未登录 Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid Atf4在急性葡萄糖诱导的应激条件下保护胰岛β细胞身份和功能，但在游离脂肪酸存在的情况下促进β细胞功能衰竭。 Yagan, Mahircan; Najam, Sadia; Hu, Ruiying; Wang, Yu; Dickerson, Mathew T.; Dadi, Prasanna K.; Xu, Yanwen; Simmons, Alan J.; Stein, Roland; Adams, Christopher M.; Jacobson, David A.; Lau, Ken S.; Liu, Qi; Gu, Guoqiang 分享 收藏
Defining unique structural features in the MAFA and MAFB transcription factors that control Insulin gene activity Cha, Jeeyeon; Tong, Xin; Coate, Katie C.; Guo, Min; Liu, Jin-hua; Reynolds, Garrett; Walker, Emily M.; Stein, Richard A.; Mchaourab, Hassane; Stein, Roland 分享 收藏
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Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity Cha, Jeeyeon; Tong, Xin; Walker, Emily M.; Dahan, Tehila; Cochrane, Veronica A.; Ashe, Sudipta; Russell, Ronan; Osipovich, Anna B.; Mawla, Alex M.; Guo, Min; Liu, Jin-hua; Loyd, Zachary A.; Huising, Mark O.; Magnuson, Mark A.; Hebrok, Matthias; Dor, Yuval; Stein, Roland 分享 收藏
Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets Coate, Katie C.; Tong, Xin; Liu, Jin-Hua; Jenkins, Regina; Aramandla, Radhika; Dey, Nandita; Kim, Seung; Brissova, Marcela; Powers, Alvin C.; Stein, Roland 分享 收藏
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FoxA2, Nkx2.2, and PDX-1 regulate islet β-cell-specific mafA expression through conserved sequences located between base pairs-8118 and-7750 upstream from the transcription start site Raum, Jeffrey C.; Gerrish, Kevin; Artner, Isabella; Henderson, Eva; Guo, Min; Sussel, Lori; Schisler, Jonathan C.; Newgard, Christopher B.; Stein, Roland 分享 收藏
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression Wiebe, Peter O.; Kormish, Jay D.; Roper, Venus T.; Fujitani, Yoshio; Alston, Ninche I.; Zaret, Kenneth S.; Wright, Christopher V. E.; Stein, Roland W.; Gannon, Maureen 分享 收藏
Islet β-Cell-Specific MafA Transcription Requires the 5'-Flanking Conserved Region 3 Control Domain Raum, Jeffrey C.; Hunter, Chad S.; Artner, Isabella; Henderson, Eva; Guo, Min; Elghazi, Lynda; Sosa-Pineda, Beatriz; Ogihara, Takeshi; Mirmira, Raghavendra G.; Sussel, Lori; Stein, Roland 分享 收藏
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Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation Simonett, Shane P.; Shin, Sunyoung; Herring, Jacob A.; Bacher, Rhonda; Smith, Linsin A.; Dong, Chenyang; Rabaglia, Mary E.; Stapleton, Donnie S.; Schueler, Kathryn L.; Choi, Jeea; Bernstein, Matthew N.; Turkewitz, Daniel R.; Perez-Cervantes, Carlos; Spaeth, Jason; Stein, Roland; Tessem, Jeffery S.; Kendziorski, Christina; Keles, Sunduz; Moskowitz, Ivan P.; Keller, Mark P.; Attie, Alan D. 分享 收藏
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males 性别偏向的胰岛 β 细胞功能障碍是由MODY MAFA S64F变体通过诱导男性过早衰老和衰老引起的 Walker, Emily M.; Cha, Jeeyeon; Tong, Xin; Guo, Min; Liu, Jin-Hua; Yu, Sophia; Iacovazzo, Donato; Mauvais-Jarvis, Franck; Flanagan, Sarah E.; Korbonits, Marta; Stafford, John; Jacobson, David A.; Stein, Roland 分享 收藏
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells 组合转录因子谱预测成熟和功能性人类胰岛 α 和 β 细胞 Shrestha, Shristi; Saunders, Diane C.; Walker, John T.; Camunas-Soler, Joan; Dai, Xiao-Qing; Haliyur, Rachana; Aramandla, Radhika; Poffenberger, Greg; Prasad, Nripesh; Bottino, Rita; Stein, Roland; Cartailler, Jean-Philippe; Parker, Stephen C. J.; MacDonald, Patrick E.; Levy, Shawn E.; Powers, Alvin C.; Brissova, Marcela 分享 收藏
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Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival (vol 53, 390.e1, 2020) Hu, Ruiying; Walker, Emily; Huang, Chen; Xu, Yanwen; Weng, Chen; Erickson, Gillian E.; Coldren, Anastasia; Yang, Xiaodun; Brissova, Marcela; Kaverina, Irina; Balamurugan, Appakalai N.; Wright, Christopher V. E.; Li, Yan; Stein, Roland; Gu, Guoqiang 分享 收藏
MAFA S64F Missense Mutation Causes Islet Beta-Cell Aging and Senescence Cha, Jeeyeon; Walker, Emily M.; Tong, Xin; Guo, Min; Liu, Jin Hua; Yu, Sophia; Iacovazzo, Donato; Mauvais-Jarvis, Franck; Flanagan, Sarah E.; Korbonits, Marta; Stafford, John M.; Stein, Roland 分享 收藏
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