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Understanding tumor-immune-stromal dynamics driving response and resistance to immune checkpoint blockade in melanoma Tarantino, Giuseppe; He, Yiwen; Solanky, Priyanka; Cui, Xinyu; Pfaff, Kathleen; Thorner, Aaron R.; Blosser, Timothy; Boblitt, Elliot; Frangieh, Allison; Aprati, Tyler; Zhang, Boyang; Chen, Jiajia; Faulkner, Hannah Mae; Lawless, Aleigha; Manos, Michael; Helvie, Karla; Sharova, Tatyana; Frederick, Dennie; Krishna, Sachi; Mangum, Chanell; Abbondanza, Domenic; Mccann, Cai; Johnson, Bruce; Shalek, Alex K.; Van Allen, Eliezer; Zhuang, Xiaowei; Sullivan, Ryan; Engelhardt, Barbara; Farhi, Sami; Rodig, Scott; Hodi, F. Stephen; Boland, Genevieve M.; Liu, David 分享 收藏
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SlideCNA: spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data SlideCNA: 从slide-seq-like空间转录组学数据中检测空间拷贝数改变 Zhang, Diane; Segerstolpe, Asa; Slyper, Michal; Waldman, Julia; Murray, Evan; Strasser, Robert; Watter, Jan; Cohen, Ofir; Ashenberg, Orr; Abravanel, Daniel; Jane-Valbuena, Judit; Mages, Simon; Lako, Ana; Helvie, Karla; Rozenblatt-Rosen, Orit; Rodig, Scott; Chen, Fei; Wagle, Nikhil; Regev, Aviv; Klughammer, Johanna 分享 收藏
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features 跨临床病理特征的转移性乳腺癌活检的多模态单细胞和空间表达图 Klughammer, Johanna; Abravanel, Daniel L.; Segerstolpe, Asa; Blosser, Timothy R.; Goltsev, Yury; Cui, Yi; Goodwin, Daniel R.; Sinha, Anubhav; Ashenberg, Orr; Slyper, Michal; Vigneau, Sebastien; Jane-Valbuena, Judit; Alon, Shahar; Caraccio, Chiara; Chen, Judy; Cohen, Ofir; Cullen, Nicole; DelloStritto, Laura K.; Dionne, Danielle; Files, Janet; Frangieh, Allison; Helvie, Karla; Hughes, Melissa E.; Inga, Stephanie; Kanodia, Abhay; Lako, Ana; MacKichan, Colin; Mages, Simon; Moriel, Noa; Murray, Evan; Napolitano, Sara; Nguyen, Kyleen; Nitzan, Mor; Ortiz, Rebecca; Patel, Miraj; Pfaff, Kathleen L.; Porter, Caroline B. M.; Rotem, Asaf; Strauss, Sarah; Strasser, Robert; Thorner, Aaron R.; Turner, Madison; Wakiro, Isaac; Waldman, Julia; Wu, Jingyi; Zanudo, Jorge Gomez Tejeda; Zhang, Diane; Lin, Nancy U.; Tolaney, Sara M.; Winer, Eric P.; Boyden, Edward S.; Chen, Fei; Nolan, Garry P.; Rodig, Scott J.; Zhuang, Xiaowei; Rozenblatt-Rosen, Orit; Johnson, Bruce E.; Regev, Aviv; Wagle, Nikhil 分享 收藏
Characterization and proposed therapeutic exploitation of fusion RNAs in metastatic breast cancers Priedigkeit, Nolan; Lebron-Torres, Alines; Liao, Janny; Alberge, Jean-Baptiste; Morganti, Stefania; Weiss, Jakob; Zanudo, Jorge Gomez Tejeda; Grinshpun, Albert; Hughes, Melissa; Helvie, Karla; Sendrick, Kerry; Nguyen, Kyleen; Strauss, Sarah; Files, Janet; Lloyd, Maxwell; Wagle, Nikhil; Stewart, Chip; Winer, Eric; Johnson, Bruce; Li, Yvonne; Jeselsohn, Rinath; Tolaney, Sara; Abravanel, Daniel; Lin, Nancy; Parsons, Heather; Getz, Gad; Oesterreich, Steffi; Lee, Adrian; Golub, Todd 分享 收藏
