Carl Blobel - Publications, H-index & Citations

Carl Blobel

Weill Cornell Medicine

78H指数

192论文数

2.0W被引数

收录论文 82

发表时间

Structural basis for ADAM17 activation by the iRhom1 pseudoprotease iRhom1伪蛋白酶对ADAM17活化的结构基础

Cell Reports

IF6.9

2026-04-22

OAAI

Joseph N. Ungvary; Joseph J. Maciag; Hala F. Alnajjar; Eliud Morales Dávila; Conner E. Slone; Joel E. Thomas; Maria F. Rich; Sophia A. Carazo; Igal Ifergan; Jose Manuel Perez-Aguilar; Carl P. Blobel; Tom C.M. Seegar

The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis

LIFE SCIENCE ALLIANCE

IF2.9

2025-03-13

OAAI

Jocher, Georg; Ozcelik, Gozde; Mueller, Stephan A.; Hsia, Hung-En; Lastra Osua, Miranda; Hofmann, Laura, I; Assfalg, Marlene; Dinkel, Lina; Feng, Xiao; Schlepckow, Kai; Willem, Michael; Haass, Christian; Tahirovic, Sabina; Blobel, Carl P.; Lichtenthaler, Stefan F.

Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan-Binding Substrates of ADAM17

PROTEOMICS

IF3.9

2024-09-24

OAAI

Calligaris, Matteo; Spano, Donatella Pia; Puccio, Maria Chiara; Mueller, Stephan A.; Bonelli, Simone; Lo Pinto, Margot; Zito, Giovanni; Blobel, Carl P.; Lichtenthaler, Stefan F.; Troeberg, Linda; Scilabra, Simone Dario

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

ELIFE

IF0

2024-06-11

OAAI

Li, Thomas Morgan; Zyulina, Victoria; Seltzer, Ethan S.; Dacic, Marija; Chinenov, Yurii; Daamen, Andrea R.; Veiga, Keila R.; Schwartz, Noa; Oliver, David J.; Cabahug-Zuckerman, Pamela; Lora, Jose; Liu, Yong; Shipman, William D.; Ambler, William G.; Taber, Sarah F.; Onel, Karen B.; Zippin, Jonathan H.; Rashighi, Mehdi; Krueger, James G.; Anandasabapathy, Niroshana; Rogatsky, Inez; Jabbari, Ali; Blobel, Carl P.; Lipsky, Peter E.; Lu, Theresa T.

Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis

JCI INSIGHT

IF6.1

2024-06-10

OAAI

Burg, Nathalie; Malpass, Ryan; Alex, Linda; Tran, Miles; Englebrecht, Eric; Kuo, Andrew; Pannelini, Tania; Minett, Margaret; Athukorala, Kalana; Worgall, Tilla; Faust, Heather J.; Goodman, Susan; Mehta, Bella; Brenner, Michael; Vestweber, Dietmar; Wei, Kevin; Blobel, Carl; Hla, Timothy; Salmon, Jane E.

iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I iRhom2调节主要组织相容性复合体 (MHC) I类的胞外域脱落和表面表达

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2024-04-04

OAAI

Calligaris, Matteo; Spano, Donatella P.; Bonelli, Simone; Mueller, Stephan A.; Carcione, Claudia; D'apolito, Danilo; Amico, Giandomenico; Miele, Monica; Di Bella, Mariangela; Zito, Giovanni; Nuti, Elisa; Rossello, Armando; Blobel, Carl P.; Lichtenthaler, Stefan F.; Scilabra, Simone D.

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

JOURNAL OF IMMUNOLOGY

IF3.4

2023-05-01

OAAI

Zyulina, Victoria; Li, Thomas M.; Seltzer, Ethan S.; Dacic, Marija; Chinenov, Yurii; Daamen, Andrea; Veiga, Keila R.; Schwartz, Noa; Oliver, David J.; Lora, Jose; Jabbari, Ali; Liu, Yong; Munir, Hafsa; Shipman, William D.; Sandoval, Marvin J.; Sollohub, Isabel F.; Ambler, William G.; Mishra, Bikash; Taber, Sarah F.; Onel, Karen B.; Zippin, Jonathan; Rashighi, Mehdi; Krueger, James G.; Anandasabapathy, Niroshana; Rogatsky, Inez; Blobel, Carl P.; Lipsky, Peter E.; Lu, Theresa

L1 is sequentially processed by two differently activated metalloproteases and presenilin/γ-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

233

OAAI

Maretzky, T; Schulte, M; Ludwig, A; Rose-John, S; Blobel, C; Hartmann, D; Altevogt, P; Saftig, P; Reiss, K

ADAM9 Is Involved in Pathological Retinal Neovascularization

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Guaiquil, Victor; Swendeman, Steven; Yoshida, Tsunehiko; Chavala, Sai; Campochiaro, Peter A.; Blobel, Carl P.

ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Hall, Katherine C.; Hill, Daniel; Otero, Miguel; Plumb, Darren A.; Froemel, Dara; Dragomir, Cecilia L.; Maretzky, Thorsten; Boskey, Adele; Crawford, Howard C.; Selleri, Licia; Goldring, Mary B.; Blobel, Carl P.

ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion

EMBO REPORTS

IF6.2

2022-05-08

OAAI

Jocher, Georg; Grass, Vincent; Tschirner, Sarah K.; Riepler, Lydia; Breimann, Stephan; Kaya, Tugberk; Oelsner, Madlen; Hamad, M. Sabri; Hofmann, Laura, I; Blobel, Carl P.; Schmidt-Weber, Carsten B.; Gokce, Ozgun; Jakwerth, Constanze A.; Trimpert, Jakob; Kimpel, Janine; Pichlmair, Andreas; Lichtenthaler, Stefan F.

The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system

FASEB JOURNAL

IF4.2

2021-10-06

OAAI

Tueshaus, Johanna; Mueller, Stephan A.; Shrouder, Joshua; Arends, Martina; Simons, Mikael; Plesnila, Nikolaus; Blobel, Carl P.; Lichtenthaler, Stefan F.

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Lora, Jose; Weskamp, Gisela; Li, Thomas M.; Maretzky, Thorsten; Shola, Dorjee T. N.; Monette, Sebastien; Lichtenthaler, Stefan F.; Lu, Theresa T.; Yang, Chingwen; Blobel, Carl P.

Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice

ANGIOGENESIS

IF9.2

2020-05-08

OAAI

Guahmich, Nicole Lustgarten; Farber, Gregory; Shafiei, Shiva; McNally, Dylan; Redmond, David; Kallinos, Eleni; Stuhlmann, Heidi; Dufort, Daniel; James, Daylon; Blobel, Carl P.

ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)ADAM17稳定其相互作用的伴侣非活性菱形2 (iRhom2)，但不是非活性菱形1 (iRhom1)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-03-01

OAAI

Weskamp, Gisela; Tueshaus, Johanna; Li, Daniel; Feederle, Regina; Maretzky, Thorsten; Swendemann, Steven; Falck-Pedersen, Erik; McIlwain, David R.; Mak, Tak W.; Salmon, Jane E.; Lichtenthaler, Stefan F.; Blobel, Carl P.

Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

FASEB JOURNAL

IF4.2

2020-02-26

OAAI

Tang, Beiyu; Li, Xue; Maretzky, Thorsten; Perez-Aguilar, Jose Manuel; McIlwain, David; Xie, Yifang; Zheng, Yufang; Mak, Tak W.; Weinstein, Harel; Blobel, Carl P.

ADAM10 controls the differentiation of the coronary arterial endothelium

ANGIOGENESIS

IF9.2

2018-11-16

OAAI

Farber, Gregory; Parks, Matthew M.; Guahmich, Nicole Lustgarten; Zhang, Yi; Monette, Sebastien; Blanchard, Scott C.; Di Lorenzo, Annarita; Blobel, Carl P.

INTRIGUING ROLES FOR ENDOTHELIAL ADAM10/NOTCH SIGNALING IN THE DEVELOPMENT OF ORGAN-SPECIFIC VASCULAR BEDS 内皮ADAM10/NOTCH信号在器官特异性血管床发育中的有趣作用

PHYSIOLOGICAL REVIEWS

IF28.7

2018-10-01

OAAI

Alabi, Rolake O.; Farber, Gregory; Blobel, Carl P.

A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2018-08-15

OAAI

Shipman, William D.; Chyou, Susan; Ramanathan, Anusha; Izmirly, Peter M.; Sharma, Sneh; Pannellini, Tania; Dasoveanu, Dragos C.; Qing, Xiaoping; Magro, Cynthia M.; Granstein, Richard D.; Lowes, Michelle A.; Pamer, Eric G.; Kaplan, Daniel H.; Salmon, Jane E.; Mehrara, Babak J.; Young, James W.; Clancy, Robert M.; Blobel, Carl P.; Lu, Theresa T.

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2018-03-05

OAAI

Qing, Xiaoping; Chinenov, Yurii; Redecha, Patricia; Madaio, Michael; Roelofs, Joris J. T. H.; Farber, Gregory; Issuree, Priya D.; Donlin, Laura; Mcllwain, David R.; Mak, Tak W.; Blobel, Carl P.; Salmon, Jane E.

研究方向