未登录 Multi-Omic Transcription Regulatory Network Mapping Identifies Targetable Oncogenic TF-Cofactor Relationship between IRF4 and p300 in Multiple Myeloma, and Is Used to Improve TF Protein-Protein Interaction Methodology 多组学转录调控网络映射识别出多发性骨髓瘤中IRF4和p300之间可靶向的癌基因TF协同因子关系，并用于改进TF蛋白质-蛋白质相互作用方法学 Zheng, Yupeng; Lenoir, Walter F.; Kobylarz, Marek J.; Li, Jun; Hopkins, Tamara D.; McKeown, Michael R.; Shum, Michelle G.; Mori, Kameron R.; Townsend, Elizabeth C.; Trotter, Benjamin W.; Rahl, Peter B.; Obholzer, Nikolaus D.; Lin, Charles Y. 分享 收藏
Oncogenic human papillomavirus hijacks p300 to drive viral transcription, creating a therapeutic vulnerability that can be exploited with selective p300/CBP catalytic inhibitors Kobylarz, M.; Larke, M.; Glore, W.; Shum, M.; Mori, K.; Cohen, E.; Pandey, A.; Hopkins, T.; McKeown, M.; Obholzer, N.; Trotter, B.; Carvajal, L.; Rahl, P.; Lin, C. 分享 收藏
Foundation AI models predict molecular measurements of tumor purity Gerardin, Ylaine; Shenker, Daniel; Hipp, Jennifer; Harguindeguy, Natalia; Juyal, Dinkar; Shah, Chintan; Javed, Syed Ashar; Thibault, Marc; Nercessian, Michael; Sanghavi, Darpan; Trotter, Benjamin; Leung, Ryan 分享 收藏
p300 catalytic inhibition selectively targets IRF4 oncogenic activity in multiple myeloma McKeown, Michael R.; Giorgetti, Giulia; Lenoir, Walter F.; Kobylarz, Marek J.; Hopkins, Tamara D.; Glore, Wayne L.; Shum, Michelle G.; Calderon, Yare; Mori, Kameron R.; Gao, Hua; Carvajal, Luis A.; Obholzer, Nikolaus D.; Trotter, Benjamin W.; Dinsmore, Christopher D.; Munshi, Nikhil C.; Rahl, Peter B.; Fulciniti, Mariateresa; Lin, Charles Y. 分享 收藏
Small molecule microarray screening identifies novel androgen receptor ligands Kobylarz, Marek J.; Shum, Michelle G.; Glore, Wayne L.; Saffren, Ava; Carpenter, Shannon; Pingili, Mulini; Clay, Andrew; Hopkins, Tamara D.; Gao, Hua; Schinzel, Anna C.; Pop, Marius S.; Obholzer, Nikolaus D.; Freeman, David B.; Dinsmore, Christopher J.; Trotter, Benjamin W.; Lin, Charles Y.; Rahl, Peter B. 分享 收藏
Small molecule microarray lysate screen identifies bromodomain ligands that target the MYC transcription regulatory network Cohen, Emily B.; Ma, Zhihua; Glore, Wayne L.; Volkov, Oleg A.; Liang, Tong; Obholzer, Nikolaus D.; Clay, Andrew C.; Pingili, Mulini Reddy; Zheng, Yupeng; Li, Jun; Wang, Shi Yun; Chen, Tom; Freeman, David B.; Gao, Hua; Zhou, Minyun; Cheung, Priscilla; Hopkins, Tamara D.; Pop, Marius S.; Dinsmore, Christopher J.; Trotter, B. Wesley; Lin, Charles Y.; Rahl, Peter B. 分享 收藏
Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers Freeman, David B.; Hopkins, Tamara D.; Mikochik, Peter J.; Vacca, Joseph P.; Gao, Hua; Naylor-Olsen, Adel; Rudra, Sonali; Li, Huixu; Pop, Marius S.; Villagomez, Rosa A.; Lee, Christina; Li, Heng; Zhou, Minyun; Saffran, Douglas C.; Rioux, Nathalie; Hood, Tressa R.; Day, Melinda A. L.; Mckeown, Michael R.; Lin, Charles Y.; Bischofberger, Norbert; Trotter, B. Wesley 分享 收藏