Dissecting tumor- immune interaction in response and resistance to immune checkpoint blockade in metastatic melanoma Tarantino, Giuseppe; He, Yiwen; Solanky, Priyanka; Thorner, Aaron; Aprati, Tyler; Sullivan, Ryan; Robitschek, Emily; Blosser, Timothy; Zhuang, Xiaowei; Zhuang, Xiaowei; Boblitt, Elliot; Frangieh, Allison; Holovatska, Marta; Lawless, Aleigha; Manos, Michael; Pfaff, Kathleen; Helvie, Karla; Sharova, Tatyana; Frederick, Dennie; Fahey, James Liam; Villamarin, Diego; Farhi, Sami; Rodig, Scott; Johnson, Bruce; Shalek, Alex K.; Van Allen, Eliezer; Hodi, Stephen; Boland, Genevieve M.; Liu, David 分享 收藏
Exemestane plus everolimus and palbociclib in metastatic breast cancer: clinical response and genomic/transcriptomic determinants of resistance in a phase I/II trial Zanudo, Jorge Gomez Tejeda; Barroso-Sousa, Romualdo; Jain, Esha; Jin, Qingchun; Li, Tianyu; Buendia-Buendia, Jorge E.; Pereslete, Alyssa; Abravanel, Daniel L.; Ferreira, Arlindo R.; Wrabel, Eileen; Helvie, Karla; Hughes, Melissa E.; Partridge, Ann H.; Overmoyer, Beth; Lin, Nancy U.; Tayob, Nabihah; Tolaney, Sara M.; Wagle, Nikhil 分享 收藏
Genomic and transcriptomic analysis reveals known and novel resistance mechanisms to CDK4/6 inhibitors and sensitivity factors for the response to triplet therapy (palbociclib plus everolimus plus exemestane) in a phase I/IIb study in hormone-receptor positive (HR+)/HER2-metastatic breast cancer (MBC) after progression on a CDK4/6 inhibitor (CDK4/6i) Zanudo, Jorge Gomez Tejeda; Barroso-Sousa, Romualdo; Jain, Esha; Buendia-Buendia, Jorge; Li, Tianyu; Tayob, Nabihah; Rees, Rebecca; Pereslete, Alyssa; Ferreira, Arlindo R.; Abravanel, Daniel L.; Helvie, Karla; Partridge, Ann H.; Overmoyer, Beth; Winer, Eric P.; Wagle, Nikhil; Tolaney, Sara M. 分享 收藏
Spatio-molecular dissection of the breast cancer metastatic microenvironment Abravanel, Daniel L.; Klughammer, Johanna; Blosser, Timothy; Goltsev, Yury; Jiang, Sizun; Bai, Yunjao; Murray, Evan; Alon, Shahar; Cui, Yi; Goodwin, Daniel R.; Sinha, Anubhav; Cohen, Ofir; Slyper, Michal; Ashenberg, Orr; Dionne, Danielle; Jane-Valbuena, Judit; Porter, Caroline BM.; Segerstolpe, Asa; Waldman, Julia; Vigneau, Sebastien; Helvie, Karla; Frangieh, Allison; DelloStritto, Laura; Patel, Miraj; We, Jingyi; Pfaff, Kathleen; Cullen, Nicole; Lako, Ana; Turner, Madison; Wakiro, Isaac; Napolitano, Sara; Kanodia, Abhay; Ortiz, Rebecca; MacKichan, Colin; Inga, Stephanie; Chen, Judy; Thorner, Aaron R.; Rotem, Asaf; Rodig, Scott; Chen, Fei; Boyden, Edward S.; Nolan, Garry P.; Zhuang, Xiaowei; Rozenblatt-Rosen, Orit; Johnson, Bruce E.; Regev, Aviv; Wagle, Nikhil 分享 收藏
