未登录 Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS Awan, Seemal F.; Pegu, Amarendra; Strom, Larisa; Carter, Cristina A.; Hendel, Cynthia S.; Holman, LaSonji A.; Costner, Pamela J.; Trofymenko, Olga; Dyer, Renunda; Gordon, Ingelise J.; Rothwell, Ro Shauna S.; Hickman, Somia P.; Conan-Cibotti, Michelle; Doria-Rose, Nicole A.; Lin, Bob C.; O'Connell, Sarah; Narpala, Sandeep R.; Almasri, Cassandra G.; Liu, Cuiping; Ko, Sungyoul; Kwon, Young D.; Namboodiri, Aryan M.; Pandey, Janardan P.; Arnold, Frank J.; Carlton, Kevin; Gall, Jason G.; Kwong, Peter D.; Capparelli, Edmund, V; Bailer, Robert T.; Mcdermott, Adrian B.; Chen, Grace L.; Koup, Richard A.; Mascola, John R.; Coates, Emily E.; Ledgerwood, Julie E.; Gaudinski, Martin R. 分享 收藏
Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials Happe, Myra; Hofstetter, Amelia R.; Wang, Jing; Yamshchikov, Galina V.; Holman, LaSonji A.; Novik, Laura; Strom, Larisa; Kiweewa, Francis; Wakabi, Salim; Millard, Monica; Kelley, Colleen F.; Kabbani, Sarah; Edupuganti, Srilatha; Beck, Allison; Kaltovich, Florence; Murray, Tamar; Tsukerman, Susanna; Carr, Derick; Ashman, Carl; Stanley, Daphne A.; Ploquin, Aurelie; Bailer, Robert T.; Schwartz, Richard; Cham, Fatim; Tindikahwa, Allan; Hu, Zonghui; Gordon, Ingelise J.; Rouphael, Nadine; Houser, Katherine V.; Coates, Emily E.; Graham, Barney S.; Koup, Richard A.; Mascola, John R.; Sullivan, Nancy J.; Robb, Merlin L.; Ake, Julie A.; Lyke, Kirsten E.; Mulligan, Mark J.; Ledgerwood, Julie E.; Kibuuka, Hannah; Casazza, Joseph P.; Chen, Grace L.; Enama, Mary E.; Gaudinski, Martin R.; Hendel, Cynthia Starr; Costner, Pamela J. M.; Larkin, Brenda; Mendoza, Floreliz; Sanders, Jamie; Whalen, William R.; Zephir, Kathryn L.; Straling, Judith; Decederfelt, Hope; Conan-Cibotti, Michelle; Stein, Judy; Pittman, Iris R.; Vasilenko, Olga; Dezure, Adam; Sitar, Sandra; Dropulic, Lesia K.; Plummer, Sarah H.; Nguyen, Thuy A.; Berkowitz, Nina M.; Greenberg, Nancy; Chrisley, Lisa; Billington, Melissa; Wang, Xiaolin; Becker, Joanna; Campbell, James D.; Chen, Wilbur H.; Kwon, Alyson; Dorsey, Brenda; Courneya, Jennifer; Komninou, Panagiota; Lee, Myounghee; Bower, Mary; Bailey, Charles A.; Nesheim, Wendy; Girmay, Tigisty; Xu, Jianguo; Ogilvie, Melinda; Sadowski, Joann; Osinski, Eileen; Lai, Lilin; Grimes, Vicki; Kamya, Moses R.; Michael, Nelson L.; Kajumba, Francis; Ananworanich, Jinantat; Mwesigwa, Betty; Kimbugne, Geofrey; Luzinda, Kenneth; Nakabuye, Immaculate; Mukyala, Maureen G.; Kabahubya, Mable; Nakibuuka, Lydia; Matovu, Robinah 分享 收藏
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial Houser, Katherine, V; Chen, Grace L.; Carter, Cristina; Crank, Michelle C.; Nguyen, Thuy A.; Florez, Maria Claudia Burgos; Berkowitz, Nina M.; Mendoza, Floreliz; Hendel, Cynthia Starr; Gordon, Ingelise J.; Coates, Emily E.; Vazquez, Sandra; Stein, Judy; Case, Christopher L.; Lawlor, Heather; Carlton, Kevin; Gaudinski, Martin R.; Strom, Larisa; Hofstetter, Amelia R.; Liang, C. Jason; Narpala, Sandeep; Hatcher, Christian; Gillespie, Rebecca A.; Creanga, Adrian; Kanekiyo, Masaru; Raab, Julie E.; Andrews, Sarah F.; Zhang, Yi; Yang, Eun Sung; Wang, Lingshu; Leung, Kwanyee; Kong, Wing-Pui; Freyn, Alec W.; Nachbagauer, Raffael; Palese, Peter; Bailer, Robert T.; McDermott, Adrian B.; Koup, Richard A.; Gall, Jason G.; Arnold, Frank; Mascola, John R.; Graham, Barney S.; Ledgerwood, Julie E. 分享 收藏
