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Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors Sharp, Phillip P.; Garnier, Jean-Marc; Hatfaludi, Tamas; Xu, Zhen; Segal, David; Jarman, Kate E.; Jousset, Helene; Garnham, Alexandra; Feutrill, John T.; Cuzzupe, Anthony; Hall, Peter; Taylor, Scott; Walkley, Carl R.; Tyler, Dean; Dawson, Mark A.; Czabotar, Peter; Wilks, Andrew F.; Glaser, Stefan; Huang, David C. S.; Burns, Christopher J. 分享 收藏
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Resto, Yesmalie Aleman; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Juergen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Cassera, Maria Belen; Cheng, Ken Chih-Chien; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colon-Lopez, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L.; Du, Alan Y.; Duffy, Sandra; El-Sayed, Shimaa Abd El-Salam; Ferdig, Michael T.; Robledo, Jose A. Fernandez; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Javier Gamo, Francisco; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; van Huijsduijnen, Rob Hooft; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Jensen, Amornrat Naranuntarat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Jose Lafuente, Maria; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinas, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Vera, Iset Medina; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Rodrigues da Costa, Francielly Morais; Mueller, Joachim; Muriana, Arantza; Hewitt, Stephen Nakazawa; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Ngoc Pham; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Rizk, Mohamed Abdo; Ruecker, Andrea; St Onge, Robert; Ferreira, Rafaela Salgado; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Villela, Filipe Silva; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmueller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Phat Voong Vinh; Hoan Vu; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoit; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A. 分享 收藏
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death 假激酶MLKL的激活释放四螺旋束结构域以诱导膜定位和坏死性细胞死亡 Hildebrand, Joanne M.; Tanzer, Maria C.; Lucet, Isabelle S.; Young, Samuel N.; Spall, Sukhdeep K.; Sharma, Pooja; Pierotti, Catia; Garnier, Jean-Marc; Dobson, Renwick C. J.; Webb, Andrew I.; Tripaydonis, Anne; Babon, Jeffrey J.; Mulcair, Mark D.; Scanlon, Martin J.; Alexander, Warren S.; Wilks, Andrew F.; Czabotar, Peter E.; Lessene, Guillaume; Murphy, James M.; Silke, John 分享 收藏
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Phase I, pharmacokinetic and pharmacodynamic evaluation of CYT997, an orally-bioavailable cytotoxic and vascular-disrupting agent Burge, Matthew; Francesconi, Alessandra B.; Kotasek, Dusan; Fida, Rosa; Smith, Gregg; Wilks, Andrew; Vasey, Paul A.; Lickliter, Jason D. 分享 收藏
The Microtubule Depolymerizing Agent CYT997 Causes Extensive Ablation of Tumor Vasculature In Vivo Burns, Christopher J.; Fantino, Emmanuelle; Powell, Andrew K.; Shnyder, Steven D.; Cooper, Patricia A.; Nelson, Stuart; Christophi, Christopher; Malcontenti-Wilson, Cathy; Dubljevic, Valentina; Harte, Michael F.; Joffe, Max; Phillips, Ian D.; Segal, David; Wilks, Andrew F.; Smith, Gregg D. 分享 收藏
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Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent Lickliter, J. D.; Francesconi, A. B.; Smith, G.; Burge, M.; Coulthard, A.; Rose, S.; Griffin, M.; Milne, R.; McCarron, J.; Yeadon, T.; Wilks, A.; Cubitt, A.; Wyld, D. K.; Vasey, P. A. 分享 收藏
CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo Burns, Christopher J.; Fantino, Emmanuelle; Phillips, Ian D.; Su, Stephen; Harte, Michael F.; Bukczynska, Patricia E.; Frazzetto, Mark; Joffe, Max; Kruszelnicki, Irma; Wang, Bing; Wang, Yue; Wilson, Neil; Dilley, Rodney J.; Wan, Soo S.; Charman, Susan A.; Shackleford, David M.; Fida, Rosa; Malcontenti-Wilson, Cathy; Wilks, Andrew F. 分享 收藏
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages Irvine, Katharine M.; Andrews, Melanie R.; Fernandez-Rojo, Manuel A.; Schroder, Kate; Burns, Christopher J.; Su, Stephen; Wilks, Andrew F.; Parton, Robert G.; Hume, David A.; Sweet, Matthew J. 分享 收藏
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Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk Halford, MM; Armes, J; Buchert, M; Meskenaite, V; Grail, D; Hibbs, ML; Wilks, AF; Farlie, PG; Newgreen, DF; Hovens, CM; Stacker, SA 分享 收藏
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Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach Lackmann, M; Bucci, T; Mann, RJ; Kravets, LA; Viney, E; Smith, F; Moritz, RL; Carter, W; Simpson, RJ; Nicola, NA; Mackwell, K; Nice, EC; Wilks, AF; Boyd, AW 分享 收藏
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