Manfred Kansy - Publications, H-index & Citations

Manfred Kansy

ETH Zurich

42H指数

95论文数

8.8K被引数

收录论文 37

发表时间

New therapeutic modalities in drug discovery and development: Insights & opportunities

ADMET AND DMPK

IF4.3

2021-12-15

OAAI

Kansy, Manfred; Caron, Giulia

The Critical Role of Passive Permeability in Designing Successful Drugs 被动渗透性在设计成功药物中的关键作用

CHEMMEDCHEM

IF3.4

2020-09-10

PREAI

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z.; Houston, J. Brian; Kansy, Manfred; Kerns, Edward H.; Lennernaes, Hans; Smith, Dennis A.; Sugano, Kiyohiko

Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?

ADMET AND DMPK

IF4.3

2020-04-25

OAAI

Avdeef, Alex; Kansy, Manfred

Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-09-26

PREAI

Klein, Marco J.; Schmidt, Samuel; Wadhwani, Parvesh; Buerck, Jochen; Reichert, Johannes; Afonin, Sergii; Berditsch, Marina; Schober, Tim; Brock, Roland; Kansy, Manfred; Ulrich, Anne S.

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

CHEMMEDCHEM

IF3.4

2016-09-15

PREAI

Vorberg, Raffael; Trapp, Nils; Zimmerli, Daniel; Wagner, Bjorn; Fischer, Holger; Kratochwil, Nicole A.; Kansy, Manfred; Carreira, Erick M.; Muller, Klaus

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-11-17

181

PREAI

Huchet, Quentin A.; Kuhn, Bernd; Wagner, Bjorn; Kratochwil, Nicole A.; Fischer, Holger; Kansy, Manfred; Zimmerli, Daniel; Carreira, Erick M.; Muller, Klaus

Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2015-09-01

PREAI

Matsson, Par; Fenu, Luca A.; Lundquist, Patrik; Wisniewski, Jacek R.; Kansy, Manfred; Artursson, Per

Quantifying the impact of transporters on cellular drug permeability

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2015-05-01

OAAI

Matsson, Par; Fenu, Luca A.; Lundquist, Patrik; Wisniewski, Jacek R.; Kansy, Manfred; Artursson, Per

Carrier Mediated Distribution System (CAMDIS): A new approach for the measurement of octanol/water distribution coefficients

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2015-02-01

PREAI

Wagner, Bjoern; Fischer, Holger; Kansy, Manfred; Seelig, Anna; Assmus, Frauke

pKa determination by 1H NMR spectroscopy - An old methodology revisited

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2014-05-01

PREAI

Bezencon, Jacqueline; Wittwer, Matthias B.; Cutting, Brian; Smiesko, Martin; Wagner, Bjoern; Kansy, Manfred; Ernst, Beat

Physicochemical characterization and in vitro permeation of an indirubin derivative

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2013-11-01

PREAI

Heshmati, Nasim.; Wagner, Bjoern; Cheng, Xinlai; Scholz, Therese; Kansy, Manfred; Eisenbrand, Gerhard; Fricker, Gert

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

DRUG DISCOVERY TODAY

IF7.5

2012-08-01

131

PREAI

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F.; Faller, Bernard; Fischer, Holger; Houston, J. Brian; Kansy, Manfred; Kerns, Edward H.; Kraemer, Stefanie D.; Lennernas, Hans; Sugano, Kiyohiko

From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2012-06-26

PREAI

Barandun, Luzi Jakob; Immekus, Florian; Kohler, Philipp C.; Tonazzi, Sandro; Wagner, Bjoern; Wendelspiess, Severin; Ritschel, Tina; Heine, Andreas; Kansy, Manfred; Klebe, Gerhard; Diederich, Francois

Can we discover pharmacological promiscuity early in the drug discovery process?

DRUG DISCOVERY TODAY

IF7.5

2012-04-01

PREAI

Peters, Jens-Uwe; Hert, Jerome; Bissantz, Caterina; Hillebrecht, Alexander; Gerebtzoff, Gregori; Bendels, Stefanie; Tillier, Fabien; Migeon, Jacques; Fischer, Holger; Guba, Wolfgang; Kansy, Manfred

Comparative Evaluation of in Silico Systems for Ames Test Mutagenicity Prediction: Scope and Limitations

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2011-05-02

PREAI

Hillebrecht, Alexander; Muster, Wolfgang; Brigo, Alessandro; Kansy, Manfred; Weiser, Thomas; Singer, Thomas

Extending pKa prediction accuracy: High-throughput pKa measurements to understand pKa modulation of new chemical series

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2010-09-01

106

PREAI

Milletti, Francesca; Storchi, Loriano; Goracci, Laura; Bendels, Stefanie; Wagner, Bjoern; Kansy, Manfred; Cruciani, Gabriele

Coexistence of passive and carrier-mediated processes in drug transport

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2010-08-01

544

PREAI

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex; Bendels, Stefanie; Di, Li; Ecker, Gerhard F.; Faller, Bernard; Fischer, Holger; Gerebtzoff, Gregori; Lennernaes, Hans; Senner, Frank

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

CHEMMEDCHEM

IF3.4

2009-04-09

138

PREAI

Peters, Jens-Uwe; Schnider, Patrick; Mattei, Patrizio; Kansy, Manfred

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2008-08-01

PREAI