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Timothy R. Billiar

university of pittsburgh
H指数:140
被引数:7.8万
浏览量:0

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Metabolic-epigenetic rewiring of CCR5hi monocytes sustains long-term trained immunity against lethal sepsis

CCR5高表达单核细胞的代谢-表观遗传重编程维持对致命性败血症的长期训练性免疫

Science Advances
IF12.5
2026-08-210
OA
Lingqi Xu; Wenyan Hao; Yingyi Yang; Yu Wang; Yaoshuang Li; Yuan Gong; Yifang Ding; Jie Huang; Zhenjiang Bai; Qiang Shan; Rui Kang; Jiang Huai Wang; Haichao Wang; Timothy R. Billiar; Jian Wang; Daolin Tang; Huiting Zhou
Hallmarks of the multidimensional immune response to trauma in humans

创伤的多维免疫反应特征

Nature Immunology
IF27.6
2026-08-180
PRE
Markus Huber-Lang; Tianmeng Chen; Rebecca Halbgebauer; Timothy Billiar
Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis

髓过氧化物酶锚定的ENO1介导中性粒细胞胞外陷阱DNA，以增强Treg分化，并通过IFITM2在脓毒症期间发挥作用。

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-11-030
OA
Jiang, Yi; Gao, Shenjia; Li, Xiya; Sun, Hao; Wu, Xinyi; Gu, Jiahui; Chen, Zhaoyuan; Wu, Han; Zhao, Xiaoqiang; Zhang, Tongtong; Ben-Ami, Ronen; Le, Yuan; Billiar, Timothy R.; Miao, Changhong; Zhang, Jie; Wang, Jun; Chen, Wankun
A non-canonical immunometabolic function of BRD3 during sepsis

脓毒症期间BRD3的非经典免疫代谢功能

Developmental Cell
IF8.7
2025-10-200
PRE
Nian Wang; Jiao Liu; Runliu Wu; Feng Chen; Chunhua Yu; Herbert Zeh; Xianzhong Xiao; Haichao Wang; Timothy R. Billiar; Ling Zeng; Jianxin Jiang; Daolin Tang; Rui Kang
Correction: Plumbagin protects mice from lethal Sepsis by modulating immunometabolism upstream of PKM2

更正：白花丹素通过调节PKM2上游的免疫代谢来保护小鼠免受致命性脓毒症的影响

Molecular Medicine
IF6.4
2025-07-250
OAAI
Zhaoxia Zhang; Wenjun Deng; Rui Kang; Min Xie; Timothy Billiar; Haichao Wang; Lizhi Cao; Daolin Tang
Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

STING1的核内定位与经典信号通路竞争，以激活AHR，从而维持共生菌和肠道稳态。

Immunity
IF26.3
2025-05-280
PRE
Ruoxi Zhang; Chunhua Yu; Herbert J. Zeh; Haichao Wang; Guido Kroemer; Daniel J. Klionsky; Timothy R. Billiar; Rui Kang; Daolin Tang
A neuroimmune pathway drives bacterial infection

神经免疫通路驱动细菌感染

SCIENCE ADVANCES
IF12.5
2025-05-020
OA
Wang, Nian; Liu, Jiao; Wu, Runliu; Chen, Feng; Zhang, Ruoxi; Yu, Chunhua; Zeh, Herbert; Xiao, Xianzhong; Wang, Haichao; Billiar, Timothy R.; Zeng, Ling; Jiang, Jianxin
Value of animal sepsis research in navigating the translational labyrinth

动物脓毒症研究的价值：在转化医学迷宫中的导航

FRONTIERS IN IMMUNOLOGY
IF5.9
2025-04-150
OA
Wang, Haichao; Ayala, Alfred; Aziz, Monowar; Billiar, Timothy R.; Deutschman, Clifford S.; Jeyaseelan, Samithamby; Tang, Daolin; Wang, Ping
Roles of TLR4 in macrophage immunity and macrophage-pulmonary vascular/lymphatic endothelial cell interactions in sepsis

TLR4在巨噬细胞免疫及巨噬细胞-脓毒症肺血管/淋巴管内皮细胞相互作用中的作用

COMMUNICATIONS BIOLOGY
IF5.1
2025-03-210
OA
Fu, Yu; Gong, Ting; Loughran, Patricia A.; Li, Yuehua; Billiar, Timothy R.; Liu, Youtan; Wen, Zongmei; Fan, Jie
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia (vol 43,114237,2024)

由复合物II产生的ROS氧化的心磷脂作为gasdermin D的靶点，驱动内毒素血症中的线粒体孔形成和心脏功能障碍 (vol 43,114237,2024)

