未登录 Discovery of ORIC-533, an Orally Bioavailable CD73 Inhibitor That Maintains Activity in High AMP Environments to Reverse Tumor Immunosuppression Moore, Jared T.; Kawai, Hiroyuki; Blank, Brian R.; Wu, Kejia; Yeh, Chien-Hung; Zhu, Liusheng; Pham, Johnny D.; Rew, Yosup; Eksterowicz, John; Salaniwal, Sumeet; Sutimantanapi, Dena; Warne, Robert; Yuen, Natalie; Metzger, Todd C.; Chan, Brenda; Huang, Tom; Chen, Xi; Chen, Yuping; Duong, Frank; Kong, Wayne; Chang, Jae H.; Sun, Jessica D.; Zavorotinskaya, Tatiana; Ye, Quiping; Al-Sayah, Mohammad A.; Jackson, Erica; Junttila, Melissa R.; Fantin, Valeria R.; Ndubaku, Chudi O.; Sun, Daqing; Du, Xiaohui; Friedman, Lori S. 分享 收藏
ORIC-114, a highly selective, brain penetrant EGFR and HER2 inhibitor, demonstrates best-in-class properties against Exon 20 insertions and other atypical EGFR mutations Junttila, M.; Repellin, C. E.; Warne, R.; Long, J. E.; Sambucetti, L.; Ashley, P.; Andreatta, G.; Baik, J.; Salaniwal, S.; Colas, C.; Romero, A.; Soroceanu, L.; Patel, R.; Maneval, E. Chow; Multani, P. S.; Daemen, A.; Friedman, L. 分享 收藏
A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death 新型小分子CD73抑制剂引发免疫介导的多发性骨髓瘤细胞死亡 Ray, Arghya; Du, Ting; Wan, Xueping; Song, Yan; Pillai, Sindhu C.; Musa, Md. Abu; Fang, Teng; Moore, Jared; Blank, Brian; Du, Xiaohui; Chen, Xi; Warne, Robert; Sutimantanapi, Dena; Lui, Fang; Zavorotinskaya, Tatiana; Colas, Christophe; Friedman, Lori; Junttila, Melissa R.; Chauhan, Dharminder; Anderson, Kenneth C. 分享 收藏
Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S. 分享 收藏
ORIC-944, a potent and selective allosteric PRC2 inhibitor with best-in-class properties, demonstrates combination synergy with AR pathway inhibitors in prostate cancer models Daemen, Anneleen; Yuen, Natalie; Wang, Amber; Pankov, Aleksandr; Ulicna, Livia; Chen, Chelsea; Duong, Frank L.; Long, Jason; Marx, Matthew A.; Christensen, James G.; Friedman, Lori S.; Junttila, Melissa R. 分享 收藏
ORIC-613, a potential first- and best-in-class, orally bioavailable, potent and selective PLK4 inhibitor with synthetic lethality in TRIM37 high cancer models Edgar, Kyle A.; McRee, Siobhan; Andretta, Gina; Chen, Chelsea; Colas, Christophe; Fang, Wei; Kong, Wayne; Long, Jason; Liu, Fang; Moore, Jared; Pankov, Aleskandr; Shore, Dan; Tan, Joanne; Warne, Robert; Ulicna, Livia; Vekariya, Rakesh; Daemen, Anneleen; Romero, F.; Junttila, Melissa R.; Friedman, Lori S. 分享 收藏
Preclinical activity of ORIC-114, a highly selective, brain penetrant, irreversible kinase inhibitor, against atypical mutations in EGFR Junttila, M. R.; Warne, R.; Repellin, C.; Sambucetti, L.; Chang, J.; Kim, S.; Kim, H. Y.; Shin, D. G.; Park, D. H.; Patel, R.; Maneval, E. Chow; Multani, P. S.; Daemen, A.; Friedman, L. 分享 收藏
Selective PLK4 inhibition demonstrates synthetic lethality in TRIM37 amplified neuroblastoma and breast cancer models while less selective inhibitors do not Mcree, Siobhan K.; Chen, Chelsea; Colas, Christophe; Fang, Wie; Kong, Wayne; Liu, Fang; Long, Jason; Moore, Jared; Pankov, Alex; Shore, Dan; Tan, Joanne; Warne, Robert; Vekariya, Rakesh; Young, Amy; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S.; Edgar, Kyle A. 分享 收藏
Biomarker strategy for a phase 1 study of ORIC-944, a potent and selective allosteric PRC2 inhibitor, in patients with metastatic prostate cancer Daemen, Anneleen; Yuen, Natalie; Pankov, Aleksandr; Ariazi, Eric A.; Katewa, Subhash D.; Duong, Frank L.; Wang, Amber; Barkund, Shravani; Kaushik, Shelly; Sun, Jessica D.; Friedman, Lori S.; Junttila, Melissa R. 分享 收藏
分享 收藏
EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation EHMT2甲基转移酶控制肺中的细胞身份，并且是KRAS G12D肿瘤发展和传播所必需的 Pribluda, Ariel; Daemen, Anneleen; Lima, Anthony Nelson; Wang, Xi; Hafner, Marc; Poon, Chungkee; Modrusan, Zora; Katakam, Anand Kumar; Foreman, Oded; Eastham, Jefferey; Hung, Jefferey; Haley, Benjamin; Garcia, Julia T.; Jackson, Erica L.; Junttila, Melissa R. 分享 收藏
