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PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors PERCEPTION使用肿瘤的单细胞转录组学预测患者对治疗的反应和抵抗力 Sinha, Sanju; Vegesna, Rahulsimham; Mukherjee, Sumit; Kammula, Ashwin V.; Dhruba, Saugato Rahman; Wu, Wei; Kerr, D. Lucas; Nair, Nishanth Ulhas; Jones, Matthew G.; Yosef, Nir; Stroganov, Oleg V.; Grishagin, Ivan; Aldape, Kenneth D.; Blakely, Collin M.; Jiang, Peng; Thomas, Craig J.; Benes, Cyril H.; Bivona, Trever G.; Schaeffer, Alejandro A.; Ruppin, Eytan 分享 收藏
A landscape of response to drug combinations in non-small cell lung cancer Nair, Nishanth Ulhas; Greninger, Patricia; Zhang, Xiaohu; Friedman, Adam A.; Amzallag, Arnaud; Cortez, Eliane; Sahu, Avinash Das; Lee, Joo Sang; Dastur, Anahita; Egan, Regina K.; Murchie, Ellen; Ceribelli, Michele; Crowther, Giovanna S.; Beck, Erin; McClanaghan, Joseph; Klump-Thomas, Carleen; Boisvert, Jessica L.; Damon, Leah J.; Wilson, Kelli M.; Ho, Jeffrey; Tam, Angela; McKnight, Crystal; Michael, Sam; Itkin, Zina; Garnett, Mathew J.; Engelman, Jeffrey A.; Haber, Daniel A.; Thomas, Craig J.; Ruppin, Eytan; Benes, Cyril H. 分享 收藏
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers Shi, Lei; Shen, William; Davis, Mindy I.; Kong, Ke; Vu, Phuong; Saha, Supriya K.; Adil, Ramzi; Kreuzer, Johannes; Egan, Regina; Lee, Tobie D.; Greninger, Patricia; Shrimp, Jonathan H.; Zhao, Wei; Wei, Ting-Yu; Zhou, Mi; Eccleston, Jason; Sussman, Jonathan; Manocha, Ujjawal; Weerasekara, Vajira; Kondo, Hiroshi; Vijay, Vindhya; Wu, Meng-Ju; Kearney, Sara E.; Ho, Jeffrey; McClanaghan, Joseph; Murchie, Ellen; Crowther, Giovanna S.; Patnaik, Samarjit; Boxer, Matthew B.; Shen, Min; Ting, David T.; Kim, William Y.; Stanger, Ben Z.; Deshpande, Vikram; Ferrone, Cristina R.; Benes, Cyril H.; Haas, Wilhelm; Hall, Matthew D.; Bardeesy, Nabeel 分享 收藏
Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells Sun, Yang; Hu, Lu; Tao, Zhipeng; Jarugumilli, Gopala K.; Erb, Hannah; Singh, Alka; Li, Qi; Cotton, Jennifer L.; Greninger, Patricia; Egan, Regina K.; Ip, Y. Tony; Benes, Cyril H.; Che, Jianwei; Mao, Junhao; Wu, Xu 分享 收藏
Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models Jacob, Sheeba; Turner, Tia H.; Cai, Jinyang; Floros, Konstantinos V.; Yu, Ann K.; Coon, Colin M.; Khatri, Rishabh; Alzubi, Mohammad A.; Jakubik, Charles T.; Bouck, Ynes M.; Puchalapalli, Madhavi; Shende, Mayuri; Dozmorov, Mikhail G.; Boikos, Sosipatros A.; Hu, Bin; Harrell, J. Chuck; Benes, Cyril H.; Koblinski, Jennifer E.; Costa, Carlotta; Faber, Anthony C. 分享 收藏
High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition Cai, Jinyang; Jacob, Sheeba; Kurupi, Richard; Dalton, Krista M.; Coon, Colin; Greninger, Patricia; Egan, Regina K.; Stein, Giovanna T.; Murchie, Ellen; McClanaghan, Joseph; Adachi, Yuta; Hirade, Kentaro; Dozmorov, Mikhail; Glod, John; Boikos, Sosipatros A.; Ebi, Hiromichi; Hao, Huaixiang; Caponigro, Giordano; Benes, Cyril H.; Faber, Anthony C. 分享 收藏
EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma Wu, Qibiao; Zhen, Yuanli; Shi, Lei; Vu, Phuong; Greninger, Patricia; Adil, Ramzi; Merritt, Joshua; Egan, Regina; Wu, Meng-Ju; Yin, Xunqin; Ferrone, Cristina R.; Deshpande, Vikram; Baiev, Islam; Pinto, Christopher J.; McLoughlin, Daniel E.; Walmsley, Charlotte S.; Stone, James R.; Gordan, John D.; Zhu, Andrew X.; Juric, Dejan; Goyal, Lipika; Benes, Cyril H.; Bardeesy, Nabeel 分享 收藏
Screening and Validation of Molecular Targeted Radiosensitizers Willers, Henning; Pan, Xiao; Borgeaud, Nathalie; Korovina, Irina; Koi, Lydia; Egan, Regina; Greninger, Patricia; Rosenkranz, Aliza; Kung, Jong; Liss, Andrew S.; Parsels, Leslie A.; Morgan, Meredith A.; Lawrence, Theodore S.; Lin, Steven H.; Hong, Theodore S.; Yeap, Beow Y.; Wirth, Lori J.; Hata, Aaron N.; Ott, Christopher J.; Benes, Cyril H.; Baumann, Michael; Krause, Mechthild 分享 收藏
