未登录MOMA-313 is a potent, selective Pol. inhibitor that enhances response to PARP inhibition in HR-deficient tumor models
Evans, E.; Reutershan, M.; Motwani, V.; McGlynn, K.; Bai, Y.; Quinn, C.; Dhingra, M.; Gao, C.; Waller, D.; Nabhan, S.; Bitter, H.; Guzi, T.; Hammerman, P.; Krall, J. .png)
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收藏Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug ToleranceCotton, Jennifer L.; Diez, Javier Estrada; Sagar, Vivek; Chen, Julie; Piquet, Michelle; Alford, John; Song, Youngchul; Li, Xiaoyan; Riester, Markus; Dimare, Matthew T.; Schumacher, Katja; Boulay, Gaylor; Sprouffske, Kathleen; Fan, Lin; Burks, Tyler; Mansur, Leandra; Wagner, Joel; Bhang, Hyo-eun C.; Iartchouk, Oleg; Reece-Hoyes, John; Morris, Erick J.; Hammerman, Peter S.; Ruddy, David A.; Korn, Joshua M.; Engelman, Jeffrey A.; Niederst, Matthew J. 分享 收藏 分享 收藏 ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancerDeng, Jiehui; Thennavan, Aatish; Dolgalev, Igor; Chen, Ting; Li, Jie; Marzio, Antonio; Poirier, John T.; Peng, David H.; Bulatovic, Mirna; Mukhopadhyay, Subhadip; Silver, Heather; Papadopoulos, Eleni; Pyon, Val; Thakurdin, Cassandra; Han, Han; Li, Fei; Li, Shuai; Ding, Hailin; Hu, Hai; Pan, Yuanwang; Weerasekara, Vajira; Jiang, Baishan; Wang, Eric S.; Ahearn, Ian; Philips, Mark; Papagiannakopoulos, Thales; Tsirigos, Aristotelis; Rothenberg, Eli; Gainor, Justin; Freeman, Gordon J.; Rudin, Charles M.; Gray, Nathanael S.; Hammerman, Peter S.; Pagano, Michele; Heymach, John V.; Perou, Charles M.; Bardeesy, Nabeel; Wong, Kwok-Kin 分享 收藏 Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal MicroenvironmentWang, Hui Qin; Mulford, Iain J.; Sharp, Fiona; Liang, Jinsheng; Kurtulus, Sema; Trabucco, Gina; Quinn, David S.; Longmire, Tyler A.; Patel, Nidhi; Patil, Roshani; Shirley, Matthew D.; Chen, Yan; Wang, Hao; Ruddy, David A.; Fabre, Claire; Williams, Juliet A.; Hammerman, Peter S.; Mataraza, Jennifer; Platzer, Barbara; Halilovic, Ensar 分享 收藏 Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockadeSehgal, Kartik; Portell, Andrew; Ivanova, Elena, V; Lizotte, Patrick H.; Mahadevan, Navin R.; Greene, Jonathan R.; Vajdi, Amir; Gurjao, Carino; Teceno, Tyler; Taus, Luke J.; Thai, Tran C.; Kitajima, Shunsuke; Liu, Derek; Tani, Tetsuo; Noureddine, Moataz; Lau, Christie J.; Kirschmeier, Paul T.; Liu, David; Giannakis, Marios; Jenkins, Russell W.; Gokhale, Prafulla C.; Goldoni, Silvia; Pinzon-Ortiz, Maria; Hastings, William D.; Hammerman, Peter S.; Miret, Juan J.; Paweletz, Cloud P.; Barbie, David A. 