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Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain 通过tmv-tmvi结构域靶向受体纳米簇对CXCR4:CXCL12轴的变构调节 Garcia-Cuesta, Eva M.; Martinez, Pablo; Selvaraju, Karthik; Ulltjarn, Gabriel; Pozo, Adrian Miguel Gomez; D'Agostino, Gianluca; Gardeta, Sofia; Quijada-Freire, Adriana; Gabella, Patricia Blanco; Roca, Carlos; Hoyo, Daniel del; Jimenez-Saiz, Rodrigo; Garcia-Rubia, Alfonso; Palacios, Blanca Soler; Lucas, Pilar; Ayala-Bueno, Rosa; Acerete, Noelia Santander; Carrasco, Yolanda; Sorzano, Carlos Oscar; Martinez, Ana; Campillo, Nuria E.; Jensen, Lasse D.; Frade, Jose Miguel Rodriguez; Santiago, Cesar; Mellado, Mario 分享 收藏
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases Peixoto, Christophe; Joncour, Agnes; Temal-Laib, Taoues; Tirera, Amynata; Dos Santos, Aurelie; Jary, Helene; Bucher, Denis; Laenen, Wendy; Fernandes, Anna Pereira; Lavazais, Stephanie; Delachaume, Carole; Merciris, Didier; Saccomani, Corinne; Drennan, Michael; Lopez-Ramos, Miriam; Wakselman, Emanuelle; Dupont, Sonia; Borgonovi, Monica; Magadan, Carlos Roca; Monjardet, Alain; Brys, Reginald; De Vos, Steve; Andrews, Martin; Jimenez, Juan-Miguel; Amantini, David; Desroy, Nicolas 分享 收藏
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312 Temal-Laib, Taoues; Peixoto, Christophe; Desroy, Nicolas; De Lemos, Elsa; Bonnaterre, Florence; Bienvenu, Natacha; Picolet, Olivier; Sartori, Eric; Bucher, Denis; Lopez-Ramos, Miriam; Magadan, Carlos Roca; Laenen, Wendy; Flower, Thomas; Mollat, Patrick; Bugaud, Olivier; Touitou, Robert; Fernandes, Anna Pereira; Lavazais, Stephanie; Monjardet, Alain; Borgonovi, Monica; Gosmini, Romain; Brys, Reginald; Amantini, David; De Vos, Steve; Andrews, Martin 分享 收藏
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QSAR Classification Models for Predicting the Activity of Inhibitors of Beta-Secretase (BACE1) Associated with Alzheimer's Disease Ponzoni, Ignacio; Sebastian-Perez, Victor; Martinez, Maria J.; Roca, Carlos; De la Cruz Perez, Carlos; Cravero, Fiorella; Vazquez, Gustavo E.; Paez, Juan A.; Diaz, Monica F.; Campillo, Nuria E. 分享 收藏
Indazolylketones as new multitarget cannabinoid drugs Gonzalez-Naranjo, Pedro; Perez-Macias, Natalia; Perez, Concepcion; Roca, Carlos; Vaca, Gabriela; Giron, Rocio; Sanchez-Robles, Eva; Isabel Martin-Fontelles, Maria; de Ceballos, Maria L.; Martin-Requero, Angeles; Campillo, Nuria E.; Paez, Juan A. 分享 收藏
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease 阿尔茨海默氏病中丁酰胆碱酯酶的高效和选择性aryl-1，2，3-三唑基苄基哌啶抑制剂 de Andrade, Peterson; Mantoani, Susimaire P.; Goncalves Nunes, Paulo Sergio; Magadan, Carlos Roca; Perez, Concepcion; Xavier, Danilo Jordao; Sakamoto Hojo, Elza Tiemi; Campillo, Nuria E.; Martinez, Ana; Carvalho, Ivone 分享 收藏
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors Gandini, Annachiara; Bartolini, Manuela; Tedesco, Daniele; Martinez-Gonzalez, Loreto; Roca, Carlos; Campillo, Nuria E.; Zaldivar-Diez, Josefa; Perez, Concepcion; Zuccheri, Giampaolo; Miti, Andrea; Feoli, Alessandra; Castellano, Sabrina; Petralla, Sabrina; Monti, Barbara; Rossi, Martina; Moda, Fabio; Legname, Giuseppe; Martinez, Ana; Bolognesi, Maria Laura 分享 收藏
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators Roca, Carlos; Martinez-Gonzalez, Loreto; Daniel-Mozo, Miguel; Sastre, Javier; Infantes, Lourdes; Mansilla, Alicia; Chaves-Sanjuan, Antonio; Maria Gonzalez-Rubio, Juana; Gil, Carmen; Javier Canada, H. F.; Martinez, Ana; Jose Sanchez-Barrena, Maria; Campillo, Nuria E. 分享 收藏
Identification of new allosteric sites and modulators of AChE through computational and experimental tools 通过计算和实验工具鉴定AChE的新变构位点和调节剂 Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Malhotra, Sony; Radoux, Chris; Perez, Concepcion; Martinez, Ana; Antonio Paez, Juan; Blundell, Tom L.; Campillo, Nuria E. 分享 收藏
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Sebastian-Perez, Victor; Martinez-Gonzalez, Loreto; Perez, Daniel I.; Perez, Concepcion; Canales, Angeles; Javier Canada, F.; Campillo, Nuria E.; Carvalho, Ivone; Martinez, Ana 分享 收藏
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Castillo, Willian O.; Moreira, Natalia C. S.; Perez, Concepcion; Sakamoto-Hojo, Elza T.; Takahashi, Catarina S.; Jimenez-Barbero, Jesus; Javier Canada, F.; Campillo, Nuria E.; Martinez, Ana; Carvalho, Ivone 分享 收藏
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Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases Palomo, Valle; Perez, Daniel I.; Roca, Carlos; Anderson, Cara; Rodriguez-Muela, Natalia; Perez, Concepcion; Morales-Garcia, Jose A.; Reyes, Julio A.; Campillo, Nuria E.; Perez-Castillo, Ana M.; Rubin, Lee L.; Timchenko, Lubov; Gil, Carmen; Martinez, Ana 分享 收藏
Hybridizing Feature Selection and Feature Learning Approaches in QSAR Modeling for Drug Discovery Ponzoni, Ignacio; Sebastian-Perez, Victor; Requena-Triguero, Carlos; Roca, Carlos; Martinez, Maria J.; Cravero, Fiorella; Diaz, Monica F.; Paez, Juan A.; Gomez Arrayas, Ramon; Adrio, Javier; Campillo, Nuria E. 分享 收藏
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