未登录A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers
Spriano, Filippo; Sartori, Giulio; Sgrignani, Jacopo; Barnabei, Laura; Arribas, Alberto J.; Guala, Matilde; Del Amor, Ana Maria Carrasco; Tomasso, Meagan R.; Tarantelli, Chiara; Cascione, Luciano; Golino, Gaetanina; Riveiro, Maria E.; Bortolozzi, Roberta; Lupia, Antonio; Paduano, Francesco; Huguet, Samuel; Rezai, Keyvan; Rinaldi, Andrea; Margheriti, Francesco; Ventura, Pedro; Guarda, Greta; Costa, Giosue; Rocca, Roberta; Furlan, Alberto; Verdonk, Luuk M.; Innocenti, Paolo; Martin, Nathaniel I.; Viola, Giampietro; Driessen, Christoph; Zucca, Emanuele; Stathis, Anastasios; Gahtory, Digvijay; van den Nieuwboer, Maurits; Bornhauser, Beat; Alcaro, Stefano; Trapasso, Francesco; Cristobal, Susana; Padrick, Shae B.; Pazzi, Natalina; Cavalli, Franco; Cavalli, Andrea; Gaudio, Eugenio; Bertoni, Francesco .png)
分享.png)
收藏A first-in-human Phase 1a/b of PEP-010, a proapoptotic bifunctional peptide, administered as single agent and in combination with paclitaxel in patients with recurrent and/or metastatic solid cancer: results from the dose escalation studyDu Rusquec, Pauline; Coquan, Elodie; Berger, Frederique; Rezai, Keyvan; Brachet, Pierre-Emmanuel; Postel-Vinay, Sophie; Castel-Ajgal, Zahra; Marret, Gregoire; Sablin, Marie-Paule; Hescot, Segolene; Sanchez, Raphael; Coyne, Anne-Claire; Bertrand, Claire; Bouchez, Clementine; Lafitte, Elsa; Frezouls, Lucas; Mardesson, Carole; Taamma, Abdelkrim; Krezel, Chantal; Dadon, Laura; Le Tourneau, Christophe 分享 收藏 TAKTIC: A prospective, multicentre, uncontrolled, phase IB/II study of LY2780301, a p70S6K/AKT inhibitor, in combination with weekly paclitaxel in HER2-negative advanced breast cancer patientsTAKTIC: LY2780301 (一种p70S6K/AKT抑制剂) 联合每周紫杉醇治疗HER2-negative晚期乳腺癌患者的前瞻性、多中心、非对照、IB/II期研究Vicier, Cecile; Sfumato, Patrick; Isambert, Nicolas; Dalenc, Florence; Robert, Marie; Levy, Christelle; Rezai, Keyvan; Provansal, Magali; Adelaide, Jose; Garnier, Severine; Guille, Arnaud; Carbuccia, Nadine; Popovici, Cornel; Charafe-Jauffret, Emmanuelle; Chaffanet, Max; Birnbaum, Daniel; Pakradouni, Jihane; Bertucci, Francois; Boher, Jean M.; Sabatier, Renaud; Goncalves, Anthony 分享 收藏 Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profileSestito, Simona; Bacci, Andrea; Chiarugi, Sara; Runfola, Massimiliano; Gado, Francesca; Margheritis, Eleonora; Gul, Sheraz; Riveiro, Maria E.; Vazquez, Ramiro; Huguet, Samuel; Manera, Clementina; Rezai, Keyvan; Garau, Gianpiero; Rapposelli, Simona 分享 收藏 A phase II randomised study of preoperative trastuzumab alone or combined with everolimus in patients with early HER2-positive breast cancer and predictive biomarkers (RADHER trial)Campone, Mario; Bachelot, Thomas; Treilleux, Isabelle; Pistilli, Barbara; Salleron, Julia; Seegers, Valerie; Arnedos, Monica; Loussouarn, Delphine; Wang, Qing; Vanlemmens, Laurence; Jimenez, Marta; Rios, Maria; Dieras, Veronique; Leroux, Agnes; Paintaud, Gilles; Rezai, Keyvan; Andre, Fabrice; Lion, Maeva; Merlin, Jean-Louis 分享 收藏 Phase I trial of copanlisib, a selective PI3K inhibitor, in combination with cetuximab in patients with recurrent and/or metastatic head and neck squamous cell carcinomaMarret, Gregoire; Isambert, Nicolas; Rezai, Keyvan; Gal, Jocelyn; Saada-Bouzid, Esma; Rolland, Frederic; Chausson, Maggy; Borcoman, Edith; Alt, Marie; Klijanienko, Jerzy; Vansteene, Damien; Guigay, Joel; Kamal, Maud; Bieche, Ivan; Le Tourneau, Christophe 分享 收藏 分享 收藏 Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) networkSoussain, C.; Choquet, S.; Blonski, M.; Leclercq, D.; Houillier, C.; Rezai, K.; Bijou, F.; Houot, R.; Boyle, E.; Gressin, R.; Nicolas-Virelizier, E.; Barrie, M.; Molucon-Chabrot, C.; Lelez, M. L.; Clavert, A.; Coisy, S.; Leruez, S.; Touitou, V.; Cassoux, N.; Daniau, M.; de la Bretonniere, M. Ertault; El Yamani, A.; Ghesquieres, H.; Hoang-Xuan, K. 