未登录 An open-label Phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosis van Eijk, Ruben P. A.; Steyn, Frederik J.; van Mantgem, Mark R. Janse; Schmidt, Angela; Meyjes, Myrte; Allen, Sally; Daygon, Dara, V; Loeffler, Jean-Philippe; Al-Chalabi, Ammar; van den Berg, Leonard H.; Henderson, Robert D.; Ngo, Shyuan T. 分享 收藏
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1(G93A) mice Scaricamazza, Silvia; Salvatori, Illari; Amadio, Susanna; Nesci, Valentina; Torcinaro, Alessio; Giacovazzo, Giacomo; Primiano, Aniello; Gloriani, Michela; Candelise, Niccolo; Pieroni, Luisa; Loeffler, Jean-Philippe; Rene, Frederique; Quessada, Cyril; Tefera, Tesfaye W.; Wang, Hao; Steyn, Frederik J.; Ngo, Shyuan T.; Dobrowolny, Gabriella; Lepore, Elisa; Urbani, Andrea; Musaro, Antonio; Volonte, Cinzia; Ferraro, Elisabetta; Coccurello, Roberto; Valle, Cristiana; Ferri, Alberto 分享 收藏
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Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis 肌萎缩性侧索硬化症中骨骼肌葡萄糖-脂肪酸通量的改变 Steyn, Frederik J.; Li, Rui; Kirk, Siobhan E.; Tefera, Tesfaye W.; Xie, Teresa Y.; Tracey, Timothy J.; Kelk, Dean; Wimberger, Elyse; Garton, Fleur C.; Roberts, Llion; Chapman, Sarah E.; Coombes, Jeff S.; Leevy, W. Matthew; Ferri, Alberto; Valle, Cristiana; Rene, Frederique; Loeffler, Jean-Philippe; McCombe, Pamela A.; Henderson, Robert D.; Ngo, Shyuan T. 分享 收藏
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Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis Henriques, Alexandre; Huebecker, Mylene; Blasco, Helene; Keime, Celine; Andres, Christian R.; Corcia, Philippe; Priestman, David A.; Platt, Frances M.; Spedding, Michael; Loeffler, Jean-Philippe 分享 收藏
A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia Vernay, Aurelia; Therreau, Ludivine; Blot, Beatrice; Risson, Valerie; Dirrig-Grosch, Sylvie; Waegaert, Robin; Lequeu, Thiebault; Sellal, Francois; Schaeffer, Laurent; Sadoul, Remy; Loeffler, Jean-Philippe; Rene, Frederique 分享 收藏
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Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase Henriques, Alexandre; Croixmarie, Vincent; Priestman, David A.; Rosenbohm, Angela; Dirrig-Grosch, Sylvie; D'Ambra, Eleonora; Huebecker, Mylene; Hussain, Ghulam; Boursier-Neyret, Claire; Echaniz-Laguna, Andoni; Ludolph, Albert C.; Platt, Frances M.; Walther, Bernard; Spedding, Michael; Loeffler, Jean-Philippe; De Aguilar, Jose-Luis Gonzalez 分享 收藏
A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis 在肌萎缩性侧索硬化症小鼠模型中，糖酵解肌肉向脂质使用的代谢转换是早期病理事件。 Palamiuc, Lavinia; Schlagowski, Anna; Ngo, Shyuan T.; Vernay, Aurelia; Dirrig-Grosch, Sylvie; Henriques, Alexandre; Boutillier, Anne-Laurence; Zoll, Joffrey; Echaniz-Laguna, Andoni; Loeffler, Jean-Philippe; Rene, Frederique 分享 收藏
Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients Bruneteau, Gaelle; Bauche, Stephanie; de Aguilar, Jose Luis Gonzalez; Brochier, Guy; Mandjee, Nathalie; Tanguy, Marie-Laure; Hussain, Ghulam; Behin, Anthony; Khiami, Frederic; Sariali, Elhadi; Hell-Remy, Caroline; Salachas, Francois; Pradat, Pierre-Francois; Lacomblez, Lucette; Nicole, Sophie; Fontaine, Bertrand; Fardeau, Michel; Loeffler, Jean-Philippe; Meininger, Vincent; Fournier, Emmanuel; Koenig, Jeanine; Hantai, Daniel 分享 收藏
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Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age Eschbach, Judith; Sinniger, Jerome; Bouitbir, Jamal; Fergani, Anissa; Schlagowski, Anna-Isabel; Zoll, Joffrey; Geny, Bernard; Rene, Frederique; Larmet, Yves; Marion, Vincent; Baloh, Robert H.; Harms, Matthew B.; Shy, Michael E.; Messadeq, Nadia; Weydt, Patrick; Loeffler, Jean-Philippe; Ludolph, Albert C.; Dupuis, Luc 分享 收藏
Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation Rona-Voros, Krisztina; Eschbach, Judith; Vernay, Aurelia; Wiesner, Diana; Schwalenstocker, Birgit; Geniquet, Pauline; De Camaret, Benedicte Mousson; Echaniz-Laguna, Andoni; Loeffler, Jean-Philippe; Ludolph, Albert C.; Weydt, Patrick; Dupuis, Luc 分享 收藏
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Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis Kabashi, Edor; El Oussini, Hajer; Bercier, Valerie; Gros-Louis, Francois; Valdmanis, Paul N.; McDearmid, Jonathan; Mejier, Inge A.; Dion, Patrick A.; Dupre, Nicolas; Hollinger, David; Sinniger, Jerome; Dirrig-Grosch, Sylvie; Camu, William; Meininger, Vincent; Loeffler, Jean-Philippe; Rene, Frederique; Drapeau, Pierre; Rouleau, Guy A.; Dupuis, Luc 分享 收藏
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Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity Vidimar, Vania; Meng, Xiangjun; Klajner, Marcelina; Licona, Cynthia; Fetzer, Ludivine; Harlepp, Sebastien; Hebraud, Pascal; Sidhoum, Marjorie; Sirlin, Claude; Loeffler, Jean-Philippe; Mellitzer, Georg; Sava, Gianni; Pfeffer, Michel; Gaiddon, Christian 分享 收藏
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