Safety, tolerability, and immunogenicity of the respiratory syncytial virus prefusion F subunit vaccine DS-Cav1: a phase 1, randomised, open-label, dose-escalation clinical trial Ruckwardt, Tracy J.; Morabito, Kaitlyn M.; Phung, Emily; Crank, Michelle C.; Costner, Pamela J.; Holman, LaSonji A.; Chang, Lauren A.; Hickman, Somia P.; Berkowitz, Nina M.; Gordon, Ingelise J.; Yamshchikov, Galina, V; Gaudinski, Martin R.; Lin, Bob; Bailer, Robert; Chen, Man; Ortega-Villa, Ana M.; Nguyen, Thuy; Kumar, Azad; Schwartz, Richard M.; Kueltzo, Lisa A.; Stein, Judith A.; Carlton, Kevin; Gall, Jason G.; Nason, Martha C.; Mascola, John R.; Chen, Grace; Graham, Barney S. 分享 收藏
Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound Cale, Evan M.; Bai, Hongjun; Bose, Meera; Messina, Michael A.; Colby, Donn J.; Sanders-Buell, Eric; Dearlove, Bethany; Li, Yifan; Engeman, Emily; Silas, Daniel; O'Sullivan, Anne Marie; Mann, Brendan; Pinyakorn, Suteeraporn; Intasan, Jintana; Benjapornpong, Khunthalee; Sacdalan, Carlo; Kroon, Eugene; Phanuphak, Nittaya; Gramzinski, Robert; Vasan, Sandhya; Robb, Merlin L.; Michael, Nelson L.; Lynch, Rebecca M.; Bailer, Robert T.; Pagliuzza, Amelie; Chomont, Nicolas; Pegu, Amarendra; Doria-Rose, Nicole A.; Trautmann, Lydie; Crowell, Trevor A.; Mascola, John R.; Ananworanich, Jintanat; Tovanabutra, Sodsai; Rolland, Morgane 分享 收藏
Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes A Randomized Clinical Trial 基孔肯雅病毒样颗粒疫苗对安全性和耐受性结果的影响随机临床试验 Chen, Grace L.; Coates, Emily E.; Plummer, Sarah H.; Carter, Cristina A.; Berkowitz, Nina; Conan-Cibotti, Michelle; Cox, Josephine H.; Beck, Allison; O'Callahan, Mark; Andrews, Charla; Gordon, Ingelise J.; Larkin, Brenda; Lampley, Rebecca; Kaltovich, Florence; Gall, Jason; Carlton, Kevin; Mendy, Jason; Haney, Doug; May, Jeanine; Bray, Amy; Bailer, Robert T.; Dowd, Kimberly A.; Brockett, Brittanie; Gordon, David; Koup, Richard A.; Schwartz, Richard; Mascola, John R.; Graham, Barney S.; Pierson, Theodore C.; Donastorg, Yeycy; Rosario, Nicolas; Pape, Jean William; Hoen, Bruno; Cabie, Andre; Diaz, Clemente; Ledgerwood, Julie E. 分享 收藏
Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants Cunningham, Coleen K.; McFarland, Elizabeth J.; Morrison, R. Leavitt; Capparelli, Edmund, V; Safrit, Jeffrey T.; Mofenson, Lynne M.; Mathieson, Bonnie; Valentine, Megan E.; Perlowski, Charlotte; Smith, Betsy; Hazra, Rohan; Purdue, Lynette; Muresan, Petronella; Harding, Paul A.; Mbengeranwa, Tapiwa; Robinson, Lisa-Gaye; Wiznia, Andrew; Theron, Gerhard; Lin, Bob; Bailer, Robert T.; Mascola, John R.; Graham, Barney S. 分享 收藏
