George S. Bloom - Publications, H-index & Citations

George S. Bloom

university of virginia

52H指数

146论文数

1.2W被引数

收录论文 40

发表时间

The use of memantine for prevention of Alzheimer's disease: Pilot feasibility study rationale and protocol 美金刚用于预防阿尔茨海默病：初步可行性研究的理由与方案

Contemporary Clinical Trials Communications

IF1.4

2026-06-01

OAAI

Arp, Anna M.; Bloom, George S.; D'Abreu, Anelyssa; Fansler, Amy; Meegan, Kimberlee; Ratcliffe, Sarah; Kapur, Jaideep; Manning, Carol

The use of Benzonase to produce ribosome footprints simplifies translational levels quantification by Ribo-seq 利用Benzonase产生核糖体足迹简化了Ribo-seq对翻译水平的定量分析

NAR Genomics and Bioinformatics

IF2.8

2026-05-23

PREAI

Eastman, Guillermo; Bloom, George S.; Sotelo-Silveira, Jose R.

Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer's disease 线粒体对营养素的反应被破坏是阿尔茨海默氏病APPSAA敲入小鼠模型皮质中的症状前事件

ALZHEIMERS & DEMENTIA

IF11.1

2024-08-22

OAAI

Norambuena, Andres; Sagar, Vijay Kumar; Wang, Zhuoying; Raut, Prakash; Feng, Ziang; Wallrabe, Horst; Pardo, Evelyn; Kim, Taylor; Alam, Shagufta Rehman; Hu, Song; Periasamy, Ammasi; Bloom, George S.

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers

ALZHEIMERS & DEMENTIA

IF11.1

2023-12-09

OAAI

Sun, Xuehan; Eastman, Guillermo; Shi, Yu; Saibaba, Subhi; Oliveira, Ana K.; Lukens, John R.; Norambuena, Andres; Thompson, Joseph A.; Purdy, Michael D.; Dryden, Kelly; Pardo, Evelyn; Mandell, James W.; Bloom, George S.

Inceptor as a regulator of brain insulin sensitivity

SCIENTIFIC REPORTS

IF3.9

2023-07-18

OAAI

Post, Lisa A.; Kulas, Joshua A.; Milstein, Joshua L.; Sebastian, Sarah V. L.; Hosseini-Barkooie, Seyyedmohsen; Stevenson, Max E.; Bloom, George S.; Ferris, Heather A.

Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations

FEBS JOURNAL

IF4.2

2023-07-17

PREAI

Sharlow, Elizabeth R. R.; Llaneza, Danielle C. C.; Tewari, Bhanu P. P.; Mingledorff, Garnett A. A.; Mendelson, Anna J. J.; Sontheimer, Harald; Bloom, George S. S.; Lazo, John S. S.

Extracellular Tau Oligomers Damage the Axon Initial Segment

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2023-05-09

OAAI

Best, Merci N.; Lim, Yunu; Ferenc, Nina N.; Kim, Nayoung; Min, Lia; Wang, Dora Bigler; Sharifi, Kamyar; Wasserman, Anna E.; McTavish, Sloane A.; Siller, Karsten H.; Jones, Marieke K.; Jenkins, Paul M.; Mandell, James W.; Bloom, George S.

Localization, induction, and cellular effects of tau phosphorylated at threonine 2171

ALZHEIMERS & DEMENTIA

IF11.1

2023-01-12

OAAI

Rajbanshi, Binita; Guruacharya, Anuj; Mandell, James W.; Bloom, George S.

Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2022-07-20

OAAI

Wu, Ling; Wang, Zerui; Lad, Shradha; Gilyazova, Nailya; Dougharty, Darren T.; Marcus, Madeleine; Henderson, Frances; Ray, W. Keith; Siedlak, Sandra; Li, Jianyong; Helm, Richard F.; Zhu, Xiongwei; Bloom, George S.; Wang, Shih-Hsiu J.; Zou, Wen-Quan; Xu, Bin

SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers

NEUROBIOLOGY OF DISEASE

IF5.6

2022-07-01

OAAI

Norambuena, Andres; Sun, Xuehan; Wallrabe, Horst; Cao, Ruofan; Sun, Naidi; Pardo, Evelyn; Shivange, Nutan; Wang, Dora Bigler; Post, Lisa A.; Ferris, Heather A.; Hu, Song; Periasamy, Ammasi; Bloom, George S.

A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic Mice

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2021-08-17

OAAI

Kuwar, Ram; Rolfe, Andrew; Di, Long; Blevins, Hallie; Xu, Yiming; Sun, Xuehan; Bloom, George S.; Zhang, Shijun; Sun, Dong

Accelerated Maturation of Non-cycling Human Induced Pluripotent Stem Cell-derived neurons for High Content Screening

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Sharlow, Elizabeth; Mendelson, Anna; Llaneza, Danielle; Porterfield, Veronica; Bloom, George; Lazo, John

A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype

NEUROBIOLOGY OF AGING

IF3.5

2020-06-01

OAAI

Porterfield, Veronica; Khan, Shahzad S.; Foff, Erin P.; Koseoglu, Mehmet Murat; Blanco, Isabella K.; Jayaraman, Sruthi; Lien, Eric; McConnell, Michael J.; Bloom, George S.; Lazo, John S.; Sharlow, Elizabeth R.

Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-β Oligomers

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2019-10-15

OAAI

Rudenko, Lauren K.; Wallrabe, Horst; Periasamy, Ammasi; Siller, Karsten H.; Svindrych, Zdenek; Seward, Matthew E.; Best, Merci N.; Bloom, George S.

Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer's Disease and Brain Insulin Resistance, and Its Relation to Cancer

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2019-01-08

OAAI

Koseoglu, Mehmet Murat; Norambuena, Andres; Sharlow, Elizabeth R.; Lazo, John S.; Bloom, George S.

A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers 一种被 β 淀粉样蛋白寡聚体破坏的新型溶酶体-线粒体信号通路

EMBO JOURNAL

IF8.3

2018-10-22

OAAI

Norambuena, Andres; Wallrabe, Horst; Cao, Rui; Wang, Dora Bigler; Silva, Antonia; Svindrych, Zdenek; Periasamy, Ammasi; Hu, Song; Tanzi, Rudolph E.; Kim, Doo Yeon; Bloom, George S.

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

ACTA NEUROPATHOLOGICA

IF9.3

2018-07-11

OAAI

Khan, Shahzad S.; LaCroix, Michael; Boyle, Gabriel; Sherman, Mathew A.; Brown, Jennifer L.; Amar, Fatou; Aldaco, Jacqeline; Lee, Michael K.; Bloom, George S.; Lesne, Sylvain E.

N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease

ALZHEIMERS & DEMENTIA

IF11.1

2018-07-04

OAAI

Kodis, Erin J.; Choi, Sophie; Swanson, Eric; Ferreira, Gonzalo; Bloom, George S.

Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2017-06-05

OAAI

Swanson, Eric; Breckenridge, Leigham; McMahon, Lloyd; Som, Sreemoyee; McConnell, Ian; Bloom, George S.

mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease

ALZHEIMERS & DEMENTIA

IF11.1

2016-09-28

OAAI

Norambuena, Andres; Wallrabe, Horst; McMahon, Lloyd; Silva, Antonia; Swanson, Eric; Khan, Shahzad S.; Baerthlein, Daniel; Kodis, Erin; Oddo, Salvatore; Mandell, James W.; Bloom, George S.

研究方向