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L

Larry H. Matherly

wayne state university

54H指数
408论文数
9.4K被引数
收录论文 156
发表时间
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Determination of the pyrrolo[2,3-d] pyrimidine antifolate AGF94 from a preclinical murine study using a simple UHPLC-MS/MS assay通过简单的UHPLC-MS/MS方法测定来自一项临床前小鼠研究的吡咯并[2,3-d]嘧啶抗叶酸剂AGF94
errJournal of Chromatography B
IF0
err2025-10-21
err0
PREAI
errTryston T. Metz; Rachel C. Ashe; Alexis C. Duncan; Ethan C. Wilner; Keith T. Schmidt; Kristbjorn O. Gudmundsson; Zhanjun Hou; Aleem Gangjee; Larry H. Matherly; Serguei V. Kozlov; William D. Figg
err分享
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Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors人瘤中与线粒体一碳流及丝氨酸羟甲基转移酶抑制相关的药效动力学决定因素
errDrug Metabolism and Disposition
IF4
err2025-07-17
err0
PREAI
errMathew Schneider; Carrie O’Connor; Xun Bao; Md. Junayed Nayeen; Tejashree Magdum; Abhishekh Sharma; Jing Li; Seongho Kim; Charles E. Dann; Aleem Gangjee; Zhanjun Hou; Larry H. Matherly
err分享
err收藏
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates
errMOLECULAR PHARMACOLOGY
IF3
err2024-10-01
err0
PREAI
errO'Connor, Carrie; Schneider, Mathew; Katinas, Jade M.; Nayeen, Md. Junayed; Shah, Khushbu; Magdum, Tejashree; Sharma, Abhishekh; Kim, Seongho; Bao, Xun; Li, Jing; Dann, Charles E.; Gangjee, Aleem; Matherly, Larry H.; Hou, Zhanjun
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Pharmacodynamic determinants of anti tumor activity of SHMT2 inhibitors
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSchneider, Mathew Joseph; O'Connor, Carrie; Bao, Xun; Nayeen, Md. Junayed; Hou, Zhanjun; Li, Jing; Gangjee, Aleem; Matherly, Larry
err分享
err收藏
Role of major facilitative folate transporters SLC19A1 and SLC46A1 in cyclic dinucleotide transport and STING signaling
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errMcQuithey, Holly; Brzezinski, Madelyn; O'Connor, Carrie; Matherly, Larry; Hou, Zhanjun
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Development of folate receptor alpha targeted FOXM1 inhibitors for ovarian cancer
errCANCER RESEARCH
IF16.6
err2024-03-04
err0
PREAI
errKarpf, Adam R.; Vorderbruggen, Makenzie; Rikhtechi, Pedram; Munoz-Trujillo, Catalina; Liu, Cassie; Matherly, Larry H.; Kim, Sung Hoon; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.; Garrison, Jered C.
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Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-02-20
err3
PREAI
errWallace-Povirk, Adrianne; O'Connor, Carrie; Dekhne, Aamod S.; Bao, Xun; Nayeen, Md. Junayed; Schneider, Mathew; Katinas, Jade M.; Wong-Roushar, Jennifer; Kim, Seongho; Polin, Lisa; Li, Jing; Back, Jessica B.; Dann, Charles E.; Gangjee, Aleem; Hou, Zhanjun; Matherly, Larry H.
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Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-02-01
err7
PREAI
errHurrish, Katie H.; Su, Yongwei; Patel, Shraddha; Ramage, Cassandra L.; Zhao, Jianlei; Temby, Brianna R.; Carter, Jenna L.; Edwards, Holly; Buck, Steven A.; Wiley, Sandra E.; Huttemann, Maik; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn; Bao, Xun; Li, Jing; Yang, Jay; Boerner, Julie; Hou, Zhanjun; Al-Atrash, Gheath; Konoplev, Sergej N.; Busquets, Jonathan; Tiziani, Stefano; Matherly, Larry H.; Taub, Jeffrey W.; Konopleva, Marina; Ge, Yubin; Baran, Natalia
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Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2023-11-15
err4
errOAAI
errKaku, Krishna; Ravindra, Manasa P.; Tong, Nian; Choudhary, Shruti; Li, Xinxin; Yu, Jianming; Karim, Mohammad; Brzezinski, Madelyn; O'Connor, Carrie; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem
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Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-08-15
err5
errOAAI
errNayeen, Md. Junayed; Katinas, Jade. M. M.; Magdum, Tejashree; Shah, Khushbu; Wong, Jennifer. E. E.; O'Connor, Carrie. E. E.; Fifer, Alexandra. N. N.; Wallace-Povirk, Adrianne; Hou, Zhanjun; Matherly, Larry. H. H.; Dann III, Charles. E. E.; Gangjee, Aleem
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err收藏