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability Dubrovskaya, Viktoriya; Tran, Karen; Ozorowski, Gabriel; Guenaga, Javier; Wilson, Richard; Bale, Shridhar; Cottrell, Christopher A.; Turner, Hannah L.; Seabright, Gemma; O'Dell, Sijy; Torres, Jonathan L.; Yang, Lifei; Feng, Yu; Leaman, Daniel P.; Bernat, Nestor Vazquez; Liban, Tyler; Louder, Mark; McKee, Krisha; Bailer, Robert T.; Movsesyan, Arlette; Doria-Rose, Nicole A.; Pancera, Marie; Hedestam, Gunilla B. Karlsson; Zwick, Michael B.; Crispin, Max; Mascola, John R.; Ward, Andrew B.; Wyatt, Richard T. 分享 收藏
Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial Gaudinski, Martin R.; Houser, Katherine V.; Doria-Rose, Nicole A.; Chen, Grace L.; Rothwell, Ro Shauna S.; Berkowitz, Nina; Costner, Pamela; Holman, LaSonji A.; Gordon, Ingelise J.; Hendel, Cynthia S.; Kaltovich, Florence; Conan-Cibotti, Michelle; Lorenzo, Margarita Gomez; Carter, Cristina; Sitar, Sandra; Carlton, Kevin; Gall, Jason; Laurencot, Carolyn; Lin, Bob C.; Bailer, Robert T.; McDermott, Adrian B.; Ko, Sung-Youl; Pegu, Amarendra; Kwon, Young D.; Kwong, Peter D.; Namboodiri, Aryan M.; Pandey, Janardan P.; Schwartz, Richard; Arnold, Frank; Hu, Zonghui; Zhang, Lily; Huang, Yunda; Koup, Richard A.; Capparelli, Edmund V.; Graham, Barney S.; Mascola, John R.; Ledgerwood, Julie E.; Mendoza, Floreliz; Novik, Laura; Zephir, Kathy; Whalen, William; Larkin, Brenda; Saunders, Jamie; Cunningham, Jennifer; Levinson, Carol; Wang, Xiaolin; Plummer, Sarah; Victorino, Milalynn; Ola, Abidemi; Boyd, Catina; Jayasinghe, Nilusha; Apte, Preeti; Cartagena, Cora Trelles; Hicks, Renunda; Williams, Pernell; Vasilenko, Olga; Yamshchikov, Galina; Florez, Maria Burgos; Pittman, Iris; Gama, Lucio; Casazza, Joseph; DeCederfelt, Hope; Cheng, K. C.; Stein, Judy 分享 收藏
Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields Gorman, Jason; Mason, Rosemarie D.; Nettey, Leonard; Cavett, Nicole; Chuang, Gwo-Yu; Peng, Dongjun; Tsybovsky, Yaroslav; Verardi, Raffaello; Nguyen, Richard; Ambrozak, David; Biris, Kristin; LaBranche, Celia C.; Ramesh, Akshaya; Schramm, Chaim A.; Zhou, Jing; Bailer, Robert T.; Kepler, Thomas B.; Montefiori, David C.; Shapiro, Lawrence; Douek, Daniel C.; Mascola, John R.; Roederer, Mario; Kwong, Peter D. 分享 收藏
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope Schoofs, Till; Barnes, Christopher O.; Suh-Toma, Nina; Golijanin, Jovana; Schommers, Philipp; Gruell, Henning; West, Anthony P., Jr.; Bach, Franziska; Lee, Yu Erica; Nogueira, Lilian; Georgiev, Ivelin S.; Bailer, Robert T.; Czartoski, Julie; Mascola, John R.; Seaman, Michael S.; McElrath, M. Juliana; Doria-Rose, Nicole A.; Klein, Florian; Nussenzweig, Michel C.; Bjorkman, Pamela J. 分享 收藏
Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial Crowell, Trevor A.; Colby, Donn J.; Pinyakorn, Suteeraporn; Sacdalan, Carlo; Pagliuzza, Amelie; Intasan, Jintana; Benjapornpong, Khunthalee; Tangnaree, Kamonkan; Chomchey, Nitiya; Kroon, Eugene; de Souza, Mark S.; Tovanabutra, Sodsai; Rolland, Morgane; Eller, Michael A.; Paquin-Proulx, Dominic; Bolton, Diane L.; Tokarev, Andrey; Thomas, Rasmi; Takata, Hiroshi; Trautmann, Lydie; Krebs, Shelly J.; Modjarrad, Kayvon; McDermott, Adrian B.; Bailer, Robert T.; Doria-Rose, Nicole; Patel, Bijal; Gorelick, Robert