CELL REPORTS
IF6.9
2025-03-010
OAAI
Tang, Yan; Wu, Junru; Sun, Xuejing; Tan, Shasha; Li, Wenbo; Yin, Siyu; Liu, Lun; Chen, Yuanyuan; Liu, Yuanyuan; Tan, Qian; Jiang, Youxiang; Yang, Wenjing; Huang, Wei; Weng, Chunyan; Wu, Qing; Lu, Yao; Yuan, Hong; Xiao, Qingzhong; Chen, Alex F.; Xu, Qingbo; Billiar, Timothy R.; Cai, Jingjing
Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
MILITARY MEDICAL RESEARCH
IF22.9
2024-10-281
OAAI
Gong, Ting; Wang, Qing-De; Loughran, Patricia A.; Li, Yue-Hua; Scott, Melanie J.; Billiar, Timothy R.; Liu, You-Tan; Fan, Jie
Decoding the multiple functions of ZBP1 in the mechanism of sepsis-induced acute lung injury
COMMUNICATIONS BIOLOGY
IF5.1
2024-10-211
OAAI
Gong, Ting; Fu, Yu; Wang, Qingde; Loughran, Patricia A.; Li, Yuehua; Billiar, Timothy R.; Wen, Zongmei; Liu, Youtan; Fan, Jie
Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress (vol 288, pg 15947, 2023)
JOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
2024-09-010
OAAI
Sun, Qian; Gao, Wentao; Loughran, Patricia; Shapiro, Rick; Fan, Jie; Billiar, Timothy R.; Scott, Melanie J.
A unified model-based framework for doublet or multiplet detection in single-cell multiomics data
NATURE COMMUNICATIONS
IF15.7
2024-07-020
OAAI
Hu, Haoran; Wang, Xinjun; Feng, Site; Xu, Zhongli; Liu, Jing; Heidrich-O'Hare, Elisa; Chen, Yanshuo; Yue, Molin; Zeng, Lang; Rong, Ziqi; Chen, Tianmeng; Billiar, Timothy; Ding, Ying; Huang, Heng; Duerr, Richard H.; Chen, Wei
IRG1/ACOD1 promotes neutrophil reverse migration and alleviates local inflammation
JOURNAL OF LEUKOCYTE BIOLOGY
IF3.1
2024-05-071
PRE
Ji, Jingjing; Zhong, Hanhui; Li, Yuehua; Billiar, Timothy R.; Wilson, Mark A.; Scott, Melanie J.; Fan, Jie
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia
CELL REPORTS
IF6.9
2024-05-012
OA
Tang, Yan; Wu, Junru; Sun, Xuejing; Tan, Shasha; Li, Wenbo; Yin, Siyu; Liu, Lun; Chen, Yuanyuan; Liu, Yuanyuan; Tan, Qian; Jiang, Youxiang; Yang, Wenjing; Huang, Wei; Weng, Chunyan; Wu, Qing; Lu, Yao; Yuan, Hong; Xiao, Qingzhong; Chen, Alex F.; Xu, Qingbo; Billiar, Timothy R.; Cai, Jingjing
Patient, family caregiver, and economic outcomes of an integrated screening and novel stepped collaborative care intervention in the oncology setting in the USA (CARES): a randomised, parallel, phase 3 trial
LANCET
IF88.5
2024-04-013
PRE
Steel, Jennifer L.; George, Charles J.; Terhorst, Lauren; Yabes, Jonathan G.; Reyes, Vincent; Zandberg, Dan P.; Nilsen, Marci; Kiefer, Gauri; Johnson, Jonas; Marsh, Christopher; Bierenbaum, Jason; Tageja, Nishant; Krauze, Michal; VanderWeele, Robert; Goel, Gaurav; Ramineni, Gopala; Antoni, Michael; Vodovotz, Yoram; Walker, Jon; Tohme, Samer; Billiar, Timothy; Geller, David A.
Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury
KIDNEY INTERNATIONAL
IF12.6
2024-03-017
OA
Li, Yiming; Hu, Chang; Zhai, Pan; Zhang, Jing; Jiang, Jun; Suo, Jinmeng; Hu, Bo; Wang, Jing; Weng, Xiaocheng; Zhou, Xiang; Billiar, Timothy R.; Kellum, John A.; Deng, Meihong; Peng, Zhiyong
Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials
SCIENTIFIC REPORTS
IF3.9
2024-02-024
OAAI
Donohue, Jack K.; Gruen, Danielle S.; Iyanna, Nidhi; Lorence, John M.; Brown, Joshua B.; Guyette, Francis X.; Daley, Brian J.; Eastridge, Brian J.; Miller, Richard S.; Nirula, Raminder; Harbrecht, Brian G.; Claridge, Jeffrey A.; Phelan, Herb A.; Vercruysse, Gary A.; O'Keeffe, Terence; Joseph, Bellal; Neal, Matthew D.; Billiar, Timothy R.; Sperry, Jason L.
Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery: Impact of Aging and Comparison with Traumatic Injury Response
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
IF3.4
2023-12-141
OAAI
Bonaroti, Jillian W.; Ozel, Mehves; Chen, Tianmeng; Darby, Jennifer L.; Sun, Xuejing; Moheimani, Hamed; Reitz, Katherine M.; Kar, Upendra K.; Zuckerbraun, Brian S.; Das, Jishnu; Okonkwo, David O.; Billiar, Timothy R.

研究方向

暂未获取到该数据
Y
Yoram Vodovotz
H 指数:76论文数:544被引数:2.2万
J
Jason L. Sperry
H 指数:62论文数:369被引数:1.2万
M
Melanie J. Scott
H 指数:46论文数:183被引数:8,371
A
Andrew B. Peitzman
H 指数:82论文数:722被引数:2.5万
P
Patricia Loughran
H 指数:46论文数:195被引数:9,067
J
Joshua B. Brown
H 指数:43论文数:190被引数:6,439
A
Allan Tsung
H 指数:84论文数:598被引数:2.5万
B
Brian S. Zuckerbraun
H 指数:64论文数:272被引数:1.8万
J
Jie Fan
H 指数:57论文数:200被引数:1.7万
D
David A. Geller
H 指数:93论文数:773被引数:3.5万