David H. Perlmutter - Publications, H-index & Citations

David H. Perlmutter

pennsylvania commonwealth system of higher education (pcshe)

49H指数

125论文数

1.5W被引数

收录论文 47

发表时间

Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency

HEPATOLOGY

IF15.8

2024-04-01

OAAI

Tafaleng, Edgar N.; Li, Jie; Wang, Yan; Hidvegi, Tunda; Soto-Gutierrez, Alex; Locke, Adam E.; Nicholas, Thomas J.; Wang, Yung-Chun; Pak, Stephen; Cho, Michael H.; Silverman, Edwin K.; Silverman, Gary A.; Jin, Sheng Chih; Fox, Ira J.; Perlmutter, David H.

Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in a1-Antitrypsin Deficiency

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

IF7.4

2024-01-01

OAAI

Li, Jie; Moretti, Francesca; Hidvegi, Tunda; Sviben, Sanja; Fitzpatrick, James A. J.; Sundaramoorthi, Hemalatha; Pak, Stephen C.; Silverman, Gary A.; Knapp, Britta; Filipuzzi, Ireos; Alford, John; Reece-Hoyes, John; Nigsch, Florian; Murphy, Leon O.; Nyfeler, Beat; Perlmutter, David H.

Detecting lithium plating dynamics in a solid-state battery with operando X-ray computed tomography using machine learning

NPJ COMPUTATIONAL MATERIALS

IF11.9

2023-06-01

OAAI

Huang, Ying; Perlmutter, David; Su, Andrea Fei-Huei; Quenum, Jerome; Shevchenko, Pavel; Parkinson, Dilworth Y.; Zenyuk, Iryna V.; Ushizima, Daniela

Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency

HEPATOLOGY COMMUNICATIONS

IF4.6

2023-03-01

OAAI

Li, Yanfeng; Guha, Chandan; Asp, Patrik; Wang, Xia; Tchaikovskya, Tatyana L.; Kim, Kenneth; Mendel, Matthew; Cost, Gregory J.; Perlmutter, David H.; Roy-Chowdhury, Namita; Fox, Ira J.; Conway, Anthony; Roy-Chowdhury, Jayanta

Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome

HEPATOLOGY

IF15.8

2019-03-21

OAAI

Berauer, John-Paul; Mezina, Anya I.; Okou, David T.; Sabo, Aniko; Muzny, Donna M.; Gibbs, Richard A.; Hegde, Madhuri R.; Chopra, Pankaj; Cutler, David J.; Perlmutter, David H.; Bull, Laura N.; Thompson, Richard J.; Loomes, Kathleen M.; Spinner, Nancy B.; Rajagopalan, Ramakrishnan; Guthery, Stephen L.; Moore, Barry; Yandell, Mark; Harpavat, Sanjiv; Magee, John C.; Kamath, Binita M.; Molleston, Jean P.; Bezerra, Jorge A.; Murray, Karen F.; Alonso, Estella M.; Rosenthal, Philip; Squires, Robert H.; Wang, Kasper S.; Finegold, Milton J.; Russo, Pierre; Sherker, Averell H.; Sokol, Ronald J.; Karpen, Saul J.

NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms

CELL DEATH AND DIFFERENTIATION

IF15.4

2018-05-23

OAAI

Mukherjee, Amitava; Hidvegi, Tunda; Araya, Patrick; Ewing, Michael; Stolz, Donna B.; Perlmutter, David H.

Induced pluripotent stem cells model personalized variations in liver disease resulting from 1-antitrypsin deficiency

HEPATOLOGY

IF15.8

2015-04-13

OAAI

Tafaleng, Edgar N.; Chakraborty, Souvik; Han, Bing; Hale, Pamela; Wu, Wanquan; Soto-Gutierrez, Alejandro; Feghali-Bostwick, Carol A.; Wilson, Andrew A.; Kotton, Darrell N.; Nagaya, Masaki; Strom, Stephen C.; Roy-Chowdhury, Jayanta; Stolz, Donna B.; Perlmutter, David H.; Fox, Ira J.

The Aggregation-Prone Intracellular Serpin SRP-2 Fails to Transit the ER in Caenorhabditis elegans

GENETICS

IF5.1

2015-03-18

OAAI

Silverman, Richard M.; Cummings, Erin E.; O'Reilly, Linda P.; Miedel, Mark T.; Silverman, Gary A.; Luke, Cliff J.; Perlmutter, David H.; Pak, Stephen C.

Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2014-07-05

PREAI

O'Reilly, Linda P.; Benson, Joshua A.; Cummings, Erin E.; Perlmutter, David H.; Silverman, Gary A.; Pak, Stephen C.

A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency

HUMAN MOLECULAR GENETICS

IF3.2

2014-05-16

OAAI

O'Reilly, Linda P.; Long, Olivia S.; Cobanoglu, Murat C.; Benson, Joshua A.; Luke, Cliff J.; Miedel, Mark T.; Hale, Pamela; Perlmutter, David H.; Bahar, Ivet; Silverman, Gary A.; Pak, Stephen C.

A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover

HUMAN MOLECULAR GENETICS

IF3.2

2014-05-16

OAAI

Long, Olivia S.; Benson, Joshua A.; Kwak, Joon Hyeok; Luke, Cliff J.; Gosai, Sager J.; O'Reilly, Linda P.; Wang, Yan; Li, Jie; Vetica, Anne C.; Miedel, Mark T.; Stolz, Donna B.; Watkins, Simon C.; Zuechner, Stephan; Perlmutter, David H.; Silverman, Gary A.; Pak, Stephen C.

C. elegans in high-throughput drug discovery 秀丽隐杆线虫在高通量药物发现中的应用

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2014-04-01

206

OAAI

O'Reilly, Linda P.; Luke, Cliff J.; Perlmutter, David H.; Silverman, Gary A.; Pak, Stephen C.

αl-Antitrypsin deficiency and the hepatocytes - An elegans solution to drug discovery Α1-抗胰蛋白酶缺乏症和肝细胞-线虫药物发现的解决方案

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2014-02-01

OAAI

O'Reilly, Linda P.; Perlmutter, David H.; Silverman, Gary A.; Pak, Stephen C.

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-10-01

OAAI

Gregory, Alyssa D.; Hale, Pamela; Perlmutter, David H.; Houghton, A. McGarry

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2011-05-02

OAAI

Ding, Jianqiang; Yannam, Govardhana R.; Roy-Chowdhury, Namita; Hidvegi, Tunda; Basma, Hesham; Rennard, Stephen I.; Wong, Ronald J.; Avsar, Yesim; Guha, Chandan; Perlmutter, David H.; Fox, Ira J.; Roy-Chowdhury, Jayanta

Hepatic Fibrosis and Carcinogenesis in α1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders

cold spring harbor perspectives in medicine

IF8.4

2011-01-12

OAAI

Perlmutter, David H.; Silverman, Gary A.

Microvascular Decompression in Patient With Atypical Features of Hemifacial Spasm Secondary to Compression by a Tortuous Vertebrobasilar System: Case Report

NEUROSURGERY

IF3.9

2010-06-01

PREAI

Perlmutter, David H.; Petraglia, Anthony L.; Barbano, Richard; Schwalb, Jason M.