J.; Fullmer, Brandie A.; Schuetz, Alexandra; Grandin, Pornsuk V.; O'Connell, Robert J.; Ledgerwood, Julie E.; Graham, Barney S.; Tressler, Randall; Mascola, John R.; Chomont, Nicolas; Michael, Nelson L.; Robb, Merlin L.; Phanuphak, Nittaya; Ananworanich, Jintanat; Ake, Julie; Akapirat, Siriwat; Bose, Meera; Cale, Evan; Chan, Phillip; Chanthaburanun, Sararut; Churikanont, Nampueng; Dawson, Peter; Dumrongpisutikul, Netsiri; Getchalarat, Saowanit; Jongrakthaitae, Surat; Jongsakul, Krisada; Lerdlum, Sukalaya; Manasnayakorn, Sopark; McCullough, Corinne; Milazzo, Mark; Nuntapinit, Bessara; Om, Kier; Ouellette, Madelaine; Phanuphak, Praphan; Sanders-Buell, Eric; Sangnoi, Nongluck; Shangguan, Shida; Sirivichayakul, Sunee; Tragonlugsana, Nipattra; Trichavaroj, Rapee; Ubolyam, Sasiwimol; Vasan, Sandhya; Wattanaboonyongcharoen, Phandee; Yamchuenpong, Thipvadee 分享 收藏
Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine Matsuda, Kenta; Huang, Jinghe; Zhou, Tongqing; Sheng, Zizhang; Kang, Byong H.; Ishida, Elise; Griesman, Trevor; Stuccio, Sarah; Bolkhovitinov, Lyuba; Wohlbold, Teddy J.; Chromikova, Veronika; Cagigi, Alberto; Leung, Kwanyee; Andrews, Sarah; Cheung, Crystal S. F.; Pullano, Alyssa A.; Plyler, Jason; Soto, Cinque; Zhang, Baoshan; Yang, Yongping; Joyce, M. Gordon; Tsybovsky, Yaroslav; Wheatley, Adam; Narpala, Sandeep R.; Guo, Yicheng; Darko, Sam; Bailer, Robert T.; Poole, April; Liang, C. Jason; Smith, Jon; Alexander, Jeff; Gurwith, Marc; Migueles, Stephen A.; Koup, Richard A.; Golding, Hana; Khurana, Surender; McDermott, Adrian B.; Shapiro, Lawrence; Krammer, Florian; Kwong, Peter D.; Connors, Mark 分享 收藏
Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study 靶向埃博拉病毒糖蛋白 (VRC 608) 的治疗性单克隆抗体mAb114的安全性，耐受性，药代动力学和免疫原性: 开放标签1期研究 Gaudinski, Martin R.; Coates, Emily E.; Novik, Laura; Widge, Alicia; Houser, Katherine V.; Burch, Eugeania; Holman, LaSonji A.; Gordon, Ingelise J.; Chen, Grace L.; Carter, Cristina; Nason, Martha; Sitar, Sandra; Yamshchikov, Galina; Berkowitz, Nina; Andrews, Charla; Vazquez, Sandra; Laurencot, Carolyn; Misasi, John; Arnold, Frank; Carlton, Kevin; Lawlor, Heather; Gall, Jason; Bailer, Robert T.; McDermott, Adrian; Capparelli, Edmund; Koup, Richard A.; Mascola, John R.; Graham, Barney S.; Sullivan, Nancy J.; Ledgerwood, Julie E. 分享 收藏
Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual Krebs, Shelly J.; Kwon, Young D.; Schramm, Chaim A.; Law, William H.; Donofrio, Gina; Zhou, Kenneth H.; Gift, Syna; Dussupt, Vincent; Georgiev, Ivelin S.; Schatzle, Sebastian; McDaniel, Jonathan R.; Lai, Yen-Ting; Sastry, Mallika; Zhang, Baoshan; Jarosinski, Marissa C.; Ransier, Amy; Chenine, Agnes L.; Asokan, Mangaiarkarasi; Bailer, Robert T.; Bose, Meera; Cagigi, Alberto; Cale, Evan M.; Chuang, Gwo-Yu; Darko, Samuel; Driscoll, Jefferson, I; Druz, Aliaksandr; Gorman, Jason; Laboune, Farida; Louder, Mark K.; McKee, Krisha; Mendez, Letzibeth; Moody, M. Anthony; O'Sullivan, Anne Marie; Owen, Christopher; Peng, Dongjun; Rawi, Reda; Sanders-Buell, Eric; Shen, Chen-Hsiang; Shiakolas, Andrea R.; Stephens, Tyler; Tsybovsky, Yaroslav; Tucker, Courtney; Verardi, Raffaello; Wang, Keyun; Zhou, Jing; Zhou, Tongqing; Georgiou, George; Alam, S. Munir; Haynes, Barton F.; Rolland, Morgane; Matyas, Gary R.; Polonis, Victoria R.; McDermott, Adrian B.; Douek, Daniel C.; Shapiro, Lawrence; Tovanabutra, Sodsai; Michael, Nelson L.; Mascola, John R.; Robb, Merlin L.; Kwong, Peter D.; Doria-Rose, Nicole A. 分享 收藏