Levels of folate transporters impact the compartmentalization of one-carbon metabolism in the mitochondria vs cytosol providing a unique vulnerability to SHMT inhibition
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errSchneider, Mathew Joseph; O'connor, Carrie; Bao, Xun; Nayeen, Md. Junayed; Hou, Zhanjun; Li, Jing; Gangjee, Aleem; Matherly, Larry H.
err分享
err收藏
Mitochondrial and cytosolic folylpolyglutamate synthetase in one-carbon metabolism and anti- tumor efficacy of mitochondrial- targeted antifolates
errCANCER RESEARCH
IF16.6
err2023-04-04
err1
PREAI
errO'Connor, Carrie; Katinas, Jade; Schneider, Mathew; Nayeen, Md. Junayed; Bao, Xun; Li, Jing; Dann, Charles; Gangjee, Aleem; Matherly, Larry H.; Hou, Zhanjun
err分享
err收藏
Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy (vol 18, pg 1787, 2019)
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-01-05
err0
errOAAI
errDekhne, Aamod S.; Shah, Khushbu; Ducker, Gregory S.; Katinas, Jade M.; Wong-Roushar, Jennifer; Nayeen, Md. Junayed; Doshi, Arpit; Ning, Changwen; Bao, Xun; Fruhauf, Josephine; Liu, Jenney; Wallace-Povirk, Adrianne; O'Connor, Carrie; Dzinic, Sijana H.; White, Kathryn; Kushner, Juiwanna; Kim, Seongho; Huttemann, Maik; Polin, Lisa; Rabinowitz, Joshua D.; Li, Jing; Hou, Zhanjun; Dann, Charles E., III; Gangjee, Aleem; Matherly, Larry H.
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err收藏
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
errNATURE COMMUNICATIONS
IF15.7
err2022-11-01
err14
errOAAI
errMitchell, Allison, V; Wu, Ling; Block, C. James; Zhang, Mu; Hackett, Justin; Craig, Douglas B.; Chen, Wei; Zhao, Yongzhong; Zhang, Bin; Dang, Yongjun; Zhang, Xiaohong; Zhang, Shengping; Wang, Chuangui; Gibson, Heather; Pile, Lori A.; Kidder, Benjamin; Matherly, Larry; Yang, Zhe; Dou, Yali; Wu, Guojun
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err收藏
Biology and therapeutic applications of the proton-coupled folate transporter质子偶联叶酸转运蛋白的生物学和治疗应用
errEXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
IF3.4
err2022-10-20
err4
errOAAI
errMatherly, Larry H.; Schneider, Mathew; Gangjee, Aleem; Hou, Zhanjun
err分享
err收藏
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment
errSCIENTIFIC REPORTS
IF3.9
err2022-07-05
err13
errOAAI
errWallace-Povirk, Adrianne; Rubinsak, Lisa; Malysa, Agnes; Dzinic, Sijana H.; Ravindra, Manasa; Schneider, Mathew; Glassbrook, James; O'Connor, Carrie; Hou, Zhanjun; Kim, Seongho; Back, Jessica; Polin, Lisa; Morris, Robert T.; Gangjee, Aleem; Gibson, Heather; Matherly, Larry H.
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Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data
errPROTEOMES
IF3.6
err2022-05-23
err7
errOAAI
errBurton, Jordan B.; Carruthers, Nicholas J.; Hou, Zhanjun; Matherly, Larry H.; Stemmer, Paul M.
err分享
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Lipid metabolism reprogramming in renal cell carcinoma肾细胞癌的脂质代谢重编程
errCANCER AND METASTASIS REVIEWS
IF8.7
err2021-11-06
err53
errOAAI
errHeravi, Gioia; Yazdanpanah, Omid; Podgorski, Izabela; Matherly, Larry H.; Liu, Wanqing
err分享
err收藏
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoi- midazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2021-05-01
err10
errOAAI
errWallace-Povirk, Adrianne; Tong, Nian; Wong-Roushar, Jennifer; O'Connor, Carrie; Zhou, Xilin; Hou, Zhanjun; Bao, Xun; Garcia, Gloria E.; Li, Jing; Kim, Seongho; Dann, Charles E., III; Matherly, Larry H.; Gangjee, Aleem
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Folate transporter dynamics and therapy with classic and tumor-targeted antifolates
errSCIENTIFIC REPORTS
IF3.9
err2021-03-18
err23
errOAAI
errO'Connor, Carrie; Wallace-Povirk, Adrianne; Ning, Changwen; Fruhauf, Josephine; Tong, Nian; Gangjee, Aleem; Matherly, Larry H.; Hou, Zhanjun
err分享
err收藏

研究方向

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合作学者
合作期刊
J
Joshua D. Rabinowitz
H 指数: 127 · 论文数: 773
张晓红 封面图
张晓红 (Xiaohong Zhang)
H 指数: 119 · 论文数: 1.9K
B
Benita S. Katzenellenbogen
H 指数: 114 · 论文数: 497
P
Philip S. Low
H 指数: 108 · 论文数: 712
S
Samuel H. Wilson
H 指数: 103 · 论文数: 813
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