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Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter-Compounds with Novel Mechanisms from High-Throughput Screening Profiles Thomas, Jason R.; Shelton, Claude; Murphy, Jason; Brittain, Scott; Bray, Mark-Anthony; Aspesi, Peter; Concannon, John; King, Frederick J.; Ihry, Robert J.; Ho, Daniel J.; Henault, Martin; Hadjikyriacou, Andrea; Neri, Marilisa; Sigoillot, Frederic D.; Pham, Helen T.; Shum, Matthew; Barys, Louise; Jones, Michael D.; Martin, Eric J.; Blechschmidt, Anke; Rieffel, Sebastien; Troxler, Thomas J.; Mapa, Felipa A.; Jenkins, Jeremy L.; Jain, Rishi K.; Kutchukian, Peter S.; Schirle, Markus; Renner, Steffen 分享 收藏
Allosteric Inhibition Restricts Motion of the SMURF1 Glycine Hinge and Reverses Experimental Pulmonary Arterial Hypertension Rothman, Alex M.; Florentin, Amir; Quigley, Catherine; Zink, Florence; Bonneau, Olivier; Hemming, Rene; Hachey, Amanda; Rejtar, Tomas; Thaker, Maulik; Jain, Rishi; Zhang, Ji-Hu; Cotesta, Simona; Ottl, Johannes; Kordinsky, Alina; Avishid, Reut; Troxler, Thomas; Binmahfooz, Sarah K.; Morrell, Nicholas W.; Humbert, Marc; Cobb, Jennifer; Osterman, Nils; Tallerico, John 分享 收藏
Activation of human STING by a molecular glue-like compound 通过分子胶样化合物激活人类STING Li, Jie; Canham, Stephen M.; Wu, Hua; Henault, Martin; Chen, Lihao; Liu, Guoxun; Chen, Yu; Yu, Gary; Miller, Howard R.; Hornak, Viktor; Brittain, Scott M.; Michaud, Gregory A.; Tutter, Antonin; Broom, Wendy; Digan, Mary Ellen; Mcwhirter, Sarah M.; Sivick, Kelsey E.; Pham, Helen T.; Chen, Christine H.; Tria, George S.; Mckenna, Jeffery M.; Schirle, Markus; Mao, Xiaohong; Nicholson, Thomas B.; Wang, Yuan; Jenkins, Jeremy L.; Jain, Rishi K.; Tallarico, John A.; Patel, Sejal J.; Zheng, Lianxing; Ross, Nathan T.; Cho, Charles Y.; Zhang, Xuewu; Bai, Xiao-Chen; Feng, Yan 分享 收藏
Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction Ding, Jian; Liu, Lulu; Chiang, Ying-Ling; Zhao, Mengxi; Liu, Hejun; Yang, Fei; Shen, Lingling; Lin, Ying; Deng, Huiwen; Gao, Jingyan; Sage, David R.; West, Laura; Llamas, Luis A.; Hao, Xin; Kawatkar, Sameer; Li, En; Jain, Rishi K.; Tallarico, John A.; Canham, Stephen M.; Wang, He 分享 收藏
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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy 用于癌症免疫治疗的选择性IKZF2胶降解剂的发现和表征 Bonazzi, Simone; d'Hennezel, Eva; Beckwith, Rohan E. J.; Xu, Lei; Fazal, Aleem; Magracheva, Anna; Ramesh, Radha; Cernijenko, Artiom; Antonakos, Brandon; Bhang, Hyo-eun C.; Caro, Roxana Garcia; Cobb, Jennifer S.; Ornelas, Elizabeth; Ma, Xiaolei; Wartchow, Charles A.; Clifton, Matthew C.; Forseth, Ry R.; Fortnam, Bethany Hughes; Lu, Hongbo; Csibi, Alfredo; Tullai, Jennifer; Carbonneau, Seth; Thomsen, Noel M.; Larrow, Jay; Chie-Leon, Barbara; Hainzl, Dominik; Gu, Yi; Lu, Darlene; Meyer, Matthew J.; Alexander, Dylan; Kinyamu-Akunda, Jacqueline; Sabatos-Peyton, Catherine A.; Dales, Natalie A.; Zecri, Frederic J.; Jain, Rishi K.; Shulok, Janine; Wang, Y. Karen; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Engelman, Jeffrey A.; Dranoff, Glenn; Bradner, James E.; Visser, Michael; Solomon, Jonathan M. 分享 收藏
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction Ding, Jian; Li, Guo; Liu, Hejun; Liu, Lulu; Lin, Ying; Gao, Jingyan; Zhou, Guoqiang; Shen, Lingling; Zhao, Mengxi; Yu, Yanyan; Guo, Weihui; Hommel, Ulrich; Ottl, Johannes; Blank, Jutta; Aubin, Nicola; Wei, Yi; He, Hu; Sage, David R.; Atadja, Peter W.; Li, En; Jain, Rishi K.; Tallarico, John A.; Canham, Stephen M.; Chiang, Ying-Ling; Wang, He 分享 收藏