AI-based quantitation of cancer cell and fibroblast nuclear morphology reflects transcriptomic heterogeneity and predicts survival in breast cancer Abel, John; Kirkup, Christian; Kos, Filip; Gerardin, Ylaine; Srinivasan, Sandhya; Brosnan-Cashman, Jacqueline; Leidal, Ken; Vasudevan, Sanjana; Rajan, Deepta; Jain, Suyog; Prakash, Aaditya; Padigela, Harshith; Conway, Jake; Patel, Neel; Trotter, Benjamin; Yu, Limin; Taylor-Weiner, Amaro; Krause, Emma L.; Bronnimann, Matthew; Chambre, Laura; Glass, Ben; Parmar, Chintan; Hennek, Stephanie; Khosla, Archit; Resnick, Murray; Beck, Andrew H.; Montalto, Michael; Najdawi, Fedaa; Drage, Michael G.; Wapinski, Ilan 分享 收藏
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer Chang, Wonsuk; Altman, Michael D.; Lesburg, Charles A.; Perera, Samanthi A.; Piesvaux, Jennifer A.; Schroeder, Gottfried K.; Wyss, Daniel F.; Cemerski, Saso; Chen, Yiping; DiNunzio, Edward; Haidle, Andrew M.; Ho, Thu; Kariv, Ilona; Knemeyer, Ian; Kopinja, Johnny E.; Lacey, Brian M.; Laskey, Jason; Lim, Jongwon; Long, Brian J.; Ma, Yanhong; Maddess, Matthew L.; Pan, Bo-Sheng; Presland, Jeremy P.; Spooner, Edward; Steinhuebel, Dietrich; Quang Truong; Zhang, Zhibo; Fu, Jianmin; Addona, George H.; Northrup, Alan B.; Parmee, Emma; Tata, James R.; Bennett, David Jonathan; Cumming, Jared N.; Siu, Tony; Trotter, B. Wesley 分享 收藏
Preclinical pharmacokinetics and pharmacodynamics of KB-0742, a selective, oral CDK9 inhibitor Day, Melinda A. L.; Saffran, Douglas C.; Rioux, Nathalie; Chen, Tom; Lee, Christina; Freeman, David B.; MacKenzie, Crystal; Vacca, Joseph P.; Rahl, Peter B.; Trotter, Benjamin Wesley; Lin, Charles Y.; Kumar, Pavan; DiMartino, Jorge 分享 收藏
Long-term exposure of Daphnia magna to polystyrene microplastic (PS-MP) leads to alterations of the proteome, morphology and life-history Trotter, Benjamin; Wilde, Magdalena, V; Brehm, Julian; Dafni, Evdokia; Aliu, Arlinda; Arnold, Georg J.; Froehlich, Thomas; Laforsch, Christian 分享 收藏
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction Reutershan, Michael H.; Machacek, Michelle R.; Altman, Michael D.; Bogen, Stephane; Cai, Mingmei; Cammarano, Carolyn; Chen, Dapeng; Christopher, Matthew; Cryan, John; Daublain, Pierre; Fradera, Xavier; Geda, Prasanthi; Goldenblatt, Peter; Hill, Armetta D.; Kemper, Raymond A.; Kutilek, Victoria; Li, Chaomin; Martinez, Michelle; McCoy, Mark; Nair, Latha; Pan, Weidong; Thompson, Christopher F.; Scapin, Giovanna; Shizuka, Manami; Spatz, Marianne L.; Steinhuebel, Dietrich; Sun, Binyuan; Voss, Matthew E.; Wang, Xiao; Yang, Liping; Yeh, Tammie C.; Dussault, Isabelle; Marshall, C. Gary; Trotter, B. Wesley 分享 收藏
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators Methot, Joey L.; Zhou, Hua; McGowan, Meredeth A.; Anthony, Neville John; Christopher, Matthew; Garcia, Yudith; Achab, Abdelghani; Lipford, Kathryn; Trotter, Benjamin Wesley; Altman, Michael D.; Fradera, Xavier; Lesburg, Charles A.; Li, Chaomin; Alves, Stephen; Chappell, Craig P.; Jain, Renu; Mangado, Ruban; Pinheiro, Elaine; Williams, Sybill M. G.; Goldenblatt, Peter; Hill, Armetta; Shaffer, Lynsey; Chen, Dapeng; Tong, Vincent; McLeod, Robbie L.; Lee, Hyun-Hee; Yu, Hongshi; Shah, Sanjiv; Katz, Jason D. 分享 收藏