分享 收藏 Combinations of SHP2 inhibitor to overcome RAS activation by receptor tyrosine kinases in response to ERK inhibitionHao, Huaixiang; Liu, Chen; Wang, Hongyun; Lu, Hengyu; Delach, Scott; LaMarche, Matthew; Engelman, Jeffrey; Hammerman, Peter; Caponigro, Giordano; Moody, Susan; Mohseni, Morvarid 分享 收藏 In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma体内表观遗传CRISPR筛选将Asf1a鉴定为Kras突变肺腺癌的免疫治疗靶点Li, Fei; Huang, Qingyuan; Luster, Troy A.; Hu, Hai; Zhang, Hua; Ng, Wai-Lung; Khodadadi-Jamayran, Alireza; Wang, Wei; Chen, Ting; Deng, Jiehui; Ranieri, Michela; Fang, Zhaoyuan; Pyon, Val; Dowling, Catriona M.; Bagdatlioglu, Ece; Almonte, Christina; Labbe, Kristen; Silver, Heather; Rabin, Alexandra R.; Jani, Kandarp; Tsirigos, Aristotelis; Papagiannakopoulos, Thales; Hammerman, Peter S.; Velcheti, Vamsidhar; Freeman, Gordon J.; Qi, Jun; Miller, George; Wong, Kwok-Kin 分享 收藏 Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant CancersHao, Huai-Xiang; Wang, Hongyun; Liu, Chen; Kovats, Steven; Velazquez, Roberto; Lu, Hengyu; Pant, Bhavesh; Shirley, Matthew; Meyer, Matthew J.; Pu, Minying; Lim, Joanne; Fleming, Michael; Alexander, Leigh Ann; Farsidjani, Ali; LaMarche, Matthew J.; Moody, Susan; Silver, Serena J.; Caponigro, Giordano; Stuart, Darrin D.; Abrams, Tinya J.; Hammerman, Peter S.; Williams, Juliet; Engelman, Jeffrey A.; Goldoni, Silvia; Mohseni, Morvarid 分享 收藏 Molecular barcoding and single cell approaches to investigate drug tolerance in EGFRmut NSCLCCotton, Jennifer L.; KrishnamurthyRadhakrishna, Viveksagar; Chen, Julie; Piquet, Michelle; Wagner, Joel; Boulay, Gaylor; Sprouffske, Kathleen; Song, Youngchul; Li, Xiaoyan; Schumacher, Katja; Thierry, Raphael; Kirkpatrick, Nathaniel D.; Ruddy, David A.; Korn, Joshua; Morris, Erick J.; Hammerman, Peter S.; Engelman, Jeffrey A.; Niederst, Matthew J. 分享 收藏 Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer靶向FGFR克服EGFR突变非小细胞肺癌EMT介导的耐药Raoof, Sana; Mulford, Iain J.; Frisco-Cabanos, Heidie; Nangia, Varuna; Timonina, Daria; Labrot, Emma; Hafeez, Nafeeza; Bilton, Samantha J.; Drier, Yotam; Ji, Fei; Greenberg, Max; Williams, August; Kattermann, Krystina; Damon, Leah; Sovath, Sosathya; Rakiec, Daniel P.; Korn, Joshua M.; Ruddy, David A.; Benes, Cyril H.; Hammerman, Peter S.; Piotrowska, Zofia; Sequist, Lecia, V; Niederst, Matthew J.; Barretina, Jordi; Engelman, Jeffrey A.; Hata, Aaron N. 分享 收藏 分享 收藏 SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS mutant tumors treated with MEK inhibitorsLu, Hengyu; Liu, Chen; Velazquez, Roberto; Wang, Hongyun; Dunkl, Lukas M.; Kazic-Legueux, Malika; Haberkorn, Anne; Billy, Eric; Manchado, Eusebio; Brachmann, Saskia M.; Moody, Susan; Engelman, Jeffrey A.; Hammerman, Peter S.; Caponigro, Giordano; Mohseni, Morvarid; Hao, Huaixiang 分享 收藏 SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK InhibitorsLu, Hengyu; Liu, Chen; Velazquez, Roberto; Wang, Hongyun; Dunkl, Lukas