Scott D. Larsen - Publications, H-index & Citations

Scott D. Larsen

michigan state university

45H指数

162论文数

5.0K被引数

收录论文 60

发表时间

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence and chemotherapy resistance in cancer.鉴定MRTFA/SRF通路为癌症中休眠和化疗耐药的关键调节因子。

Cancer Letters

IF10.1

2026-03-12

PREAI

Santiago Panesso-Gómez; Alexander J. Cole; Austin Arrigo; Alex Roberts; Maya Bello; Alyssa Wield; Vivian I. Anyaeche; Stacy McGonigal; Amjad Hijazi; Jaynish Shah; Qi Jiang; Tonge Ebai; Allison C. Sharrow; George Tseng; Euisik Yoon; Daniel D. Brown; Amanda M. Clark; Scott D. Larsen; Ian Eder; David Gau

Occludin S471 Phosphorylation Contributes to Epithelial Monolayer Maturation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Bolinger, Mark T.; Ramshekar, Aniket; Waldschmidt, Helen V.; Larsen, Scott D.; Bewley, Maria C.; Flanagan, John M.; Antonetti, David A.

Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-02-01

OAAI

Huddle, Brandt C.; Grimley, Edward; Chtcherbinine, Mikhail; Buchman, Cameron D.; Takahashi, Cyrus; Debnath, Bikash; McGonigal, Stacy C.; Mao, Shuai; Li, Siwei; Felton, Jeremy; Pan, Shu; Wen, Bo; Sun, Duxin; Neamati, Nouri; Buckanovich, Ronald J.; Hurley, Thomas D.; Larsen, Scott D.

Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-10-09

OAAI

Wilson, Michael W.; Shu, Liming; Hinkovska-Galcheva, Vania; Jin, Yafei; Rajeswaran, Walajapet; Abe, Akira; Zhao, Ting; Luo, Ruijuan; Wang, Lu; Wen, Bo; Liou, Benjamin; Fannin, Venette; Sun, Duxin; Sun, Ying; Shayman, James A.; Larsen, Scott D.

A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor

MOLECULAR PHARMACOLOGY

IF3

2020-06-01

OAAI

Bouley, Renee A.; Weinberg, Zara Y.; Waldschmidt, Helen, V; Yen, Yu-Chen; Larsen, Scott D.; Puthenveedu, Manojkumar A.; Tesmer, John J. G.

Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-02-06

OAAI

Zwicker, Jeffery D.; Smith, David; Guerra, Alfredo J.; Hitchens, Jacob R.; Haug, Nicole; Roest, Steve Vander; Lee, Pil; Wen, Bo; Sun, Duxin; Wang, Lu; Keep, Richard F.; Xiang, Jianming; Carruthers, Vern B.; Larsen, Scott D.

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2019-11-12

OAAI

Rowlands, Rachel A.; Cato, M. Claire; Waldschmidt, Helen V.; Bouley, Renee A.; Chen, Qiuyan; Avramova, Larisa; Larsen, Scott D.; Tesmer, John J. G.; White, Andrew D.

Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells

ONCOGENE

IF7.3

2019-10-28

OAAI

Misek, S. A.; Appleton, K. M.; Dexheimer, T. S.; Lisabeth, E. M.; Lo, R. S.; Larsen, S. D.; Gallo, K. A.; Neubig, R. R.

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine (vol 60, pg 3052, 2017)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-06-12

OAAI

Waldschmidt, Helen V.; Homan, Kristoff T.; Cato, Marilyn C.; Cruz-Rodriguez, Osvaldo; Cannavo, Alessandro; Wilson, Michael W.; Song, Jianliang; Cheung, Joseph Y.; Koch, Walter J.; Tesmer, John J. G.; Larsen, Scott D.