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors Richters, Andre; Doyle, Shelby K.; Freeman, David B.; Lee, Christina; Leifer, Becky S.; Jagannathan, Sajjeev; Kabinger, Florian; Koren, Jost Vrabic; Struntz, Nicholas B.; Urgiles, Julie; Stagg, Ryan A.; Curtin, Brice H.; Chatterjee, Deep; Mathea, Sebastian; Mikochik, Peter J.; Hopkins, Tamara D.; Gao, Hua; Branch, Jonathan R.; Xin, Hong; Westover, Lori; Bignan, Gilles C.; Rupnow, Brent A.; Karlin, Kristen L.; Olson, Calla M.; Westbrook, Thomas F.; Vacca, Joseph; Wilfong, Chris M.; Trotter, B. Wesley; Saffran, Douglas C.; Bischofberger, Norbert; Knapp, Stefan; Russo, Joshua W.; Hickson, Ian; Bischoff, James R.; Gottardis, Marco M.; Balk, Steven P.; Lin, Charles Y.; Pop, Marius S.; Koehler, Angela N. 分享 收藏
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen Bukhtiyarova, Marina; Cook, Erica M.; Hancock, Paula J.; Hruza, Alan W.; Shaw, Anthony W.; Adam, Gregory C.; Barnard, Richard J. O.; McKenna, Philip M.; Holloway, M. Katharine; Bell, Ian M.; Carroll, Steve; Cornella-Taracido, Ivan; Cox, Christopher D.; Kutchukian, Peter S.; Powell, David A.; Strickland, Corey; Trotter, B. Wesley; Tudor, Matthew; Wolkenberg, Scott; Li, Jing; Tellers, David M. 分享 收藏
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors 多功能氧吲哚作为选择性PI3Kδ 抑制剂的优化 Methot, Joey L.; Achab, Abdelghani; Christopher, Matthew; Zhou, Hua; McGowan, Meredeth A.; Trotter, B. Wesley; Fradera, Xavier; Lesburg, Charles A.; Goldenblatt, Peter; Hill, Armetta; Chen, Dapeng; Otte, Karin M.; Augustin, Martin; Shah, Sanjiv; Katz, Jason D. 分享 收藏
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases Zhang, Hongjun; Lapointe, Blair T.; Anthony, Neville; Azevedo, Rita; Cals, Jos; Correll, Craig C.; Daniels, Matthew; Deshmukh, Sujal; van Eenenaam, Hans; Ferguson, Heidi; Hegde, Laxminarayan G.; Karstens, Willem Jan; Maclean, John; Miller, J. Richard; Moy, Lily Y.; Simov, Vladimir; Nagpal, Sunil; Oubrie, Arthur; Palte, Rachel L.; Parthasarathy, Gopal; Sciammetta, Nunzio; van der Stelt, Mario; Woodhouse, Janice D.; Trotter, B. Wesley; Barr, Kenneth 分享 收藏
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Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1 Methot, Joey L.; Zhou, Hua; McGowan, Meredith A.; Trotter, Benjamin W.; Altman, Michael; Fradera, Xavier; Lesburg, Charles; Li, Chaomin; Alves, Stephen; Chappell, Craig P.; Jain, Renu; Mangado, Ruban; Pinheiro, Elaine; Williams, Sybil M.; Goldenblatt, Peter; Hill, Armetta D.; Shaffer, Lynsey; Chen, Dapeng; McLeod, Robbie L.; Lee, Hyun-Hee; Shah, Sanjiv; Katz, Jason D. 分享 收藏
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability Methot, Joey L.; Zhou, Hua; Kattar, Sam D.; McGowan, Meredeth A.; Wilson, Kevin; Garcia, Yudith; Deng, Yongi; Altman, Michael; Fradera, Xavier; Lesburg, Charles; Fischmann, Thierry; Li, Chaomin; Alves, Steve; Shah, Sanjiv; Fernandez, Rafael; Goldenblatt, Peter; Hill, Armetta; Shaffer, Lynsey; Chen, Dapeng; Tong, Vince; McLeod, Robbie L.; Yu, Hongshi; Bass, Alan; Kemper, Ray; Gatto, Nicholas T.; LaFranco-Scheuch, Lisa; Trotter, Benjamin Wesley; Guzi, Timothy; Katz, Jason D. 分享 收藏
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