Pharmaceutical Interference of the EWS-FLI1-driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma Heisey, Daniel A. R.; Jacob, Sheeba; Lochmann, Timothy L.; Kurupi, Richard; Ghotra, Maninderjit S.; Calbert, Marissa L.; Shende, Mayuri; Maves, Yuki Kato; Koblinski, Jennifer E.; Dozmorov, Mikhail G.; Boikos, Sosipatros A.; Benes, Cyril H.; Faber, Anthony C. 分享 收藏
A large cellular screen charting the landscape of synergistic drug combinations in lung cancer. Nair, Nishanth Ulhas; Friedman, Adam; Greninger, Patricia; Sahu, Avinash D.; Murchie, Ellen; Crowther, Giovanna Stein; McClanaghan, Joe; Lee, Joo Sang; Haber, Daniel A.; Engelman, Jeffrey; Ruppin, Eytan; Benes, Cyril 分享 收藏
Venetoclax-based Rational Combinations are Effective in Models of MYCN-amplified Neuroblastoma Dalton, Krista M.; Krytska, Kateryna; Lochmann, Timothy L.; Sano, Renata; Casey, Colleen; D'Aulerio, Alessia; Khan, Qasim A.; Crowther, Giovanna Stein; Coon, Colin; Cai, Jinyang; Jacob, Sheeba; Kurupi, Richard; Hu, Bin; Dozmorov, Mikhail; Greninger, Patricia; Souers, Andrew J.; Benes, Cyril H.; Mosse, Yael P.; Faber, Anthony C. 分享 收藏
Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma 灾难性的ATP损失是针对MYCN扩增的神经母细胞瘤量身定制的代谢联合疗法的基础 Dalton, Krista M.; Lochmann, Timothy L.; Floros, Konstantinos, V; Calbert, Marissa L.; Kurupi, Richard; Stein, Giovanna T.; McClanaghan, Joseph; Murchie, Ellen; Egan, Regina K.; Greninger, Patricia; Dozmorov, Mikhail; Ramamoorthy, Sivapriya; Puchalapalli, Madhavi; Hu, Bin; Shock, Lisa; Koblinski, Jennifer; Glod, John; Boikos, Sosipatros A.; Benes, Cyril H.; Faber, Anthony C. 分享 收藏
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer Wang, Yuezhou; Zhang, Lei; Wei, Yanling; Huang, Wei; Li, Li; Wu, An-an; Dastur, Anahita; Greninger, Patricia; Bray, Walter M.; Zhang, Chen-Song; Li, Mengqi; Lian, Wenhua; Hu, Zhiyu; Wang, Xiaoyong; Liu, Gang; Yao, Luming; Guh, Jih-Hwa; Chen, Lanfen; Wang, Hong-Rui; Zhou, Dawang; Lin, Sheng-Cai; Xu, Qingyan; Shen, Yuemao; Zhang, Jianming; Jurica, Melissa S.; Benes, Cyril H.; Deng, Xianming 分享 收藏
PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ka inhibitors in breast cancer Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan 分享 收藏
IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology Prabhu, Varun Vijay; Morrow, Sara; Cuoco, Caroline A.; Kawakibi, Abed R.; Jung, Jinkyu; Madhukar, Neel; Garnett, Matthew J.; McDermott, Ultan; Benes, Cyril H.; Wechsler-Reya, Robert; Anantharaman, Lakshmi; Charter, Neil; Rucker, Joseph B.; Doranz, Benjamin J.; Basken, Joel; Elemento, Olivier; Free, R. Benjamin; Sibley, David R.; Stogniew, Martin; Oster, Wolfgang; Gilbert, Mark R.; DeMorrow, Sharon 分享 收藏
Predicting and affecting response to cancer therapy based on pathway-level biomarkers 基于通路水平生物标志物预测和影响癌症治疗反应 Ben-Hamo, Rotem; Berger, Adi Jacob; Gavert, Nancy; Miller, Mendy; Pines, Guy; Oren, Roni; Pikarsky, Eli; Benes, Cyril H.; Neuman, Tzahi; Zwang, Yaara; Efroni, Sol; Getz, Gad; Straussman, Ravid 分享 收藏
Genomic screening reveals UBA1 as a potent and druggable target in diverse models of triple negative breast cancer Jacob, Sheeba; Turner, Tia H.; Yu, Ann K.; Coon, Colin M.; Alzubi, Mohammad A.; Jakubik, Charles T.; Bouck, Ynes; Dozmorov, Mikhail G.; Boikos, Sosipatros A.; Koblinski, Jennifer; Harrell, Joshua C.; Benes, Cyril H.; Costa, Carlotta; Faber, Anthony C. 分享 收藏
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer PTEN缺失介导乳腺癌对CDK4/6和PI3Kα 抑制剂的临床交叉耐药 Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James R.; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan 分享 收藏
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