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收藏分享 收藏 Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix基于αC螺旋构象调控的结构设计：高效且选择性MerTK抑制剂的研发
Peng, Yi-Hui; Li, Mu-Chun; Yen, Wan-Ching; Yeh, Teng-Kuang; Hsueh, Ching-Cheng; Kuo, Fu-Ming; Lai, You-Liang; Chang, Ling; Lee, Lung-Chun; Chen, Pei-Yi; Yen, Kuei-Jung; Chang, Teng-Yuan; Sun, Hsu-Yi; Chang, Chun-Yu; Hsieh, Su-Huei; Yang, Chen-Ming; Wu, Su-Ying 分享 收藏 Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid口服生物利用且位点选择性的基于大环海洋二萜类化合物的共价STING抑制剂Niu, Guang-Hao; Hsiao, Wan-Chi; Lee, Po-Hsun; Zheng, Li-Guo; Yang, Yu-Shao; Huang, Wei-Cheng; Hsieh, Chih-Chien; Chiu, Tai-Yu; Wang, Jing-Ya; Chen, Ching-Ping; Huang, Chen-Lung; You, May-Su; Kuo, Yi-Ping; Wang, Chien-Ming; Wen, Zhi-Hong; Yu, Guann-Yi; Chen, Chiung-Tong; Chi, Ya-Hui; Tung, Chun-Wei; Hsu, Shu-Ching; Yeh, Teng-Kuang; Sung, Ping-Jyun; Zhang, Mingzi M.; Tsou, Lun Kelvin 分享 收藏 Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological CharacterizationChang, Hsin-Huei; Lee, Lung-Chun; Hsu, Tsu; Peng, Yi-Hui; Huang, Chih-Hsiang; Yeh, Teng-Kuang; Lu, Cheng-Tai; Huang, Zih-Ting; Hsueh, Ching-Cheng; Kung, Fang-Chun; Lin, Li-Mei; Huang, Yu-Chen; Wang, Yi-Hsin; Li, Li-Hsuan; Tang, Ya-Chu; Chang, Ling; Hsieh, Chih-Chien; Jiaang, Weir-Torn; Kuo, Ching-Chuan; Wu, Su-Ying 分享 收藏 Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesiaHuang, Yi-Han; Lin, Shu-Yu; Ou, Li-Chin; Huang, Wei-Cheng; Chao, Po-Kuan; Chang, Yung-Chiao; Chang, Hsiao-Fu; Lee, Pin-Tse; Yeh, Teng-Kuang; Kuo, Yu-Hsien; Tien, Ya-Wen; Xi, Jing-Hua; Tao, Pao-Luh; Chen, Pin-Yuan; Chuang, Jian-Ying; Shih, Chuan; Chen, Chiung-Tong; Tung, Chun-Wei; Loh, Horace H.; Ueng, Shau-Hua; Yeh, Shiu-Hwa 分享 收藏 DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral AdministrationLin, Shu-Yu; Chang, Yung-Chiao; Tien, Ya-Wen; Kuo, Yu-Hsien; Chang, Hsiao-Fu; Ou, Li-Chin; Chen, Ya-Ping; Chang, Kuei-Hua; Hsu, Ying-Ting; Huang, Yu-Chen; Yang, Chen-Ming; Law, Ping-Yee; Xi, Jing-Hua; Tao, Pao-Luh; Loh, Horace H.; Yeh, Teng-Kuang; Zhuang, Hong; Hsieh, Hsing-Pang; Shih, Chuan; Chen, Chiung-Tong; Yeh, Shiu-Hwa; Ueng, Shau-Hua 分享 收藏 Development of a Humanized Antibody Targeting Extracellular HSP90α to Suppress Endothelial-Mesenchymal Transition-Enhanced Tumor Growth of Pancreatic Adenocarcinoma CellsFan, Chi-Shuan; Hung, Hui-Chen; Chen, Chia-Chi; Chen, Li-Li; Ke, Yi-Yu; Yeh, Teng-Kuang; Huang, Chin-Ting; Chang, Teng-Yuan; Yen, Kuei-Jung; Chen, Chung-Hsing; Chua, Kee Voon; Hsu, John Tsu-An; Huang, Tze-Sing 分享 收藏 Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with