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury Larraufie, Marie-Helene; Gao, Xiaolin; Xia, Xiaobo; Devine, Patrick J.; Kallen, Joerg; Liu, Dong; Michaud, Gregory; Harsch, Andreas; Savage, Nik; Ding, Jian; Tan, Kian; Mihalic, Manuel; Roggo, Silvio; Canham, Stephen M.; Bushell, Simon M.; Krastel, Philipp; Gao, Jinhai; Izaac, Aude; Altinoglu, Erhan; Lustenberger, Philipp; Salcius, Michael; Harbinski, Fred; Williams, Eric T.; Zeng, Liling; Loureiro, Joseph; Cong, Feng; Fryer, Christy J.; Klickstein, Lloyd; Tallarico, John A.; Jain, Rishi K.; Rothman, Deborah M.; Wang, Shaowen 分享 收藏
Systematic Chemogenetic Library Assembly Canham, Stephen M.; Wang, Yuan; Cornett, Allen; Auld, Douglas S.; Baeschlin, Daniel K.; Patoor, Maude; Skaanderup, Philip R.; Honda, Ayako; Llamas, Luis; Wendel, Greg; Mapa, Felipa A.; Aspesi, Peter, Jr.; Labbe-Giguere, Nancy; Gamber, Gabriel G.; Palacios, Daniel S.; Schuffenhauer, Ansgar; Deng, Zhan; Nigsch, Florian; Frederiksen, Mathias; Bushell, Simon M.; Rothman, Deborah; Jain, Rishi K.; Hemmerle, Horst; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Jenkins, Jeremy L. 分享 收藏
Discovery of a ZIP7 inhibitor from a Notch pathway screen Nolin, Erin; Gans, Sara; Llamas, Luis; Bandyopadhyay, Somnath; Brittain, Scott M.; Bernasconi-Elias, Paula; Carter, Kyle P.; Loureiro, Joseph J.; Thomas, Jason R.; Schirle, Markus; Yang, Yi; Guo, Ning; Roma, Guglielmo; Schuierer, Sven; Beibel, Martin; Lindeman, Alicia; Sigoillot, Frederic; Chen, Amy; Xie, Kevin X.; Ho, Samuel; Reece-Hoyes, John; Weihofen, Wilhelm A.; Tyskiewicz, Kayla; Hoepfner, Dominic; McDonald, Richard, I; Guthrie, Nicolette; Dogra, Abhishek; Guo, Haibing; Shao, Jian; Ding, Jian; Canham, Stephen M.; Boynton, Geoff; George, Elizabeth L.; Karig, Zhao B.; Antcza, Christophe; Porter, Jeffery A.; Wallace, Owen; Tallarico, John A.; Palmer, Amy E.; Jenkins, Jeremy L.; Jain, Rishi K.; Bushell, Simon M.; Fryer, Christyj 分享 收藏
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Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action Wang, Andrew C.; Pham, Helen T.; Lipps, Jennifer M.; Brittain, Scott M.; Harrington, Edmund; Wang, Yuan; King, Fred J.; Russ, Carsten; Pan, Xuewen; Hoepfner, Dominic; Tallarico, John; Feng, Yan; Jain, Rishi K.; Schirle, Markus; Thomas, Jason R. 分享 收藏
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Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists 2-吡啶基嘧啶作为第一个口服生物可利用的GPR39激动剂的发现 Peukert, Stefan; Hughes, Richard; Nunez, Jill; He, Guo; Yan, Zhao; Jain, Rishi; Llamas, Luis; Luchansky, Sarah; Carlson, Adam; Liang, Guiqing; Kunjathoor, Vidya; Pietropaolo, Mike; Shapiro, Jeffrey; Castellana, Anja; Wu, Xiaoping; Bose, Avirup 分享 收藏
Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 Bassilana, Frederic; Carlson, Adam; DaSilva, Jennifer A.; Grosshans, Bianka; Vidal, Solange; Beck, Valerie; Wilmeringwetter, Barbara; Llamas, Luis A.; Showalter, Todd B.; Rigollier, Pascal; Bourret, Aaron; Ramamurthy, Arun; Wu, Xu; Harbinski, Fred; Plonsky, Samantha; Lee, Lac; Ruffner, Heinz; Grandi, Paola; Schirle, Markus; Jenkins, Jeremy; Sailer, Andreas W.; Bouwmeester, Tewis; Porter, Jeffrey A.; Myer, Vic; Finan, Peter M.; Tallarico, John A.; Kelleher, Joseph F., III; Seuwen, Klaus; Jain, Rishi K.; Luchansky, Sarah J. 分享 收藏
1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity Miller-Moslin, Karen; Peukert, Stefan; Jain, Rishi K.; McEwan, Michael A.; Karki, Rajesh; Llamas, Luis; Yusuff, Naeem; He, Feng; Li, Yanhong; Sun, Yingchuan; Dai, Miao; Perez, Lawrence; Michael, Walter; Sheng, Tao; Lei, Huangshu; Zhang, Rui; Williams, Juliet; Bourret, Aaron; Ramamurthy, Arun; Yuan, Jing; Guo, Ribo; Matsumoto, Melissa; Vattay, Anthony; Maniara, Wieslawa; Amaral, Adam; Dorsch, Marion; Kelleher, Joseph F., III 分享 收藏
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