未登录 Beyond NAMs versus animal models: Context of use as the governing framework for integrated nonclinical strategies in drug development 超越NAMs与动物模型：使用情境作为药物开发中综合非临床策略的指导框架 Gaburro, Stefano; Berridge, Brian; Kelley, Nicholas W.; von Keutz, Eckhard; Ferrer, Marc; Roper, Clive; Fossler, Michael J.; Bajramovic, Jeffrey J.; Valentin, Jean-Pierre; McGovern, Timothy; Bourcier, Todd; Wange, Ronald L.; Snyder, Kevin; Phelan, Michael A.; Oliphant, Jessica H.; Leishman, Derek J.; Proctor, William R.; Maguire, Sean; Dama, Paola; Nag, Madhu; Williams, Dominic P.; Roth, Adrian; Kanda, Yasunari; Baran, Szczepan 分享 收藏
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Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody 临床前B细胞耗竭及经脑穿梭的结晶片段沉默CD20抗体的安全性特征 Schumacher, Vanessa L.; Pichereau, Solen; Bessa, Juliana; Bachl, Juergen; Herter, Sylvia; Weber, Felix C.; Auer, Johannes; Kipar, Anja; Winter, Michael; Stirn, Martina; Otteneder, Michael B.; Brady, Kevin; Eichinger-Chapelon, Anne; Roth, Adrian; Stokar-Regenscheit, Nadine; Clemann, Nicole; Seger, Shanon; Senn, Claudia; Honig, Juliane; Jany, Cordula; Di Lenarda, Elisa; Tissot, Alain C.; Klein, Christian; von Budingen, H. -Christian; Mader, Robert; Ullah, Mohammed; Janssen, Niels; Urich, Eduard 分享 收藏
Biology-Inspired Dynamic Microphysiological System Approaches to Revolutionize Basic Research, Healthcare and Animal Welfare 仿生动态微生理系统方法：革新基础研究、医疗保健和动物福利 Marx, U; Beken, S; Chen, ZZ; Dehne, EM; Doherty, A; Ewart, L; Fitzpatrick, SC; Griffith, LG; Gu, ZZ; Hartung, T; Hickman, J; Ingber, DE; Ishida, S; Jeong, J; Leist, M; Levin, L; Mendrick, DL; Pallocca, G; Platz, S; Raschke, M; Smirnova, L; Tagle, DA; Trapecar, M; van Balkom, BWM; van den Eijnden-van Raaij, J; van der Meer, A; Roth, A 分享 收藏
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Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems Parvatam, Surat; Pamies, David; Pistollato, Francesca; Beken, Sonja; Mariappan, Indumathi; Roth, Adrian; Piergiovanni, Monica; Maisonneuve, Benoit G. C.; Ewart, Lorna; Majumder, Abhijit; Dandekar, Prajakta; Date, Rahul; Mahadik, Kasturi; Thiyagarajan, Saravanan; Coecke, Sandra 分享 收藏
New approach methodologies in human regulatory toxicology-Not if, but how and when! 人类监管毒理学的新方法-不是如果，而是如何以及何时! Schmeisser, Sebastian; Miccoli, Andrea; von Bergen, Martin; Berggren, Elisabet; Braeuning, Albert; Busch, Wibke; Desaintes, Christian; Gourmelon, Anne; Grafstrom, Roland; Harrill, Joshua; Hartung, Thomas; Herzler, Matthias; Kass, George E. N.; Kleinstreuer, Nicole; Leist, Marcel; Luijten, Mirjam; Marx-Stoelting, Philip; Poetz, Oliver; van Ravenzwaay, Bennard; Roggeband, Rob; Rogiers, Vera; Roth, Adrian; Sanders, Pascal; Thomas, Russell S.; Vinggaard, Anne Marie; Vinken, Mathieu; van de Water, Bob; Luch, Andreas; Tralau, Tewes 分享 收藏
