Leonard Guarente - Publications, H-index & Citations

Leonard Guarente

Ottawa Hospital Research Institute

117H指数

264论文数

7.1W被引数

收录论文 84

发表时间

Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment 高同型半胱氨酸升高与轻度认知功能障碍人群的表观遗传衰老率增加有关

AGING CELL

IF7.1

2024-06-27

OAAI

Holmes, Holly E.; Valentin, Rafael E.; Jerneren, Fredrik; Loots, Celeste A. de Jager; Refsum, Helga; Smith, A. David; Guarente, Leonard; Dellinger, Ryan W.; Sampson, Dayle

Human trials exploring anti-aging medicines 探索抗衰老药物的人体试验

CELL METABOLISM

IF30.9

2024-02-01

OAAI

Guarente, Leonard; Sinclair, David A.; Kroemer, Guido

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

108

OAAI

Horiuchi, J; Silverman, N; Pina, B; Marcus, GA; Guarente, L

The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

102

OAAI

McNabb, DS; Tseng, KAS; Guarente, L

High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

158

OAAI

Kaeberlein, M; Andalis, AA; Fink, GR; Guarente, L

Telomere shortening exposes functions for the mouse Werner and bloom syndrome genes

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

208

OAAI

Du, XB; Shen, J; Kugan, N; Furth, EE; Lombard, DB; Cheung, C; Pak, S; Luo, GB; Pignolo, RJ; DePinho, RA; Guarente, L; Johnson, FB

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

163

OAAI

Lombard, DB; Beard, C; Johnson, B; Marciniak, RA; Dausman, J; Bronson, R; Buhlmann, JE; Lipman, R; Curry, R; Sharpe, A; Jaenisch, R; Guarente, L

Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

1.2K

OAAI

Lombard, David B.; Alt, Frederick W.; Cheng, Hwei-Ling; Bunkenborg, Jakob; Streeper, Ryan S.; Mostoslavsky, Raul; Kim, Jennifer; Yancopoulos, George; Valenzuela, David; Murphy, Andrew; Yang, Yinhua; Chen, Yaohui; Hirschey, Matthew D.; Bronson, Roderick T.; Haigis, Marcia; Guarente, Leonard P.; Farese, Robert V., Jr.; Weissman, Sherman; Verdin, Eric; Schwer, Bjoern

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial

HEPATOLOGY

IF15.8

2022-11-22

OAAI

Dellinger, Ryan W. W.; Holmes, Holly E. E.; Hu-Seliger, Tina; Butt, Rodney W. W.; Harrison, Stephen A. A.; Mozaffarian, Dariush; Chen, Oliver; Guarente, Leonard

Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease

LIFE SCIENCE ALLIANCE

IF2.9

2019-05-27

OAAI

Glorioso, Christin A.; Pfenning, Andreas R.; Lee, Sam S.; Bennett, David A.; Sibille, Etienne L.; Kellis, Manolis; Guarente, Leonard P.

NAD+ supplementation rejuvenates aged gut adult stem cells NAD补充使衰老的肠道成体干细胞恢复活力

AGING CELL

IF7.1

2019-03-27

105

OAAI

Igarashi, Masaki; Miura, Masaomi; Williams, Eric; Jaksch, Frank; Kadowaki, Takashi; Yamauchi, Toshimasa; Guarente, Leonard

SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis

AGING CELL

IF7.1

2018-10-08

OAAI

Herskovits, Adrianna Z.; Hunter, Tegan A.; Maxwell, Nicholas; Pereira, Katherine; Whittaker, Charles A.; Valdez, Gregorio; Guarente, Leonard P.

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

HEPATOLOGY

IF15.8

2018-05-21

OAAI

Chen, Hanqing; Shen, Feng; Sherban, Alex; Nocon, Allison; Li, Yu; Wang, Hua; Xu, Ming-Jiang; Rui, Xianliang; Han, Jinyan; Jiang, Bingbing; Lee, Donghwan; Li, Na; Keyhani-Nejad, Farnaz; Fan, Jian-gao; Liu, Feng; Kamat, Amrita; Musi, Nicolas; Guarente, Leonard; Pacher, Pal; Gao, Bin; Zang, Mengwei

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota 肠上皮Sirtuin 1通过改变肠道菌群调节小鼠衰老过程中的肠道炎症

GASTROENTEROLOGY

IF25.1

2017-09-01

146

OAAI

Wellman, Alicia S.; Metukuri, Mallikarjuna R.; Kazgan, Nevzat; Xu, Xiaojiang; Xu, Qing; Ren, Natalie S. X.; Czopik, Agnieszka; Shanahan, Michael T.; Kang, Ashley; Chen, Willa; Azcarate-Peril, M. Andrea; Gulati, Ajay S.; Fargo, David C.; Guarente, Leonard; Li, Xiaoling

The brain, sirtuins, and ageing

NATURE REVIEWS NEUROSCIENCE

IF26.7

2017-05-18

146

PREAI

Satoh, Akiko; Imai, Shin-ichiro; Guarente, Leonard

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment 允许SIR2直系同源物在NAD耗尽的环境中发挥作用的突变

CELL REPORTS

IF6.9

2017-03-01

OAAI