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry Lai, Yen-Ting; Wang, Tao; O'Dell, Sijy; Louder, Mark K.; Schon, Arne; Cheung, Crystal S. F.; Chuang, Gwo-Yu; Druz, Aliaksandr; Lin, Bob; McKee, Krisha; Peng, Dongjun; Yang, Yongping; Zhang, Baoshan; Herschhorn, Alon; Sodroski, Joseph; Bailer, Robert T.; Doria-Rose, Nicole A.; Mascola, John R.; Langley, David R.; Kwong, Peter D. 分享 收藏
Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART Riddler, Sharon A.; Zheng, Lu; Durand, Christine M.; Ritz, Justin; Koup, Richard A.; Ledgerwood, Julie; Bailer, Robert T.; Koletar, Susan L.; Eron, Joseph J.; Keefer, Michael C.; Macatangay, Bernard J. C.; Cyktor, Joshua C.; Mellors, John W. 分享 收藏
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1 Xu, Kai; Acharya, Priyamvada; Kong, Rui; Cheng, Cheng; Chuang, Gwo-Yu; Liu, Kevin; Louder, Mark K.; O'Dell, Sijy; Rawi, Reda; Sastry, Mallika; Shen, Chen-Hsiang; Zhang, Baoshan; Zhou, Tongqing; Asokan, Mangaiarkarasi; Bailer, Robert T.; Chambers, Michael; Chen, Xuejun; Choi, Chang W.; Dandey, Venkata P.; Doria-Rose, Nicole A.; Druz, Aliaksandr; Eng, Edward T.; Farney, S. Katie; Foulds, Kathryn E.; Geng, Hui; Georgiev, Ivelin S.; Gorman, Jason; Hill, Kurt R.; Jafari, Alexander J.; Kwon, Young D.; Lai, Yen-Ting; Lemmin, Thomas; McKee, Krisha; Ohr, Tiffany Y.; Ou, Li; Peng, Dongjun; Rowshan, Ariana P.; Sheng, Zizhang; Todd, John-Paul; Tsybovsky, Yaroslav; Viox, Elise G.; Wang, Yiran; Wei, Hui; Yang, Yongping; Zhou, Amy F.; Chen, Rui; Yang, Lu; Scorpio, Diana G.; McDermott, Adrian B.; Shapiro, Lawrence; Carragher, Bridget; Potter, Clinton S.; Mascola, John R.; Kwong, Peter D. 分享 收藏
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope Zhou, Tongqing; Zheng, Anqi; Baxa, Ulrich; Chuang, Gwo-Yu; Georgiev, Ivelin S.; Kong, Rui; O'Dell, Sijy; Shahzad-ul-Hussan, Syed; Shen, Chen-Hsiang; Tsybovsky, Yaroslav; Bailer, Robert T.; Gift, Syna K.; Louder, Mark K.; McKee, Krisha; Rawi, Reda; Stevenson, Catherine H.; Stewart-Jones, Guillaume B. E.; Taft, Justin D.; Waltari, Eric; Yang, Yongping; Zhang, Baoshan; Shivatare, Sachin S.; Shivatare, Vidya S.; Lee, Chang-Chun D.; Wu, Chung-Yi; Mullikin, James C.; Bewley, Carole A.; Burton, Dennis R.; Polonis, Victoria R.; Shapiro, Lawrence; Wong, Chi-Huey; Mascola, John R.; Kwong, Peter D.; Wu, Xueling 分享 收藏
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity Steinhardt, James J.; Guenaga, Javier; Turner, Hannah L.; McKee, Krisha; Louder, Mark K.; O'Dell, Sijy; Chiang, Chi-I; Lei, Lin; Galkin, Andrey; Andrianov, Alexander K.; Doria-Rose, Nicole A.; Bailer, Robert T.; Ward, Andrew B.; Mascola, John R.; Li, Yuxing 分享 收藏
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