A phase II study of efficacy, toxicity, and the potential impact of genomic alterations on response to eribulin mesylate in combination with trastuzumab and pertuzumab in women with human epidermal growth factor receptor 2 (HER2)+ metastatic breast cancer Balch, Sara M.; Vaz-Luis, Ines; Li, Tianyu; Tayob, Nabihah; Jain, Esha; Helvie, Karla; Buendia-Buendia, Jorge E.; Shannon, Erin; Isakoff, Steven J.; Tung, Nadine M.; Krop, Ian E.; Lin, Nancy U.; Wagle, Nikhil; Freedman, Rachel A. 分享 收藏
The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor-Positive Metastatic Breast Cancer 激素受体阳性转移性乳腺癌患者对细胞周期蛋白依赖性激酶4/6抑制剂的内在和获得性耐药的基因组景观 Wander, Seth A.; Cohent, Ofir; Gong, Xueqian; Johnson, Gabriela N.; Buendia-Buendia, Jorge E.; Lloyd, Maxwell R.; Kim, Dewey; Luo, Flora; Mao, Pingping; Helvie, Karla; Kowalski, Kalley J.; Nayar, Utthara; Waks, Adrienne G.; Parsons, Stephen H.; Martinez, Ricardo; Litchfield, Lacey M.; Ye, Xiang S.; Yu, Chunping; Jansen, Valerie M.; Stille, John R.; Smith, Patricia S.; Oakley, Gerard J.; Chu, Quincy S.; Batist, Gerald; Hughes, Melissa E.; Kremer, Jill D.; Garraway, Levi A.; Winer, Erik P.; Tolaney, Sara M.; Lin, Nancy U.; Buchanan, Sean G.; Wagle, Nikhil 分享 收藏
Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer BRCA1/2突变转移性乳腺癌对PARP抑制剂或铂类化疗耐药的逆转和非逆转机制 Waks, A. G.; Coheny, O.; Kochupurakkal, B.; Kim, D.; Dunn, C. E.; Buendia, J. Buendia; Wander, S.; Helvie, K.; Lloyd, M. R.; Marini, L.; Hughes, M. E.; Freeman, S. S.; Ivy, S. P.; Geradts, J.; Isakoff, S.; LoRusso, P.; Adalsteinsson, V. A.; Tolaney, S. M.; Matulonis, U.; Krop, I. E.; D'Andrea, A. D.; Winer, E. P.; Lin, N. U.; Shapiro, G. I.; Wagle, N. 分享 收藏
A phase I/IIb study of palbociclib (PALBO) plus everolimus (EVE) and exemestane (EXE) in hormone-receptor positive (HR+)/HER2-metastatic breast cancer (MBC) after progression on a CDK4/6 inhibitor (CDK4/6i): Results of the phase II study Barroso-Sousa, Romualdo; Li, Tianyu; Trippa, Lorenzo; Rees, Rebecca; Andrews, Chelsea; Ferreira, Arlindo R.; Helvie, Karla; Partridge, Ann H.; Overmoyer, Beth; Winer, Eric P.; Wagle, Nikhil; Tolaney, Sara M. 分享 收藏
Acquired activating mutations in RTKs confer endocrine resistance in ER plus metastatic breast cancer through ER-reprogramming, MAPK signaling, and an induced stem-like cell state Cohen, Ofir; Mao, Pingping; Nayar, Utthara; Buendia-Bue, Jorge E.; Kim, Dewey; Jain, Esha; Helvie, Karla; Abravanel, Daniel; Kowalski, Kailey J.; Kapstad, Christian; Freeman, Samuel; Adalsteinsson, Victor; Wander, Seth A.; Waks, Adrienne G.; Getz, Gad; Regev, Aviv; Winer, Eric P. Winer; Lin, Nancy U. Nancy U.; Wagle, Nikhil 分享 收藏
A joint atlas of single-cell and bulk RNA-seq in metastatic breast cancer allows inference of oncogenic and drug-resistant transcriptional programs in malignant cells and the tumor microenvironment Cohen, Ofir; Abravanel, Daniel; Slyper, Michal; Klughammer, Johanna; Jane-Valbuena, Judit; Helvie, Karla; Dellostritto, Laura; Frangieh, Allison; Vigneau, Sebastien; Wu, Jingyi; Mayorga, Angie; Waldman, Julia; Nguyen, Lan; Dionne, Danielle; Ashenberg, Orr; Hofree, Matan; Cuoco, Mike; Rodman, Christopher; Winer, Eric P.; Lin, Nancy; Johnson, Bruce; Rotem, Asaf; Rozenblatt-Rosen, Orit; Regev, Aviv; Wagle, Nikhil 分享 收藏