EverolimusChang, Chun-Ping; Yeh, Teng-Kuang; Chen, Chiung-Tong; Wang, Wan-Ping; Chen, Yen-Ting; Tsai, Chia-Hua; Chen, Yan-Fu; Ke, Yi-Yu; Wang, Jing-Ya; Chen, Ching-Ping; Hsieh, Tsung-Chih; Wu, Mine-Hsine; Huang, Chen-Lung; Chen, Ya-Ping; Zhuang, Hong; Chi, Ya-Hui 分享 收藏 Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimusChi, Ya-Hui; Chang, Chun-Ping; Yeh, Teng-Kuang; Chen, Chiung-Tong; Wang, Wan-Ping; Chen, Yen-Ting; Tsai, Chia-Hua; Chen, Yan-Fu; Ke, Yi-Yu; Wang, Jing-Ya; Chen, Ching-Ping; Hsieh, Tsung-Chih; Wu, Mine-Hsine; Huang, Chen-Lung; Chen, Ya-Ping; Zhuang, Hong 分享 收藏 分享 收藏 A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effectsHsu, Ying-Ting; Chen, Shen-Ren; Chang, Yung-Chiao; Chang, Hsiao-Fu; Yeh, Teng-Kuang; Chuang, Jian-Ying; Loh, Horace H.; Hsieh, Hsing-Pang; Ueng, Shau-Hua; Yeh, Shiu-Hwa 分享 收藏 Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver diseaseYao, Chun-Hsu; Shen, Zhao-Qing; Rajan, Yesudoss Christu; Huang, Yu-Wen; Lin, Chin -Yu; Song, Jen-Shin; Shiao, Hui-Yi; Ke, Yi-Yu; Fan, Yu-Shiou; Tsai, Chi -Hui; Yeh, Teng-Kuang; Tsai, Ting-Fen; Lee, Jinq-Chyi 分享 收藏 Targeting mycamplified cancers with a novel prodrug inhibiting aurora A kinaseChi, Ya-Hui; Chang, Chun-Ping; Yeh, Teng-Kuang; Wang, Wan-Ping; Chen, Yen-Ting; Tsai, Chia-Hua; Chen, Yan-Fu; Ke, Yi-Yu; Wang, Jing-Ya; Chen, Ching-Ping; Hsieh, Tsung-Chih; Wu, Mine-Hsine; Chen, Chiung-Tong 分享 收藏 Development of Furanopyrimidine-Based Orally Active Third- Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung CancerLi, Mu -Chun; Coumar, Mohane Selvaraj; Lin, Shu-Yu; Lin, Yih-Shyan; Huang, Guan-Lin; Chen, Chun-Hwa; Lien, Tzu-Wen; Wu, Yi-Wen; Chen, Yen-Ting; Chen, Ching-Ping; Huang, Yu-Chen; Yeh, Kai-Chia; Yang, Chen -Ming; Kalita, Bikashita; Pan, Shiow-Lin; Hsu, Tsu-An; Yeh, Teng-Kuang; Chen, Chiung-Tong; Hsieh, Hsing-Pang 分享 收藏 分享 收藏 Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipationKuppusamy, Ramajayam; Hsu, Ying-Ting; Ke, Yi-Yu; Chang, Po-Wei; Chang, Yung-Chiao; Chang, Hsiao-Fu; Wang, Pei-Chen; Lin, Yu-Hao; Huang, Yu-Chen; Yeh, Teng-Kuang; Chuang, Jian-Ying; Loh, Horace H.; Shih, Chuan; Chen, Chiung-Tong; Yeh, Shiu-Hwa; Ueng, Shau-Hua 分享 收藏 Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid ConjugateLo, Chen-Fu; Chiu, Tai-Yu; Liu, Yu-Tzu; Pan, Pei-Yun; Liu, Kuan-Liang; Hsu, Chia-Yu; Fang, Ming-Yu; Huang, Yu-Chen; Yeh, Teng-Kuang; Hsu, Tsu-An; Chen, Chiung-Tong; Huang, Li-Rung; Tsou, Lun Kelvin 分享 收藏 分享 收藏 分享 收藏 
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