分享 收藏 A phase I-II pharmacokinetic drug-drug interaction evaluation of oral palbociclib in combination with vemurafenib in patients suffering metastatic melanoma with BRAF V600 mutated and CDKN2A loss & expression of RbHuguet, Samuel; Lesimple, Thierry; Geraud, Arthur; Amini-Adle, Mouna; Dutriaux, Caroline; Da Meda, Laetitia; Capelle, Florence; Ghrieb, Zineb; Mourah, Samia; Madar, Olivier; Bouton, Didier; Resche-Rigon, Mathieu; Lebbe, Celest; Rezai, Keyvan 分享 收藏 Evaluation of porphyrin biodistribution for use in photodynamic therapy of retinoblastoma in transgenic micePoyer, Florent; Hugeut, Samuel; Lemaitre, Stephanie; Madar, Olivier; Thomas, Carole D.; Maillard, Philippe; Teulade-Fichou, Marie-Paule; Cassoux, Nathalie; Doz, Francois; Rezai, Keyvan 分享 收藏 Population pharmacokinetic modeling of ibrutinib administered in patients with relapsed or refractory B cell malignancies eligible for autologous stem cell transplantationRezai, Keyvan; Madar, Olivier; Bonnet, Christophe; Dupuis, Jean; Tilly, Herve; de la Chapelle, Thierry Lamy; Le Gouill, Steven; Verite, Ombeline; Assemat, Julie; Bret, Fanny; Weill, Sophie; Lokiec, Francois; Salles, Gilles 分享 收藏 分享 收藏 BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistanceTarantelli, Chiara; Bernasconi, Elena; Gaudio, Eugenio; Cascione, Luciano; Restelli, Valentina; Arribas, Alberto Jesus; Spriano, Filippo; Rinaldi, Andrea; Mensah, Afua Adjeiwaa; Kwee, Ivo; Ponzoni, Maurilio; Zucca, Emanuele; Carrassa, Laura; Riveiro, Maria E.; Rezai, Keyvan; Stathis, Anastasios; Cvitkovic, Esteban; Bertoni, Francesco 分享 收藏 PIKHER2: A phase IB study evaluating buparlisib in combination with lapatinib in trastuzumab-resistant HER2-positive advanced breast cancerPIKHER2: IB期研究评估buparlisib联合拉帕替尼治疗曲妥珠单抗耐药的HER2-positive晚期乳腺癌Guerin, Mathilde; Rezai, Keyvan; Isambert, Nicolas; Campone, Mario; Autret, Aurelie; Pakradouni, Jihane; Provansal, Magali; Camerlo, Jacques; Sabatier, Renaud; Bertucci, Francois; Charafe-Jauffret, Emmanuelle; Hervieu, Alice; Extra, Jean-Marc; Viens, Patrice; Lokiec, Francois; Boher, Jean-Marie; Goncalves, Anthony 分享 收藏 Pharmacokinetic study of RCHOP protocol in elderly patients with non-Hodgkin lymphomaBaudry, Elodie; Coudrec, Anne Laure; Chaibi, Pascal; Bret, Fanny; Djebnoun, Sara; Weill, Sophie; Huguet, Samuel; Boyault, Alexandre; Lokiec, Francois; Rezai, Keyvan 分享 收藏 A phase lb trial with MK-8628/OTX015, a small molecule inhibitor of bromodomain (BRD) and extra-terminal (BET) proteins, in patients with selected advanced solid tumorsMassard, C.; Soria, J. C.; Stathis, A.; Delord, J. P.; Awada, A.; Peters, S.; Lewin, J.; Bekradda, M.; Rezai, K.; Zeng, Z.; Azher, H.; Perez, S.; Siu, L. 分享 收藏 OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma modelsBerenguer-Daize, Caroline; Astorgues-Xerri, Lucile; Odore, Elodie; Cayol, Mylene; Cvitkovic, Esteban; Noel, Kay; Bekradda, Mohamed; MacKenzie, Sarah; Rezai, Keyvan; Lokiec, Francois; Riveiro, Maria E.; Ouafik, L'Houcine 分享 收藏 A phase lb pharmacokinetic drug-drug interaction evaluation of oral buparlisib in combination with lapatinib in HER2+/PI3K-activated, trastuzumab-resistant locally advanced, recurrent and metastatic breast cancer (MBC)Lokiec, Francois; Goncalves, Anthony; Bret, Fanny; Pakradouni, Jihane; Provansal, Magali; Sabatier, Renaud; Extra, Jean-Marc; Tarpin, Carole; Isambert, Nicolas; Campone, Mario; Rezai, Keyvan 分享 收藏 Pharmacokinetic drug-drug interaction: a phase lb dose escalation study of LY2780301 in combination with weekly paclitaxelRezai, Keyvan; Huguet, Samuel; Madar, Olivier; Extra, Jean -Marc; Provansal, Magali; Tarpin, Carole; Isambert, Nicolas; Pakradouni, Jihane; Goncalves, Anthony; Lokiec, Francois 分享 收藏 Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 studyBerthon, Celine; Raffoux, Emmanuel; Thomas, Xavier; Vey, Norbert; Gomez-Roca, Carlos; Yee, Karen; Taussig, David Christopher; Rezai, Keyvan; Roumier, Christophe; Herait, Patrice; Kahatt, Carmen; Quesnel, Bruno; Michallet, Mauricette; Recher, Christian; Lokiec, Francois; Preudhomme, Claude; Dombret, Herve 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