The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in patients with hormone receptor-positive (HR+)/HER2-metastatic breast cancer (MBC) Wander, Seth A.; Cohen, Ofir; Gong, Xueqian; Johnson, Gabriela N.; Buendia-Buendia, Jorge; Lloyd, Maxwell; Kim, Dewey; Luo, Flora; Mao, Pingping; Helvie, Karla; Kowalski, Kailey; Nayar, Utthara; Parsons, Stephen; Martinez, Ricardo; Litchfield, Lacey; Ye, Xiang; Yu, Chun Ping; Jansen, Valerie; Garraway, Levi A.; Winer, Eric P.; Tolaney, Sara M.; Lin, Nancy U.; Buchanan, Sean; Wagle, Nikhil 分享 收藏
Evolutionary analysis of 462 serial metastatic biopsies from 208 patients with estrogen receptor-positive (ER plus ) metastatic breast cancer (MBC) using whole exome sequencing (WES) Cohen, O.; Buendia-Buendia, J.; Wander, S.; Nayar, U.; Mao, P.; Waks, A.; Kim, D.; Freeman, S.; Adalsteinsson, V.; Helvie, K.; Livitz, D.; Rosebrock, D.; Leshchiner, I.; Dellostritto, L.; Garrido-Castro, A.; Jain, E.; Periyasamy, S.; Mackichan, C.; Lloyd, M.; Marini, L.; Krop, I.; Garraway, L.; Getz, G.; Winer, E.; Lin, N.; Wagle, N. 分享 收藏
Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor-directed therapies Nayar, Utthara; Cohen, Ofir; Kapstad, Christian; Cuoco, Michael S.; Waks, Adrienne G.; Wander, Seth A.; Painter, Corrie; Freeman, Samuel; Persky, Nicole S.; Marini, Lori; Helvie, Karla; Oliver, Nelly; Rozenblatt-Rosen, Orit; Ma, Cynthia X.; Regev, Aviv; Winer, Eric P.; Lin, Nancy U.; Wagle, Nikhil 分享 收藏
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine 晚期胰腺癌的实时基因组表征以实现精准医学 Aguirre, Andrew J.; Nowak, Jonathan A.; Camarda, Nicholas D.; Moffitt, Richard A.; Ghazani, Arezou A.; Hazar-Rethinam, Mehlika; Raghavan, Srivatsan; Kim, Jaegil; Brais, Lauren K.; Ragon, Dorisanne; Welch, Marisa W.; Reilly, Emma; McCabe, Devin; Marini, Lori; Anderka, Kristin; Helvie, Karla; Oliver, Nelly; Babic, Ana; Da Silva, Annacarolina; Nadres, Brandon; Van Seventer, Emily E.; Shahzade, Heather A.; St Pierre, Joseph P.; Burke, Kelly P.; Clancy, Thomas; Cleary, James M.; Doyle, Leona A.; Jajoo, Kunal; McCleary, Nadine J.; Meyerhardt, Jeffrey A.; Murphy, Janet E.; Ng, Kimmie; Patel, Anuj K.; Perez, Kimberly; Rosenthal, Michael H.; Rubinson, Douglas A.; Ryou, Marvin; Shapiro, Geoffrey I.; Sicinska, Ewa; Silverman, Stuart G.; Nagy, Rebecca J.; Lanman, Richard B.; Knoerzer, Deborah; Welsch, Dean J.; Yurgelun, Matthew B.; Fuchs, Charles S.; Garraway, Levi A.; Getz, Gad; Hornick, Jason L.; Johnson, Bruce E.; Kulke, Matthew H.; Mayer, Robert J.; Miller, Jeffrey W.; Shyn, Paul B.; Tuveson, David A.; Wagle, Nikhil; Yeh, Jen Jen; Hahn, William C.; Corcoran, Ryan B.; Carter, Scott L.; Wolpin, Brian M. 分享 收藏
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