Manuel; Kazic-Legueux, Malika; Haberkorn, Anne; Billy, Eric; Manchado, Eusebio; Brachmann, Saskia M.; Moody, Susan E.; Engelman, Jeffrey A.; Hammerman, Peter S.; Caponigro, Giordano; Mohseni, Morvarid; Hao, Huai-Xiang 分享 收藏 In vivo shRNA screens under treatment pressure by BRAF and MEK inhibitors to identify novel combination treatment strategies for BRAF-mutant colorectal cancerBhang, Hyo-eun C.; DiMare, Matthew T.; Kodack, David P.; Tan, Lujian; Kerr, Grainne; Radhakrishna, Viveksagar Krishnamurthy; Golji, Javad; Ruddy, David A.; Yuan, Tina; Niederst, Matthew J.; Korn, Joshua M.; Porta, Diana Graus; Hammerman, Peter S.; Engelman, Jeffrey A.; Abrams, Tinya; Williams, Juliet 分享 收藏 Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patientsOsa, Akio; Uenami, Takeshi; Koyama, Shohei; Fujimoto, Kosuke; Okuzaki, Daisuke; Takimoto, Takayuki; Hirata, Haruhiko; Yano, Yukihiro; Yokota, Soichiro; Kinehara, Yuhei; Naito, Yujiro; Otsuka, Tomoyuki; Kanazu, Masaki; Kuroyama, Muneyoshi; Hamaguchi, Masanari; Koba, Taro; Futami, Yu; Ishijima, Mikako; Suga, Yasuhiko; Akazawa, Yuki; Machiyama, Hirotomo; Iwahori, Kota; Takamatsu, Hyota; Nagatomo, Izumi; Takeda, Yoshito; Kida, Hiroshi; Akbay, Esra A.; Hammerman, Peter S.; Wong, Kwok-Kin; Dranoff, Glenn; Mori, Masahide; Kijima, Takashi; Kumanogoh, Atsushi 分享 收藏 Suppression of myeloid cell arginase activity leads to therapeutic response in Kras mutant lung cancer by activating anti-tumor immunityMiret, Juan J.; Kirschmeier, Paul; Wu, Min; Huang, Wei; Walker, William; Palakurti, Sangeetha; Saccomano, Nick; Hammerman, Peter S.; Wong, Kwok-Kin; Akbay, Esra 分享 收藏 RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK BlockadeRas-mapk的重新激活促进了FGFR1-Amplified肺癌的获得性耐药，并为fgfr-mek的前期阻断提供了基础。Bockorny, Bruno; Rusan, Maria; Chen, Wankun; Liao, Rachel G.; Li, Yvonne; Piccioni, Federica; Wang, Jun; Tan, Li; Thorner, Aaron R.; Li, Tianxia; Zhang, Yanxi; Miao, Changhong; Ovesen, Therese; Shapiro, Geoffrey I.; Kwiatkowski, David J.; Gray, Nathanael S.; Meyerson, Matthew; Hammerman, Peter S.; Bass, Adam J. 分享 收藏 BET bromodomain inhibition synergizes with PD-1 blockade to facilitate anti-tumor response in Kras-mutant non-small cell lung cancerAdeegbe, Dennis O.; Liu, Shengwu; Bowden, Michaela; Hammerman, Peter S.; Bradner, James E.; Rustgi, Anil K.; Bass, Adam J.; Freeman, Gordon J.; Chen, Huawei; Wong, Kwok-Kin 分享 收藏 PD-1/PD-L1 blockade enhances MDM2 inhibitor activity in p53 wild-type cancersWang, Hui Qin; Liang, Jinsheng; Mulford, Iain; Sharp, Fiona; Gaulis, Swann; Chen, Yan; Trabucco, Gina; Quinn, David; Growney, Joseph D.; Meyer, Matthew J.; Williams, Juliet; Hammerman, Peter; Hofmann, Francesco; Dranoff, Glenn; Engelman, Jeffrey; Mataraza, Jennifer; Halilovic, Ensar 分享 收藏 
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