, Ashok; Hung, Huynh The; Cheok, Chit Fang; Goh, Boon Cher 分享 收藏
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Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1 Polo样激酶1的Polo盒结构域的新型细胞渗透性蛋白质-蛋白质相互作用抑制剂的开发 Huggins, David J.; Hardwick, Bryn S.; Sharma, Pooja; Emery, Amy; Laraia, Luca; Zhang, Fengzhi; Narvaez, Ana J.; Roberts-Thomson, Meredith; Crooks, Alex T.; Boyle, Robert G.; Boyce, Richard; Walker, David W.; Mateu, Natalia; McKenzie, Grahame J.; Spring, David R.; Venkitaraman, Ashok R. 分享 收藏
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation polo样激酶PLK1的polo盒结构域中的一个隐蔽的疏水口袋调节底物识别和有丝分裂染色体分离 Sharma, Pooja; Mahen, Robert; Rossmann, Maxim; Stokes, Jamie E.; Hardwick, Bryn; Huggins, David J.; Emery, Amy; Kunciw, Dominique L.; Hyvonen, Marko; Spring, David R.; McKenzie, Grahame J.; Venkitaraman, Ashok R. 分享 收藏
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A systems view of spliceosomal assembly and branchpoints with iCLIP Briese, Michael; Haberman, Nejc; Sibley, Christopher R.; Faraway, Rupert; Elser, Andrea S.; Chakrabarti, Anob M.; Wang, Zhen; Koenig, Julian; Perera, David; Wickramasinghe, Vihandha O.; Venkitaraman, Ashok R.; Luscombe, Nicholas M.; Saieva, Luciano; Pellizzoni, Livio; Smith, Christopher W. J.; Curk, Tomaz; Ule, Jernej 分享 收藏
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