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L

Leslie Z. Benet

School of Pharmacy and Medicine

89H指数
628论文数
3.8W被引数
收录论文 153
发表时间
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Mathematical Modeling in Drug Metabolism and Pharmacokinetics: Correct In Vitro, Not Always Valid In Vivo药物代谢与药代动力学中的数学建模：体外正确，体内未必有效
errPharmaceuticals
IF4.8
err2026-01-16
err0
errOAAI
errLeslie Z. Benet; Jasleen K. Sodhi
err分享
err收藏
Net Influx Rather Than Directional Rates: Re-evaluating Transporter Characterization In Vivo and In Vitro for Renal and Hepatic Clearance净流入而非定向速率：重新评估肾和肝清除率的体内和体外转运蛋白表征
errThe AAPS Journal
IF0
err2025-10-23
err0
errOAAI
errLeslie Z. Benet; Jasleen K. Sodhi
err分享
err收藏
Simplifying Pharmacokinetics, Applying it to Drug and Dosage Form Development, and Making Drug Dosage Decisions in Clinical Medicine: The Adaptation of Kirchhoff’s Laws from Physics简化药代动力学，并将其应用于药物和剂型开发，以及在临床医学中制定药物剂量决策：从物理学中借鉴基尔霍夫定律
erraaps journal
IF0
err2025-07-03
err0
errOAAI
errLeslie Z. Benet; Jasleen K. Sodhi
err分享
err收藏
Is there a possibility that P-glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not?是否存在P-糖蛋白降低男性生殖毒性但乳腺癌耐药蛋白不能降低的可能性？
errCTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
err2024-10-02
err0
errOAAI
errYu, Zhiheng; Liu, Wei; Wang, Ziyu; Chen, Yidong; Yan, Jie; Benet, Leslie Z.; Zhai, Suodi
err分享
err收藏
Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance?
errEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
IF4.7
err2024-05-01
err5
errOAAI
errBenet, L. Z.; Sodhi, J. K.
err分享
err收藏
An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing解释为什么替代给药途径的剂量校正曲线下面积可能大于静脉给药
errAAPS JOURNAL
IF3.7
err2024-01-30
err4
errOAAI
errWakuda, Hirokazu; Xiang, Yue; Sodhi, Jasleen K.; Uemura, Naoto; Benet, Leslie Z.
err分享
err收藏
Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential溶解度-渗透性相互作用，促进预测药物处置途径，吸收程度，食物效应，脑渗透和药物诱导的肝损伤潜力
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2023-09-01
err3
PREAI
errBenet, Leslie Z.
err分享
err收藏
The Uses and Advantages of Kirchhoff's Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry基尔霍夫定律与微分方程在药理学，药代动力学和 (甚至) 化学中的用途和优势
errAAPS JOURNAL
IF3.7
err2023-04-10
err9
errOAAI
errBenet, Leslie Z.; Sodhi, Jasleen K.
err分享
err收藏
Using an animal model to predict the effective human dose for oral multiple sclerosis drugs利用动物模型预测口服多发性硬化症药物的有效人体剂量
errCTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
err2022-11-23
err4
errOAAI
errLiu, Wei; Yu, Zhiheng; Wang, Ziyu; Waubant, Emmanuelle L.; Zhai, Suodi; Benet, Leslie Z.
err分享
err收藏
Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance
errPHARMACOLOGY & THERAPEUTICS
IF12.5
err2022-11-01
err11
errOAAI
errPachter, Jonathan Asher; Dill, Ken A.; Sodhi, Jasleen K.; Benet, Leslie Z.
err分享
err收藏
State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References生物药剂学药物处置分类系统（BDDCS）的最新进展与应用：新增内容、修订及引用文献
errAAPS JOURNAL
IF3.7
err2022-02-23
err36
errOAAI
errBocci, Giovanni; Oprea, Tudor I.; Benet, Leslie Z.
err分享
err收藏
Can In Vitro-In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2021-12-08
err21
errOAAI
errBenet, Leslie Z.; Sodhi, Jasleen K.
err分享
err收藏
Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies分析潜在的肠道转运蛋白药物相互作用: 重新评估替格瑞洛相互作用研究
errPHARMACEUTICAL RESEARCH
IF4.3
err2021-11-02
err6
errOAAI
errLiu, Shuaibing; Sodhi, Jasleen K.; Benet, Leslie Z.
err分享
err收藏
Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing
errAAPS PHARMSCITECH
IF4
err2021-08-19
err4
PREAI
errGetz, Elise Burmeister; Carroll, Kevin J.; Mielke, Johanna; Jones, Byron; Benet, Leslie Z.
err分享
err收藏
Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans在人类和临床前动物模型中检查未改变药物的尿排泄: 增加人类代谢不良的可预测性
errPHARMACEUTICAL RESEARCH
IF4.3
err2021-07-12
err6
errOAAI
errBamfo, Nadia O.; Hosey-Cojocari, Chelsea; Benet, Leslie Z.; Remsberg, Connie M.
err分享
err收藏
Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers
errCLINICAL PHARMACOLOGY & THERAPEUTICS
IF5.5
err2021-05-16
err4
errOAAI
errXiang, Yue; Okochi, Hideaki; Kozachenko, Ivan; Sodhi, Jasleen K.; Frassetto, Lynda A.; Benet, Leslie Z.
err分享
err收藏
There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions只有一个有效的清除率定义: 对清除率概念的严格检查揭示了临床药物剂量决定中潜在的错误
errAAPS JOURNAL
IF3.7
err2021-05-10
err20
errOAAI
errBenet, Leslie Z.; Sodhi, Jasleen K.; Makrygiorgos, George; Mesbah, Ali
err分享
err收藏
Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption通过检查吸收变化调查肠道转运体参与利伐沙班处置
errPHARMACEUTICAL RESEARCH
IF4.3
err2021-04-13
err9
errOAAI
errKou, Wen; Sodhi, Jasleen K.; Wu, Xin'an; Benet, Leslie Z.
err分享
err收藏
Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization成功和不成功的预测用于导线优化的人肝清除率
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-03-25
err40
errOAAI
errSodhi, Jasleen K.; Benet, Leslie Z.
err分享
err收藏
Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition肠外排转运蛋白p-gp和BCRP与阿哌沙班处置无临床相关性
errPHARMACEUTICAL RESEARCH
IF4.3
err2020-09-29
err18
errOAAI
errSodhi, Jasleen K.; Liu, Shuaibing; Benet, Leslie Z.
err分享
err收藏

研究方向

暂无研究方向
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