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-04-05

OAAI

Kahl, Dylan J.; Hutchings, Kim M.; Lisabeth, Erika Mathes; Haak, Andrew J.; Leipprandt, Jeffrey R.; Dexheimer, Thomas; Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.; Wen, Bo; Sun, Duxin; Bailie, Marc; Neubig, Richard R.; Larsen, Scott D.

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

CELL REPORTS

IF6.9

2019-03-01

124

OAAI

Chefetz, Ilana; Grimley, Edward; Yang, Kun; Hong, Linda; Vinogradova, Ekaterina V.; Suciu, Radu; Kovalenko, Ilya; Karnak, David; Morgan, Cynthia A.; Chtcherbinine, Mikhail; Buchman, Cameron; Huddle, Brandt; Barraza, Scott; Morgan, Meredith; Bernstein, Kara A.; Yoon, Euisik; Lombard, David B.; Bild, Andrea; Mehta, Geeta; Romero, Iris; Chiang, Chun-Yi; Landen, Charles; Cravatt, Benjamin; Hurley, Thomas D.; Larsen, Scott D.; Buckanovich, Ronald J.

PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-12-01

PREAI

Tanis, Steven P.; Colca, Jerry R.; Parker, Timothy T.; Artman, Gerald D., III; Larsen, Scott D.; McDonald, William G.; Gadwood, Robert C.; Kletzien, Rolf F.; Zeller, James B.; Lee, Pil H.; Adams, Wade J.

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-09-17

OAAI

Huddle, Brandt C.; Grimley, Edward; Buchman, Cameron D.; Chtcherbinine, Mikhail; Debnath, Bikash; Mehta, Pooja; Yang, Kun; Morgan, Cynthia A.; Li, Siwei; Felton, Jeremy; Sun, Duxin; Mehta, Geeta; Neamati, Nouri; Buckanovich, Ronald J.; Hurley, Thomas D.; Larsen, Scott D.

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5 Gedunin和Khivorin衍生物是粘附g蛋白偶联受体GPR56/ADGRG1和GPR114/ADGRG5的小分子部分激动剂

MOLECULAR PHARMACOLOGY

IF3

2018-05-01

OAAI

Stoveken, Hannah M.; Larsen, Scott D.; Smrcka, Alan V.; Tall, Gregory G.

The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2018-03-01

OAAI

Murashov, Mikhail D.; LaLone, Vernon; Rzeczycki, Phillip M.; Keswani, Rahul K.; Yoon, Gi S.; Sud, Sudha; Rajeswaran, Walajapet; Larsen, Scott; Stringer, Kathleen A.; Rosania, Gus R.

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors

MOLECULAR PHARMACOLOGY

IF3

2017-12-01

OAAI

Bouley, Renee; Waldschmidt, Helen V.; Cato, M. Claire; Cannavo, Alessandro; Song, Jianliang; Cheung, Joseph Y.; Yao, Xin-Qiu; Koch, Walter J.; Larsen, Scott D.; Tesmer, John J. G.

Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease

CHEMMEDCHEM

IF3.4

2017-10-09

OAAI

Beck, Michael W.; Derrick, Jeffrey S.; Suh, Jong-Min; Kim, Mingeun; Korshavn, Kyle J.; Kerr, Richard A.; Cho, Woo Jong; Larsen, Scott D.; Ruotolo, Brandon T.; Ramamoorthy, Ayyalusamy; Lim, Mi Hee

Targeting Rho/MRTF regulated gene transcription in drug-resistant melanoma

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Misek, Sean A.; Larsen, Scott D.; Gallo, Kathleen A.; Neubig, Richard R.

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis

SCIENTIFIC REPORTS

IF3.9

2017-03-31

OAAI

Yu-Wai-Man, Cynthia; Spencer-Dene, Bradley; Lee, Richard M. H.; Hutchings, Kim; Lisabeth, Erika M.; Treisman, Richard; Bailly, Maryse; Larsen, Scott D.; Neubig, Richard R.; Khaw, Peng T.

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-03-29

OAAI

研究方向