The evolving role of investigative toxicology in the pharmaceutical industry Pognan, Francois; Beilmann, Mario; Boonen, Harrie C. M.; Czich, Andreas; Dear, Gordon; Hewitt, Philip; Mow, Tomas; Oinonen, Teija; Roth, Adrian; Steger-Hartmann, Thomas; Valentin, Jean-Pierre; Van Goethem, Freddy; Weaver, Richard J. J.; Newham, Peter 分享 收藏
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A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs Baier, Vanessa; Clayton, Olivia; Nudischer, Ramona; Cordes, Henrik; Schneider, Annika R. P.; Thiel, Christoph; Wittenberger, Timo; Moritz, Wolfgang; Blank, Lars M.; Neumann, Ulf P.; Trautwein, Christian; Kelm, Jens; Schrooders, Yannick; Caiment, Florian; Gmuender, Hans; Roth, Adrian; Castell, Jose, V; Kleinjans, Jos; Kuepfer, Lars 分享 收藏
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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies Kerns, S. Jordan; Belgur, Chaitra; Petropolis, Debora; Kanellias, Marianne; Barrile, Riccardo; Sam, Johannes; Weinzierl, Tina; Fauti, Tanja; Freimoser-Grundschober, Anne; Eckmann, Jan; Hage, Carina; Geiger, Martina; Ng, Patrick Ray; Tien-Street, William; Manatakis, Dimitris, V; Micallef, Virginie; Gerard, Regine; Bscheider, Michael; Breous-Nystrom, Ekaterina; Schneider, Anneliese; Giusti, Anna Maria; Bertinetti-Lapatki, Cristina; Grant, Heather Shannon; Roth, Adrian B.; Hamilton, Geraldine A.; Singer, Thomas; Karalis, Katia; Moisan, Annie; Bruenker, Peter; Klein, Christian; Bacac, Marina; Gjorevski, Nikolce; Cabon, Lauriane 分享 收藏
Translational precision medicine: an industry perspective 转化精准医学: 行业视角 Hartl, Dominik; de Luca, Valeria; Kostikova, Anna; Laramie, Jason; Kennedy, Scott; Ferrero, Enrico; Siegel, Richard; Fink, Martin; Ahmed, Sohail; Millholland, John; Schuhmacher, Alexander; Hinder, Markus; Piali, Luca; Roth, Adrian 分享 收藏
Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies Vormann, Marianne K.; Vriend, Jelle; Lanz, Henriette L.; Gijzen, Linda; van den Heuvel, Angelique; Hutter, Simon; Joore, Jos; Trietsch, Sebastiaan J.; Stuut, Christiaan; Nieskens, Tom T. G.; Peters, Janny G. P.; Ramp, Daniela; Caj, Michaela; Russel, Frans G. M.; Jacobsen, Bjoern; Roth, Adrian; Lu, Shuyan; Polli, Joseph W.; Naidoo, Anita A.; Vulto, Paul; Masereeuw, Rosalinde; Wilmer, Martijn J.; Suter-Dick, Laura 分享 收藏
Nephroscreen: A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment Vriend, Jelle; Vormann, Marianne K.; Lanz, Henriette L.; Joore, Jos; Trietsch, Sebastiaan J.; Russel, Frans G. M.; Jacobsen, Bjoern; Roth, Adrian; Lu, Shuyan; Polli, Joseph W.; Naidoo, Anita A.; Masereeuw, Rosalinde; Wilmer, Martijn J.; Suter-Dick, Laura 分享 收藏
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Interleukin-2-induced vascular leak syndrome: clinically relevant in vitro recapitulation with a patient-derived lung-on-chip Raggi, Giulia; Roldan, Nuria; Micallef, Virginie; Rapet, Aude; De Maddalena, Lea; Imler, Theo; Froment, Laurene; Marti, Thomas M.; Schmid, Ralph A.; Breous-Nystrom, Ekaterina; Roth, Adrian B.; Cabon, Lauriane; Hobi, Nina 分享 收藏
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