CRAF dimerization with ARAF regulates KRAS-driven tumor growth Venkatanarayan, Avinashnarayan; Liang, Jason; Yen, Ivana; Shanahan, Frances; Haley, Benjamin; Phu, Lilian; Verschueren, Erik; Hinkle, Trent B.; Kan, David; Segal, Ehud; Long, Jason E.; Lima, Tony; Liau, Nicholas P. D.; Sudhamsu, Jawahar; Li, Jason; Klijn, Christiaan; Piskol, Robert; Junttila, Melissa R.; Shaw, Andrey S.; Merchant, Mark; Chang, Matthew T.; Kirkpatrick, Donald S.; Malek, Shiva 分享 收藏
ORIC-114, an orally bioavailable, irreversible kinase inhibitor, has superior brain penetrant properties and enhanced potency in preclinical studies of HER2-positive breast cancer Junttila, Melissa R.; Long, Jason E.; Warne, Robert; Kim, Sunghwan; Lee, Younho; Kim, Hwan; Kang, Juhee; Seok, Jiyoon; Yoo, Jihye; Lee, Youngyi; Seo, Dong-Hyuk Seo; Son, Jung Beom; Kim, Daekwon; Choi, Hwan Geun; Kim, Nam Doo; Zavorotinskaya, Tatiana; Chan, Chelsea; Panuwat, Matthew; Sun, Jessica; Chang, Jae H.; Friedman, Lori S. 分享 收藏
Compressive stress-mediated p38 activation required for ERα plus phenotype in breast cancer Munne, Pauliina M.; Martikainen, Lahja; Raty, Iiris; Bertula, Kia; Nonappa; Ruuska, Janika; Ala-Hongisto, Hanna; Peura, Aino; Hollmann, Babette; Euro, Lilya; Yavuz, Kerim; Patrikainen, Linda; Salmela, Maria; Pokki, Juho; Kivento, Mikko; Vaananen, Juho; Suomi, Tomi; Nevalaita, Liina; Mutka, Minna; Kovanen, Panu; Leidenius, Marjut; Meretoja, Tuomo; Hukkinen, Katja; Monni, Outi; Pouwels, Jeroen; Sahu, Biswajyoti; Mattson, Johanna; Joensuu, Heikki; Heikkila, Paivi; Elo, Laura L.; Metcalfe, Ciara; Junttila, Melissa R.; Ikkala, Olli; Klefstrom, Juha 分享 收藏
分享 收藏
Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production Du, Xiaohui; Moore, Jared; Blank, Brian R.; Eksterowicz, John; Sutimantanapi, Dena; Yuen, Natalie; Metzger, Todd; Chan, Brenda; Huang, Tom; Chen, Xi; Chen, Yuping; Duong, Frank; Kong, Wayne; Chang, Jae H.; Sun, Jessica; Zavorotinskaya, Tatiana; Ye, Qiuping; Junttila, Melissa R.; Ndubaku, Chudi; Friedman, Lori S.; Fantin, Valeria R.; Sun, Daqing 分享 收藏
CD73 inhibition with a novel orally bioavailable small molecule blocks adenosine production and rescues T-cells activation Zavorotinskaya, Tatiana; Blank, Brian; Chan, Brenda; Chen, Chelsea; Chen, Yuping; Du, Xiaohui; Duong, Frank; Friedman, Lori; Huang, Tom; Junttila, Melissa R.; Kong, Wayne; Metzger, Todd C.; Moore, Jared T.; Sun, Daqing; Sun, Jessica; Sutimantanapi, Dena; Yuen, Natalie 分享 收藏
ORIC-101 overcomes glucocorticoid receptor-mediated chemoresistance in pancreatic cancer models Sun, Jessica D.; Zhou, Haiying; Kong, Wayne; Yuen, Natalie; Duong, Frank L.; Barkund, Shravani; Pankov, Aleksandr; McWeeney, Dan; Ye, Qiuping; Kabbarah, Omar; Friedman, Lori S.; Daemen, Anneleen; Junttila, Melissa 分享 收藏
An orally bioavailable inhibitor of CD73 reverts intratumoral immunosuppression and promotes anti-tumor responses Metzger, Todd; Blank, Brian; Chan, Brenda; Chen, Chelsea; Chen, Yuping; Du, Xiaohui; Duong, Frank; Friedman, Lori; Junttila, Melissa; Kawai, Hiro; Kong, Wayne; Moore, Jared; Pham, Johnny; Rew, Yosup; Sun, Daqing; Sun, Jessica; Sutimantanapi, Dena; Wu, Kejia; Yeh, Chien-Hung; Yuen, Natalie; Zavorotinskaya, Tatiana 分享 收藏
Orally available small molecule CD73 inhibitor reverses immunosuppression through blocking of adenosine production Du, Xiaohui; Blank, Brian; Chan, Brenda; Chen, Xi; Chen, Yuping; Duong, Frank; Friedman, Lori; Huang, Tom; Junttila, Melissa R.; Kong, Wayne; Metzger, Todd; Moore, Jared; Sun, Daqing; Sun, Jessica; Sutimantanapi, Dena; Yuen, Natalie; Zavorotinskaya, Tatiana 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
