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An epigenetic editor targeting human PCSK9 efficiently and durably lowers Low Density Lipoprotein Cholesterol (LDL-C) in non-human primates Tremblay, F.; Kelly, K.; Shah, S.; El Sebae, G.; Ko, C. W.; Clarkson, S.; Ramirez, R. N.; Hildebrand, E.; Wright, S.; Morrison, M.; Voytek, S.; Abubucker, S.; Friedland, A.; Maeder, M.; Xiong, J. 分享 收藏
Efficacy and safety of bosutinib in previously treated patients with chronic myeloid leukemia: final results from the BYOND trial Gambacorti-Passerini, Carlo; Bruemmendorf, Tim H.; Abruzzese, Elisabetta; Kelly, Kevin R.; Oehler, Vivian G.; Garcia-Gutierrez, Valentin; Hjorth-Hansen, Henrik; Ernst, Thomas; Leip, Eric; Purcell, Simon; Luscan, Gerald; Viqueira, Andrea; Giles, Francis J.; Hochhaus, Andreas 分享 收藏
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Indatuximab ravtansine plus dexamethasone with lenalidomide or pomalidomide in relapsed or refractory multiple myeloma: a multicentre, phase 1/2a study Indatuximab ravtansine联合地塞米松与来那度胺或泊马度胺治疗复发或难治性多发性骨髓瘤: 一项多中心1/2a期研究 Kelly, Kevin R.; Ailawadhi, Sikander; Siegel, David S.; Heffner, Leonard T.; Somlo, George; Jagannath, Sundar; Zimmerman, Todd M.; Munshi, Nikhil C.; Madan, Sumit; Chanan-Khan, Asher; Lonial, Sagar; Chandwani, Suraj; Minasyan, Ashot; Ruehle, Markus; Barmaki-Rad, Farima; Abdolzade-Bavil, Afsaneh; Rharbaoui, Faiza; Herrmann-Keiner, Eva; Haeder, Thomas; Wartenberg-Demand, Andrea; Anderson, Kenneth C. 分享 收藏
GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer GRP78在他莫昔芬耐药乳腺癌中调节CD44v膜稳态和细胞扩散 Tseng, Chun-Chih; Stanciauskas, Ramunas; Zhang, Pu; Woo, Dennis; Wu, Kaijin; Kelly, Kevin; Gill, Parkash S.; Yu, Min; Pinaud, Fabien; Lee, Amy S. 分享 收藏
The novel autophagy inhibitor ROC-325 augments the antileukemic activity of azacitidine Nawrocki, Steffan T.; Han, Yingchun; Visconte, Valeria; Przychodzen, Bartlomiej; Espitia, Claudia M.; Phillips, James; Anwer, Faiz; Advani, Anjali; Carraway, Hetty E.; Kelly, Kevin R.; Sekeres, Mikkael A.; Maciejewski, Jaroslaw P.; Carew, Jennifer S. 分享 收藏
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Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling 内质网应激激活SRC，将分子伴侣重新定位到GRP78/CD109阻断tgf-β 信号传导的细胞表面 Tsai, Yuan-Li; Ha, Dat P.; Zhao, He; Carlos, Anthony J.; Wei, Shan; Pun, Tsam Kiu; Wu, Kaijin; Zandi, Ebrahim; Kelly, Kevin; Lee, Amy S. 分享 收藏
CUDC-907 in relapsed/refractory diffuse large B-cell lymphoma, including patients with MYC-alterations: results from an expanded phase I trial Oki, Yasuhiro; Kelly, Kevin R.; Flinn, Ian; Patel, Manish R.; Gharavi, Robert; Ma, Anna; Parker, Jefferson; Hafeez, Amir; Tuck, David; Younes, Anas 分享 收藏
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Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations Siddiqi, Imran N.; Friedman, Julia; Barry-Holson, Keegan Q.; Ma, Charles; Thodima, Venkata; Kang, Irene; Padmanabhan, Raghavendra; Dias, Lizalynn M.; Kelly, Kevin R.; Brynes, Russell K.; Kamalakaran, Sitharthan; Houldsworth, Jane 分享 收藏
Phase I study of single-agent CC-292, a highly selective Bruton's tyrosine kinase inhibitor, in relapsed/refractory chronic lymphocytic leukemia Brown, Jennifer R.; Harb, Wael A.; Hill, Brian T.; Gabrilove, Janice; Sharman, Jeff P.; Schreeder, Marshall T.; Barr, Paul M.; Foran, James M.; Miller, Thomas P.; Burger, Jan A.; Kelly, Kevin R.; Mahadevan, Daruka; Ma, Shuo; Li, Yan; Pierce, Daniel W.; Barnett, Evelyn; Marine, Jeffrey; Miranda, Monika; Azaryan, Ada; Yu, Xujie; Nava-Parada, Pilar; Mei, Jay; Kipps, Thomas J. 分享 收藏
Acute myeloid leukemia patients' clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts Reis, Bernhard; Jukofsky, Lori; Chen, Gong; Martinelli, Giovanni; Zhong, Hua; So, W. Venus; Dickinson, Michael J.; Drummond, Mark; Assouline, Sarit; Hashemyan, Maneja; Theron, Michel; Blotner, Steven; Lee, Je-Hwan; Kasner, Margaret; Yoon, Sung-Soo; Rueger, Ruediger; Seiter, Karen; Middleton, Steven A.; Kelly, Kevin R.; Vey, Norbert; Yee, Karen; Nichols, Gwen; Chen, Lin-Chi; Pierceall, William E. 分享 收藏
p53-Based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study Ha, Chul S.; Michalek, Joel E.; Elledge, Richard; Kelly, Kevin R.; Ganapathy, Suthakar; Su, Hang; Jenkins, Carol A.; Argiris, Athanassios; Swords, Ronan; Eng, Tony Y.; Karnad, Anand; Crownover, Richard L.; Swanson, Gregory P.; Goros, Martin; Pollock, Brad H.; Yuan, Zhi-Min 分享 收藏
Comprehensive quantitative proteomic profiling of the pharmacodynamic changes induced by MLN4924 in acute myeloid leukemia cells establishes rationale for its combination with azacitidine Visconte, V.; Nawrocki, S. T.; Espitia, C. M.; Kelly, K. R.; Possemato, A.; Beausoleil, S. A.; Han, Y.; Carraway, H. E.; Nazha, A.; Advani, A. S.; Maciejewski, J. P.; Sekeres, M. A.; Carew, J. S. 分享 收藏
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia Kelly, Kevin R.; Shea, Thomas C.; Goy, Andre; Berdeja, Jesus G.; Reeder, Craig B.; McDonagh, Kevin T.; Zhou, Xiaofei; Danaee, Hadi; Liu, Hua; Ecsedy, Jeffrey A.; Niu, Huifeng; Benaim, Ely; Iyer, Swaminathan Padmanabhan 分享 收藏
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